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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Global Health Management Journal Manuju : Malahayati Nursing Journal PREPOTIF : Jurnal Kesehatan Masyarakat Tunas Medika Jurnal Kedokteran & Kesehatan Indonesian Journal of Applied Research (IJAR) JPM: JURNAL PENGABDIAN MASYARAKAT PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) International Journal of Health and Pharmaceutical (IJHP) Jurnal Sehat Indonesia (JUSINDO) InaBHS (Indonesian Journal of Biomedicine and Health Science)
Marfuati, Sri
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Pengaruh Pemberian Ekstrak Daging Buah Mangga (Mangifera Indica.L) Varietas Gedong Gincu Terhadap Kadar Asam Urat Tikus Putih Jantan yang Dibuat Hiperurisemia Brajawikalpa, Rama Samara; Herdwiyanti, Menik; Marfuati, Sri; Rahayu, Esa Giri; Pitaloka, Amalia Dwi Ayu; Albab, Arthur Ulil
Malahayati Nursing Journal Vol 6, No 3 (2024): Volume 6 Nomor 3 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v6i3.12939

Abstract

ABSTRACT Indonesia has produced many new herbal medicines made from natural ingredients. One of them is the Mango (Mangifera indica L.) gedong gincu variety which has unique phytochemical content including high levels of vitamin C, flavonoids and antioxidants. Flavonoids are known to inhibit xanthine oxidase so they can be used as an alternative treatment for gout.  To analyze the effect of administering gedong gincu variety mango (Mangifera indica L.) extract on the uric acid levels of white rats that cause hyperuricemia.  This is experimental study with pre and post test research design and control group. using 25 male white rats (Rattus norvegicus) Sprague Dawley strain divided into 5 groups, as normal control group (KK1), positive control (KK2), control and 3 experimental groups (KP) received gedong gincu mango pulp extract with doses of 75, 150, and 300 mg/200grBW rats. The data was tested using a One way ANOVA and Post Hoc. There was a statistical difference between before and after being given gedong gincu mango extract from KP 1, KP 2, and KP 3 (p<0.05) and a decrease in uric acid levels (p<0.05) of 3.83, 4.084, and 4.248 mg/dl. Conclusion: There was a significant difference in the uric acid levels of the treatment groups, where gedong gincu mango peel extract at a dose of 300mg/200grBB had the most effective results compared to other doses. Keywords: Hyperuricemia, Mangifera Indica L, Extract of Gedong Gincu Mango Flesh  ABSTRAK Indonesia banyak melahirkan obat-obat herbal baru yang berbahan dasar dari alam. Salah satunya adalah Mangga (Mangifera indica L.) varietas gedong gincu yang memiliki kandungan fitokimia yang khas diantaranya, kandungan vitamin C, flavonoid dan antioksidan yang tinggi tinggi. Flavonoid diketahui dapat menghambat xantin oksidase sehingga dapat dijadikan sebagai alternatif pengobatan pada penyakit asam urat. Menganalisis pengaruh pemberian ekstrak buah mangga (Mangifera indica L.) varietas gedong gincu terhadap kadar asam urat tikus putih yang dibuat hiperurisemia. Penelitian ini bersifat eksperimental dengan rancangan penelitian pre and post test with control group design dengan menggunakan 25 tikus Putih (Rattus norvegicus) jantan galur Sprague dawley yang dibagi menjadi 5 kelompok, yaitu kelompok kontrol normal (KK1), kontrol positif (KK2), dan 3 kelompok perlakuan (KP) yang mendapat ekstrak daging buah mangga gedong gincu dengan dosis bertingkat 75, 150, dan 300 mg/200grBB tikus. Data diuji menggunakan uji one-way ANOVA dan post hoc. Terdapat perbedaan antara sebelum dan sesudah diberikan ekstrak buah mangga gedong gincu dari KP 1, KP 2, dan KP 3 secara statistik (p<0,05) dan penurunan kadar asam urat (p<0,05) sebesar 3,83, 4,084, dan 4,248 mg/dl. Terdapat perbedaan bermakna dari kadar asam urat kelompok perlakuan, dimana ekstrak kulit buah mangga gedong gincu dosis 300mg/200grBB memiliki hasil yang paling efektif dibandingkan dengan dosis lainnya. Kata Kunci: Hiperurisemia, Mangifera Indica L, Ekstrak Daging Buah Mangga Gedong Gincu
Antibacterial Activity of Ethyl Acetat Fraction of Basil Leave (Ocimum Basilicum L) Toward Escherichia Coli Growth Marfuati, Sri; Weni, Mustika; Putri, Inayati Diana
Indonesian Journal of Applied Research (IJAR) Vol. 5 No. 1 (2024): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v5i1.433

Abstract

Antibiotic resistance to Escherichia coli is commonly found. Several studies have found that basil leaves contain chemical compounds: flavonoids, alkaloids, tannins, and saponins, which act as antibacterials. This research aimed to determine the inhibitory power of the ethyl acetate fraction of basil leaves (Ocimum basilicum L) on the growth of Escherichia coli. This study used a post-test-only control group design. This study contained five groups: one positive control group, one negative control group, and three treatment groups. The treatment group consisted of the ethyl acetate fraction of basil leaves at 12.5% μ, 25% μ, and 50% μ. The control group was a positive control K(+) with co-trimoxazole and a negative control K(-) with 10% Dimethyl Sulfoxide (DMSO). Kruskal walls test was chosen, followed by the Mann-Whitney difference test. In the Kruskal Walls test, a significant difference was found (p-value < 0.050) for basil leaf ethyl acetate fraction treatment. The largest average was obtained, namely the ethyl acetate fraction with a concentration of 12.5%. The Mann-Whitney test was carried out to determine fundamental differences between groups. The results of ethyl acetate fraction showed that the Minimum inhibitory concentration (MIC) for Escherichia coli was 12.5%.
PENGARUH EKSTRAK DAUN KELOR (Moringa oleifera) TERHADAP PERTUMBUHAAN FOLIKEL RAMBUT PADA LUKA INSISI TIKUS PUTIH JANTAN Rafsanjani, Ali Rafi; Marfuati, Sri; Nurbaiti
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 2 No 1 (2023)
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v2i1.9261

Abstract

Latar Belakang : Batang rambut merupakan struktur keratin keras yang dihasilkan oleh bangunan epitelial berbentuk kantung yaitu folikel rambut. Rambut yang tebal, panjang, hitam, berkilau dan sehat merupakan keinginan setiap orang, namun tidak semua orang dapat memilikinya. kebotakan juga dapat terjadi apabila kulit mengalami jejas. Pada kondisi ini, kulit akan kehilangan struktur folikel rambut, sehingga pertumbuhan rambut menjadi bermasalah. Salah satu tanaman yang diduga mampu meningkatkan pertumbuhan rambut adalah daun kelor (Moringa oleifera). Tanaman kelor mengandung gizi yang sangat tinggi yang mampu menjadi terapi fitofarmaka. Tujuan : Untuk membuktikan pengaruh ekstrak daun kelor (Moringa oleifera) terhadap pertumbuhan folikel rambut pada luka insisi pada tikus putih jantan. Metode : Penelitian ini merupakan penelitian eksperimental dengan rancangan penelitian post test only control group design. Menggunakan 24 ekor tikus putih jantan (Rattus norvegicus) Galur Sprague dawley yang dikelompokan menjadi empat perlakuan berbeda. Perlakuan dibagi atas kelompok K: kontrol negatif (tidak diberi apa-apa), P1: ekstrak kelor 50%, P2: ekstrak kelor 75%, P3: ekstrak kelor 100%. Hasil : Hasil dari penelitian ini adalah pemberian ekstrak kelor 100% berpengaruh terhadap pertumbuhan budding folikel rambut pada luka insisi tikus putih jantan. Simpulan : Terdapat perbedaan hasil dari tiap-tiap kelompok perlakuan dari masing-masing dosis ekstrak daun kelor dan yang paling berpengaruh terhadap jumlah budding folikel pada luka insisi tikus putih jantan adalah dosis 100%.
UJI AKTIVITAS EKSTRAK BIJI MANGGA (Mangifera indica L.) VARIETAS GEDONG GINCU TERHADAP PERTUMBUHAN Escherichia coli ATCC 6739 Januar, Henny Sholihat; Marfuati, Sri; Apriyanto, Dadan Ramadhan
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 3 No 2 (2024): Indonesian Journal of Biomedicine and Health Science
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v3i2.10522

Abstract

Latar Belakang: Bakteri Escherichia coli termasuk bakteri yang dapat menyebabkan keluhan diare yang disebut sebagai diarrheagenic E. coli. Kejadian diare di dunia mencapai 2 miliar setiap tahunnya dengan angka kematian sebanyak 1,9 juta anak. Namun penggunaan antibiotik jangka panjang dapat menyebabkan terjadinya resistensi, sehingga diperlukan pengobatan alternatif dari bahan alami dari tanaman seperti biji, daun, kulit dan yang lainnya. Salah satunya yaitu biji mangga mengandung senyawa yang bersifat antibakteri yaitu senyawa alkaloid, flavonoid, saponin dan tanin. Tujuan: Mengetahui aktivitas ekstrak biji mangga (Mangifera Indica L.) varietas gedong gincu terhadap pertumbuhan Escherichia coli. Metode: Penelitian ini merupakan penelitian eksperimental dengan menggunakan rancangan penelitian post-test only control group design. Sampel penelitian ini adalah bakteri Escherichia coli galur murni yang dibiakan pada media Muller Hinton Agar yang sesuai standar Mc Farland. Pengujian antibakteri menggunakan metode sumuran untuk melihat zona hambat ekstrak ini terhadap pertumbuhan bakteri Escherichia coli. Hasil: Pada hasil daya hambat paling besar terdapat pada kelompok perlakuan dengan kosentrasi 100% dengan rerata daya hambat 16,1 mm dan daya hambat paling rendah pada konsentrasi 0,1% sebesar 2,41 mm. Hasil uji oneway anova didapatkan hasil p < 0,001 yang menunjukan terdapat adanya perbedaan daya hambat pada setiap kosentrasi ekstrak biji mangga (Mangifera Indica L.) varietas gedong gincu terhadap pertumbuhan Escherichia coli. Simpulan: Ekstrak biji mangga (Mangifera indica L.) varietas memiliki aktivitas antibakteri terhadap Escherichia coli. Kata Kunci: Biji Mangga Gedong Gincu, Escherichia coli. ABSTRACT Introduction: Escherichia coli bacteria including bacteria that can cause complaints of diarrhea are called diarrheagenic E. coli. The incidence of diarrhea in the world reaches 2 billion each year with a mortality rate of 1.9 million children. However, long-term use of antibiotics can cause resistance, so alternative treatments are needed from natural ingredients from plants such as seeds, leaves, skin and others. One of them is that mango seeds contain compounds that are antibacterial, namely alkaloid compounds, flavonoids, saponins and tannins. Aim: To determine the activity of mango seed extract (Mangifera Indica L.) gedong gincu variety on the growth of Escherichia coli. Methods: This research is an experimental research using a post-test only control group design. The sample for this study was a pure strain of Escherichia coli bacteria cultured on Muller Hinton Agar media according to Mc Farland standards. Antibacterial testing used the well method to see the zone of inhibition of this extract against the growth of Escherichia coli bacteria. Results The results of the greatest inhibition were found in the treatment group with a concentration of 100% with an average inhibition of 16.1 mm and the lowest inhibition at a concentration of 0.1% of 2.41 mm. The results of the oneway anova test obtained p <0.001 which indicated that there were differences in inhibition at each concentration of the seed extract of the gedong gincu variety of mango (Mangifera Indica L.) on the growth of Escherichia coli. Conclutions: Mango seed extract (Mangifera indica L.) varieties have antibacterial activity against Escherichia coli.
UJI AKTIVITAS ANTIBAKTERI FRAKSI ETIL ASETAT DAUN KEMANGI (Ocimum basilicum L) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli Putri, Inayati Diana; Marfuati, Sri; Weni, Mustika
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 3 No 2 (2024): Indonesian Journal of Biomedicine and Health Science
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v3i2.10523

Abstract

Latar Belakang : Escherichia coli merupakan bakteri penyebab diare. Banyak yang melaporkan terjadinya resistensi antibiotik terhadap Escherichia coli. Oleh karena itu dibutuhkan alternatif pengobatan. Beberapa penelitian mengatakan Daun Kemangi mengandung zat metabolit sekunder seperti alkaloid, flavonoid, saponin dan tanin yang berfungsi sebagai antibakteri. Tujuan : Mengetahui Daya Hambat Fraksi Etil Asetat Daun Kemangi (Ocimum basilicum L) Terhadap Pertumbuhan Escherichia coli. Metode : Penelitian ini adalah penelitian eksperimental laboratorium dengan rancangan penelitian post-test only control grup design. Penelitian ini menggunakan 5 kelompok, yaitu 2 kelompok kontrol dan 3 kelompok perlakuan. Kelompok perlakuan terdiri dari fraksi etil asetat dari daun kemangi konsentrasi 12,5%, 25% , 50% . Kelompok kontrol yaitu kontrol positif (K(+)) dengan cotrimoxazole dan kontrol negatif (K(-)) yaitu Dimetil Sulfoksida (DMSO) 10%. Data diuji menggunakan uji Kruskal wallis dan dilanjutkan dengan uji beda Mann Whitney Hasil : Pada uji Kruskal walls terdapat perbedaan yang signifikan (p-value < 0,050), terhadap pemberian perlakuan fraksi etil asetat daun kemangi. Didapat rerata terbesar yaitu pada fraksi etil asetat konsentrasi 12,5% 28960000000. Dilanjutkan dengan uji Mann whitney untuk mengetahui perbedaan antar kelompok, didapatkan perbedaan daya hambat pada masing-masing konsentrasi Kesimpulan : Kadar hambat minimum dari fraksi etil asetat daun kemangi terhadap pertumbuhan Escherichia coli konsentrasi 12,5% dengan nilai TPC sebesar 28960000000, dan terdapat perbedaan yang bermakna setiap konsentrasi fraksi etil asetat daun kemangi terhadap pertumbuhan Escherichia coli Kata Kunci : Daun Kemangi, Fraksi, Escherichia coli
Antibiotic Prescription Patterns in Children with Pneumonia at the Waled Regional General Hospital in Cirebon Regency, West Java, 2023 Istiharah, Sherin Nadia; Marfuati, Sri; Brajawikalpa, Rama Samara
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 5 No. 1 (2026): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v5i1.1940

Abstract

Irrational antibiotic use and inappropriate prescribing in pneumonia remain major public health concerns, as they contribute significantly to the development of antimicrobial resistance worldwide. This study aimed to describe the pattern of antibiotic prescribing for pneumonia patients under five years old treated at Waled Hospital, Cirebon Regency, in 2023. A descriptive study design was employed using medical record data, with total sampling applied to all eligible cases. Data were analyzed using univariate analysis and presented as frequencies and percentages. A total of 193 pediatric pneumonia cases were included, consisting of both inpatients and outpatients. Lobular pneumonia was the most common diagnosis in both groups. The majority of patients were one year of age. Third-generation cephalosporins were the most frequently prescribed antibiotic class for inpatients (62.3%) and outpatients (89.1%). Parenteral antibiotic formulations were predominantly administered to inpatients, whereas oral antibiotics were used for all outpatients. The duration of antibiotic therapy was appropriate in all cases. Adverse drug reactions were observed in a small proportion of inpatients and were not reported among outpatients. The predominant use of third-generation cephalosporins, particularly in outpatient settings, suggests a potential overreliance on broad-spectrum antibiotics and may reflect deviation from standard first-line treatment recommendations for pediatric pneumonia. These findings highlight the need for regular evaluation of prescribing practices and the implementation of antimicrobial stewardship programs to promote rational antibiotic use and reduce the risk of resistance.
Potential of Kersen Leaf Extract (Muntingia calabura L) and Basil Leaf Extract (Ocimum basilicum L.) as Natural Antibacterial Candidates against Salmonella typhi Weni, Mustika; Marfuati, Sri; Fitriani, Hikmah
Indonesian Journal of Applied Research (IJAR) Vol. 6 No. 3 (2025): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v6i3.771

Abstract

Salmonella typhi remains a global health issue with rising antibiotic resistance, necessitating alternative natural therapies. Kersen (Muntingia calabura L.) and basil (Ocimum basilicum L.) leaves contain bioactive compounds with antibacterial potential. The purpose of this research was to examine the antibacterial activity of kersen and basil leaf ethanol extracts against Salmonella typhi at various concentrations. The research applied an experimental Post-Test Only Control Group Design. Antibacterial activity assessment was performed using the well diffusion method with varying extract concentrations of 20%, 35%, 45%, 50%, and 75%. Data analysis was performed using the Shapiro–Wilk test was used to examine data normality, while group differences were evaluated with the Kruskal–Wallis non-parametric test. Kersen extract contained saponins, tannins, alkaloids, flavonoids; basil extract contained phenolics, saponins, tannins, alkaloids, steroids, flavonoids. Both showed concentration-dependent inhibition. At 75%, inhibition zones reached 13.15 mm (strong), while the lowest were 4.70 mm (kersen, weak) and 7.30 mm (basil, moderate). Negative control showed no activity. Statistical test p=0.005 confirmed significant differences between groups. Ethanol extracts of kersen and basil leaves possess significant antibacterial activity against S. typhi, supporting their potential as natural phytotherapeutics for typhoid.
The Correlation Between Self Care Management and Blood Sugar Levels in Type 2 Diabetes Melitus Patient in The Working Area of The Kedaton Health Center Nur Aisyah, Tiara; Khasanah, Uswatun; Marfuati, Sri
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 10 No 01 (2026): Qanun Medika Vol 10 No 01 January 2026
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v10i01.24885

Abstract

Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action, or both. Uncontrolled DM progresses to complications. A way to prevent complications is self-care management. To analyze the correlation between self-care management and the blood sugar levels in type 2 diabetes mellitus patients in the working area of Kedaton Health Center. An analytical observational study with a cross-sectional design. Data were collected by completing a questionnaire and measuring blood sugar levels. The sample consisted of 158 respondents, selected using a purposive sampling technique. The analysis test used the Spearman correlation test. There are 98 respondents (62.0%) with poor self-care management and 60 respondents (38.0%) with good self-care management. The majority of respondents have uncontrolled blood sugar levels, namely 132 respondents (83.5%). The results of the Spearman correlation test showed a significant correlation between self-care management and blood sugar levels in type 2 diabetes mellitus patients in the working area of Kedaton Health Center (p-value = 0.002), with a weak positive correlation (r = 0.242). There is a significant correlation between self-care management and blood sugar levels in type 2 diabetes mellitus patients in the working area of Kedaton Health Center. The worse self-care management of the respondents, the more uncontrolled the blood sugar levels will be (³180 mg/dL).
The Antibacterial Activity Test using Ethyl Acetate Fraction from Kersen Leaves (Muntingia calabura L.) against the Staphylococcus aureus Fadilah, Mutiara; Weni, Mustika; Marfuati, Sri
GHMJ (Global Health Management Journal) Vol. 9 No. 1 (2026)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-911232

Abstract

Background: Staphylococcus aureus is a common cause of skin and soft tissue infections (pyoderma) and has developed resistance to multiple antibiotics. Kersen (Muntingia calabura L.) leaves contain bioactive compounds such as flavonoids, triterpenoids, steroids, tannins, and saponins, which have been reported to possess antibacterial properties. Aim: This study aimed to evaluate the in vitro antibacterial activity of the ethyl acetate fraction of M. calabura leaves against S. aureus. Methods: An experimental study with a post-test-only control group design was conducted. Phytochemical screening was performed to identify the secondary metabolites present in the fraction. Antibacterial testing was done using the well diffusion method on Mueller-Hinton Agar (MHA). Five treatment groups (ethyl acetate fractions at concentrations of 100%, 60%, 20%, 10%, and 1%) were compared to a negative control (10% DMSO) and a positive control (doxycycline). Inhibition zones were measured manually in millimeters and analyzed using one-way ANOVA (p < 0.05). Results: The ethyl acetate fraction demonstrated a concentration-dependent antibacterial effect. Mean ± SD inhibition zones were 17.20 ± 1.92 mm (100%), 12.94 ± 1.13 mm (60%), 7.99 ± 0.70 mm (20%), 7.34 ± 0.35 mm (10%), and 6.71 ± 0.85 mm (1%). The positive control showed a significantly higher inhibition zone (33.82 ± 1.62 mm), while the negative control showed no inhibition. Phytochemical screening of the kersen leaf ethyl acetate fraction includes tannins, saponins, steroids, triterpenoids, and phenolics. Conclusion: The ethyl acetate fraction of M. calabura leaves exhibited antibacterial activity against S. aureus. These findings support its potential development as a plant-based antibacterial agent, although further in vivo studies are needed.
Co-Authors Abda Abda Albab, Arthur Ulil Amal, Ichlasul Apriyanto, Dadan Ramadhan Dewi, Asri Permata Emallia Fitriani Fadilah, Mutiara Fathunnisa, Firda Fauzah, Shofa Nur Herdwiyanti, Menik Hery Widijanto Hikmah Fitriani Ignatius Hapsoro Wirandoko Istiharah, Sherin Nadia Istisakinah, Rini Januar, Henny Sholihat Loren, Azzahro Maharani Nasution, Aulia Ananta Nur Aisyah, Tiara Nurbaiti Pitaloka, Amalia Dwi Ayu Putri, Inayati Diana Rafsanjani, Ali Rafi Rahayu, Esa Giri Rama Samara Brajawikalpa Riawan, Firanda Putri Thysa Thysmelia Affandi Weni, Mustika Witri Pratiwi Zaidah, Niklah