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All Journal Pharmascience Jurnal Sehat Mandiri INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Best Journal (Biology Education, Sains and Technology) Journal of Pharmaceutical and Health Research Jurnal EduHealth Jurnal Pijar MIPA Jurnal Matematika Dan Ilmu Pengetahuan Alam LLDikti Wilayah 1 (JUMPA) Jurnal Kedokteran Hewan PharmaCine : Journal of Pharmacy, Medical and Health Science
Mierza, Vriezka
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Journal : Jurnal Sehat Mandiri

 1 
Tinjauan Literatur : Potensi Senyawa Bioaktif Senggugu (Clerodendrum Serratum) sebagai Tanaman Obat Tradisional Andri, Ihsan Alfi; Mierza, Vriezka
Jurnal Sehat Mandiri Vol 20 No 1 (2025): Jurnal Sehat Mandiri, Volume 20 Nomor 1 Juni 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1734

Abstract

This study aims to explore in depth the potential of bioactive compounds contained in the Senggugu plant (Clerodendrum serratum) as a traditional medicinal plant useful in traditional medicine. This research is a systematic review of the literature with data search using PubMed and Google Scholar databases. Inclusion criteria included research related to Clerodendrum serratum, research articles, and published in the last 10 years. From the initial search results of 61 articles, 8 relevant articles were selected for further analysis and it was found that various parts of the plant, especially roots and leaves, contain active compounds such as ursolic acid, flavonoids, saponins, and silver nanoparticles, which exhibit significant anti-inflammatory, antioxidant, antimicrobial, and antarthritic properties. Laboratory and in silico studies support the effectiveness of the compound in inhibiting the activity of inflammatory enzymes and proinflammatory cytokines, such as COX-2 and TNF-α, which are involved in inflammatory processes and other chronic diseases. This therapeutic potential suggests that Senggugu can be a safe and natural alternative in the treatment of various diseases, while supporting efforts to utilize local plant resources to improve public health.
Kajian Literatur: Efektivitas Tanaman Kumis Kucing (Orthosiphon Stamineus) sebagai Alternatif Obat Anti-Diabetik Ardhita, Intan; Mierza, Vriezka
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1735

Abstract

Diabetes mellitus (DM) is one of the degenerative diseases that requires long-term management to maintain stable blood glucose levels. The side effects of conventional antidiabetic drugs have prompted the search for alternative therapies that are safer and more effective. Orthosiphon stamineus (commonly known as Java tea or cat’s whiskers), a herbal plant well-known in Indonesia, contains active compounds such as flavonoids, tannins, and saponins that have potential antidiabetic properties. This article aims to review the potential of Orthosiphon stamineus in lowering blood glucose levels through a literature review of previous research findings. The method used is a literature review by searching databases such as Google Scholar and PubMed using keywords like "Orthosiphon stamineus", "antidiabetic", and "blood glucose." A total of seven relevant scientific journals published between 2015 and 2023 were selected based on topic relevance, full-text accessibility, and the use of both in vitro and in vivo tests. The study results show that Orthosiphon stamineus leaf extract significantly reduces blood glucose levels, inhibits the α-glucosidase enzyme, and enhances GLUT4 translocation and insulin secretion. Conclusion: Cat’s whisker extract (Orthosiphon stamineus) has been proven to significantly reduce blood glucose levels through mechanisms of GLUT4 enhancement, insulin secretion, and α-glucosidase inhibition in diabetic animal models. Further research is recommended to confirm its effectiveness and safety in humans.
Article Review: Potensi Senyawa Xanthone dalam Ekstrak Kulit Manggis (Garcinia Mangostana l.) sebagai Senyawa Aktif Obat Khuriyah, Khuriyah; Mierza, Vriezka
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1736

Abstract

The high prevalence of communicable and non-communicable diseases in Indonesia, such as periodontal disease, malaria, diabetes, and Alzheimer’s, highlights the need for safer and more affordable alternative therapies. One promising natural source is mangosteen (Garcinia mangostana L.), which contains xanthone compounds with diverse biological activities. This study aims to review the potential of xanthones from mangosteen pericarp extract as active drug candidates. A comprehensive literature review was conducted by searching articles in Scopus, Google Scholar, and PubMed databases using relevant keywords including “xanthone” and “Garcinia mangostana.” Eligible articles were selected based on inclusion criteria (2014–2024, full-text availability, relevance, and reputable indexing). From 221 identified studies, 9 key articles were analyzed in detail. The findings reveal that xanthone compounds exhibit a wide range of pharmacological activities, including antibacterial, antimalarial, antidiabetic, anticancer, cardioprotective, anti-Alzheimer’s, protective effects against oxidative stress in keratinocytes, and potential COVID-19 therapy through ACE2 and Mpro blockade. These results suggest that xanthones from mangosteen peel hold great potential to be developed as active compounds in modern herbal medicines. Nevertheless, further studies, particularly clinical trials, are required to validate their safety and efficacy.
Co-Authors Advaita, Chalisya Vanya Aisiyah, Adella Ananda, Meisya Dwi Andri, Ihsan Alfi Andriani, Nadia Apriani, Risa Dwi Ardhita, Intan Ariani, Peny Arsylrakhmatika, Giga Anugrah BAKRI, TEDY KURNIAWAN Barus, Bunga Rimta Debora, Priscinya Christiana GINTING, SELAMAT Hasna, Vina Luthfiana Irwansyah, Silvana Lestari Iskandar, Putri Mutiara Jekmal Malau Khaerunisa, Aulia Khuriyah . Meliala, Linta Muhammad Hanafi Munir Alinu Mulki Nailuvar, Regita Nerdy, Nerdy Nilsya Febrika Zebua, Nilsya Febrika Nisa, Dila Qhoirul Odhia, Febry Nola Pandiangan, Martina Panjaitan, M Ridho Pangestu PUJI LESTARI Razali, Mariany Sakinah, Irene Virda Saputri, Muharni Septimar, Elviza Sudarjat, Hadi Tyasna, Putri Setya Urbaningrum , Lestari Mahardika Yessi Febriani