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All Journal Folia Medica Indonesiana Jurnal NERS MNJ (Malang Neurology Journal) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology AKSONA Asian Journal of Health Research
Machin, Abdulloh
3Departement Of Neuorology, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

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Analysis of Potential Cinnamomum zeylanicum Blume Essential Oil Against Alzheimer's Disease: A Molecular Docking Study Muhammad Ja'far Shodiq; Farmindo Hartono; Siti Khaerunnisa; Abdulloh Machin
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 1 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i12023.111-125

Abstract

Background: Alzheimer's Disease (AD) is a neurodegenerative disorder with progressive impairment of behavioural and cognitive functions and the most common cause of dementia. The pathophysiology of AD is associated with low acetylcholine, accumulation of amyloid beta plaque, and neurofibrillary tangles in the brain. Cinnamomum zeylanicum is known to have many medicinal properties, especially neuroprotective effects. Objective: This research was designed to determine the neuroprotective potential of the phytochemicals C. zeylanicum using an in silico study. Methods: There are 5 phytochemicals compounds of C. zeylanicum used in this study. It's qualified for Lipinski's rules of five and can cross blood brain barrier. The protein targets were AChE, BACE1, and GSK-3. Molecular docking and visualization were performed using Avogadro, AutoDock 4.2 PyMol and Biovia Discovery Studio 2019. Results: In silico results show that the main phytochemical compounds of C. zeylanicum Blume essential oil have great potency as an AD drug. The best interaction model of the compound was shown by trans-cinnamyl acetate and coumaric acid. Although the binding energy of the compounds is lower than AD drugs (donepezil, rivastigmine, galantamine), the binding energy is not much different from rivastigmine and galantamine. Conclusion: The phytochemical compounds of C. zeylanicum Blume essential oil have an effect as a neuroprotective agent for AD and should be investigated in future research.
Co-Authors Afif Nurul Hidayati, Afif Nurul Alia, Safia Anny Hanifah Aris Widayati Arlia Ayu Damayanti Ayu Imamatun Nisa Azizah Amimathul Firdha Baarid Luqman Hamidi Basuki, Mudjiani Beom Joon Kim Christrijogo Soemartono Waloejo Dedy Kurniawan Devi Ariani Sudibyo Dewi Sekarsari Didik Hasmono Djoko Agus Suprapto Edfina Rahmarini Fahmi Achmad Faisal Fahmi, Achmad Farmindo Hartono Farmindo Hartono Fauzi, Asra Al Fedik Abdul Rantam Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Husni, Nadya Imami, Nabilah Hasna Isti Suharjanti Jakfar Shodiq Jeffri Nagasastra Jenar Harumi Jovian Philip Swatan M Fata Fatihuddin Meo, Maria Lettisia Mohammad Fathul Qorib Muhammad Hamdan Muhammad Hamdan Muhammad Ja'far Shodiq Muhammad Ja'far Shodiq Nabilah Hasna Imami Nadiva, Shafa Karin Nugraha, Priya Paulus Sugianto Paulus Sugianto, Paulus Pearl Dhodik Wirasman Prastiya I. Gunawan Priya Nugraha Rahmarini, Edfina Retnaningsih Safia Alia Savira Dienanta Sensusiati, Anggraini Dwi Setjaputra, Vina Lidya Shodiq, Muhammad Ja'far Siti Khaerunnisa Siti Khaerunnisa Soetjipto Soetjipto Steven Christian Susianto Sugondo, Alexander Tikara Susianto, Steven Christian Swatan, Jovian Philip Talaway, Athalia Anastasia Turchan, Agus Vina Lidya Setjaputra Viskasari P. Kalanjati Wibi Riawan