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All Journal Jurnal NERS MNJ (Malang Neurology Journal) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology AKSONA Asian Journal of Health Research Folia Medica Indonesiana

Machin, Abdulloh

3Departement Of Neuorology, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia

Author-ID : 1784012

Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

Published : 24 Documents Claim Missing Document

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Articles

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Penyakit Parkinson: Tinjauan Tentang Salah Satu Penyakit Neurodegeneratif yang Paling Umum Safia Alia; Hanik Badriyah Hidayati; Muhammad Hamdan; Priya Nugraha; Achmad Fahmi; Agus Turchan; Yudha Haryono
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Penyakit Parkinson (PP) adalah penyakit neurodegeneratif paling umum ke dua yang melibatkan hilangnya neuron dopaminergik di otak tengah yang menyebabkan gejala motorik dan nonmotorik pada pasien yang mengalaminya. Gejala motorik ini dapat dikelola dan dikendalikan dalam jangka waktu tertentu dengan menggunakan obat-obatan seperti levodopa. PP mempengaruhi jutaan orang di seluruh dunia, oleh karena itu tinjauan pustaka tinjauan pustaka tentang PP menjadi penting dan kami akan menyampaikan berbagai hal penting dari PP mulai dari patofisiologi hingga tindakan pengobatan baik medikamentosa maupun tindakan intervensi.

Are Abbreviated Mental Test (AMT) and Ascertain Dementia 8 Indonesia (AD8-INA) Questionnaires More Superior than Mini-Mental State Examination (MMSE) as Dementia Screening Instrument among Elderly in Rural Areas? Jovian Philip Swatan; Yudha Haryono
AKSONA Vol. 2 No. 1 (2022): JANUARY 2022
Publisher : Universitas Airlangga

Introduction: Dementia screening provides numerous benefits to its users. However, current screening methods have several limitations regarding applicability and accuracy, making it difficult to accommodate the results. Objective: To describe whether the Abbreviated Mental Test (AMT) and Ascertain Dementia 8 Indonesia (AD8-INA) questionnaire is superior to Mini-Mental State Examination (MMSE) questionnaire as a dementia screening instrument for the elderly in rural areas. Methods: A cross-sectional study was conducted in February 2020 at Banyuwangi residence. Dementia screening was conducted among elderly respondents using MMSE, AMT, and AD8-INA questionnaires. Sensitivity and specificity of AMT, AD8-INA and combined AMT+AD8-INA were compared with the MMSE questionnaire using crosstabs. Comparison of time required to complete each questionnaire was analyzed using Wilcoxon Signed Rank Test. Results: Mean age among 59 respondents was 68.44 years. The average MMSE score was 24.54. Compared with MMSE, the AMT questionnaire had a sensitivity of 47.37% and specificity of 100% (X2 = 22.36, p <0.001). Meanwhile, the AD8-INA questionnaire had a sensitivity of 63.16% and specificity of 45% (X2 = 24.64, p <0.001). The average questionnaire completion time of AMT, AD8-INA, and combined AMT+AD8-INA each was significantly shorter than MMSE (122.59, 121.17, and 243.76 seconds vs 319.83 seconds, p<0.001, <0.001, and <0.001, respectively). Conclusion: This study found that the combined AMT+AD8-INA questionnaire could be used as a dementia screening instrument among the elderly in rural areas with considerable sensitivity and shorter administration time.

Multiple Sistem Atrophy: Sebuah Laporan Kasus Edfina Rahmarini; Muhammad Hamdan; Priya Nugraha; Paulus Sugianto; Yudha Haryono
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Pendahuluan: Multiple sistem atrophy adalah penyakit degeneratif yang dapat menyebabkan kecacatan bahkan kematian. Sedikit jurnal yang yang membahas tentang diagnosis dan penanganan multiple system atrophy secara menyeluruh. Kasus: Seorang laki-laki berusia 44 tahun datang ke poli saraf dengan keluhan kelemahan pada keempat ekstremitas dengan disertai gejala parkinsonisme yang khas. Pada pemeriksaan neurologis didapatkan gangguan fungsi serebelum. Pada pemeriksaan MRI kepala dengan kontras didapatkan gambaran khas suatu multipel system atrophy tipe cerebellar. Kesimpulan: Multipel system atrophy adalah kasus degeneratif yang bersifat jarang namun seringkali dapat menyebabkan kematian. Dibutuhkan diagnosis yang cepat dan penanganan yang memadai secara multidisiplin untuk mencegah beratnya gejala multiple system atrophy. Terapi simptomatik dan suportif sangat dibutuhkan untuk meningatkan kualitas hidup pasien.

Komorbiditas Pasien Demensia di RSUD Dr. Soetomo Periode Januari–Desember 2017 Nabilah Hasna Imami; Yudha Haryono; Anggraini Dwi Sensusiati; Muhammad Hamdan; Hanik Badriyah Hidayati
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Pendahuluan: Demensia merupakan proses hilangnya fungsi kognitif seperti berpikir, mengingat, dan bernalar sehingga penderita demensia terganggu dalam melakukan kehidupan dan aktivitas sehari-hari pada seseorang. WHO menyebutkan bahwa jumlah pasien demensia di dunia terus meningkat. Pada tahun 2015, pasien demensia diprediksi mencapai 47,47 juta pasien dan dapat mencapai 75,63 juta pada 2030. Semakin meningkat usia lansia, faktor komorbiditas yang menyerang lansia juga semakin meningkat. Faktor komorbiditas dapat berupa penyakit kronik seperti stroke, hipertensi, DM, juga penyakit jantung. Tujuan: Untuk mengetahui prevalensi komorbiditas pada pasien lansia demensia di RSUD Dr. Soetomo Surabaya. Metode: Data diambil dari rekam medis pasien pada periode Januari hingga Desember 2017 di RSUD Dr. Soetomo Surabaya berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan. Hasil: Faktor komorbiditas yang paling banyak terjadi pada pasien demensia adalah stroke (57,3%), diikuti oleh hipertensi (50,6%), DM (30,3%), penyakit Parkinson (24,7%), dan penyakit Jantung (19,1%). Kesimpulan: Stroke merupakan komorbiditas paling banyak terjadi pada pasien dengan demensia. Hipertensi berada di tempat kedua paling banyak diderita lansia demensia. Pengendalian komorbiditas pada lansia sangat penting untuk dilaksanakan untuk mengendalikan risiko terjadinya penurunan fungsi kognitif.

In Silico Analysis of Pongamia pinnata to Inhibit Neuronal Apoptosis after Ischemic Stroke via NMDAR and Caspase-3 Muhammad Ja'far Shodiq; Farmindo Hartono; Siti Khaerunnisa; Abdulloh Machin
AKSONA Vol. 3 No. 2 (2023): JULY 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v3i2.44759

Highlight: The potential of Pongamia pinnata as an inhibitor of apoptosis in ischemic stroke has never been evaluated before. Pongamia pinnata has potential to inhibit neuronal apoptosis via NMDAR and Caspase-3 in ischemic stroke. Karanjachromene has the best binding interaction to inhibit NMDAR. ABSTRACT Introduction: One of the cardiovascular diseases with the highest mortality rate is stroke. Stroke is the second-leading cause of death worldwide. Each year, 12.2 million new cases of stroke occur, of which 7.6 million are ischemic strokes. In ischemic stroke, there are several pathways that cause neuronal apoptosis. The activity of NMDAR and caspase-3 is one of the pathways. Pongamia pinnata phytochemicals have a neuroprotective function against neurological disorders. However, its use as an inhibitor of apoptosis in ischemic stroke has never been evaluated before. Objective: This research was designed to evaluate the phytochemicals of Pongamia pinnata as inhibitors of neuronal apoptosis in ischemic stroke using an in silico study. Methods: This study used four main phytochemicals of Pongamia pinnata, namely Karanjin, Karanjachromene, Pongapin, and Pongachromene. The protein targets for neuronal apoptosis were NMDAR and caspase-3. The molecular docking processes were ligand preparation, protein preparation, grid box determination, molecular docking, and visualized molecular docking. Results: In silico results showed that at NMDAR target proteins, Karanjin, Karanjachromene, Pongapin, and Pongachromene have binding energies of -5.12, -5.83, -5.03, and -5.13 kcal/mol. At protein targets, Caspase-3, Karanjin, Karanjachromene, Pongapin, and Pongachromene have binding energies of -4.87, -4.98, -4.88, and -5.08 kcal/mol. Conclusion: The phytochemicals of Pongamia pinnata have the potential to inhibit neuronal apoptosis via NMDAR and caspase-3 in ischemic stroke. The binding of Karanjachromene to NMDAR demonstrated the compound's best interaction.

D-Dimer Levels as a Predictor of Clinical Outcome and Mortality in Acute Ischemic Stroke Patients: A Systematic Review and Meta-Analysis Pearl Dhodik Wirasman; Abdulloh Machin; Jenar Harumi
AKSONA Vol. 3 No. 2 (2023): JULY 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v3i2.44770

Highlight: An increase in the D-dimer level indicates activation of the coagulation system through thrombus formation and fibrinolysis. The meta-analysis found a significant relationship between elevated d-dimer levels and worsening clinical outcomes and increased mortality. The D-dimer level can be used as a predictor for predicting clinical outcomes and mortality in acute ischemic stroke patients at each duration of follow-up. ABSTRACT Introduction: In ischemic stroke, high D-dimer levels are frequently found, indicating coagulation with ongoing thrombus formation and fibrinolysis. Objective: The purpose of this study was to analyze the role of D-dimer in predicting clinical outcomes and mortality in acute ischemic stroke patients. Methods: A systematic literature search was conducted using the PRISMA method through the PubMed, Science Direct, and Google Scholar databases. The quality of the article was assessed using the Newcastle-Ottawa Scale (NOS) and statistically analyzed using Review Manager software version 5.4.1. Results: Eight articles had good quality according to NOS and matched the criteria for the literature search. Elevated D-dimer levels and worsened clinical outcomes have a significant result when discharged from the hospital: OR 2.37 (95% CI 1.68–3.35); I2 = 45% p < 0.00001; 1-month: OR 1.75 (95% CI 1.38–2.23), I2 = 47% p < 0.00001; 3-months: OR 2.43 (95% CI 2.00–2.95), I2 0% p < 0.00001; 6-months: OR 2.64 (95% CI 1.92–3.63), I2 = 0% p < 0.00001; and 12-months: OR 1.92 (95% CI 1.31–2.82), I2 = 62% p < 0.0008. Elevated D-dimer level and increased mortality have a significant result with OR 2.25 (95% CI 1.78–2.85), I2 = 45% p < 0.00001. Conclusion: D-dimer can be used as a predictor of clinical outcome and mortality in acute ischemic stroke.

Clinical Improvement of Chronic Spinal Cord Injury and Immune Thrombocytopenia (ITP) with Corticosteroids Administration: A Case Report Talaway, Athalia Anastasia; Machin, Abdulloh; Kurniawan, Dedy
AKSONA Vol. 5 No. 2 (2025): JULY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i2.53453

Highlight: Understanding the causes and associated factors of of spinal cord injury (SCI) is important. Immune thrombocytopenia may contribute to spinal cord injury. Corticosteroid therapy for ITP, has shown improved clinical outcomes. ABSTRACT Introduction: Spinal cord injury (SCI) is a significant medical condition caused by either traumatic events or pathological diseases, which leads to neurological deficits and various levels of motor, sensory, and autonomic dysfunction. Several treatments, including corticosteroids, have been proposed to reduce secondary neuronal damage, but they are still controversial. Meanwhile, immune thrombocytopenia (ITP) can be treated with corticosteroids. The lack of research necessitates a review of steroids as a therapy for ITP and spinal cord trauma. Case: A 76-year-old woman complained of weakness in both legs for 15 days before being admitted to the hospital.The weakness was noticed after experiencing a fall. Additionally, the patient complained about having difficulty with both defecating and urinating. On examination, muscle strength in the lower limbs was graded 4 on both sides according to the Medical Research Council (MRC) scale. The classification of the American Spinal Injury Association (ASIA) score was D, with neurological level injury (NLI) at the 6th thoracic level with immune thrombocytopenia (ITP). Considering the patient's condition, steroids were administered as a treatment option. Fortunately, the patient showed clinical improvements, with the ASIA score improving from D to E, suggesting a positive response to steroids and potential for neurological recovery. Conclusion: Steroids may be regarded as a possible treatment alternative for individuals suffering from spinal cord injuries and immune thrombocytopenic purpura (ITP).

Co-Authors , Retnaningsih Afif Nurul Hidayati, Afif Nurul Alia, Safia Ardiansyah, Djohan Aris Widayati Arlia Ayu Damayanti Ayu Imamatun Nisa Baarid Luqman Hamidi Basuki, Mudjiani Christrijogo Soemartono Waloejo Damayanti, Arlia Ayu Dedy Kurniawan Dewi Sekarsari Didik Hasmono Dienanta, Savira DYAH FAUZIAH, DYAH Edfina Rahmarini Fahmi Achmad Faisal Fahmi, Achmad Farmindo Hartono Farmindo Hartono Fatihuddin, M Fata Fauzan, Rizki Ahmad Fauzi, Asra Al Fedik Abdul Rantam Firdha, Azizah Amimathul Hamidi, Baarid Luqman Hanifah, Anny Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Husni, Nadya Imami, Nabilah Hasna Jeffri Nagasastra Jenar Harumi Jovian Philip Swatan Kim, Beom Joon Meo, Maria Lettisia Mohammad Fathul Qorib Muhammad Hamdan Muhammad Hamdan Muhammad Ja'far Shodiq Muhammad Ja'far Shodiq Nabilah Hasna Imami Nadiva, Shafa Karin Nagasastra, Jeffri Nisa, Ayu Imamatun Nugraha, Priya Paulus Sugianto Paulus Sugianto, Paulus Pearl Dhodik Wirasman Prastiya I. Gunawan Priya Nugraha Qorib, Mohammad Fathul Rahmarini, Edfina Retnaningsih Safia Alia Sensusiati, Anggraini Dwi Setjaputra, Vina Lidya Shodiq, Jakfar Shodiq, Muhammad Ja'far Siti Khaerunnisa Siti Khaerunnisa SOETJIPTO . Steven Christian Susianto Sudibyo, Devi Ariani Sugondo, Alexander Tikara Suharjanti, Isti Suprapto, Djoko Agus Susianto, Steven Christian Swatan, Jovian Philip Talaway, Athalia Anastasia Turchan, Agus Vina Lidya Setjaputra Viskasari P. Kalanjati Wibi Riawan

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