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All Journal Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) JMM (Jurnal Masyarakat Mandiri) Window of Health : Jurnal Kesehatan Jurnal Midpro Jurnal Surya Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Sinteza Jurnal Info Kesehatan
Utami, Primanitha Ria
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Other

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Journal : Sinteza

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Pengaruh Faktor Risiko terhadap Efek Samping Hipotensi Ortostatik pada Pasien Hipertensi dengan Komorbid Diabetes Mellitus Utami, Primanitha Ria; Pratiwi, Elasari Dwi; Ayuning Tiyas, Danur Sukma
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.31990

Abstract

Orthostatic hypotension is a common side effect of antihypertensive therapy that can lead to serious outcomes such as falls, injuries, and death. The risk increases in patients with comorbidities like diabetes mellitus, which affect autonomic regulation and often require multiple medications (polypharmacy). This study aimed to assess the influence of risk factors gender, age, duration of use, body mass index, and polypharmacy on the incidence of orthostatic hypotension in hypertensive patients with comorbidities at the Lamongan District Health Center. Using a cross-sectional design, 78 Prolanis program participants were observed from January to March 2025. Data were collected through direct observation, medical records, and the Naranjo algorithm questionnaire, then analyzed with Spearman Rank correlation. Results showed that most respondents experienced possible (41.03%) to very certain (39.74%) side effects of orthostatic hypotension linked to antihypertensive use. Age (ρ=0.698; p=0.000), gender (ρ=0.308; p=0.006), and polypharmacy (ρ=0.277; p=0.014) were significantly associated with orthostatic hypotension, with age as the strongest factor. Duration of use (ρ=0.122; p=0.287) and body mass index (ρ=−0.006; p=0.961) showed no significant correlation. These findings highlight the need for heightened vigilance in elderly patients and those on multiple medications to prevent orthostatic hypotension. Further studies with larger samples and longer follow-up are recommended. Educating patients on proper medication use is crucial to reduce adverse effects.
Co-Authors Amala, Siti Nur Arifa, Anzalna Firza Ayuning Tiyas, Danur Sukma Bintang, Sri Budi, Fery Setiya Devi Ristian Octavia Dian Nurafifah Dianda Aryntya Firia Ferlania ELASARI DWI PRATIWI, ELASARI DWI Fadhila, Salsabila Nur Fransisca Dita Mayangsari Handayani, Riana Prastiwi Heni Lutfiyati, Heni Irma Susanti, Irma Khoiriyah, Fina Khurin'in, Ayu Melinda, Sinta Oktavia Muhtaromah, Muhtaromah Nasyanka, Anindi Lupita Octavia, Devi Ristian Prabowo, Mochamad Aji Rahmah, Faroha Nur Ramadhani, Novely Dwita Rosadi, Tiara Jeni Wahyudi, Afiv Wibowo, Alfina Wijayanti