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All Journal Molecular and Cellular Biomedical Sciences (MCBS) KACANEGARA Jurnal Pengabdian pada Masyarakat Eksakta : Berkala Ilmiah Bidang MIPA Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Kesehatan Tambusai Muhammadiyah Journal of Geriatric Journal Of Human And Education (JAHE) Bengawan :Jurnal Pengabdian Masyarakat Sriwijaya Journal of Obstetrics and Gynecology PLENARY HEALTH : Jurnal Kesehatan Paripurna
Dewi, Yulia Ratna
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Journal : Muhammadiyah Journal of Geriatric

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Moringa oleifera as the potential herb medicine for neurodegenerative diseases: a narrative review Dewi, Yulia Ratna; Barinda, Agian Jeffilano; Arozal, Wawaimuli
Muhammadiyah Journal of Geriatric Vol. 5 No. 1 (2024): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.5.1.1-13

Abstract

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, significantly burden the global older adult population. These diseases are characterized by the degeneration of nerve cells and subsequent damage, leading to the gradual loss of neurological function and subsequently affecting the quality of life of older adult people. This study explores the potential role of Moringa oleifera (MO) on neurological diseases. MO, a plant rich in bioactive compounds such as flavonoids, polyphenols, saponins, and tannins, has been proven to possess potent antioxidant effects. Oxidative stress is a primary contributor to the pathogenesis of neurodegenerative diseases, and MO can protect nerve cell damage by enhancing antioxidant activity. In the context of Parkinson's disease, MO has demonstrated the ability to reduce cataleptic symptoms and protect dopaminergic neurons, which are crucial in preventing a decline in dopamine production in the brain. In Alzheimer's disease, MO can improve memory function, reduce oxidative stress, and inhibit the activity of Acetylcholinesterase (AChE) enzymes involved in neurotransmitter dysfunction. While further research is needed to gain a deeper understanding of MO's mechanisms and more specific therapeutic potential, the existing evidence suggests that its constituents and effects hold significant promise as a natural solution for combating the effects of neurodegenerative diseases. As the number of individuals affected by these diseases continues to rise worldwide, further investigation into MO as a neuroprotective agent could pave the way for developing more effective therapies for these conditions.
Co-Authors Agian Jeffilano Barinda De araujo, Joanico moises Eko Sumargiyanto Emma Ismawatie Emma, Ismawatie Eziefule, Oluebube Magnificient Fernandes, Recardina Fernandes, Recardina da Gunawan, Lucia Sincu Hasanah, Ria Hidayat, Mohamad Sofyan Intan Kusumo, Rianto Ismawatie, Emma Ismawatie, Ismawatie Jimat, Resi Thondo Jimat, Resi Tondho Kadarwati, Ristia Lisa Rahmawati Maryoto, Maryoto Maulani, Yulita Melva Louisa Mustikatun, Laela Siti Nabillah, Deya Adiby Nafrialdi Nafrialdi Nanda Kusuma, Rahmayani Agustin Puspita Eka Wuyung Putri, Arum Kusuma Retnani, Dyah Dwi Roid, Roid Rosário, Celita Osório do S.ST., M.Kes, Emma Ismawatie, SEPTELIA INAWATI WANANDI Supriyanto, Eka Evan Supriyanto, ka Evan Syarifah Dewi Tiara, Tiara Wahyuningsih, Sandra Tri Wawaimuli Arozal Yulita Maulani