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All Journal Risâlah, Jurnal Pendidikan dan Studi Islam Jurnal Penelitian Pendidikan IPA (JPPIPA) YUSTISI Unes Law Review Yustisi: Jurnal Hukum dan Hukum Islam Journal of Computer Science and Informatics Engineering JURNAL PERMADI: PERANCANGAN, MANUFAKTUR, MATERIAL DAN ENERGI Journal of Indonesian Rural and Regional Government (JIRReG) Jurnal Sistem Informasi dan Teknologi (SINTEK) Counselia: Jurnal Bimbingan Konseling Pendidikan Islam Jurnal Abdi Masyarakat Journal Of Computer Science And Technology JRIIN :Jurnal Riset Informatika dan Inovasi APPA : Jurnal Pengabdian Kepada Masyarakat Jurnal Rekayasa Sistem Informasi dan Teknologi Journal of Computer Science and Information Technology Indonesian Journal of Biomedicine and Clinical Sciences Jurnal Computer and Technology Indonesian Journal of Education and Learning Multidisciplinary Indonesian Center Journal Sintek Kuwera
Zaenudin
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Religion Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Islam Versus Pancasila: Literature Review Mengenai Konstruksi Pluralisme Substantif Melalui Model Harmonisasi Syariah-Falsafah Ibn Rusyd Zaenudin; Ali Miftakhu Rosyad; Affy Khoiriyah
Risâlah Jurnal Pendidikan dan Studi Islam Vol. 11 No. 4 (2025)
Publisher : Fakultas Agama Islam Universitas Wiralodra Indramayu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/jurnal_risalah.v11i4.3268

Abstract

Dikotomi antara Islam dan Pancasila telah menjadi perdebatan epistemologis berkepanjangan dalam diskursus ketatanegaraan Indonesia. Penelitian ini bertujuan mengkonstruksi model pluralisme substantif melalui pendekatan harmonisasi syariah-falsafah Ibn Rusyd sebagai jembatan intelektual antara prinsip Islam dan nilai Pancasila. Menggunakan metode Systematic Literature Review dengan framework PRISMA, penelitian ini menganalisis 67 literatur dari Scopus, Google Scholar, dan repositori akademik periode 2010-2024. Analisis tematik mengidentifikasi dua dimensi utama: konvergensi epistemologi tauhid-ketuhanan melalui keselarasan wahyu-akal Ibn Rusyd, dan harmonisasi aksiologi maqasid syariah dengan nilai keadilan sosial Pancasila. Hasil penelitian menunjukkan bahwa falsafah Ibn Rusyd tentang ta'wil progresif dan universalitas hukum natural memberikan landasan teoretis bagi rekonsiliasi substantif Islam-Pancasila. Model harmonisasi ini menghasilkan paradigma pluralisme substantif yang melampaui toleransi pasif menuju koeksistensi aktif-produktif, dimana syariah dipahami sebagai prinsip etis universal yang kompatibel dengan konstitusionalisme Pancasila. Signifikansi penelitian terletak pada kontribusinya terhadap resolusi konflik ideologis melalui pendekatan filosofis-teologis transformatif, menawarkan sintesis integratif yang memperkuat fondasi kebangsaan Indonesia.
Modulation of Caspase-3 Expression and Spermatogenic Cells by Urtica dioica Extract in Obesity-Induced Male Rats Tangkari, Kabir Ardiansyah; Tyas, Jurnalis Gempaning; Sutiani, Harni; Zaenudin; Rizal, Dicky Mochammad; Setyawan, Jajar
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 1 (2026)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i1.24429

Abstract

Obesity is associated with impaired steroidogenesis and spermatogenesis through mechanisms involving hypogonadism, inflammation, and oxidative stress. Pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) contribute to apoptotic signaling pathways, including caspase-3 activation, leading to germ cellloss. Urtica dioica contains bioactive compounds with reported antioxidant and anti-apoptotic properties. This study aimed to evaluate the effects of U. dioica extract on TNF-α and caspase-3 mRNA expression as well as spermatogenic cell counts of the testes of obese male Sprague Dawley rats. This experimental study employed a post-test-only control group design using 25 rats divided into five groups: healthy control (C1), obese control induced by a high-fat and fructose diet (C2), and three intervention groups receiving U. dioica extract at doses of 125 mg/kg (D1), 250 mg/kg (D2), and 500 mg/kg (D3) for four weeks. The results showed no significant differences in TNF-α mRNA expression were observed between the intervention groups and the obese control. In contrast, caspase-3 mRNA expression was significantly reduced in all U. dioica–treated groups comparedwith the obese control. No significant differences were observed in the number of primary or secondary spermatocytes among groups. However, spermatid counts were significantly higher in D2 and D3 groups compared with the obese control. In conclusion, U. dioica extract demonstrated potential anti-apoptoticeffects and was associated with improved post-meiotic spermatogenic outcomes in obese rats.
Co-Authors Achmad Lutfi Fuadi Affy Khoiriyah Ahmad Subki Akbar, Ardiyallah Andayani, Nopi Ardiyallah Akbar Arif Rizqi Nugroho Asbah Aspari, Roni Ayuni Badru Duja, Reja Bagas Adi Kurniawan Bagus Sampurno Kuncoro Putro Baiq Hanna Kurratul Aini Baiq Ida Astini Beno Kusnadi Cecep Sumarna Didin Nurul Rosidin Efendi, Masjun Efendi, Muhamad Masjun Fadia Karunia Utami Fasya, Muhammad Rafli Hafizh Agil Musyaffa Hidayah Haris, Oscar Hendarto Himawan Dwiatmodjo Ibrohim Syakur Ilham Syazili, Muhammad Ines Heidiani Ikasari Irwanto Irwanto Jaka Surya Jaya Wijaya Kemal, Isthifa Laela Uziah Lalu Delsi Samsumar, M.Eng. mahmud ali Maulidah Turokhmah Miftah Faiz Ali Ramdhani Muammar Muhammad Ilham Syadzili Muhammad, Adji Suradji Ni Luh Nopi Andayani Nurlaeliyah, M.Pd.I . Raka Permana Ramdhani, Miftah Faiz Ali Reja Badru Duja Rizal, Dicky Mochammad Rosyad, Ali Miftakhu Rudi Muslim Sahida, Nirmala Said, Syukroni Saprudin Sembiring, Rinawati Setyawan, Jajar Silpa Rani Zain Siti Aina Firdaus Sumarno Suryadi, Emi Susilawati Sutar Sutiani, Harni Tangkari, Kabir Ardiansyah Tarlam, Alam Tyas, Jurnalis Gempaning Warno Yudin Citriadin Zaeniah Zeva Imanuel Purba Zulpan Hadi