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Yufika, Amanda
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Can smartphone-based diabetes control apps improve cardiovascular risk among patients with diabetes? A systematic review and meta-analysis Refin, Randa Y.; Andika, Fina F.; Abudurrahman, Muhammad F.; Maidar, Maidar; Yufika, Amanda; Mulya, Intan C.; Parperis, Konstantinos; Abdeen, Ziad
Narra X Vol. 2 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i1.123

Abstract

Despite being the most prevalent complication, cardiovascular risk factors such as blood pressure, weight, and lipid profile have been less considered in digital health studies. The aim of this systematic review and meta-analysis was to gather evidence regarding the impact of digital health applications on cardiovascular risk factors in patients with diabetes. Literature search was conducted following the PRISMA guideline on September 4, 2023, using databases including PubMed, Scilit, Scopus, Embase, and Web of Science, with a pre-planned combination of keywords. Selected studies were original research reporting the influence of smartphone applications on cardiovascular risk factors in diabetic patients. Standardized mean differences (SMD) between the intervention and control groups were analyzed using fixed or random-effects models. Eighteen studies met the criteria, consisting of 1152 patients in the intervention group and 1072 patients in the control group. The results of the meta-analysis showed that the smartphone applications significantly controlled systolic blood pressure (SMD: -5.03 mmHg; 95%CI: -7.018, -3.041, p<0.001). There was no significance effect on weight, body mass index, total cholesterol, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c) and diastolic blood pressure. In the subgroup analysis, triglycerides were lower in the intervention group compared to the control group (SMD: -0.459%; 95%CI: -0.787, -0.132, p=0.006). Publication bias and the limited number of studies suggest that the evidence from this study is in moderate level. In conclusion, smartphone apps are not only effective in aiding blood sugar control but also in preventing cardiovascular issues in diabetic patients. Further research is still needed to confirm these findings.
Disruption of childhood vaccination during the COVID-19 pandemic in Indonesia Fahriani, Marhami; Anwar, Samsul; Yufika, Amanda; Bakhtiar, Bakhtiar; Wardani, Elly; Winardi, Wira; Akel, Kaitlyn B.; Wagner, Abram L.; Harapan, Harapan
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.7

Abstract

The aim of this study was to assess the magnitude of childhood vaccination disruption and to determine the predictors of delaying childhood vaccinations during the coronavirus disease 2019 (COVID-19) pandemic among Indonesian parents. We conducted a nationwide, online, cross-sectional study. A set of questionnaires assessed the disruption of childhood vaccinations and possible explanatory variables, including demographic characteristics, current underlying disease, exposure to and confidence in COVID-19 information, perceived risk, attitude and practice on vaccination, and COVID-19 prevention practice. A multivariable linear regression was used to characterize the relationship between explanatory variables and delayed childhood vaccination. We included 1137 respondents for analysis, of which 52.6% were males and 58.4% participants aged between 31 and 50-years old. Disruption of childhood vaccination service in local health facilities was reported in 42.2% (480/1137) of respondents and 13.3% (193/1137) of respondents explained that their children could not be vaccinated because a healthcare facility temporary stopped the vaccination service. Of all respondents, 312 (27.4%) delayed vaccinating their children for a compulsory vaccination shot. Factors associated with higher odds of delaying compulsory vaccinations for children were employment and chronic disease status, flu vaccination status in the past year, and prior COVID-19 infection. In conclusion, there was a significant disruption of childhood vaccination practices in Indonesia during the COVID-19 pandemic. This is not only due to healthcare closures but also due to parents’ practice - delaying the compulsory childhood vaccination for their children. We urge the government to strengthen strategies to ensure childhood vaccination services are available to all children in the country during a pandemic.
Attitude towards Zika among frontline physicians in a dengue-endemic country: A preliminary cross-sectional study in Indonesia Yufika, Amanda; Anwar, Samsul; Maulana, Reza; Wahyuniati, Nur; Ramadana, Rizki R.; Ikram, Ikram; Mudatsir, Mudatsir; Utomo, Prattama S.; Te, Haypheng; Enitan, Seyi Samson; Sirinam, Salin; Müller, Ruth; Setiawan, Abdul Malik
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.32

Abstract

In dengue-endemic countries such as Indonesia, Zika may be misdiagnosed as dengue, leading to underestimates of Zika disease and less foreknowledge of pregnancy-related complications such as microcephaly. Objective: To assess the attitudes of frontline physicians in a dengue-endemic country toward testing for Zika infection among patients with dengue-like illnesses. Methods: A cross-sectional online survey was conducted among general practitioners (GPs) in Indonesia. The survey assessed their attitude and also collected sociodemographic data, characteristics of their medical education, professional background, and workplace, and exposure to Zika cases. A two-step logistic regression analysis was used to assess possible variables associated with these attitudes. Results: A total of 370 GPs were included in the final analysis of which 70.8% had good attitude. Unadjusted analyses suggested that GPs who were 30 years old or older and those who had medical experience five years or longer had lower odds of having a positive attitude compared to those who aged younger than 30 years and those who had medical experience less than five years, OR: 0.58; 95%CI: 0.37, 0.91 and OR: 0.55; 95%CI: 0.35, 0.86, respectively. No explanatory variable was associated with attitude in the fully adjusted model. Conclusion: Our findings point to younger GPs with a shorter medical experience being more likely to consider testing for Zika infection among their patients presenting with dengue-like illnesses. Strategic initiatives may be needed to enhance older or longer-experienced physicians' capacity in diagnosing Zika infection.
Acceptance of COVID-19 vaccination at different hypothetical efficacy and safety levels in ten countries in Asia, Africa, and South America Rosiello, Dott F.; Anwar, Samsul; Yufika, Amanda; Adam, Rashed Y.; Ismaeil, Mohajer IH.; Ismail, Asma Y.; Dahman, Nesrine BH.; Hafsi, Montacer; Ferjani, Manel; Sami, Farah S.; Monib, Fatma A; R, Subramaniam; Anandu, Sunil; Haque, Md Ariful; Ferreto, Lirane ED.; Aburto, José TO.; Rojas, Jorge ET.; Enitan, Seyi S.; Yomi, Akele R.; Ezigbo, Eyiuche D.; Babadi, Elham; Kakemam, Edris; Malik, Najma I.; Ullah, Irfan; Sallam, Malik
Narra J Vol. 1 No. 3 (2021): December 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v1i3.55

Abstract

Vaccine hesitancy, defined as the reluctance or rejection in receiving a vaccine despite its availability, represents a major challenge to global health efforts aiming to control the ongoing COVID-19 pandemic. Understanding the possible factors correlated with COVID-19 vaccine hesitancy using a refined well-informed approach can be helpful to address the phenomenon. The current study aimed to evaluate COVID-19 vaccine acceptance rates using four hypothetical scenarios of varying levels of vaccine efficacy and safety profiles in ten Asian, African and South American countries. These scenarios included: 95% efficacy and 20% side effects (Vaccine A), 75% efficacy and 5% side effects (Vaccine B); 75% efficacy and 20% side effects (Vaccine C) and 50% efficacy and 5% side effects (Vaccine D). This study used a self-administered online survey that was distributed during February–May 2021. The total number of study respondents was 1337 with countries of residence as follows: India (21.1%), Pakistan (12.9%), Sudan (11.2%), Nigeria (9.3%), Iran (8.2%), Bangladesh and Brazil (7.9%), Chile (7.7%), Tunisia (7.6%), and Egypt (6.2%). The overall acceptance rates for COVID-19 vaccination were variable based on varying degrees of safety and efficacy as follows: 55.6% for Vaccine C, 58.3% for Vaccine D, 74.0% for Vaccine A and 80.1% for Vaccine B. The highest levels of COVID-19 vaccine acceptance were observed in Brazil followed by Chile across the four different safety and efficacy scenarios. The lowest COVID-19 vaccine acceptance rates were reported in Egypt and Tunisia for the low safety scenarios (20% side effects), and the low efficacy scenario (50% efficacy). The study revealed the potential effect of vaccine safety and efficacy on the intention to get COVID-19 vaccination. At the same efficacy level, higher possibility of side effects caused a large drop in COVID-19 vaccine acceptance rate. This indicates the importance of accurate communication regarding vaccine safety and efficacy on attitude towards the vaccine and intentions to get vaccinated. Regional differences in COVID-19 vaccine acceptance were observed with the Middle East/North African countries showing the lowest rates and the South American countries displaying the highest vaccine acceptance rates.
Willingness-to-pay for COVID-19 vaccine in ten low-middle-income countries in Asia, Africa and South America: A cross-sectional study Sallam, Malik; Anwar, Samsul; Yufika, Amanda; Fahriani, Marhami; Husnah, Milda; Kusuma, Hendrix I.; Raad, Rawan; Khiri, Namareg ME.; Abdalla, Rashed YA.; Adam, Rashed Y.; Ismaeil, Mohajer IH.; Ismail, Asma Y.; Kacem, Wajdi; Teyeb, Zeineb; Aloui , Khaoula; Hafsi , Montacer; Dahman, Nesrine Ben Hadj; Ferjani, Manel; Deeb, Dalia; Emad , Dina; Sami, Farah S.; Abbas, Kirellos Said; Monib, Fatma A.; R , Subramaniam; Panchawagh, Suhrud; Sharun, Khan; Anandu, Sunil; Gachabayov, Mahir; Haque , Md A.; Emran, Talha B.; Wendt, Guilherme W.; Ferreto, Lirane ED.; Castillo-Briones, María F.; Inostroza-Morales, Rocío B.; Lazcano-Díaz, Sebastián A.; Ordóñez-Aburto, José T.; Troncoso-Rojas, Jorge E.; Balogun, Emmanuel O.; Yomi, Akele R.; Durosinmi, Abiodun; Adejumo, Esther N.; Ezigbo, Eyiuche D.; Arab-Zozani, Morteza; Babadi, Elham; Kakemam, Edris; Ullah, Irfan; Malik, Najma I.; Dababseh, Deema; Rosiello, Francesco; Enitan , Seyi S.
Narra J Vol. 2 No. 1 (2022): April 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i1.74

Abstract

Vaccine hesitancy is considered as one of the greatest challenges to control the ongoing coronavirus disease 2019 (COVID-19) pandemic. A related challenge is the unwillingness of the general public to pay for vaccination. The objective of this study was to determine willingness-to-pay (WTP) for COVID-19 vaccine among individuals from ten low-middle-income countries (LMICs) in Asia, Africa, and South America. Data were collected using an online questionnaire distributed during February - May 2021 in ten LMICs (Bangladesh, Brazil, Chile, Egypt, India, Iran, Nigeria, Pakistan, Sudan, and Tunisia). The major response variable of in this study was WTP for a COVID-19 vaccine. The assessment of COVID-19 vaccine hesitancy was based on items adopted from the World Health Organization (WHO) Strategic Advisory Group of Experts (SAGE) vaccine hesitancy scale constructs. In this study, 1337 respondents included in the final analysis where the highest number of respondents was from India, while the lowest number was from Egypt. A total of 88.9% (1188/1337) respondents were willing to pay for the COVID-19 vaccination, and 11.1% (149/1337) were not. The average WTP for COVID-19 vaccination was 87.9 US dollars ($), (range: $5-$200). The multivariate model analysis showed that the country, monthly household income, having a history of respiratory disease, the agreement that routine vaccines recommended by health workers are beneficial and having received the flu vaccination within the previous 12 months were strongly associated with the WTP. Based on the country of origin, the highest mean WTP for COVID-19 vaccine was reported in Chile, while the lowest mean WTP for the vaccine was seen among the respondents from Sudan. The availability of free COVID-19 vaccination services appears as a top priority in the LMICs for successful control of the ongoing pandemic. This is particularly important for individuals of a lower socio-economic status. The effects of complacency regarding COVID-19 extends beyond vaccine hesitancy to involve less willingness to pay for COVID-19 vaccine and a lower value of WTP for the vaccine.
Acute severe hepatitis of unknown etiology in children: A mini-review Frediansyah, Andri; Sallam, Malik; Yufika, Amanda; Sharun, Khan; Iqhrammullah, Muhammad; Chandran, Deepak; Mamada, Sukamto S.; Sallam, Dina E.; Khader, Yousef; Lemu, Yohannes K.; Yusuf, Fauzi; Kretchy, James-Paul; Abdeen, Ziad; Torres-Roman, J. Smith; Acharya, Yogesh; Bondarenko, Anastasia; Ikram, Aamer; Jamil, Kurnia F.; Kotfis, Katarzyna; Koyanagi, Ai; Smith, Lee; Megawati, Dewi; Rademaker, Marius; Emran, Talha B.; Memish, Ziad A.; Vento, Sandro; Nainu, Firzan; Harapan, Harapan
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.83

Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
Effectiveness of Tai Chi as a non-invasive intervention for mild cognitive impairment in the elderly: A comprehensive review and meta-analysis Rampengan, Derren DCH.; Gunawan, Felicia A.; Rampengan, Jade AH.; Ramadhan, Roy N.; Iqhrammullah, Muhammad; Yufika, Amanda
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.724

Abstract

The aging population warrants the increase of mild cognitive impairment (MCI) prevalence, a condition that could progress to dementia. Efforts have been made to improve the MCI and prevent its progression, including the introduction of Tai Chi, a Chinese traditional exercise. The aim of this systematic review and meta-analysis was to evaluate the efficacy of Tai Chi in attenuating MCI among the elderly population. Records investigating the effect of Tai Chi exercise intervention on cognitive function among elderly patients were searched systematically from PubMed, ScienceDirect, Google Scholar, and Europe PMC as of April 13, 2023. The risk of bias (RoB 2.0) quality assessment was employed in the quality appraisal of the studies included. Review Manager 5.4.1 was used for data extraction and meta-analysis, where the standard mean difference (SMD) and 95% confidence interval (95%CI) were computed. Eight randomized control trials with a total of 1379 participants were included in this meta-analysis. Six trials assessed Montreal Cognitive Assessment scores, where its pooled analysis suggested that Tai Chi was as effective as conventional exercise (SMD=0.15, 95%CI: -0.11 to 0.40, p=0.26). However, pooled analysis of the Mini-Mental Status Examination suggested that Tai Chi intervention more effectively improved cognitive function and reduced the rate of cognitive impairment in elderly patients (SMD=0.36, 95%CI: 0.18 to 0.54, p<0.01) as compared to the control group. This systematic review and meta-analysis suggest that, in some extent, Tai Chi is efficacious in improving cognitive function and slowing down the rate of cognitive impairment among elderly patients.
Can smartphone-based diabetes control apps improve cardiovascular risk among patients with diabetes? A systematic review and meta-analysis Refin, Randa Y.; Andika, Fina F.; Abudurrahman, Muhammad F.; Maidar, Maidar; Yufika, Amanda; Mulya, Intan C.; Parperis, Konstantinos; Abdeen, Ziad
Narra X Vol. 2 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i1.123

Abstract

Despite being the most prevalent complication, cardiovascular risk factors such as blood pressure, weight, and lipid profile have been less considered in digital health studies. The aim of this systematic review and meta-analysis was to gather evidence regarding the impact of digital health applications on cardiovascular risk factors in patients with diabetes. Literature search was conducted following the PRISMA guideline on September 4, 2023, using databases including PubMed, Scilit, Scopus, Embase, and Web of Science, with a pre-planned combination of keywords. Selected studies were original research reporting the influence of smartphone applications on cardiovascular risk factors in diabetic patients. Standardized mean differences (SMD) between the intervention and control groups were analyzed using fixed or random-effects models. Eighteen studies met the criteria, consisting of 1152 patients in the intervention group and 1072 patients in the control group. The results of the meta-analysis showed that the smartphone applications significantly controlled systolic blood pressure (SMD: -5.03 mmHg; 95%CI: -7.018–(-3.041), p<0.001). There was no significance effect on weight, body mass index, total cholesterol, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c) and diastolic blood pressure. In the subgroup analysis, triglycerides were lower in the intervention group compared to the control group (SMD: -0.459%; 95%CI: -0.787–(-0.132), p=0.006). Publication bias and the limited number of studies suggest that the evidence from this study is in moderate level. In conclusion, smartphone apps are not only effective in aiding blood sugar control but also in preventing cardiovascular issues in diabetic patients. Further research is still needed to confirm these findings.
Extracorporeal shockwave therapy in managing lower urinary tract dysfunction: a scoping review Handayani, Yoshimi; Yufika, Amanda; Lestari, Lazulfa Inda; Setiono, Steven
Medical Journal of Indonesia Vol. 34 No. 2 (2025): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.rev.257696

Abstract

Extracorporeal shockwave therapy (ESWT) exerts a range of biological effects, including anti-inflammatory, immunomodulatory, angiogenic, proliferative, and differential responses, as well as promoting nerve regeneration, enhancing membrane permeability, inducing stem cell attraction, and triggering the release of exosomes. It facilitates both interstitial and extracellular responses that support tissue regeneration by transferring energy into tissues. It may also reduce pain through hyperstimulation analgesia and attenuate inflammatory responses, making it a promising non invasive approach for various lower urinary tract dysfunction (LUTD) conditions, such as underactive bladder, overactive bladder, chronic pelvic pain syndrome, stress urinary incontinence, and interstitial cystitis. This study aimed to explore the efficacy and mechanisms of ESWT in managing LUTD.
Epicutaneous immunotherapy for peanut allergy treatment in pediatrics: A literature review Fadya, Vannisa; Safira, Siti Sarah; Nabila, Amira Qisthy; Yufika, Amanda
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.109

Abstract

Peanut allergy in children is a growing public health concern that significantly affects patients' quality of life. Although oral immunotherapy (OIT) has shown effectiveness in desensitizing allergic reactions, it is associated with a threefold increased risk of anaphylaxis compared to strict avoidance. As an alternative, epicutaneous immunotherapy (EPIT) has emerged as a promising therapy due to its favorable safety profile, ease of administration, and non-invasive nature. However, despite increasing interest in EPIT, there is still limited evidence assessing its efficacy and safety in pediatric populations. This literature review aims to summarize current findings on the mechanism of desensitization, clinical efficacy, safety, and impact on quality of life associated with EPIT in managing peanut allergy in children. Relevant articles were identified through database searches in PubMed, Cochrane, Science Direct, Scopus, and Google Scholar using Medical Subject Headings (MeSH) and keyword combinations such as "Epicutaneous Immunotherapy", "Peanut Allergy", and "Pediatric Allergy". EPIT works by delivering peanut allergens through a patch applied to intact skin. The allergen is taken up by Langerhans cells and presented to the immune system, triggering regulatory T-cell (Treg) responses that reduce allergic sensitivity. Viaskin© is the most clinically advanced EPIT delivery system currently available. Findings from clinical studies indicate that EPIT is effective in inducing desensitization, with a lower risk of systemic reactions compared to OIT. Furthermore, EPIT contributes to improved quality of life in children with peanut allergy. These results support EPIT as a promising therapeutic option for pediatric peanut allergy management.
Co-Authors Abbas, Kirellos Said Abdalla, Rashed YA. Abdeen, Ziad Abdul Malik Setiawan Abudurrahman, Muhammad F. Aburto, José TO. Acharya, Yogesh Adam, Rashed Y. Adejumo, Esther N. Akel, Kaitlyn B. Aloui , Khaoula Anak Agung Dewi Megawati, Anak Agung Dewi Anandu, Sunil Andika, Fina F. Andri Frediansyah, Andri Arab-Zozani, Morteza Babadi, Elham Bakhtiar Bakhtiar Balogun, Emmanuel O. Bondarenko, Anastasia Castillo-Briones, María F. Chandran, Deepak Dababseh, Deema Dahman, Nesrine Ben Hadj Dahman, Nesrine BH. Deeb, Dalia Durosinmi, Abiodun Elfrida Ratnawati Emad , Dina Emran, Talha B. Enitan , Seyi S. Enitan, Seyi S. Enitan, Seyi Samson Ezigbo, Eyiuche D. Fadya, Vannisa Fahriani, Marhami Fauzi Yusuf, Fauzi Ferjani, Manel Ferreto, Lirane ED. Firzan Nainu Gachabayov, Mahir Gunawan, Felicia A. Hafsi , Montacer Hafsi, Montacer Handayani, Yoshimi Haque , Md A. Haque, Md Ariful Harapan Harapan Husnah, Milda Ikram, Aamer Inostroza-Morales, Rocío B. Iqhrammullah, Muhammad Ismaeil, Mohajer IH. Ismail, Asma Y. Kacem, Wajdi Kakemam, Edris Khader, Yousef Khiri, Namareg ME. Kotfis, Katarzyna Koyanagi, Ai Kretchy, James-Paul Kurnia F. Jamil Kusuma, Hendrix I. Lazcano-Díaz, Sebastián A. Lemu, Yohannes K. Lestari, Lazulfa Inda Maidar, Maidar Malik, Najma I. Mamada, Sukamto S. Memish, Ziad A. Monib, Fatma A Monib, Fatma A. Mudatsir Mudatsir Müller, Ruth Mulya, Intan C. Nabila, Amira Qisthy Nur Wahyuniati, Nur Ordóñez-Aburto, José T. Panchawagh, Suhrud Parperis, Konstantinos R , Subramaniam R, Subramaniam Raad, Rawan Rademaker, Marius Ramadana, Rizki R. Ramadhan, Roy N. Rampengan, Derren DCH. Rampengan, Jade AH. Refin, Randa Y. Reza Maulana Rojas, Jorge ET. Rosiello, Dott F. Rosiello, Francesco Safira, Siti Sarah Sallam, Dina E. Sallam, Malik Sami, Farah S. Samsul Anwar Setiono, Steven Sharun, Khan Sirinam, Salin Smith, Lee Te, Haypheng Teyeb, Zeineb Torres-Roman, J. Smith Troncoso-Rojas, Jorge E. Ullah, Irfan Utomo, Prattama S. Vento, Sandro Wagner, Abram L. Wendt, Guilherme W. Wira Winardi, Wira Wiwik Handayani Yomi, Akele R.