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All Journal MNJ (Malang Neurology Journal) Radioterapi & Onkologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Neurologico Spinale Medico Chirurgico International Islamic Medical Journal Indonesian Journal of Cancer eJournal Kedokteran Indonesia Neurona Ophthalmologica Indonesiana
Renindra Ananda Aman
Departemen Bedah Saraf, Fakultas Kedokteran Universitas Indonesia, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
Religion Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health Other

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Transcranial Supraorbital Approach for Tumor Removal of Spheno-Orbital Meningioma with Favorable Clinical Outcomes Nina Asrini Noor; Neni Anggraini; Mutmainah Mutmainah; Renindra Ananda Aman
Majalah Oftalmologi Indonesia Vol 42 No 2 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i2.76

Abstract

Background: To describe and evaluate the surgery results regarding resectability and clinical outcomes oftranscranial supraorbital approach for tumor removal of spheno-orbital meningiomaCase Illustration: A 58-year-old woman presented with proptosis of the right eye since 9 years prior.At initial examination, visual acuity was 6/15 with significant nasal visual field defect. There wereprominent proptosis and inferior globe displacement of the right eye with no palpable mass. A frontoparietalbone deformity was also observed. CT scan examination revealed hyperostosis of sphenoid,frontal, and temporal bone with extensive intraorbital mass with contrast enhancement suggestive ofmeningioma. Incisional biopsy was the performed and confirmed the histopathological diagnosis ofmeningothelial meningioma (WHO grade 1). Transcranial supraorbital in conjunction with lateralorbitotomy was performed in this patient as the definitive treatment for tumor removal of sphenoorbitalmeningioma. Craniotomy and opening of orbital roof were carried out by neurosurgeon toexpose intraorbital region. Total tumor removal was than completed.Conclusion: Transcranial supraorbital approach is an effective surgery for spheno-orbital meningiomaremoval as it offers excellent exposure. A radical resection through transcranial approach can be achievedwith low morbidity, providing a significantly improved clinical outcome in long term period. In thiscase, the spheno-orbital meningioma was grossly resected totally with excellent visual outcome andacceptable cosmetic appearance.Keywords: spheno-orbital meningioma, transcranial approach, tumor resection
Parasagittal Meningioma: A Comprehensive Case Series and Systematic Review Aman, Renindra Ananda; Desbassarie, Fitrie; Purwodito, Arief; Syarif, Ricky Rusydi; Calvin, Nicholas; Paat, Bipatra Einstein Yacobus
Jurnal Medis Islam Internasional Vol 6 No 2 (2024): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v6i2.6509

Abstract

Introduction: This case series included seven patients diagnosed with parasagittal meningioma, presenting their clinical histories, management, and outcomes. In parallel, a systematic review synthesized the existing literature on parasagittal meningioma. This comprehensive analysis combined the findings from both the case series and the systematic review to provide a holistic understanding of these tumors. This case series included seven patients diagnosed with parasagittal meningioma, presenting their clinical histories, management, and outcomes. In parallel, a systematic review synthesized the existing literature on parasagittal meningioma. This comprehensive analysis combined findings from both the case series and the systematic review to provide a holistic understanding of these tumors. Results: This case series highlights the clinical heterogeneity of parasagittal meningiomas and presents cases with various clinical presentations, treatment approaches, and outcomes. The systematic review consolidates existing knowledge and reveals gaps in the understanding of optimal management for these tumors. The combination of case series and systematic reviews provides valuable insights into the clinical behavior, treatment strategies, and prognostic factors associated with parasagittal meningioma. Conclusions: Parasagittal meningioma presents unique diagnostic and therapeutic challenges. This comprehensive study offers a multifaceted perspective on these tumors, enhancing our understanding of their clinical characteristics and management options. These findings can guide clinicians in making informed decisions and improving patient outcomes in the field of neuro-oncology.
LUARAN PERDARAHAN INTRAVENTRIKEL YANG DILAKUKAN OPERASI DI DEPARTEMEN BEDAH SARAF RSUPN DR. CIPTO MANGUNKUSUMO Sadewo, Wismaji; Amelia, Liza; Tobing, Hanif Gordang; Nugroho, Setyo Widi; Ichwan, Syaiful; Ashari, Samsul
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.45

Abstract

      INTRAVENTRICULAR HEMORRHAGE OUTCOME OPERATED ON NEUROSURGERY DEPARTMENT OF CIPTO MANGUNKUSUMO HOSPITALABSTRACTIntroduction: Intraventricular hemorrhage (IVH) is a spontaneous hemorrhage occurring within the ventricular system, 30-45% often associated with intracerebral hemorrhage (ICH). Evaluating accurate and precise daily activity in post-stroke patients is critical for the quality of care and measurement of post-stroke outcomes. Modified Rankin Scale (mRS) is a global disability measurement scale used for the evaluation of stroke recovery.Aims: Configuring outcome data of patient with intraventricular hemorrhage operated at neurosurgery department of Cipto Mangunkusumo Hospital based on mRS.Methods: A retrospective study with cross sectional design towards patient with intraventricular hemorrhage at neurosurgery department Cipto Mangunkusmo Hospital, Jakarta, between Januari 2019 and August 2016. Subject or family member was interviewed to assess the subject’s functional status 6 month after operation using mRS.Results: There were 23 subjects mostly under 60 years old (60.8%) with 6 months IVH overall outcomes independent (47.8%) based on mRS. Majority of the subjects were admitted in severe condition with IVH score mostly >15 (65.25), mean Glasgow Coma Scale (GCS) 7.6±2.14, and mean arterial pressure >100 (87%) with factor risk for hypertension (82.6%).Discussion: Operation procedure on patient with intraventricular hemorrhage gives a relatively good outcome although with poor baseline at the time of admission.Keywords: Intracerebral  hemorrhage, intraventricular hemorrhage, Modified Rankin ScaleABSTRAKPendahuluan: Perdarahan intraventrikel (intraventricular hemorrhage/IVH) merupakan perdarahan spontan yang terjadi di dalam sistem ventrikel, 30-45% sering berhubungan dengan perdarahan intraserebral (PIS). Evaluasi aktifitas sehari-hari yang akurat dan tepat pada pasien pascastroke sangat penting untuk kualitas perawatan dan pengukuran luaran pascaperawatan stroke. Modified Rankin Scale (mRS) merupakan skala pengukuran disabilitas yang dipakai secara global untuk evaluasi pemulihan dari stroke.Tujuan: Menelaah data luaran penderita perdarahan intraventrikel yang dilakukan operasi di Departemen Bedah Saraf RSUPN Dr. Cipto Mangunkusumo berdasarkan mRS.Metode: Penelitian retrospektif secara potong lintang terhadap pasien dengan perdarahan intraventrikel yang dikelola oleh Departemen Bedah Saraf RSUPN Dr. Cipto Mangunkusumo, Jakarta, pada bulan Januari 2010 hingga Agustus 2016. Subjek atau keluarga diwawancara untuk menilai status fungsional 6 bulan pascaoperasi menggunakan mRS.Hasil: Didapatkan 23 subjek yang sebagian besar berusia di bawah 60 tahun (60,8%) dengan luaran 6 bulan yang dalam keadaan independen (47,8%) berdasarkan mRS. Mayoritas subjek masuk dalam keadaan yang buruk dengan skor IVH terbanyak adalah >15 (65,2%), rerata Skala Koma Glasgow (SKG) 7,6±2,14, dan mean arterial pressure >100 (87%), serta memiliki faktor risiko hipertensi (82,6%).Diskusi: Tata laksana operasi pada pasien dengan perdarahan intraventrikel memberikan luaran yang cukup baik, walaupun pasien masuk dalam keadaan yang buruk.Kata kunci: Modified Rankin Scale, perdarahan intraserebral, perdarahan intraventrikel
The Correlation of Inflammatory Markers with Clinical Manifestation, Peritumoral Edema, and Recurrence in Meningioma Patients Aninditha, Tiara; Auliya, Putri; Mulyadi, Rahmad; Aman, Renindra Ananda; Andriani, Rini; Sofyan, Henry Riyanto
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1287

Abstract

Background: Meningiomas can induce inflammation in their tumorigenesis process, thereby linking inflammation with clinical symptoms, peritumoral edema, and recurrence of meningiomas. Easily accessible and cost-effective inflammatory markers include the neutrophillymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR). This study aims to investigate the relationship between peripheral inflammation markers, specifically the NLR and MLR, and their association with clinical symptoms, peritumoral edema, and meningioma recurrence.Method: A retrospective cohort study was conducted at Cipto Mangunkusumo National General Hospital from January 2016 to December 2019, utilizing a consecutive non-probability sampling method. Inclusion criteria were patients aged 18 years or older with meningiomas(gradesI-III), first surgery. Peripheral inflammatory markers were derived from differential blood counts, peritumoral edema data from radiological reports, and other data from medical records. The cut-off valuesfor NLR and MLR were determined to be 2.415 and 0.295, respectively. Bivariate analyses using ChiSquare and Mann-Whitney tests were followed by multivariate logistic regression analysis. Results: 173 patients were eligible for analysis. Of these, 27 had preoperative CT scans, 126 had MRIs, and 20 had no preoperative radiology data. Clinical and recurrence analyses were performed on all 173 patients, with radiology and tumor size analyses conducted on subsets of 153 and 126 patients, respectively. The majority of meningiomasin thisstudy were grade I, found in 94.2% of subjects, with the remainder being grade II and III. Higher NLR and MLR values were significantly associated with headaches (p 0.001). Elevated NLR and MLR were also correlated with peritumoral edema (p 0.001). MLR was independently associated with recurrence, with an adjusted odds ratio (aOR) of 12.647 (95% CI 2.355–67.919); p = 0.003.Conclusion: NLR and MLR as peripheral inflammatory markers demonstrated higher median values in meningioma patients with headaches and peritumoral edema. Additionally, inflammation in meningiomas was associated with the occurrence of recurrence.
Gambaran Status Gizi Penderita Tumor Otak Primer dan Metastasis serta Faktor-faktor yang Memengaruhinya Aninditha, Tiara; Tanjung, Gloria; Andayani, Diyah Eka; Aman, Renindra Ananda; Estiasari, Riwanti; Yanuar, Ahmad; Sofyan, Henry Riyanto
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.280

Abstract

Introduction: According to the pathophysiology, weight loss is a specific marker for suspected malignancy. However, this is rarely found in cases of brain tumors. The presence of the blood brain barrier is thought to play a role in differentiating nutritional status in primary and metastatic brain tumors. Therefore, it is necessary to do this research. Aim: Knowing the description, prevalence, differences in nutritional status of patients with primary and secondary brain tumors, and the affecting factors. Methods: Cross-sectional study in patients with primary and secondary brain tumors at Cipto Mangunkusumo General Hospital in 2017-2019. Malnutrition was diagnosed using the GLIM (Global Leadership Initiative on Malnutrition) criteria. Data analysis used Chi-Square/Fisher and multivariate logistic regression. There were 333 subjects: 246 primary and 87 secondary brain tumors. Description of nutritional status of patients with primary brain tumors: 47.6% obese; 6.1% malnutrition; the rest were normal, while in secondary brain tumors: 25.3% were malnourished; 24.1% obese; the rest is normal. Secondary brain tumor at risk of malnutrition with RR 1.257 (95% KI 1.108-1.426), p<0.001. Factors influencing malnutrition were the type of primary/secondary brain tumor, gender, age, decreased consciousness, anorexia, gastrointestinal complaints, intraaxial lesions, multiple lesions, and the location of the lesions involving the frontal lobes. The independently related factor was multiple lesions with an aOR of 3,423 (95% KI 1.124-10.426), p 0.03. Conclusion: The nutritional status of patients with primary and secondary brain tumors was different, with higher levels of malnutrition in secondary brain tumors and higher obesity in primary brain tumors. The number of multiple lesions in the brain affects the occurrence of malnutrition.
CORRELATION BETWEEN PREOPERATIVE OPHTHALMOLOGIC EXAMINATION AND POSTOPERATIVE VISUAL FUNCTION IN PATIENTS WITH PITUITARY ADENOMA: A RETROSPECTIVE STUDY Rahma Putri, Herdanti; Nusanti, Syntia; Ananda Aman, Renindra; M, Sidik; Dewiputri, Salmarezka; Paramita Ayuningtyas, Sita
MNJ (Malang Neurology Journal) Vol. 12 No. 1 (2026): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.01.03

Abstract

Background: Pituitary adenoma is a benign tumor of the pituitary gland that can be treated surgically. Ophthalmological examination is a standard protocol to determine surgical indications and assess postoperative visual prognosis. Objective: This study aimed to evaluate postoperative visual function in pituitary adenoma patients and compare it with preoperative findings. Methods: Retrospective study using medical record data of all pituitary adenoma patients who underwent tumor removal surgery and neuro-ophthalmological examination at Cipto Mangunkusumo Hospital from 2019-2021 . Results: 63 pituitary adenoma patients were included in the study. Median best-corrected visual acuity (BCVA) at the last follow-up improved from 0.8 to 0.45 logMAR in the new case group and from 0.45 to 0.15 logMAR in the residual case group. The most common visual field defect in this study was temporal hemianopia with significant difference in mean deviation (MD) and visual field index (VFI) after surgery on both groups (p<0,05). Moreover, the correlation between initial and final VA, MD, and VFI was significant (0,781; 0,701; 0,594, respectively). The remaining tumor volume was also a significant factor in the improvement of MD and VFI, with better MD and VFI values shown in a smaller tumor volume postoperatively. Conclusion: Neuro-ophthalmological examination after surgery showed an increase in BCVA and improvement in visual field defects. It is shown to be correlated with preoperative BCVA, preoperative MD, and VFI on Humphrey Visual Field examination, and postoperative tumor volume.
Gambaran Klinis dan Proporsi Hipotiroidisme Sekunder pada Pasien Adenoma Hipofisis di Rumah Sakit Cipto Mangunkusumo Rahmat Cahyanur; Pradana Soewondo; Budiman Darmowidjojo; Renindra Ananda Aman; Esthika Dewiasty
Majalah Kedokteran Indonesia Vol 68 No 6 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.6-2018-57

Abstract

Pendahuluan: Adenoma hipofisis merupakan tumor yang berasal dari jaringan hipofisis anterior. Manifestasi klinis timbul akibat pendesakan massa dan gangguan sekresi hormon. Salah satu gangguan hormonal yang ditimbulkan adalah hipotiroidisme sekunder. Hipotiroidisme sekunder terkait dengan penurunan kualitas hidup serta peningkatan risiko kardiovaskular. Tujuan: Mengetahui proporsi hipotiroidisme sekunder dan gambaran klinis pasien adenoma hipofisis. Metode: Penelitian ini adalah studi potong lintang. Data diambil dari rekam medis pasien di Rumah Sakit Cipto Mangunkusumo antara tahun 2007-2012. Data demografis (usia, jenis kelamin), karakteristik klinis, jenis adenoma, data radiologis, pemeriksaan hormon (T4 bebas dan TSH) dievaluasi pada peneltian ini. Hasil: Terdapat 45 pasien yang memenuhi kriteria penelitian ini. Sebagian besar subyek adalah wanita (62,2%). Keluhan utama subyek adalah gangguan penglihatan (55,6%). Gejala yang sering ditemukan adalah sakit kepala (86,7%), gangguan penglihatan (77,8%). Pada subyek wanita manifestasi yang pertama kali muncul adalah gangguan penglihatan dan gangguan fungsi seksual (39,3% dan 32,1%). Pada Usia muda, gejala pertama kali muncul lebih pada kelompok adenoma fungsional dibandingkan non fungsional (32,9 vs. 40,6). Hampir seluruh kasus yang ditemukan adalah makroadenoma (97,8%). Proporsi subyek yang mengalami hipotiroidisme sekunder adalah 40%. Subyek dengan hipotiroidisme sekunder lebih banyak mengeluhkan gangguan penglihatan dan gangguan ereksi. Kesimpulan: Gangguan penglihatan adalah keluhan utama yang sering ditemukan. Pada subyek wanita, keluhan gangguan fungsi seksual bersama dengan gangguan penglihatan adalah manifestasi yang pertama kali muncul. Proporsi hipotiroidisme sekunder pada penelitian ini adalah 40,0%. Subyek dengan hipotiroidisme sekunder lebih banyak mengeluhkan gangguan penglihatan, gangguan ereksi.
Co-Authors Abdi Reza Affan Priyambodo Affan Priyambodo Affan Priyambodo Affan Priyambodo Affan Priyambodo Ahmad Yanuar Amelia, Ria Andayani, Diyah Eka Ande Fachniadin Anggraini, Neni Tri Aninditha, Tiara Aryandhito Widhi Nugroho Aryandhito Widhi Nugroho Bhayu Rizallinoor Bismo Nugroho Bismo Nugroho PPR Budiman Darmowidjojo Budiman Darmowidjojo, Budiman Calvin, Nicholas David Tandian David Tandian David Tandian David Tandian David Tandian David Tandian David Tandian Dewiputri, Salmarezka Eka Susanto Esthika Dewiasty Esthika Dewiasty, Esthika Fabianto Santoso Fauzan Herdian Fenny Tjuatja Fitrie Desbassarie, Fitrie Harris Istianggoro Henry Kodrat Hilman Mahyuddin Hilman Mahyudin Ina S. Timan Jeremia Prasetya Pardede Jeremia Prastya Pardede Kevin Gunawan Kurniawan, Azhar Farisyabdi Liza Amelia M, Sidik Martin Susanto Moh. Saekhu Mohamad Saekhu Mohammad Saekhu Muhammad Harisyah Mutmainah Mutmainah Nina Asrini Noor Nugroho, Setyo Widi Nurwahyuni, Atik Paat, Bipatra Einstein Yacobus Padmo Santjojo Paramita Ayuningtyas, Sita Pradana Soewondo Pradana Soewondo Priyambodo, Affan Purwodito, Arief Putri Auliya, Putri Rahma Putri, Herdanti Rahmad Mulyadi Rahmat Cahyanur Rahmat Cahyanur Reki Setiawan Renindra A Aman Renindra A. Aman Renindra A. Aman Retno Asti Werdhani Rini Andriani Riwanti Estiasari Ryan Rhiveldi Keswani Sadewo, Wismaji Samsul Ashari Samsul Ashari Samsul Ashari Samsul Ashari Samsul Ashari SAMSUL ASHARI, SAMSUL Setyo W. Nugroho Setyo Widi Nugroho Setyo Widi Nugroho Setyo Widi Nugroho Setyo Widi Nugroho Setyo Widi Nugroho Setyo Widi Nugroho Soehartati A Gondhowiardjo Soehartati A. Gondhowiardjo Soehartati Gondhowiardjo Soehartati Gondhowiardjo Sofyan, Henry Riyanto Syaiful Ichwan Syaiful Ichwan Syaiful Ichwan Syaiful Ichwan Syaiful Ichwan Syarif, Ricky Rusydi Syntia Nusanti Tanjung, Gloria Tiara Aninditha Tiara Aninditha Tiara Bunga Mayang Permata Wimbo, Fitrie Desbassarie Wismaji Sadewo Wismaji Sadewo Wismaji Sadewo Wismaji Sadewo Yesi Astri Yovanka Naryai Manuhutu Yulius Seno Nugroho