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Herliawati, Putu Arik
Department Of Midwifery, STIKES Advaita Medika Tabanan, Bali, Indonesia.
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Journal : Medical Laboratory Technology Journal

 1 
Risk Of Malignancy Index 4 Performance as a Predictor Advanced Stage Epithelial Ovarian Carcinoma Used for Neoadjuvant Chemotherapy Tatit Nurseta; Dhian Eka Putri Harnandari; Putu Arik Herliawati; Mukhamad Nooryanto; Puspita Handayani
Medical Laboratory Technology Journal Vol. 7 No. 2 (2021): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.253 KB) | DOI: 10.31964/mltj.v0i0.394

Abstract

The relatively low survival rate in patients with advanced-stage carcinoma ovaries requires early detection to improve treatment outcomes. The method currently used to determine the administration of neoadjuvant chemotherapy is ascites cytology and laparoscopic. This study aims to find a non-invasive technique in determining preoperative Neoadjuvant Chemotherapy administration, and that method can use as a predictor of advanced epithelial ovarian carcinoma. The benefit of this study is to help clinicians consider administering neoadjuvant chemotherapy with a Risk Of Malignancy Index 4 score. An analytical observational study with a retrospective cross-sectional type study with samples of all patients from January 2016 to January 2020 diagnosed at the dr. Saiful Anwar Hospital in Malang indonesia. The number of initial samples of this study is 106 samples. Between the results of the Risk Of Malignancy Index 4 score and the histopathological results, it finds that the p-value was less than 0.05 (p
Effect of Vitamin C Exposure to Fibroblast Cells on Woman Uterosacral Ligament Culture Rahajeng Rahajeng; Tatit Nurseta; Edy Mustofa; Yahya Irwanto; Aditiya Fendi Uji Pamungkas; Dhian Eka Putri Harnandari; Putu Arik Herliawati
Medical Laboratory Technology Journal Vol. 9 No. 2 (2023): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v9i2.521

Abstract

Pelvic Organ Prolapse (POP) occurs when the uterosacral ligaments weaken. Vitamin C plays a major role in forming the extracellular matrix (collagen) and stimulates fibroblast cell proliferation. This study aimed to examine how a woman's uterosacral ligament culture was affected by vitamin C exposure to fibroblast cells. A straightforward experimental design investigation that is non-blind and includes analysis after exposure (Post-test control group design). This study's sample used uterosacral ligament from a woman who underwent at least two vaginal deliveries through a hysterectomy procedure. Several doses of vitamin C were given and repeated for 72 hours, followed by examining the number of fibroblast cells; then, the data was analyzed starting with the parametric prerequisite test and the one-way ANOVA test. There was a significant effect of vitamin C exposure on fibroblast cells of the uterosacral ligament at a dose of 50 μg/ml and 100 μg/ml. In contrast, at doses of 150 μg/ml and 200 μg/ml, there was no significant effect. From this study, it is hoped that the administration of vitamin C according to the optimal dose found in the study (significant impact at doses of 50 μg/ml and 100 μg/ml, can increase the proliferation of fibroblast matrix supporting the sacrouterine ligament in women, to prevent prolapse of the pelvic organs in women, and can maintain the quality of life of women.
Co-Authors Aditiya Fendi Uji Pamungkas Arghya Wicaksana Astuti, Ni Luh Seri Ayu Wulandari, Idah Bainuan, Lina Darmayanti Batiari, Ni Made Padma Cokorda Istri Mita Pemayun Dewi, Triyana Puspa Dhian Eka Putri Harnandari Dhian Eka Putri Harnandari Dhian Eka Putri Harnandari Edy Mustofa Hildayanti, Rezha Alivia Indraswari, Ni Luh Astri Kadek Sri Ariyanti Made Dewi Sariyani Made Pradnyawati Chania Mudhawaroh Mudhawaroh Mukhamad Nooryanto Nanda Agnesia Jati Pratiwi Ni Komang Yuni Rahyani Ni Made Ari Febriyanti Ni Made Dewianti Ni Made Dwi Mahayati Ni Made Indra Peratiwi Ni Nyoman Deni Witari Ni Nyoman Suindri Ni Wayan Suarniti Olivia, Brigita Pande Putu Firsta Praminingrum, I Gusti Ayu Raras Pratiwi, Nanda Agnesia Jati Puspa Dewi, Triyana Puspita Handayani Putri Kencana, Ni Luh Putu Radnyani, Ida Ayu Putu Rahajeng Rahajeng Rezha Alivia Hildayanti Rezha Alivia Hildayanti Rezha Alivia Hildayanti Rini Winangsih Saraswati, Anak Agung Sagung Ratu Putri Septi Fitrah Ningtyas Siti Zakiah Sri Aryanti, Kadek Tatit Nurseta Tatit Nurseta Widiantari, Kadek Wintariani, Ni Putu Wisnawa, I Nyoman Dharma Yahya Irwanto