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All Journal Biomedical Journal of Indonesia JFL : Jurnal Farmasi Lampung Jurnal Dunia Kesmas JKM (Jurnal Kebidanan Malahayati) JFM (Jurnal Farmasi Malahayati) Jurnal Analis Farmasi Jurnal Ilmiah Wahana Pendidikan JAF (Jurnal Analis Farmasi) CERATA
Ade Maria Ulfa
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Religion Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Biomedical Journal of Indonesia

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The Hepatoprotective Effects of Basil Leaf (Ocimum sanctum L.) Extract on Paracetamol Induced Liver Damage in Male Rat Panggabean, Ronaldo; Nofita; Ade Maria Ulfa
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.518

Abstract

Basil leaf have antioxidants such as flavonoids, so it is thought to have a hepatoprotective effect. This study aims to investigate the effect of basil leaf extract on SGOT and SGPT levels in male rats induced by paracetamol. Basil leaf extract was carried out by the percolation method using ethyl acetate solvent, Some 20 male sprague dawley rats were randomly divided into 5 groups. Basil leaf extract (400 mg/kgBB and 600 mg/kgBB) and sylimarin (100 mg/kgBB) were carried out every day for 28 days, paracetamol was induced 24 hours after giving the last day of basil leaf extract. The parameters measured were SGOT and SGPT level to assess the effect of basil leaf extract on liver damage caused by paracetamol. The results showed that basil leaf extract (400 mg/kgBB dan 600 mg/kgBB) showed that the activities of SGOT and SGPT levels were statistically significant (p<0,05) to negative control. Basil leaf extract shows the effect of hepatoprotector on liver induced by paracetamol, however the effect given was not able to equate with positive control.
The Formulation and Physical Evaluation Tests of Ethanol in Telang Flower (Clitoria ternatea L.) Extract Losio Form as Antioxidant Jayanti, Merly; Ade Maria Ulfa; Angga Saputra Yasir
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.543

Abstract

Background. Antioxidants are defined as compounds that are able to delay, slow down, or inhibit oxidation reactions. One of the plants that has the potential as natural antioxidants is the telang flower. The purpose of this study was to determine whether the ethanol extract of telang flower (Clitoria ternatea L.) can be formulated in a losion form that meets the requirements of the physical evaluation test and to determine the ethanol extract of telang flower (Clitoria ternatea L.) has antioxidant activity. Methods. The extraction using maceration techniques with 96% ethanol solvent. The yield obtained from the maceration technique was 29.16%. Phytochemical analysis of telang flowers contains alkaloids, flavonoids, polyphenols, saponins and tannins. Determination of the levels of flavonoids obtained levels of 10.05% and for polyphenols of 15.33%. Results. Telang flower extract (Clitoria ternatea L.) can be formulated into losions and meets the requirements of the physical evaluation test in the extract concentration of 0.1%. The losion of telang flower extract (Clitoria ternatea L.) with a concentration of 0.1% telang flower extract has very strong antioxidant activity because it has an IC50 value <50 ppm, and the IC50 yield of a losion with a concentration of 0.1% telang flower extract (Clitoria ternatea L.) of 37.92 ppm which means that it has very strong antioxidant activity. Conclusion. The formula of the telang flower extract lotion has strong antioxidant activity and protects the skin from free radicals.
Co-Authors Angga Saputra Yasir Anisa Lutfiana davit muhamad muslim Desti Galuh Anggraini Dewi Maysaroh Komsatun Diana Ibrahim Dwi Susanti Fitri Amalia Gusti Ayu Rai Saputri Gusti Ayu Rai Saputri Hersa Novitasari Jayanti, Merly Laila Novia Safitri Martianus Perangin Angin Mia Jasuma Miera Delima Nabella, Visca Ni Kadek Dewi Utami Ni Made Novi Puspitawati Nofita Nofita Nofita Nofita Nofita Nofita Nofita Panggabean, Ronaldo Primadiamanti, Annisa Purnama, Robby Candra Putri Anggraini Resmawati Resmawati Retnaningsih, Agustina Ridhatul Hidayah Risqi Indri Lestari Rizkina Aufa Selvi Marcellia Shinta Shinta Titim Nurjannah R Wahyuningtiyas Wahyuningtyas Wayan Sri Intan Sari Winahyu, Diah Astika Zaenal Abidin