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All Journal Berkala Kedokteran JPKMI (Jurnal Pengabdian Kepada Masyarakat Indonesia) Journal of Classroom Action Research NANAEKE IKHLAS: Jurnal Pengabdian Dosen dan Mahasiswa Sains Medisina Majalah Cendekia Mengabdi Jurnal Farmasi SYIFA Jurnal Ilmiah Manajemen Ekonomi Dan Akuntansi (JIMEA) Jurnal Pengabdian Masyarakat Indonesia (JPMI) Jurnal Pengabdian Masyarakat Wadah Publikasi Cendekia
Jannah, Ghina Raudhatul
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Determination of Flavonoid Levels and Anti-Inflammatory Activity of Lime Root Extract (Citrus aurantifolia) by Granuloma Pouch Method Mukti, Yusuf Anggoro; Rohama, Rohama; Jannah, Ghina Raudhatul; Rizantha, M. Iqbal; Daud, Muhammad Alfian
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24410

Abstract

Non-communicable diseases (NCDs) are still the leading cause of death at the global level. In Indonesia, NCDs contribute 71% of the total mortality rate. One of the causes of non-communicable diseases is the occurrence of oxidative stress in the body which is a condition of imbalance between free radical compounds and antioxidants. One of the sources of free radical formation in the body is when the inflammatory process occurs. Lime is used by the Indonesian people as a seasoning for cooking or empirically as an appetite enhancer, antipyretic and antibacterial. Research states that  lime root extract has very strong antioxidant activity with an IC50 value of 24.81 ppm and positively contains alkaloids, flavonoids, saponins and tannins. Flavonoids are thought to act as antioxidants and anti-inflammatory through their ability to donate hydrogen atoms and the ability to bind prostaglandins, COX-1 and COX-2 and lipooxygenase enzymes. The very strong antioxidant activity and the presence of flavonoids contained make lime root have the potential as an anti-inflammatory. Determination of flavonoid levels of lime root extract using UV-Vis spectrophotometry method with quercetin as a comparison and testing of anti-inflammatory activity of lime root extract using the Granuloma Pouch  method using mouse test animals. The results showed that the total flavonoid level was 36.8 mg QE (Quersetin Equialen)/g or 3.68%. And itexerts an anti-inflammatory effect through its ability to reduce the volume of exudate, lower the total exudate leukocytes, and lower the number of neutrophils in the exudate, most notably at a concentration of lime root extract of 20%.
Co-Authors Ali Rakhman Hakim amanah, nurul Audina, Sandra Azzahra, Fifi Alayda Daud, Muhammad Alfian Dinda, Thahirah Farrah Duriani Fitri, Irfani Kemala Hasnah, Eicha Febrianti Hastika, Febby Yulia Holilah, Shafira Nor Husna, Hafizatul Kustiah, Sri Lestari, Yayuk Puji M. Shabir U M. Yusuf T Melviani, Melviani Mukti, Yusuf Anggoro Mustaqimah Mustaqimah Mutia, Desy Rina Saputri Rizantha, M. Iqbal Rohama, Rohama Septianto, Gemilang Shinta, Laili Shinta Ayu Simanjuntak, Jessica Sasyani Sinaga, Fahrel Eben Ezer siti rodiah Syahran, Dayna Maharani Syawalinda, Rara Nagita syifa, Nur Tri Astuti Tumanggor, Agustina Hotma Uli