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All Journal Paediatrica Indonesiana GIZI INDONESIA Jurnal Manajemen Bisnis Eka Prasetya At-Tajdid : Jurnal Pendidikan dan Pemikiran Islam The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Katalisator
Agus Firmansyah
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Religion Agriculture, Biological Sciences & Forestry Humanities Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Library & Information Science Medicine & Pharmacology Public Health Social Sciences

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Macronutrient malabsorption in acute diarrhea: Prevalence and affecting factors Lilis D. Hendrawati; Agus Firmansyah; Darlan Darwis
Paediatrica Indonesiana Vol 45 No 5 (2005): September 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.5.2005.207-10

Abstract

Introduction Diarrhea remains a major problem for communityhealth in Indonesia. More than 25% of children with severe diar-rhea suffer from malabsorption syndrome.Objectives This study aimed to determine the age range of chil-dren with acute diarrhea, the prevalence of macronutrient malab-sorption, and the relationship between age and bacterial infec-tion in macronutrient malabsorption.Methods This was a cross-sectional study, subjects were chil-dren aged 0-59 months with acute diarrhea whose stools wereobtained and examined in the laboratory of GastrohepatologyDivision, Department of Child Health, Cipto Mangunkusumo Hospi-tal, Jakarta from January 2002 to December 2003.Results Children with acute diarrhea were mostly in the agerange of 0-11 months (61%). The prevalence of lactose malab-sorption was 11%, carbohydrate malabsorption was 19%, andfat malabsorption was 51%. Moreover, the age group of 0-11months had a 1.5 times greater possibility of lactose and fatmalabsorption compared to that of 12-59 months. The 12-59 monthsage group had a greater possibility of suffering carbohydratemaldigestion (70%). The group of children who did not sufferfrom bacterial infection had a higher prevalence of lactose mal-absorption (54%), carbohydrate maldigestion (65%), and fatmalabsorption (58%).Conclusions Acute diarrhea occurred more frequently in theage of 0-11 months. There was a significant correlation betweenthe age groups of 0-11 months and 12-59 months in experiencingmacronutrient malabsorption. Lactose malabsorption, carbohy-drate maldigestion, and fat malabsorption were encountered morefrequently in the group that did not have bacterial infection
Intestinal permeability of autistic and healthy children as measured by D-xylose test Hardiono D Pusponegoro; Tuty Rahayu; Agus Firmansyah
Paediatrica Indonesiana Vol 46 No 1 (2006): January 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.1.2006.37-40

Abstract

Background The etiopathogenesis of autistic disorder is unknown.Some authors suggest that food peptides may reach the centralnervous system through a defect of intestinal permeability and pro-duce toxic effects resulting in behavior impairment.Objectives To investigate the prevalence of increased intestinalpermeability in children with autistic disorder using oral D-xylosetest.Method A cross-sectional study was conducted on 27 childrenwith autistic disorder and 54 healthy children (27 siblings and 27unrelated children matching with those of the autistic group). Thesubjects underwent oral D-xylose test. Subjects were free fromfever, drugs, and diarrhea. Student t-test and chi-square were usedfor statistical analysis.Results Prevalence of increased intestinal permeability in the au-tistic group was 63%, which proved to be significant (P=0.007,95%CI: -0.931; -0.987) compared to controls.Conclusion The intestinal permeability significantly increased inautistic children
Growth and development profile of children at two day care centers in Jakarta Siti Budiati Widyastuti; Soedjatmiko Soedjatmiko; Agus Firmansyah
Paediatrica Indonesiana Vol 45 No 6 (2005): November 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.6.2005.275-9

Abstract

Background Working mothers with toddlers are often confusedwith the difficulties of caregiver substitutes. This leads to the con-cern about neglecting their toddlers. Day care centers are expectedto respond by substituting the absent mothers, in order for thechildren’s needs of growth and development to become optimal.Objective To examine the profile of day care centers in correla-tion with growth and development of toddlers, and to understandthe characteristics of facilities for growth and development in tod-dlers at day care centers.Method This cross-sectional study was conducted at the day carecenters (DCC) of the Department of Social Affairs of the Republicof Indonesia Harapan Ibu (HI) in Salemba, Central Jakarta andTeratai in Bekasi from February 1-August 1, 2004.Results There were 106 children enrolled in this study; 47 chil-dren in DCC HI and 59 in DCC Teratai, male:female ratio was 1:1,mostly at age 3.1-5 years. Growth status was measured accord-ing to body weight/age, body height/age, height circumference/age and found good, normal, and proper growth status in 85 chil-dren (80.2%), 48 children (45.3%), 102 children (96.2%), respec-tively. We found good nutritional status in 44 children (41.5%) andnormal developmental status (Denver II) in 81 children (76.4%).Ratio of caregivers to child was 1:10. All children had completeimmunization. No trauma or upper respiratory tract infection wasrecorded as frequent morbidity. Parents’ reasons for relying theirchildren in DCCs were to enable their children to socialize (50children/47.2%), and to allow them to become independent (49children/46.2%).Conclusion DCCs can serve as a safe alternative caregiving sub-stitute based on good growth and development, good nutritionalstatus, also good characteristics facilities
Anemia in children with chronic renal failure Special attention erythrocyte indices and iron deficiency anemia Adi Suryanto B; Partini P Trihono; Agus Firmansyah
Paediatrica Indonesiana Vol 46 No 4 (2006): July 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.4.2006.154-8

Abstract

Background Anemia in chronic renal failure (CRF) has beenproved to influence the quality of life, increasing morbidity andmortality. Early diagnosis and prompt treatments of anemia aremandatory to manage CRF appopriately. So far data of anemia inCRF in Indonesia is limited.Objective To find out the profile of anemia in children with CRF atCipto Mangunkusumo Hospital (CMH), Jakarta, with special atten-tion in erythrocyte indices and iron deficiency anemia.Methods Cross-sectional descriptive study was carried out onpatients with CRF and anemia in CMH since October 2003 to April2004.Results There were 20 CRF patients, aged between 1 year 3 month-15 year old, mostly were above 10 year old, 11 patients were malesand 9 were females. The most frequent etiologies were urinarytract infection (UTI) in 10 cases and nephrotic syndrome in 6 cases.Of those 20 patients, 14 suffered from anemia with erythrocyteindices, normochrome normocytic in 9 patients and hypochromemicrocytic in 5 patients. Of 14 anemic patients only 1 patient suf-fered from iron deficiency anemia of less than 10 mg/l and transferinsaturation of less than 12%. Based on serum iron (SI) concentra-tion only, 7 patients were diagnosed as having iron deficiency ane-mia.Conclusion Most patients with chronic renal failure havenormochrome normocytic anemia. Hypochromic microcytic irondeficiency anemia is scarcely found in this group of patients.
Relation of bleeding patterns and factor VIII levels in children with hemophilia Rina Rahardiani; H. S. Moeslichan MZ; Agus Firmansyah
Paediatrica Indonesiana Vol 46 No 4 (2006): July 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.4.2006.159-63

Abstract

Background The high costs of factor VIII examination cause thedelay in the diagnosis of hemophilia A; consequently many pa-tients do not receive adequate therapy which results in failure tosurvive into adulthood or survive with creeple.Objective To determine bleeding patterns of hemophilia A pa-tients for the prediction of its classification.Methods We perform retrospective analysis of hemophilia patientsat the Integrated Service Center of Hemophilia, Cipto Mangun-kusumo Hospital, Jakarta.Results Family history, age at the first bleeding, frequency of bleed-ing, and factor VIII examination can significantly differentiate theclassification of hemophilia A (P=0.015; 0.014; <0.0001; and<0.0001, respectively) while age groups, triggering trauma for thefirst bleeding, type of the first bleeding, history of previous trauma,the most frequent type of bleeding, age at diagnosis, and con-sumption of cryoprecipitate cannot. (P=0.985; 0.475; 0.342; 0.318;0.058; 0.477; and 0.547, respectively).Conclusion Age at first bleeding, frequency of bleeding, and fam-ily history can be used to predict classification of hemophilia A.
Morphology and disaccharidase activity of small intes- tinal mucosa in post-weaning-induced malnourished rats and after realimentation Rustadi Sosrosumihardjo; Agus Firmansyah; Asri Rasad; Daldiyono Harjodisastro; Endi Ridwan; Septilia Inawati Wanandi; Dwirini Retno
Paediatrica Indonesiana Vol 46 No 5 (2006): September 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.995 KB) | DOI: 10.14238/pi46.5.2006.229-35

Abstract

Background The most common cause of failure to thrive in in-fants is malnutrition which causes histological and biochemicalchanges of small intestine. Studies on histology and enzyme ac-tivity of small intestinal mucosa were not much developed.Objective To study about histology and disaccharidases activity ofsmall intestinal mucosa in post-weaning-induced malnourished rats.Methods We used Sprague-Dawley white rats as the subjects ofthis study with post test-control group design. The study was per-formed at the CentER for Research of Food and Nutrition Devel-opment from April 2003 to December 2004.Results There were a decrease of body weight (hypotrophy nor-moblastic) and an increase of disaccharidase activity of small in-testinal mucosa in post-weaning-induced malnourished rats. Afterrealimentation, there were an increase of body weight, an improve-ment of the hypotrophy, and a decrease of the enzyme but theystill cannot reach normal condition.Conclusion In malnourished rats, there are decrease of bodyweight hypotrophy normoblastic and increase of disaccharidasesactivity of intestinal mucosa that are improved after realimentation
Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children Sri Lestari; Agus Firmansyah; Zakiudin Munasir
Paediatrica Indonesiana Vol 46 No 6 (2006): November 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.091 KB) | DOI: 10.14238/pi46.6.2006.271-5

Abstract

Background Lactose intolerance is a common complication ofdiarrhea in young children particularly that due to rotaviral infec-tion. A meta-analysis study evaluated the use of undiluted lactosecontaining formula or cow’s milk during an episode of diarrhea. Itwas concluded that routine dilution of milk and the use of lactose-free milk formula are not necessary.Objective To evaluate the effect of lactose free formula comparedwith lactose-containing milk formula during acute diarrheal episodein outpatient setting.Methods A total of 56 children with acute diarrhea with mild-mod-erate or no dehydration attending to the outpatient clinic were ran-domly assigned to receive a lactose-free formula (Nestle Nan ® freelactose) or lactose-containing milk formula (Nestle Nan 2 ® formula)after initial rehydration. Comparisons of stool frequency, durationof diarrhea and treatment failure rates were noted. Treatment fail-ure was defined as clinical requirement for intravenous infusionafter rehydration or prolonged diarrhea (>7 days).Results The duration of diarrhea was similar between the twogroups (P=0.195) in spite of two children who received lactosefree formula did not resolve from diarrhea within 7 days of treat-ment. The median of stool frequency was indifferent in the twogroups (P=0.199) in rotavirus gastroenteritis; there were no differ-ences in the duration of diarrhea or the stool frequency.Conclusion Children without dehydration or with mild dehydra-tion tolerated to lactose-containing formula as well as lactose-freeformula for the treatment of acute diarrhea
Effects of probiotic on gut microbiota in children with acute diarrhea: a pilot study Dion Darius Samsudin; Agus Firmansyah; Eka Laksmi Hidayati; Irene Yuniar; Mulya Rahma Karyanti; Rosalina Dewi Roeslani
Paediatrica Indonesiana Vol 60 No 2 (2020): March 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (483.346 KB) | DOI: 10.14238/pi60.2.2020.83-90

Abstract

Background Acute diarrhea is a common health problem in Indonesia. During acute diarrhea, changes in gut microbiota are marked by decrease beneficial microbes Bifidobacterium and Lactobacillus, and increased pathogenic bacteria Enterobacter and Clostridium. Such microbial imbalances are known as dysbiosis. Treatment with probiotics may help repair dysbiosis, quicken healing time, and decrease complications. Objective To assess for dysbiosis during acute diarrhea, and determine if it can be normalized by probiotic treatment. Methods This placebo-controlled, unblinded clinical trial was performed in Budhi Asih District Hospital, Jakarta, from January to March 2018. Twenty-four children age 6-24 months with acute diarrhea and 12 healthy children were enrolled. First fecal specimen was collected for all subjects and analyzed using non-culture real time PCR to count the population of Lactobacillus, Bifidobacterium, Enterobacter, Clostridium, and all bacteria. Children with diarrhea were assigned to probiotic or placebo treatment for 5 days and the second fecal specimen was analyzed two weeks after the diarrhea subsided. Results Prior to treatment, significant higher amounts of Lactobacillus were observed in children with acute diarrhea than in healthy controls [median (interquartile range/IR): 1.52x103 (1.22x104) vs. 6.87x10 (2.41x102), respectively; proportion in percentage (from total bacteria population): 0.044% vs. 0.003%, respectively]. However, median (IR) Clostridium was significantly higher in healthy controls than in children with acute diarrhea [2.37x102 (4.64x103) vs. 4.67 (1.50x102), respectively (P<0.05), with proportion of 0.01% vs. 0.0001%, respectively]. Children who received probiotics had significantly higher count of Bifidobacterium compared to the placebo group [1.94x104 (4.97x104) vs. 1.74x103 (2.08x107), respectively, with proportion of 0.394% vs. 0.081%, respectively]. Conclusion This pilot study do not find evidence of dysbiosis in children with acute diarrhea. Group who received probiotic had higher Bifidobacterium count compared towards those who received placebo.
“MAKAN YANG BENAR SEHATKAN BADAN”: PROGRAM PENDIDIKAN GIZI SEIMBANG UNTUK ANAK USIA SEKOLAH DENGAN PENDEKATAN REGULASI DIRI Risatianti Kolopaking; Agus Firmansyah; Jahja Umar; Umi Fahmida
GIZI INDONESIA Vol 33, No 2 (2010): September 2010
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v33i2.93

Abstract

The school- aged years are a critical time for delivering nutrition education to children because that is the time that cognitive- motivational processes emerge as an important influence on food choices. Conventional methods of delivering nutritional message emphasize on knowledge acquisition; however, experiential knowledge is more effective to promote healthy eating behavior among children. The current study used self-regulatory approach and social cognitive learning technique to develop nutrition education program for 3rd and 4th grades mid-low income children. Until now, there has not been any study on nutrition education in Indonesia that focuses on developing skills and behaviors related to areas of food and eating habits. The general objective of the study is to identify the effectiveness of the program by assessing dietary intake as a combined measure of children’s self-regulation of food choice, children’s selfmotivation, and maternal self-efficacy on the home food environment. Based on formative study, culturally tailored and age-appropriate in-class lessons adapted from Indonesian food dietary guidelines were designed for mid- to low-income children in an urban area of Jakarta. Students received 24 in -class sessions, 45 minutes each session twice a week, for a 12-week intervention taught by nutrition professionals. Both school teachers and parents were involved in the program. Outcome evaluations were studied using a quasi-experimental design with the intervention (n=137) and comparison (n=120) groups combined for three assessment periods: pre-intervention, post-intervention and follow-up (12 weeks after post-intervention). Participants were pair of children and their mothers. To answer the research questions, a multiple group structural equation model (SEM) with a structured mean analysis was used. The results suggest that nutrition education program with a self-regulatory approach had a significant effect in improving children’s self-regulatory behaviors in terms of food choice and maternal self-efficacy on home food environment. The results also showed that the program had a significant sustain able effect in terms of improving children’s dietary intakes. Using self-regulatory model, the results suggest that there are two approaches to implement the program. One approach is to modify maternal self-efficacy on the home food environment to improve children’s self-motivation and their dietary intake; another is to directly modify children’s self-regulation of food choice to improve their dietary intake.Keywords: school-aged children; nutrition education; maternal self-efficacy; self-motivation; self-regulation
Upper Gastrointestinal Endoscopy and Histopathology Appearance in Indonesian Children with Recurrent Epigastric Pain F M Susanto; Badriul Hegar; Agus Firmansyah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 8, ISSUE 3, December 2007
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/83200767-70

Abstract

Background: Recurrent Epigastric Pain (REP) is a clinical symptom frequently found in children. Data of the correlation between duration of illness, frequency of illness, associated symptoms of REP and the abnormality of endoscopic and histopathologic appearance are still limited, especially in Indonesia. The role of Helicobacter pylori (H. pylori) infection in causing organic abnormalities of the gastrointestinal tract (GIT) is also still controversial. Aim:To know the endoscopic and histopathologic appearance and the prevalence of Helicobacter pylori infection, 169 children with REP was performed for endoscopic and histopathologic examination in Department of Pediatric, Cipto Mangunkusumo hospital. Result:Endoscopic and histopathologic abnormalities were found significantly in children who suffered from REP more than 9 months and more than 6 times during 3 months of period. Conclusion: Endoscopic and histopathologic examinations should be considered in children with REP. Keywords: recurrent abdominal pain, epigastric pain, Helicobacter pylori, endoscopy and histopathology
Co-Authors Adi Suryanto B Agnes Kurniawan Alan R. Tumbelaka Anto Apriyanto Arwin A. P. Akib Asri Rasad Asril Aminullah Aswitha Boediharso Azizul Kholis, Azizul Badriul Hegar Bambang Madiyono Bobby Setiadi Dharmawan Bulan Ginting Munthe Daldiyono Harjodisastro Darlan Darwis Deddy S Putra Dion Darius Samsudin Dwirini Retno Gunarti Edi S Tehuteru Eka Laksmi Hidayati, Eka Laksmi Endi Ridwan F M Susanto Fajar Subroto Firdaus H. S. Moeslichan MZ Hardiono D Pusponegoro Hartaniah Sadikin Herbowo A. Soetomenggolo Imral Chair Irene Yuniar, Irene Junita Elvira khafi puddin Lilis D. Hendrawati Mulya Rahma Karyanti, Mulya Rahma Murti Andriastuti, Murti Muzal Kadim Najib Advani Novik Budiwardhana Nuraini I Susanti Nurhayani Partini P Trihono Partini P. Trihono Pramita G D Pramita G Dwipoerwantoro Rina Rahardiani Rio Kurniawan Risatianti Kolopaking Rosalina Dewi Roeslani Rustadi Sosrosumihardjo Septilia Inawati Wanandi Siti Budiati Widyastuti Soedjatmiko Soedjatmiko SRI LESTARI Sri P Pulungsih Sudigdo Sastroasmoro Teny Tjitrasari Tuty Rahayu Umar, Jahja Umi Fahmida Yumidiana Tya Nugraheni Yuri Pratiwi Utami Zakiudin Munasir