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Sjahid Latief, Mutawalli
Institut Sains Dan Teknologi Al-Kamal
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KAJIAN INTERAKSI ANTAROBAT DAN HUBUNGANNYA DENGAN POLIFARMASI PADA PASIEN SKIZOFRENIA Andi Ahriansyah; Mutawalli Sjahid latief
IONTech Journal Vol 7 No 1 (2026): Februari 2026
Publisher : Institut Sains dan Teknologi Al-Kamal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62702/ion.v7i1.160

Abstract

Schizophrenia is a chronic mental disorder affecting thought processes, perception, affect, and behavior, requiring long-term pharmacotherapy. In routine practice, patients frequently receive multiple concurrent medications (polypharmacy) to control psychiatric symptoms and manage comorbid conditions, which may increase drug-related problems, particularly potential drug–drug interactions (pDDIs). This study aimed to identify pDDIs and examine their association with the number of prescribed drugs among outpatients with schizophrenia at a public hospital in Jakarta. A retrospective analytical cross-sectional study was conducted from January to June 2025. From 357 outpatients, 15 medical records met the inclusion criteria (age ≥18 years, schizophrenia as the primary diagnosis, complete demographic/clinical and medication data, and at least two drugs per visit). Patient characteristics and medication profiles were collected. pDDIs were identified based on drug combinations and categorized by severity. The association between the number of drugs (<3 vs ≥3) and pDDIs was assessed using chi-square testing with odds ratio (OR). Most patients were aged 46–55 years (53.3%), and 73.3% had no documented comorbidities. The most frequently prescribed antipsychotics were risperidone (46.7%) and clozapine (33.3%), and 66.7% of patients received ≥3 drugs. pDDIs were detected in all prescriptions (15/15; 100%), totaling 26 events, predominantly moderate (73.08%) rather than major (26.92%). The most common interaction was risperidone–trihexyphenidyl (15.38%). No statistically significant association was found between the number of drugs and pDDIs (p=0.591; OR 0.444; 95%CI 0.022–9.032). These findings highlight the need for ongoing medication review and clinical pharmacy services to mitigate interaction risks, particularly involving antipsychotics and concomitant therapies.
Co-Authors Adelia Unayah Andi Ahriansyah Bayu Eriyanto Chotimah, Siti Khusnul DAVID KURNIAWAN Destian, Lutfi Dian Rahmat Haryanto Ekadipta Ekadipta Hardiyati, Iin Hidayat, Febri Ivans Panduwiguna Jessica Charismawati Sinaga Lala Makbulah Lilistiatun Mardikayasa, I Ketut Marwan, Ujang Sofyudin Nurul Farida Oktaviani, Nabilla Reza Ismail Abdul Rahman Rizky Damayanti Saroh, Suci Retna Sri Sufiyanti Syabrina Adilas Ogiuma