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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Biotropika Jurnal Ilmu-Ilmu Peternakan (Indonesian Journal of Animal Science) The Journal of Pure and Applied Chemistry Research Jurnal Ternak Tropika Journal of Tropical Biodiversity and Biotechnology Indonesian Journal of Chemistry JSMARTech : Journal of Smart Bioprospecting and Technology Berkala Penelitian Hayati Makara Journal of Science Journal of Agriprecision & Social Impact
Hermanto, Feri Eko
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Brawijaya University, Indonesia; Science Bridge Indonesia, Department Of Biology, Faculty Of Mathematics And Natural Sciences, Brawijaya University, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Social Sciences Other

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Daruju (Acanthus ilicifolius L.) May Exhibit Anti-Breast Cancer Activity Through Inhibition of Proliferation Regulators: A Computational Study: Daruju (Acanthus ilicifolius L.) as Anti-Breast Cancer Agent Rosyadah, Nuraini; Kamila, Fairuz Sarah; Hermanto, Feri Eko; Widyananda, Muhammad Hermawan; Grahadi, Rahmat; Dwijayanti, Dinia Rizqi; Widodo, Nashi; Ulfa, Siti Mariyah
Journal of Tropical Life Science Vol. 15 No. 1 (2025)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/

Abstract

Breast cancer's increasing prevalence globally underscores the urgent need for effective and gentle therapies, positioning the exploration of herbal remedies as a critical pursuit. Daruju (Acanthus ilicifolius L.) emerges as a compelling candidate due to its inherent bioactive components. This research pioneers the application of advanced computational techniques to unveil the latent anti-breast cancer potential within A. ilicifolius. Our in-silico investigation commenced by cataloging A. ilicifolius compounds using the KNApSAcK database and existing literature. These compounds underwent rigorous screening for drug-like characteristics via SWISS-ADME and potential biological activity using PASS ONLINE. Protein targets relevant to breast cancer were predicted through SWISS Target and the STRING database, integrated with Cytoscape for network visualization. Molecular docking, performed with PyRx 0.8, assessed the binding strength between the identified compounds and target proteins, with the most promising interactions selected for further scrutiny. The stability of these crucial interactions was then evaluated through molecular dynamics simulations using YASARA. This comprehensive computational strategy aims to pinpoint potential anti-breast cancer agents derived from A. ilicifolius. Initial analysis of 17 compounds from A. ilicifolius, based on chromatography, databases, and prior studies, narrowed down to five that adhered to Lipinski’s Rule of Five for drug-likeness: 4-O-beta-D-glucosyl-4-coumaric acid, (-)-lyoniresinol, α-amyrin, adenosine, and p-coumaric acid. These compounds were predicted to directly interact with key breast cancer-related proteins across pathways like estrogen signaling, JAK/STAT, and PI3K/AKT. Notably, molecular docking revealed strong binding affinities for α-amyrin with CDK4, ER, and EGFR (-7.5 kcal/mol, -9.5 kcal/mol, and -8.7 kcal/mol, respectively), comparable to known inhibitors. Molecular dynamics simulations further corroborated the stability of these complexes, analyzing RMSD and binding affinity parameters. Consequently, α-amyrin stands out as a promising anti-breast cancer agent within A. ilicifolius, exhibiting potential to inhibit proteins crucial for breast cancer cell proliferation and survival, including CDK4, ER, and EGFR.
High-Dose Gamma Irradiation Reduces Pathogenic Bacteria While Preserving Beneficial Taxa in Indonesian Traditional Food ‘Gudeg’ Pratama, Indra Mustika; Benita, Ashri Mukti; Hermanto, Feri Eko; Lasmawati, Deudeu; Kadir, Idrus; Sugoro, Irawan
Journal of Tropical Life Science Vol. 15 No. 3
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.15.03.10

Abstract

Gudeg, a traditional Indonesian dish, is highly susceptible to microbial spoilage. Irradiation technology can be utilized to extend the shelf life of gudeg while preserving its nutritional value. However, the effects of gamma irradiation on the bacterial abundance in food products have not been widely researched. This study investigated how gamma irradiation influences its bacterial community. Vacuum-packed gudeg was gamma-irradiated in a frozen condition at a dose of 20 kGy, with a dose uniformity ratio (DUR) of 1.08. The resulting microbiome was characterized via 16S rRNA sequencing, using non-irradiated gudeg as a comparison. Gudeg samples were then amplified using the standard 16S rRNA V3-V4 primers. After taxonomic classification, alpha diversity indices—Shannon, Margalef, Chao1, and ACE—were applied to compare species richness and evenness in irradiated and non-irradiated samples. The research results showed that irradiation substantially reduced Proteobacteria, particularly staphylococcal species, while preserving beneficial lactic acid bacteria, such as Weissella sp. The overall diversity slightly decreased, but pathogenic risks diminished, indicating extended shelf stability. These findings suggest gamma irradiation as an effective strategy to enhance gudeg's safety and longevity. Furthermore, they offer insights into broader applications of irradiation for preserving high-moisture, ready-to-eat foods and indicate that sustainable research into the effects of irradiation on spoilage microbes and specific pathogens in various traditional food products is possible.
Phytochemical Screening and In Silico Prediction of Gynura divaricata Ethanolic Extract as A Potential PIM-1 Inhibitor: Phytochemical and In Silico Prediction of Gynura divaricata Puspitarini , Sapti; Hermanto, Feri Eko; Rohim, Abd; Dliyauddin, Moh; Hendratmoko, Ahmad Fauzi; Budiyanto, Mohammad; Ilhami, Fasih Bintang
Journal of Tropical Life Science Vol. 16 No. 01 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.01.06

Abstract

The pharmacological properties and traditional uses of medicinal plants often correlate with their bioactive constituents, which contribute to diverse therapeutic effects, including anticancer activity. Cancer remains one of the leading causes of mortality worldwide, and the discovery of novel anticancer agents from natural sources continues to be an important research focus. Gynura divaricata is a medicinal herb widely used in traditional Asian medicine for treating diseases. Recent studies have reported that G. divaricata contains several bioactive compounds. such as flavonoids, phenolic acids, terpenoids, and alkaloids, which are known for their antioxidant and anticancer properties. However, despite its traditional use and pharmacological potential, the molecular mechanisms underlying the anticancer activity of G. divaricata remain poorly understood. This study aimed to screen the phytochemical content of the ethanolic leaf extract of G. divaricata and to predict its potential anticancer activity through computational analysis targeting the PIM-1 protein. The DPPH inhibition, total flavonoid content, and total phenolic content of the extract were evaluated. Phytochemical profiling was performed using LC-HRMS. Molecular docking and molecular dynamics simulations were conducted to predict the interactions between the active compounds of G. divaricata and the PIM-1 protein. The extract exhibited 50% DPPH inhibition at a concentration of 2071.01 ppm, with total flavonoid and total phenolic contents of 107.44 ± 4.41 mg QE/g and 10.96 ± 0.49 mg GAE/g, respectively. Identified bioactive compounds, including curcumin, (+)-ar-turmerone, and 4-coumaric acid, were further analyzed through molecular docking to assess their interactions with the PIM-1 kinase. The docking results revealed that these compounds showed favorable binding affinities to the active site of PIM-1, suggesting their potential as anticancer agents. This study is the first to report the potential of G. divaricata active compounds as PIM-1 inhibitors, warranting further validation through both in vitro and in vivo studies.  
Co-Authors Abdilah, Riki Adzral Alamsyah Agus Susilo Ahmad Fauzi Hendratmoko Ahmad Hafidul Ahkam Ahmad Khoirul Umam Alvionita, Cicin Vinolia Andyni, Regina Shania Atika Hanoum Rahasta Benita, Ashri Mukti Budiarti, Indi Rachmaning Dedes Amertaningtyas Deudeu Lasmawati, Deudeu Dinia Rizqi Dwijayanti Dliyauddin, Moh Dodyk Pranowo Elly Purwanti Elvina Dhiaul Iftitah Eny Sri Widyastuti Essy Harnelly Fasih Bintang Ilhami, Fasih Bintang fatchiyah . Fatmala, Dina Fionita, Rina Aqila Fitriani, Chunafa Ayu Grahadi, Rahmat Herly Evanuarini I Gusti Ngurah Agung Wiwekananda Ibrahim, Mutiara Dwirosita Idrus Kadir Irawan Sugoro Iva Himmatul Aliyyah Kalle, Amalia Dzulhaj Mutia Kamila, Fairuz Sarah Khothibul Umam Al Awwaly Lailiyah, Nurun Nafi'atul Lucy Arianie Margareth Rika Wahyusari Gabriella Lorenza Marwi, Filoza Miftakhul Cahyati MOHAMMAD BUDIYANTO Muhaimin Rifa'i Muhammad Halim Natsir Narwasthu, Sekararum Nashi Widodo Nashi Widodo Nia Kurniawan Nurjannah Nurjannah Pratama, Indra Mustika Primandasari, Elma Putri Puspitarini , Sapti Ria Dewi Andriani Robiatul Adawiyah Rohim, Abd Rosyada, Nabila Nur Rosyadah, Nuraini Saleha, Rischa Amalia Sintiya Siti Mariyah Ulfa Syahraini, Aigia Tutut Indria Permana Wahyu Prihanta Warsito Warsito Widodo Widodo Widyananda, Muhammad Hermawan Wolfgang Nellen Yuli Frita Nuningtyas