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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Berkala Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Biologi Tropis Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Indonesian Journal of Pharmacy and Natural Product Academic Hospital Journal Indonesian Journal of Biomedicine and Clinical Sciences
Fuzianingsih, Eka Noviya
Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Potensi Antioksidan Biji Pepaya terhadap Parameter Oksidatif Jantung pada Tikus Jantan Model Diet Tinggi Lemak: Antioxidant Potential of Papaya Seeds on Cardiac Oxidative Parameters in Male Rats with High Fat Diet Model Arif Santoso; Choirul Huda; Sulastri; Pera Amelia; Rissa Laila Vifta; Melati Aprilliana Ramadhani; Eka Noviya Fuzianingsih
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 01 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i01.3836

Abstract

An imbalance between the body's antioxidant system capacity and free radical production can lead to oxidative stress, which ultimately causes the lipid peroxidation process. This phenomenon is commonly identified by increased superoxide dismutase (SOD) activity and reduced malondialdehyde (MDA) concentrations. The objective of this study was to assess the efficacy of ethanolic papaya seed (Carica papaya L.) extract in modulating SOD and MDA levels in the heart tissue of male Sprague-Dawley rats subjected to a high-fat diet over 17 days. A total of 30 rats were used and allocated into six groups: a positive control (K+), a negative control (K−), a standard control (KN), and three treatment arms receiving oral doses of 150 mg/kgBW (P1), 250 mg/kgBW (P2), and 350 mg/kgBW (P3). The extraction process employed 70% ethanol through maceration. The lowest MDA average was recorded in the P3 group (3.50±1.65), whereas the K-group exhibited the highest level (24.45±4.71). In terms of SOD, the K+ group had the highest mean (65.46±5.93), and the K− group the lowest (36.34±7.57). Statistical analysis using Tukey’s test showed that administration of 350 mg/kg body weight extract yielded results closely resembling those of the positive control. However, the observed differences did not reach statistical significance (p > 0.05). The conclusion is that administration of papaya seed extract at a dose of 350 mg/kgBW has the potential to reduce MDA levels and increase SOD levels, with effects similar to positive controls.   ABSTRAK Tidak seimbangnya antara kapasitas sistem antioksidan tubuh dan produksi radikal bebas dapat mengakibatkan kearah stres oksidatif, yang pada akhirnya menyebabkan proses peroksidasi lipid. Keadaan ini ditandai oleh aktivitas enzim superoxide dismutase (SOD) yang meningkat dan konsentrasi malondialdehida (MDA) yang menurun. Penelitian ini bertujuan mengevaluasi potensi ekstrak etanol biji pepaya (Carica papaya L.) dalam memodulasi kadar SOD dan MDA pada jaringan jantung tikus jantan galur Sprague Dawley yang diberi diet tinggi lemak pada rentang waktu 17 hari. Penelitian ini memakai desain eksperimental dengan melibatkan 30 ekor tikus, yang dikelompokkan menjadi enam: kelompok kontrol positif (K+), kontrol negatif (K−), kontrol normal (KN), serta tiga kelompok perlakuan dengan dosis bertingkat yaitu 150 mg/kgBB (P1), 250 mg/kgBB (P2), dan 350 mg/kgBB (P3). Ekstrak diperoleh melalui metode maserasi menggunakan pelarut etanol 70%. Hasil analisis menyatakan bahwa kadar MDA terendah ditemukan pada kelompok P3 (3,50±1,65), sedangkan kadar tertinggi terdapat pada kelompok K− (24,45±4,71). Sebaliknya, kadar SOD tertinggi dicatat pada kelompok K+ (65,46±5,93) dan terendah pada kelompok K− (36,34±7,57). Berdasarkan uji lanjut Tukey, pemberian ekstrak biji pepaya dosis 350 mg/kgBB (P3) memberikan hasil yang secara statistik mendekati kelompok kontrol positif, meskipun belum menyatakan perbedaan bermakna (p > 0,05). Kesimpulannya adalah pemberian ekstrak biji pepaya dosis 350 mg/kgBB memiliki potensi pada penurunan kadar MDA dan meningkatkan kadar SOD, dengan efek yang menyerupai kontrol positif.
The Role of TNF-α (Tumor Necrosis Factor-alpha) in Pulmonary Tuberculosis Sulistyasmi, Wiwit; Fuzianingsih, Eka Noviya; Kuncara, Rachmad Bayu
Academic Hospital Journal Vol 7, No 2 (2025)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v7i2.106190

Abstract

Background: Tuberculosis (TB) remains a primary global health concern, with Indonesia accounting for approximately 10% of international cases. Tumor necrosis factor-alpha (TNF-α) plays a crucial role in the immune response against Mycobacterium tuberculosis, particularly in pulmonary tuberculosis (TB).Method: This article is a narrative literature review that examines the role of tumor necrosis factor-alpha (TNF-α) in pulmonary tuberculosis.Result:  This pro-inflammatory cytokine is essential for activating macrophages, promoting phagolysosome fusion, and supporting the formation and maintenance of granulomas—immune structures critical for containing infection. However, dysregulated TNF-α expression can be detrimental: excessive levels contribute to inflammation and lung tissue damage, while insufficient production—such as that induced by TNF-α inhibitor therapy—can lead to reactivation of latent TB. This narrative review examines the biosynthesis, immunological functions, and regulatory mechanisms of TNF-α in the context of pulmonary tuberculosis, highlighting its dual role in protective immunity and immunopathology.Conclusion: A deeper understanding of TNF-α modulation may inform the development of targeted, host-directed therapies that improve treatment outcomes while minimizing tissue damage.
Treatment in transient synovitis cases: A review Sananta, Panji -; Anggadha, Fernaldhi -; Fuzianingsih, Eka Noviya
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.17967

Abstract

Inflammation of the synovial membrane of a joint is a common symptom of transient synovitis (TS), which is the medical term for a condition that leads to hip discomfort in juvenile patients.  The estimated annual incidence of TS is 0.2%, and the risk of developing the disease over one's lifetime is 3%.  Unfortunately, the specific pathophysiology of TS is still unclear.  Therefore, the particular treatment is still debatable.  There are several methods of treating TS, starting with bed rest in the hospital and using analgesics, steroids, skin traction, and joint aspiration.  Most of the time, transient synovitis is a self-limiting condition that heals independently and is managed conservatively by monitoring and rest.  Several medical therapy options, including analgesics, NSAIDs, and corticosteroids, speed up healing.  On the other hand, skin traction is also reported to provide beneficial therapeutic effects for TS patients.  Thus, with many therapeutic options, TS's "golden" management still needs further study.
A literature review of current surgical treatment for congenital pseudoarthrosis of the tibia Sananta, Panji -; Nasution, Ade Yahya; Fuzianingsih, Eka Noviya
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.19066

Abstract

Congenital pseudarthrosis of the tibia (CPT) is an infrequently observed condition. However, it is considered to be one of the most complex ailments in the field of pediatric orthopedics. In cases where a tibial fracture is absent, the conventional treatment approach involves using bracing as a preventive measure against fractures. Various surgical modalities have been proposed for the management of CPT, including intramedullary (IM) rod fixation, external fixators, on-lay grafts, cancellous grafts, periosteal grafts, Paley cross-union, amputation, vascularized fibula grafts, and induced membrane techniques. These modalities can be used in different combinations and permutations. The need for repetitive surgical interventions due to unsuccessful therapeutic outcomes or modifications in secondary treatments can significantly disrupt the childhood experience, resulting in prolonged and recurrent functional limitations. In certain instances, amputation may be required as a primary or secondary treatment modality. This literature review will clarify the current surgical interventions for CPT disease based on a summary of research data. The surgery the patient receives significantly impacts their general health and capacity to heal.
A literature review of diagnosing transient synovitis hip disease: English Sananta, Panji -; Ismanuworo, Agung; Eka Noviya Fuzianingsih
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.20329

Abstract

Transient synovitis (TS), an abrupt, non-specific synovium inflammation, is the most prevalent cause of pediatric hip discomfort. Transient synovitis affects 3–10-year-olds. This disease is benign and self-limiting, but clinicians must distinguish it from an acute infection. After ruling out other causes of hip discomfort and limping, clinicians detect transient synovitis. Based on the patient's history, physical examination, and hip radiography, septic arthritis (SA) and TS care are the most likely causes. Clinicians must consider clinical factors and order appropriate lab and imaging tests to rule out alternative illnesses. This review aims to determine how to propose TS hip disease. The databases used were Scopus and PubMed. We included seven articles in our review. Clinical symptoms, lab testing, and radiographs determine the diagnosis. Ultrasound is a useful TS diagnostic tool since it is widely available, and children are not directly exposed to ionizing radiation. If TS and SA illnesses, which are commonly linked, are unclear, detecting bone marrow abnormalities, soft tissue lesions, synovial enhancement, and joint effusion by MRI can be beneficial. Laboratory tests help distinguish TS from SA because there are more extensive evaluations. Additionally, the healthcare provider performs a hip joint aspiration examination under ultrasound or fluoroscopy.
Management of Habitual Patellar Dislocation in Pediatrics Sananta, Panji -; Churie Tanjaya, Ade; Fuzianingsih, Eka Noviya
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.22714

Abstract

Habitual patellar dislocation occurs when the knee is bent and returns to its usual position when straightened. Habitual patella dislocation is 13.5 per 100,000 in children under 13 and 147.7 per 100,000 in children 14–18. This review aims to present a comprehensive and complete literature on the management of habitual dislocation of the patella so that appropriate therapy can be obtained. A complete literature review was used in this investigation. Source search databases are PubMed, Science Direct, and Google Scholar. The literature study shows that habitual patellar dislocation in children is infrequent. Stability requires bone and connective tissue that match the patellofemoral joint. Patella alta, torsional, angular, trochlear dysplasia, muscular anomalies, ligamentous laxity, or ligament damage can produce lateral patellar habitual instability. The quadriceps muscle drags laterally to the limb's mechanical axis. Clinical children with recurrent patellar dislocation may experience a sudden dislocation that "disappeared somewhere." If this condition returns, patients frequently develop unusual knee edema and inflammation. MRI, CT, and plain radiography can diagnose this condition. A CT scan can detect trochlear dysplasia. Joint effusion, osteochondral lesions, medial retinaculum tears, and medial patella and lateral femoral condyle cartilaginous discolorations can be seen by MRI. Conservative or surgical treatment of habitual patellar dislocation depends on the deformity and its effects.
THE POTENCIES OF AUTOLOGOUS-CONDITIONED PLASMA FOR THE TREATMENT OF OSGOOD–SCHLATTER DISEASE: A LITERATURE REVIEW SANANTA, PANJI; PUTRA, YUDHA ANANTHA KHAERUL; FUZIANINGSIH, EKA NOVIYA
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol. 8 No. 1 (2025): Al-Iqra Medical Journal: Jurnal Berkala Ilmiah Kedokteran
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v8i1.15814

Abstract

Osgood-Schlatter disease (OSD) is characterized by inflammation of the patellar ligament at the tibial tuberosity resulting from growth-related overuse. Traction apophysitis of the anterior component of the tibial tuberosity (ATT) happens when the quadriceps muscle contracts at the point where the proximal tibial apophysis attaches to the tibia. The recommended interventions include the administration of analgesics, the provision of instruction on physical activity, and the implementation of physiotherapy. However, the duration of signs and symptoms can be extended. Autologous-conditioned plasma (ACP) injections are increasingly being employed in treating various musculoskeletal diseases due to their elevated concentration levels of growth factors compared to whole blood. The Autologous Concentrated Platelets (ACP) solution consists solely of platelet-rich plasma (PRP) devoid of leukocytes. This concentrated PRP will be administered via injection into the affected trauma region. The present literature evaluation used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. The current literature review demonstrates that autologous conditioned plasma (ACP) is a suitable alternative therapy for osteochondritis dissecans (OSD). The efficacy of OSD treatment can be enhanced by administering autologous conditioned plasma (ACP) into the affected region. Using autologous conditioned plasma (ACP) to treat orthopaedic and traumatological conditions, such as OSD and other musculoskeletal injuries, has much potential as a therapeutic intervention in orthopaedics and traumatology.         
Antibacterial Activity of Red Ginger (Zingiber officinale) Extract Against Diarrhea Causing Bacteria Using the Well Diffusion Method Fuzianingsih, Eka Noviya; Rahmawati, Ayu Sintya Citra; Safitri, Yunita Diyah
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10911

Abstract

Acute diarrhea resulting from bacterial infections remains a significant concern in public health. The improper or excessive use of antibiotics contributes to the emergence of antibiotic resistance, creating a need for safer therapeutic alternatives derived from natural sources, such as red ginger (Zingiber officinale). This study aimed to evaluate the antibacterial potential of red ginger extract against Escherichia coli, one of the common bacterial agents causing diarrheal disease. The assessment was carried out using the well-diffusion technique by observing and measuring the diameter of the inhibition zones produced by the extract. The extract was tested at concentrations of 40%, 60%, and 80%, accompanied by a positive control (ciprofloxacin 1 mg/mL) and a negative control (distilled water). The findings demonstrated that the positive control produced a mean inhibition zone of 44.375 mm, whereas the negative control showed no inhibitory activity. The 40% extract yielded an average inhibition zone of 17.125 mm, the 60% concentration produced 19.625 mm, and the 80% concentration generated an average diameter of 22 mm. Statistical evaluation using one-way ANOVA indicated a significance level of ≤ 0.05, and the Duncan post hoc analysis confirmed significant differences between all extract concentrations compared to the antibiotic control. Overall, the study demonstrated that red ginger extract possesses substantial antibacterial activity and effectively suppresses the growth of diarrhea-causing E. coli through the well-diffusion approach.
Co-Authors Ade Churie Tanjaya Ade Yahya Nasution Ade Yahya Nasution, Ade Yahya Adithya Stephana Mahendra Agung Ismanuworo Agung Ismanuworo Anggadha, Fernaldhi - Arif Santoso Choirul Huda Churie Tanjaya, Ade Cyuzuzo Callixte Dhelya Widasmara Dinda Eka Putri Fernaldhi - Anggadha Haidar Abror Firladi Hansel Hansel Heny Arwati Kuncara, Rachmad Bayu Lucia Tri Suwanti, Lucia Tri Marselaonety La’lang Melati Aprilliana Ramadhani Panji Sananta Panji Sananta Pera Amelia PUTRA, YUDHA ANANTHA KHAERUL Rahmawati, Ayu Sintya Citra Safitri, Yunita Diyah Sananta, Panji - SULASTRI vifta, rissa laila Wildan Faza Pratama Wiwit Sulistyasmi