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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Natur Indonesia Warta IHP (Warta Industri Hasil Pertanian) Jurnal Penelitian Karet Indonesian Journal of Chemistry Indonesian Journal of Cancer Teknologi dan Industri Pertanian Indonesia
SUMINAR SETIATI ACHMADI
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : hayati journal of biosciences

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Heavy Metals Bioaccumulation of Several Bradyrhizobium japonicum Strains ADE NOOR SYAMSUDIN; TEDJA -IMAS; SUMINAR SETIATI ACHMADI
HAYATI Journal of Biosciences Vol. 12 No. 3 (2005): September 2005
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.021 KB) | DOI: 10.4308/hjb.12.3.108

Abstract

Heavy metal utilization in industry and agriculture have caused an environmental problem to existing life. Bioaccumulation is made up by a concentration of certain chemical compounds in living tissues. The objective of this research was to reveal the ability of lipopolysaccharides (LPSs) of heavy metal Bradyrhizobium japonicum tolerant strains in accumulating heavy metals. The strains used were BDG 10, KDR 10, and KDR 15. The ability of each strains on heavy metal accumulation of Cu, Pb, Zn, Ni, and Cd were quantitatively determined using atomic absorption spectrophotometry. The result showed that each strains has its own capacity to accumulate heavy metals. Accumulation of Cu (0.100), Pb (0.320), and Cd (0.048) ppm/mg dry weight by KDR 10 seem higher than BDG 10 and KDR 15. The highest accumulation of Zn and Ni was shown by KDR 15 in which the value were 0.360 and 0.165 ppm/mg dry weight, respectively and the least accumulation of all heavy metal studied was shown by BDG 10.
Antigout Activity of The Spatholobus littoralis Hassk. Extract Fractions Against Xanthine Oxidase: Its Metabolite Profile and Inhibition Kinetics Rut Novalia Rahmawati Sianipar; Komar Sutriah; Dyah Iswantini; Trivadila; Suminar Setiati Achmadi
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.1-20

Abstract

The Spatholobus littoralis Hassk. (S. littoralis Hassk.) is a native plant in Indonesia and has been widely used in traditional Dayaknese medicine for non-communicable degenerative diseases. One of these illnesses, known as gout, is caused by excessive uric acid in the blood, which is the catalytic byproduct of a xanthine oxidase (XO) enzyme. In this work, we investigated the inhibition kinetics of XO and identified bioactive compounds from the stem extract fractions of S. littoralis Hassk. using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Fractionation was carried out to obtain n-hexane, dichloromethane, and 1-butanol fractions from the water and 70% ethanol extracts. Fraction of 1-butanol from 70% ethanol and water extract displayed potent inhibitors of XO with IC50 value 116.91±3.51 and 137.15±5.00 mg/L, respectively. Lineweaver-Burk plot analysis showed that the 1-butanol fraction from the two extracts inhibited XO competitively. The 1-butanol fraction from the two extracts has been further identified as a bioactive fraction. The majority of the compounds in the two active fractions were phenolics. These findings revealed that the 1-butanol fraction from the two extracts is promising as an antigout treatment in the future.
Co-Authors -, Rienoviar . TRIVADILA ADE NOOR SYAMSUDIN Adi Cifriadi Adi Cifriadi, Adi Agustin Sri Mulyatni Amalia Yunita Anjas Asmara Samsudin Anuraga Jayanegara Arif Rakhman Hakim Arif Rakhman Hakim Atep Dian Supardan Azmi Azhari Budi Arifin C Hanny Wijaya Cecep Abdurohman Putra Dian Susanthy Dumas Flis Tang Dyah Iswantini Erika B. Laconi Fretty Yurike Harsi D. Kusumaningrum Henny Purwaningsih Ihsan Anggara Irma Herawati Suparto Irmanida Batubara Komar Sutriah Laita Nurjannah Luthfan Irfana Mohamad Rafi Mohamad Rafi Muhana Nurul Hidayah Muhana Nurul Hidayah, Muhana Nurul Mulyatni, Agustin Sri Pristian Yuliana Purwantiningsih Sugita Purwantiningsih Sugita Raffi Paramawati Rienoviar - ROHAYATI SUPRIHATINI Rohayati Suprihatini Rudi Heryanto Rut Novalia Rahmawati Sianipar Septaningsih, Dewi Anggraini SILMI MARIYA Silmi Mariya Suliantari Suliantari Suryani Suryani TEDJA -IMAS Tun Tedja Irawadi Valentina Sokoastri Valentina Sokoastri Vikra Ardiansyah Zaini Yuyu Yundhana