Article Per Year (5 Year)
p-Index From 2021 - 2026
2.109
P-Index
This Author published in this journals
All Journal IAES International Journal of Artificial Intelligence (IJ-AI) Jurnal Kesehatan Masyarakat WIDYA LAKSANA Jurnal Kesehatan Tambusai Molucca Medica GANESHA MEDICINA JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Sehat Indonesia (JUSINDO) JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Ni Nyoman Mestri Agustini
Jurusan Penjaskesrek Fakultas Olahraga Dan Kesehatan UNDIKSHA, Bali
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

Published : 21 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 21 Documents
Search

 1   2   3 
Cilostazol or clopidogrel? Comparative evidence on bleeding risk, stroke recurrence, and mortality in ischemic stroke – A systematic review and meta-analysis Okaniawan, Kadek Kovaleviska; Maheswari, Ni Putu Devi; Okaniawan, Putu Enrico Pramana; Agustini, Ni Nyoman Mestri; Sastri, Ni Luh Putu Pranena
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 2, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss2.art12

Abstract

Ischemic stroke remains a major contributor to global mortality and long-term disability, with antiplatelet therapy representing a fundamental strategy for secondary prevention. Cilostazol and clopidogrel are widely utilized antiplatelet agents; however, existing comparative evidence on their safety and efficacy, particularly regarding bleeding risk, stroke recurrence, and mortality, is inconsistent. This systematic review and meta-analysis aim to evaluate and compare the efficacy and safety of cilostazol versus clopidogrel in patients with ischemic stroke. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We conducted a comprehensive literature search across PubMed, Scopus, and Google Scholar up to September 2025. Eligible studies included randomized controlled trials and retrospective cohort studies directly comparing cilostazol and clopidogrel in adult patients with ischemic stroke. Multiple reviewers independently extracted data and selected studies using Covidence software to ensure consistency. We assessed risk of bias using the RoB 2.0 and ROBINS-I tools. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using Mantel–Haenszel methods. Eight studies comprising 8,249 participants were included in the analysis. Cilostazol was associated with lower risks of hemorrhagic complications (RR 0.77; 95% CI: 0.58–1.03) and mortality (RR 0.86; 95% CI: 0.70–1.04), although neither difference was statistically significant. No significant differences were identified between cilostazol and clopidogrel in recurrent ischemic stroke events or functional outcomes. Overall, both agents demonstrated comparable efficacy and safety profiles, supporting individualized treatment decisions based on clinical characteristics, bleeding risk, and comorbidities.
Co-Authors Adibrata, Kadek Wanda Pratiwi Dinata, I Gede Surya Evelyn, Ni Putu Nirmala Gede Doddy Tisna MS I Made Kusuma Wijaya Jagadhita, I Made Ari Lanang Mahosadi Kadek Yota Ernanda Aryanto Kamelia, Luh Putu Lina Kapakisan T., I Ketut S. Kapakisan, I Ketut Kesanda, I Made Phala Landra, I Komang Gunawan Lestari, Made Widya M.Cs S.Kom I Made Agus Wirawan . Made Agus Dharmadi Maharani, Risma Maheswari, Ni Putu Devi Ni Luh Kadek Alit Arsani Ni Luh Putu Pranena Sastri, Ni Luh Putu Pranena Okaniawan, Kadek Kovaleviska Okaniawan, Putu Enrico Pramana Prajaniti, Ni Putu Kaori Putra, Bayu Pramana Suryawan S.Ked. dr. Ni Made Sri Dewi Lestari . S.Pd. M Kes I Ketut Sudiana . Savitri, Desak Nyoman Pashita Savitri, Putu Rania Apta Sukajaya, I N. Ulandari, Komang Sherly Widhiyanti Metra Putri, Dewi Arum Wiratama, Bayu Kresna Yoga, Putu Cahyani Paramita