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Pemanfaatan Spirulina Platensis sebagai Masker Gel Peel-Off Adi Permadi; Suhendra Suhendra; Mustofa Ahda; Syaeful Akbar Padya; Ananda Ranu Bachtiar; Aulia Nur Rahma; Elza Naura Syafitri; Vania Insani Syita Harmony; Yeni Triwidyastuti
Jurnal Pendidikan dan Konseling (JPDK) Vol. 4 No. 6 (2022): Jurnal Pendidikan dan Konseling
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jpdk.v4i6.8536

Spirulina merupakan mikroalga bersel tunggal yang hidup di air dan berkembang biak dengan membelah diri yang dikenal sebagai sumber nutrisi tanaman lengkap yang kaya akan asam amino esensial, vitamin, mineral dan karotenoid. Memiliki aktivitas antibakteri terhadap beberapa mikroorganisme misalnya Propionibacterium acne, Streptococcus epidermidis, dan Staphylococcus aureus, tiga bakteri jerawat terkait. Penelitian ini bertujuan untuk memformulasi ekstrak etanolik spirulina menjadi masker gel peel-off dengan Polyvinyl Alcohol (PVA) dan Hydroxypropyl Methylcellulose sebagai gelling agent. Ekstrak etanol spirulina 2% diformulasikan menjadi masker gel peel off dengan perbandingan PVA dan DMC yang bervariasi. Persentase PVA: DMC pada formula A adalah 2,25% : 1,25%, pada formula B 2,00% : 1,05%, pada formula C 1,50% : 1,15%. Pengujian stabilitas fisik dilakukan pada masing-masing formula meliputi uji organoleptik, homogenitas, pH, waktu kering, viskositas, uji dispersi, uji waktu kering. Hasil penelitian menunjukkan bahwa formula A (DMC 1, 25%: PVA 2, 25%) dan formula B (DMC 1.05%: PVA 2.00%) memenuhi semua syarat uji stabilitas fisik yaitu nilai pH 5,00, dispersi 10, 30 cm, nilai viskositas 557 CP, waktu kering 29 menit 21 detik untuk formulasi A, dan nilai pH 5,00, dispersi 11,20 cm, nilai viskositas 207 CP, waktu kering 32 menit 01 detik untuk formulasi B.

Hilirisasi Produk Sediaan Kapsul Spirulina Platensis Adi Permadi; Suhendra Suhendra; Mustofa Ahda; Syaeful Akbar Padya; Khalif Fathan Muzakki; Noor Syahdan Fitrianto; Yolanda Waldatul Marwa
Jurnal Pendidikan dan Konseling (JPDK) Vol. 4 No. 6 (2022): Jurnal Pendidikan dan Konseling
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jpdk.v4i6.8537

Indonesia berhadapan dengan masalah kesehatan khususnya pada prevalensi penyakit degeneratif. Penelitian ini bertujuan untuk mengatasi dampak radikal bebas yang memberi efek buruk pada kesehatan. Perlunya antioksidan dalam mengatasi permasalahan ini diatasi dengan pemanfaatan spirulina. Kandungan protein yang tinggi dan beragam kandungan yang bermanfaat mendorong pentingnya spirulina untuk dikonsumsi. Produk kapsul spirulina 100% telah diuji sesuai standar BPOM. Hasil analisis uji kapsul spirulina diketahui semua parameter uji telah memenuhi syarat sehingga kapsul spirulina layak untuk dikonsumsi. Kapsul spirulina menggunakan kapsul dari bahan gelatin yang telah memiliki lisensi halal MUI dan dikemas dengan botol HDPE yang telah diuji. Selain itu, produk kapsul spirulina juga dilengkapi dengan label agar memudahkan konsumen mendapatkan informasi kandungan dan manfaat dari produk spirulina.

Evaluation the Fractions from Extract Ethanol Psidium Guajava Leaves on Total Phenolic Content, Antioxidant Activity and Its Antibacterial Activity of Staphylococcus Aureus. Mustofa Ahda
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Objective: The aims of this research to find the potential extract and fraction from ethanol extract of Psidium Guajava L for natural antioxidant and antibacterial. The extract and fraction of Psidium Guajava L was analyzed the phenol total content, antioxidant activity and its antibacterial. Methods: The ethanol extract of Psidium Guajava L was extraxted using n hexane, ethyl acetate and water. The all fraction and ethanol extract of Psidium Guajava L was determined the scavenging activity, penolic compound. The scavenging activity was determined by DPPH method. The phenolic compound was determined with Folin-Ciocalteu method. Results: The result of this research showed that the fraction of ethyl acetate has highest antioxidant activity with the value is 9.07 µg/mL. It is also supported by the result of screening phytochemical that ethyl acetate fraction contains mostly complete of chemical substances. However, The highest total phenol content was found in water fraction with phenolic content of 26%. The anbacterial activity of ethanol 96% extract of Psidium guajava leaves and ethyl acetate fraction have a highly activity to inhibit the Staphylococcus Aureus. Conclusion: The fraction of ethyl acetate has a highest of antioxidant activity, although it doesn’t have highest of total phenolic content. The highest of total fenolic content from water fraction is 26%. The scheme of antibacterial activities potential of Guajava extracts are ethanol 96% extract = ethyl acetate fraction > n-hexane fraction = water fraction

Determination of Polifenol Content and Antioxidant Activity Test of Ethanol Extract 70% Awar-Awar (Ficus septica Burm. F) Leaf using DPPH Method (1,1-Difenil-2-Pikrilhidrazil) Any Guntarti; Devi Sahyuni Putri Koto; Mustofa Ahda; Zainab Zainab
Journal of Food and Pharmaceutical Sciences Vol 7, No 2 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.712

Free radicals are molecules with unpaired electrons that can react with body cell mollecules. As a result, cell became damaged or death because oxidation of the lipid components of cell membranes, proteins and DNA. The purpose of this study was to determine the antioxidant activity test, and total polyphenol content. The ethanol extract was done by phytochemical screening by KLT method and the antioxidant activity was performed with DPPH. The extract were obtained from 200 gram awar-awar leaf powder was macerated with 70% ethanol. Antioxidant activity was measured by DPPH purple color change. The antioxidant activity parameter was the ES50 yes obtained from the linear regression equation between the concentration and the percent of the damping. The results of phytochemical screening test of the awar-awar leaf ethanol extract showed that the sample contained flavonoid and polyphenol compounds. Determination of total phenolic content of 8,11 ± 0,364% EAG. The potential of antioxidant can be seen from the price of ES50, the value of ES50 standard quercetin of 4.542 ± 0.0767 μg / mL, ethanol extract of 21,19± 0,565 μg / mL. Data analyzed with non parametric test Krukal Wallis with 95% showed the result of ES50 of ethanol extract of awar-awar leaves was significantly different with ES50 quercetin. Conclusion of this research were ethanol extract 70% of awar-awar leaves had a total polyphenol content of 8.11% equivalents of gallic acid, and antioxidant activity of 21.19 μg / mL with very strong antioxidant strength, ie ES50 ˂50 μg / mL, while the standard quercetin was 4,542 μg / mL. Polyphenol compounds support the antioxidant activity of the extract.

PENINGKATAN PENGETAHUAN KONSUMEN DAN SOSIALISASI MAKANAN HALAL DAN TOYIB DI SEKOLAH DASAR MUHAMMADIYAH 3 WIROBRAJAN, YOGYAKARTA: PENINGKATAN PENGETAHUAN KONSUMEN DAN SOSIALISASI MAKANAN HALAL DAN TOYIB DI SEKOLAH DASAR MUHAMMADIYAH 3 WIROBRAJAN, YOGYAKARTA ahda, mustofa; Kusbandari, Aprilia; Pangastuti, Palupi Melati
Jurnal Pengabdian dan Peningkatan Mutu Masyarakat (Janayu) Vol. 3 No. 1 (2022): Jurnal Pengabdian dan Peningkatan Mutu Masyarakat
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/janayu.v3i1.16963

Government regulations require halal product distribution in Indonesia have been regulated in the Halal product law No 33 in 2014. Based on these rules, all producers have to market and distribute halal goods. The goal of halal is to produce healthy food. However, the big problem is that this rule has not been fully realized. In 2021, many products are not clear whether they are halal or not. Therefore, the socialization of halal food for consumers is very important to support government regulations. In this case, the consumers who are in a religious environment from one of the big Islamic organizations. The Basic score of consumers’ knowledge is very good, they have a score above 75. After promotion, the consumers’ knowledge increased. Besides, consumers also understand food additives. Based on these results, the government should drive the consumers and producers to pay attention to their religion because it can increase awareness of halal and toyib products.

Variability and pharmacological potential of bajakah (Spatholobus sp.) as an indigenous medicinal plant: a review Mahfudh, Nurkhasanah; Utami, Dwi; Nashihah, Siti; Ahda, Mustofa; Andika, Andika; Sabilla, Giriani Ayu
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.23791

Bajakah (Spatholobus sp.) is an indigenous Indonesian plant that has been traditionally used as medicine, especially in Kalimantan Island, Indonesia. The variability and potential of bajakah as a traditional Indonesian medicinal plant have attracted research attention. This review article describes the traditional use, distribution, and pharmacological activity of bajakah. An integrative review method was employed, following procedures such as literature search, data analysis, and result presentation. Understanding the variations is important to understand the therapeutic potential and differences in active compound content among different types of bajakah. Furthermore, the chemical composition of bajakah has been identified, including alkaloids, flavonoids, tannins, saponins, and triterpenoids, which can potentially exhibit pharmacological effects and mechanisms of action associated with its traditional use. This review provided additional insights into the potential of bajakah as an herbal medicinal in the future. Therefore, this review article provides an overview of the traditional use distribution, and pharmacological activity of bajakah as a promising traditional medicine. Further research, including clinical studies, is needed to scientifically validate the therapeutic potential of bajakah and further understand the mechanisms of action and potential side effects associated with it.

The Potency of Microalgae as a Marine Source: A Bibliometric Analysis Witasari, Hardi Astuti; Kintoko, Kintoko; Ahda, Mustofa; Rangkuti, Ahmad Faizal; Suhendra, Suhendra; Mahfudh, Nurkhasanah
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.18870

Microalgae were a marine source that was highly sustainable and offered numerous benefits in industrial applications. Many species were safe and effective as active ingredients in the food, cosmetics, and pharmacy industries and became raw materials for renewable energy, such as biofuel. The exploration of bioactive compounds was enticing for the research. The study of microalgae potency is a fascinating subject that deserves further exploration. The bibliometrics analysis can provide a good overview of microalgae research and its applications in industry. This overview was derived from the Scopus database, which contained all articles published between 1993 and 2023 with the keywords "microalgae" and "their application. Based on this discovery, many papers reported the potential of microalgae for antioxidants, nutrition, vaccine adjuvants, bioethanol, biofuel, and other applications for 2021-2022. This review criticizes the cultivation in a controlled environment up to the toxicity of microalgae. According to this review, many researchers focused and collaborated on exploring microalgae in the top three international journals, such as Algal Research, Marine Drugs, and Journal of Applied Phycology. Several countries, including Italy, Spain, and China, were the most focused on declaring the application of microalgae. The keywords described the core discussion and could be read generally and comprehensively. This bibliometric analysis was expected to contribute to developing microalgae for many applications.

The Potency of Microalgae as a Marine Source: A Bibliometric Analysis Witasari, Hardi Astuti; Kintoko, Kintoko; Ahda, Mustofa; Rangkuti, Ahmad Faizal; Suhendra, Suhendra; Mahfudh, Nurkhasanah
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.18870

Microalgae were a marine source that was highly sustainable and offered numerous benefits in industrial applications. Many species were safe and effective as active ingredients in the food, cosmetics, and pharmacy industries and became raw materials for renewable energy, such as biofuel. The exploration of bioactive compounds was enticing for the research. The study of microalgae potency is a fascinating subject that deserves further exploration. The bibliometrics analysis can provide a good overview of microalgae research and its applications in industry. This overview was derived from the Scopus database, which contained all articles published between 1993 and 2023 with the keywords "microalgae" and "their application. Based on this discovery, many papers reported the potential of microalgae for antioxidants, nutrition, vaccine adjuvants, bioethanol, biofuel, and other applications for 2021-2022. This review criticizes the cultivation in a controlled environment up to the toxicity of microalgae. According to this review, many researchers focused and collaborated on exploring microalgae in the top three international journals, such as Algal Research, Marine Drugs, and Journal of Applied Phycology. Several countries, including Italy, Spain, and China, were the most focused on declaring the application of microalgae. The keywords described the core discussion and could be read generally and comprehensively. This bibliometric analysis was expected to contribute to developing microalgae for many applications.

Analysis of Hydrolyzed Collagen in Facial Serum for Halal Authentication Using FTIR Spectroscopy and Multivariate Calibration Salamah, Nina; Firdaus, Rizqi Amalia; Guntarti, Any; Ahda, Mustofa; Uddin, Abm Helal; Kurniawan, Muhammad Fariez
Science and Technology Indonesia Vol. 10 No. 4 (2025): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.4.1270-1279

Cosmetic trends in Indonesia are on the rise, particularly for facial serum products. However, most of these products lack halal certification, posing an important concern for Muslim consumers due to the potential use of haram substances, such as pork gelatin. This study seeks to identify the source of gelatin in serum products using the Fourier Transform Infrared (FTIR) spectroscopy and chemometric analysis. The samples used in this study include a reference facial serum formulated with pure bovine and porcine gelatin concentrations in the ratios of 1:0, 8:2, 5:5, 2:8, and 0:1, three hydrolyzed collagen serums that are not yet labeled halal and available on Shopee, and one serum that is labeled halal. The method used was FTIR combined with PLS chemometrics and PCA. The isolation of facial serum gelatin was performed using acetone at -20oC, followed by analysis via FTIR at wave numbers ranging from 4000 to 400 cm-1. FTIR results indicated the presence of functional groups in gelatin constituents, including C O, N H, C N, and C H aliphatic. The wavelengths employed for PLS and PCA analysis ranged from 1631 to 1430 cm-1. Calibration results showed R2=0.9936 and RMSEC=3.0445%. Internal validation yielded RMSECV=0.1674% and R2=0.9994 whilst external validation yielded RMSEP=0.9981% and R2=0.9910. Lastly, PCA analysis revealed that one halal-labeled serum sample contained bovine gelatin, whereas the three examined commercial serums were free from both pork and bovine gelatin.

Aplikasi Silika Mcm-41 Sebagai Material Berpori Dalam Adsorpsi Ibuprofen Ahda, Mustofa
Media Farmasi: Jurnal Ilmu Farmasi Vol. 12 No. 2: September 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v12i2.3754

Telah dilakukan kajian terhadap proses pemanfaatan MCM-41 sebagai padatan pendukung dalam transfer ibuprofen. MCM-41 disintesis menggunakan metode hidrotermal. Aplikasi MCM-41 sebagai padatan pendukung dilakukan dengan mengamati perubahan karakter MCM-41 baik struktur kristal MCM-41 dan kemampuan adsorpsinya terhadap ibuprofen. Hasil karakterisasi dengan difraksi sinar X terdeteksi 2ÆŸ : 22,62 dan 23,10. Hal ini menunjukkan bahwa kemampuan adsorpsi MCM-41 terhadap ibuprofen terdeteksi dengan penghilangan pelarut pada temperatur kamar. Hal ini juga dibuktikan dengan data kemampuan MCM-41 dalam mengadsorpsi ibuprofen mengalami kenaikan dengan bertambahnya konsentrasi ibuprofen.Â Kata kunci: MCM-41, ibuprofen, adsorpsi

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