Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : bioeduscience

Optimization and Evaluation of the Accuracy of the C-Reactive Protein Detection Range in a Rapid Test Based on Lateral Flow Immunoassay with Two Clinical Cut-Offs Rukmi, Ai; Darmawati, Sri; Alisjahbana, Bachti; Depamede, Sulaiman Ngongu; Pambudi, Sabar; Yuwita, Anita
BIOEDUSCIENCE Vol 10 No 2 (2026): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/20220

Abstract

Background: C-Reactive Protein (CRP) is an important biomarker for infection and inflammation; however, quantitative assessment using ECLIA is costly and requires adequate laboratory facilities and trained personnel. This study aims to optimize antibody concentration and conjugate volume, and to evaluate the accuracy of the detection range of an LFIA-based CRP rapid test at two clinical cut-offs (10 and 40 mg/L). Methods: Experimental research was conducted by optimizing antibody concentrations on the T1 and T2 lines, optimizing CGC volume, and testing sensitivity, specificity, and the correlation between color intensity and Image. Results: The optimal antibody concentrations were obtained at T1 of 0.075 mg/mL and T2 of 0.025 mg/mL with a CGC volume of 2 µL. Sensitivity and specificity were 95.7% and 100% at T1, and 83.3% and 95.5% at T2. Conclusions: The developed CRP rapid test has adequate diagnostic performance as a semi-quantitative screening tool in primary healthcare facilities.
Co-Authors Afandi, Ressa Novita Agnes Rengga Indrati Ahmad Sulaeman Amaylia Oehadian Andre van der Venn Angèle JGMGerver-Jansen Angky Tririni Anita Yuwita Anna Alisjahbana Annisa Ikhsanawati, Annisa Ardini S. Raksanagara Ardini S. Raksanagara, Ardini S. Baskoro, Toni Basti Andriyoko Batubara, Jose Bestari, Muhamad Begawan Bevi Lidya Bevi Lidya Budi Santoso Budiman , Budiman Clara M Kusharto Depamede, Brian Umbu Rezi Dewi Kartika Turbawaty Dhiya Salsabila Dick van Soolingen Dida Ahmad Gurnida Dwi Agustian Dwihardiani, Bintari Edhyana Sahiratmadja Endang Sutedja Eva Mardiana Hidayat Evan Susandi Fauzian Giansyah Febriani, Ulfah Dwi Felisia . Finny Fitry Yani Gumilang, Manik Intan Guntur Darmawan Hadyana Sukandar Hafidhoh, Sanny Hendra Subroto, Hendra Henriette A Delemarre–van de Waal Henry Chandra Herry Garna Hesti Lina Wiraswati Hidayat, Eva Mardiana Hikmat Permana Hikmat Permana Hinta Meijerink Hofiyah Djauhari Ida Parwati Ida Parwati Iman Rahayu Irvan Afriandi Jeffery Malachi Candra Juhariah Juhariah Julia Hartati Koesoemadinata, Raspati C. Korry Novitriani Krishna Yana Krisnian, Tharani Kumia Wahyudi Kusumawardhani, R.N. Yasmin Lelly Yuniarti Leonardus Wiydatmoko marni banowati Menik Herdwiyanti Muhamad Zulchoir Rasyid Muhammad Yusuf Muhammad Yusuf Muhammad Yusuf Nanan Sekarwana Nanny Natalia Mulyani Soetedjo Ni Sayu Dewi B. Nina Dwi Putri Nisa Fauziah Novi Jayanti Nuni Sulastri Nurizzatun Nafsi Nurul Hidayah Chairunnisa Nururrohmah, Siti Nury Fitria Dewi obin sarwita Panji Fortuna Hadisoemarto Parse, Rocci Jack Prayudi Santoso Putri Vidyaniati Ratna Yulistya Ningrum Reinout van Crevel Reinout van Crevel Ressa Novita Afandi Resvi Livia Rina Triasih Rocci Jack Parse Rovina Ruslami Rovina Ruslami, Rovina Rukmi, Ai Sabar Pambudi Santoso, Ida Parwati Sari Syahruni Setyaningrum, Sinta Siti Soidah Sofia Imaculata Sri Darmawati Stephen M. Graham, Stephen M. Sulaiman Ngongu Depamede Suparman Hardinsyah, Suparman Susan Margaret McAllister Susandi, Evan Susantina Prodjosoewojo Syndi Nurmawati Teow Sheng Hao Tharani Krisnian Tjahjani M. Sudiro Tony Sadjimin Toto Subroto Trinugroho Heri Fadjari, Trinugroho Heri Trisasi Lestari, Trisasi Tryawan, Ilham Ngongu Tya Listiaty Ulfah Dwi Febriani Umi Baroroh Uun Sumardi, Uun Willem J Gerver Wirawan, Chevie Woro Indri Padmosiwi Yana, Krishna Yani Triyani Yanti Mulyana Yeva Rosana Yovita Hartantri Yulniar Tasli Yuwita, Anita