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All Journal E-Jurnal Medika Udayana The Indonesian Biomedical Journal Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Menara Medika Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Jurnal Muara Medika dan Psikologi Klinis Jurnal Kedokteran Meditek
Trinovita Andraini
Departemen Fisiologi Medik, Fakultas Kedokteran, Universitas Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Combination of Aerobic Exercise and Continuous Environmental Enrichment Improves Adult Male Rats’ Spatial Memory: Study on Hippocampal Insulin Like Growth Factor 1 (IGF-1) and Fibroblast Growth Factor 2 (FGF-2) Expression Sophie Yolanda; Sri Redjeki; Trinovita Andraini; Dewi Irawati Soeria Santoso; Nurhadi Ibrahim; Rena Mailani
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.731

Abstract

BACKGROUND: Memory declines with the progression of age through the neurodegeneration process. Aerobic exercise and environmental enrichment can delay neurodegeneration by improving neuroplasticity via expression of insulin like growth factor 1 (IGF-1), fibroblast growth factor 2 (FGF-2) and other proteins. Combination treatment of aerobic exercise and continuous environmental enrichment and their effect on the expression of IGF-1 and FGF-2 which were expected to improve memory function has not been studied previously. Thus, this study aimed to observe it.METHODS: This is an experimental research using 24 male Wistar rats (Rattus norvegicus, 300-400 g, age 7-8 months) divided randomly into 4 groups: control (C), aerobic exercise (A), continuous (EE), and combination of aerobic exercise and continuous environmental enrichment (A-EE). At the end of an 8-week treatment, rats were sacrificed, and an enzyme-linked immunosorbent assay (ELISA) examination was performed to assess hippocampal IGF-1 and FGF-2 levels.RESULTS: In the 8th week, A-EE group showed the best improvement in rats’ spatial memory (47.84±10.6 %) followed by EE group (45.03±4.1 %), A group (38.61±3.8 %), and C group (22.76±7.12 %). However, A-EE group’s hippocampal IGF-1 (16.21±7.56 ng/mg protein) and FGF-2 (1.29±0.57 ng/mg protein) expression were not higher than other groups.CONCLUSION: Improvement in memory function in the combination group is a result of induction of various growth factors’ expression in the hippocampus, including IGF-1 and FGF-2, but the primary pathway of memory function improvement may be from other growth factors.KEYWORDS: spatial memory, aerobic exercise, environmental enrichment, hippocampus, IGF-1, FGF-2
Neuroprotective effect of South Sulawesi propolis on neurogenesis in primary cultures of rat cerebral cortical neurons Nurhadi Ibrahim; Trinovita Andraini; Amirah Yusnidar; Putu Indah Paramita Adi Putri; Imelda Rosalyn Sianipar
Universa Medicina Vol. 42 No. 2 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.137-149

Abstract

BackgroundNeurodegenerative diseases have a significant risk factor, namely aging, which is associated with increased neuronal dysfunction and death. Propolis has been widely used as medicine due to its various benefits. This research study investigated the effect of propolis from the stingless bee (Tetragonula sapiens) from South Sulawesi, Indonesia, on neurogenesis in primary cultures of embryonic cerebral cortex of Wistar rats at 17-18 days of gestation. Methods This research was an experimental study involving 4 female pregnant Wistar rats, which were terminated and the cerebral cortex of the embryos collected and grown as primary cultures. The cultures were divided into 3 groups, i.e. control, vehicle, and propolis extract group. The research began with 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) to obtain the optimal dose among propolis doses of 0.5 μg/mL, 1 μg/mL, 5 μg/mL, 10 μg/mL, 25 μg/mL, and 100 μg/mL. The study was continued by using the best dose in immunostaining examination using microtubule-associated protein 2 (MAP2) primary antibody and qRT-PCR examination of brain-derived neurotrophic factor (BDNF) mRNA expression. One Way ANOVA and Kruskal-Wallis test were used to analyse the data. ResultsThe results showed that the propolis doses of 0.5 μg/mL and 1 μg/mL significantly increase cell viability compared to the other doses (p=0.011) and stimulate dendritic growth. The propolis dose group of 1 μg/mL induces a significantly higher expression of BDNF mRNA than the control group (p=0.031). ConclusionOur findings indicate that stingless bee propolis has neuroprotective effects against BDNF mRNA in rats. It is shown that propolis can be a candidate inhibitor in neurodegenerative diseases.
Ekspresi Protein Foxo1 dan Gen Glukosa 6 Fosfatase pada Tikus dengan Diet Restriksi Vitamin B12 Imelda Rosalyn Sianipar; Trinovita Andraini; Dewi Irawati Soeria Santoso; Irena Ujianti; Marcel Antoni
Jurnal Kedokteran Meditek Vol 28 No 2 (2022): MEI-AGUSTUS
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v28i2.2351

Abstract

Pada penelitian awal didapatkan diet restriksi vitamin B12 menyebabkan hiperhomosisteinemia dan resistensi insulin, yang ditandai oleh hiperglikemia dan meningkatnya nilai Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Dengan menggunakan sampel jaringan biologik tersimpan, hati tikus Spraque-Dawley dari penelitian tersebut, penelitian lanjutan ini bertujuan mengetahui penyebab hiperglikemia, dalam hubungannya dengan proses glukoneogenesis, dengan melihat ekspresi forkhead box protein-O1 (FoxO1) dan gen glukosa 6 fosfatase (G6Pc). Adapun sampel terdiri dari 4 kelompok: kelompok kontrol dan tiga kelompok dengan diet restriksi vitamin B12 masing-masing selama 4, 8, dan 12 minggu. Ekspresi FoxO1 diperiksa dengan metode kuantitatif Western-Blot, sedangkan gen G6Pc diperiksa dengan metode real-time Polymerase Chain Reaction (rt-PCR). Hasil yang diperoleh, tidak terdapat perbedaan bermakna ekspresi FoxO1 (P > 0,05) dan gen G6Pc (P > 0,05) antara kelompok tikus kontrol dan kelompok diet restriksi vitamin B12. Hal ini menunjukkan, hiperglikemia pada diet restriksi vitamin B12 tidak terkait dengan glukoneogenesis. Pada kondisi resistensi insulin, insulin masih dapat meneruskan efek metaboliknya melalui jalur lain, seperti melalui reseptor yang memiliki kemiripan struktur dan fungsi dengan reseptor insu   lin. Penyebab-penyebab lain terjadinya hiperglikemia seperti gangguan utilisasi glukosa oleh sel dan gangguan proses glikogenesis perlu diteliti lebih lanjut.
HIBISCUS SABDARIFFA LINN. MENCEGAH PENURUNAN FUNGSI MEMORI KERJA PADA MENCIT MODEL DIABETES TIPE 2 Anggraeni, Risa Kusuma; Andraini, Trinovita
E-Jurnal Medika Udayana Vol 11 No 12 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i12.P07

Abstract

Diabetes mellitus (DM) is a risk factor for memory impairment. Administration of herbal medicine which is rich in polyphenol has been believed have a positive impact on memory performance. Recent studies showed one of the potential candidates of herbal medicine is Hibiscus sabdariffa Linn. (HSL) which can improve memory function in several conditions. However, researches which prove will HSL affect memory function in DM is still limited. The aim of the study is to investigate the effect of HSL administrating on spatial working memory in DM. This study is an experimental study using DDY mice aged 9-11 weeks which were divided into four groups: control (K), DM control (DM), DM with HSL at a dose of 200 mg/kgBW (DM-HSL200), and DM with HSL at a dose of 400 mg/kgBW (DM-HSL400). Experimental animals were given treatment for 28 days. All groups performed Y- Maze spontaneous alternation before and after treatment. The results of this study showed a decrease in memory function in the DM group. Administration of HSL can maintain memory function in DM mice. These findings indicate that administration of HSL has potency to prevent memory impairment in DM. Keywords : Hibiscus sabdariffa Linn., spatial working memory, diabetes mellitus, Y-maze spontaneous alternation.
THE EFFECT OF TAHAJUD PRAYER ON STRESS Pranata, Lilik; Irfannuddin, Irfannuddin; Ali, Zulkhair; Andraini, Trinovita
Menara Medika Vol 7, No 2 (2025): VOL 7 NO 2 MARET 2025
Publisher : Fakultas Kesehatan Universitas Muhammadiyah Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/mm.v7i2.6951

Abstract

Introduction: Stress is a physical and emotional reaction that occurs when a person faces pressure or environmental changes that require them to adapt. If stress is left unchecked, it can lead to many disorders. One thing that can be done is to perform tahajud prayers. The purpose of this study is to determine the benefits of tahajud prayer on stress. Method: The research design uses a literature review method by analysing articles from databases such as PubMed, Science Direct, ProQuest, and Google Scholar, focusing on articles published between 2020 and 2025, using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart approach. After selection, six articles were found to meet the inclusion criteria. Results: Tahajud prayer therapy can reduce stress levels. Discussion: Every individual experiences different levels of stress, so the process of performing tahajud prayer must be adapted to the stress level. The activity of tahajud prayer should be performed regularly without coercion and with sincerity.
KUALITAS TIDUR PADA BAYI USIA 6-9 BULAN DI JAKARTA Herwanto, Herwanto; Sekartini, Rini; Batubara, Jose; Yusra; Kekalih, Aria; Lestari, Hesti; Andraini, Trinovita
Jurnal Muara Medika dan Psikologi Klinis Vol. 5 No. 1 (2025): Jurnal Muara Medika dan Psikologi Klinis
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmmpk.v5i1.35276

Abstract

Gangguan tidur dapat memengaruhi kondisi kesehatan seorang bayi. Penelitian ini bertujuan menganalisis faktor yang memengaruhi kualitas tidur bayi usia 6-9 bulan di Jakarta dengan menggunakan kuesioner Brief Infant Sleep Questionnaire-Revised (BISQ-R). Penelitian ini menggunakan desain studi potong lintang dengan pendekatan deskriptif analitik, data didapatkan melalui kuesioner BISQ-R untuk menilai kualitas tidur bayi berdasarkan pola tidur bayi, persepsi orang tua, dan kebiasaan pada orang tua yang terkait dengan tidur pada Bayi. Data dianalisis untuk mengidentifikasi faktor yang memengaruhi kualitas tidur bayi dan hubungan antar variabel. Sebanyak 88 subjek, yang terdiri dari 33 bayi perempuan dan 55 bayi laki-laki dengan rata-rata usia 7,76 bulan, terlibat dalam penelitian ini. Hasil penelitian menunjukkan mayoritas bayi memiliki kualitas tidur yang tergolong menengah serta menunjukkan bahwa faktor "jumlah waktu terbangun di malam hari" memiliki korelasi negatif yang signifikan terhadap kualitas tidur bayi (r = -0,258, p = 0,015), menunjukkan bahwa semakin sering bayi terbangun pada malam hari, semakin berkurang kualitas tidurnya. Kebiasaan orangtua merespons kebutuhan tidur dan tempat tidur bayi juga turut memengaruhi kualitas tidur. Penelitian ini menunjukkan pentingnya mengurangi frekuensi bayi terbangun di malam hari untuk meningkatkan kualitas tidurnya serta perlunya menjaga konsistensi rutinitas tidur dan menciptakan lingkungan tidur yang mendukung guna memastikan kualitas tidur bayi yang optimal.
Body Composition Parameters, Adiponectin, Leptin and Adiponectin/Leptin Ratio are Correlated with LH/FSH Ratio in Women with PCOS but not in Women without PCOS Gita Pratama; Wiweko, Budi; Asmarinah; Widyahening, Indah Suci; Andraini, Trinovita; Hartanto Bayuaji; Andon Hestiantoro
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 1 January 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i1.2031

Abstract

Objective: To investigate the correlation between body composition parameters, adiponectin, leptin and the adiponectin/leptin ratio and the LH/FSH ratio in women with polycystic ovary syndrome (PCOS). Methods: A cross-sectional study was conducted at Reproductive Cluster Yasmin, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, with sixty women with PCOS and sixty healthy women as controls (matched for age and BMI). Body composition parameters, including body weight, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), percent body fat (PBF), visceral fat area (VFA), percent subcutaneous fat (PSF) and skeletal muscle mass (SMM), were measured; levels of fasting glucose, fasting insulin, testosterone, and sex hormone binding globulin (SHBG) were measured; and homeostatic model assessment for insulin resistance (HOMA-IR) values, anti-Mullerian hormone (AMH), free androgen index (FAI), Ferriman-Gallwey (FG) score, adiponectin levels, leptin levels, adiponectin/leptin ratio, LH, FSH and LH/FSH ratio were measured. Results: Body composition parameters (body weight, BMI, WC, WHR, PBF, VFA, PSF, SMM) were not significantly different between women with PCOS and controls. Fasting insulin (P<0.05), HOMA-IR (P<0.05), AMH (P<0.01), FAI (P<0.01), FG score (P<0.01) and LH/FSH ratio (P<0.05) were higher in PCOS women. Adiponectin (P<0.01) was lower in PCOS women, while leptin and the adiponectin/leptin ratio were not significantly different between groups. Most of body composition parameters, adiponectin, leptin and adiponectin/leptin ratio were correlated with HOMA-IR in both groups. SMM was positively correlated with the LH/FSH ratio, while body weight, BMI, WC, PBF, VFA, and PSF were inversely correlated with the LH/FSH ratio in PCOS patients but not in controls. WHR was not correlated in either group. Leptin (r=-0.278; P<0.05) was negatively correlated with the LH/FSH ratio only in the PCOS group. Adiponectin (r=0.394; P<0.01) and the adiponectin/leptin ratio (r=0.413; P<0.01) were also positively correlated with the LH/FSH ratio only in the PCOS group. AMH was correlated with the LH/FSH ratio, whereas testosterone level, FAI, FG score, fasting insulin level and HOMA-IR value were not correlated with the LH/FSH ratio in PCOS women. Conclusion: Most of the body composition parameters, leptin, adiponectin and the adiponectin/leptin ratio were significantly correlated with HOMA-IR in both groups. However, correlations of those parameters with LH/FSH ratio were found only in PCOS but not in women without PCOS. Adiponectin and leptin may play a significant role in the mechanism of neuroendocrine disorders in PCOS, which is characterized by an increased LH/FSH ratio. Keywords: adiponectin, adiponectin/leptin ratio, body composition, HOMA-IR, leptin, LH/FSH ratio, PCOS
THE EFFECT OF HIBISCUS SABDARIFFA LINN ON TRABECULAR BONE MICROARCHITECTURE IN AN AGING MODEL DUE TO D-GALACTOSE INDUCTION: A HISTOMORPHOMETRIC STUDY Fransiscus Asisi Alfareza; Neng Tine Kartinah; Trinovita Andraini; Imelda Rosalyn Sianipar
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 5 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.22022656

Abstract

The aging process can cause an imbalance in bone remodeling and changes in trabecular bone microarchitecture. D-galactose induction is used as an experimental aging model because it can increase oxidative stress, while Hibiscus sabdariffa Linn. contains antioxidant compounds that have the potential to provide a protective effect on bone tissue. This study aims to analyze changes in trabecular bone microarchitecture in aging models due to D-galactose induction and the effect of Hibiscus sabdariffa Linn. This experimental study involved 22 samples divided into young normal (NM; n = 6), old normal (NA; n = 4), aging due to D-galactose induction (AA; n = 6), and aging due to D-galactose induction given by Hibiscus sabdariffa Linn. (AH; n = 6). Femur bone tissue was fixed, decalcified using formic acid, processed into paraffin blocks, and stained with hematoxylin-eosin. Trabecular bone images were taken in five fields of view using a 20× objective lens. Histomorphometric examination was performed to assess trabecular thickness (Tb.Th) and bone volume per tissue volume (BV/TV). Data met the assumptions of normality and homogeneity so they were analyzed using one-way analysis of variance followed by Tukey's post hoc test if there were significant differences. The significance level was set at p < 0.05. The mean Tb.Th in the NM, NA, AA, and AH groups were 71.61 ± 15.90 µm; 130.98 ± 11.31 µm; 120.61 ± 37.79 µm; and 100.48 ± 20.92 µm, respectively. There was a significant difference in Tb.Th values between groups with F (3,18) = 5.975 and p = 0.005. Post hoc test showed a significant difference between the NM and NA groups (p = 0.008) and between the NM and AA groups (p = 0.014). There was no significant difference between the AA and AH groups (p = 0.509). The mean BV/TV in the NM, NA, AA, and AH groups were 55.06 ± 11.06%, respectively.
Co-Authors Amirah Yusnidar Andon Hestiantoro Antoni, Marcel Aria Kekalih Asmarinah Batubara, Jose Budi Wiweko Donna N. Kahandjak Ermita I.I. Ilyas Fransiscus Asisi Alfareza Gita Pratama Hartanto Bayuaji Herwanto Herwanto Hesti Lestari Imelda Rosalyn Sianipar Indah S. Widyahening Indra Kusuma Irena Ujianti Irfannuddin Irfannuddin Lilik Pranata Mailani, Rena Neng T. Kartinah Neng Tine Kartinah Almuktabar Nurhadi Ibrahim Putu Indah Paramita Adi Putri Rini Sekartini Risa Kusuma Anggraeni Roman A. Goenarjo Santoso, Dewi Irawati Soeria Sophie Yolanda Sri Redjeki Yusra Zulkhair Ali