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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Bioscientia Medicina : Journal of Biomedicine and Translational Research Indian Journal of Forensic Medicine & Toxicology Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research MEDICINUS

Muhammad Eko Irawanto

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Author-ID : 2277877

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Korelasi Kadar Serum Nitric Oxide (NO) dengan Tipe dan Derajat Keparahan Psoriasis Fiska Rosita; Bobby Febrianto; Ambar Aliwardani; Putti Fatiharani; Wibisono Nugraha; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Psoriasis is a chronic, immune-mediated disorder that results from a polygenic predisposition. Nitric oxide (NO) has been considered as important factors in the pathogenesis of psoriasis. This study aims to determine the correlation of serum NO levels with the type and severity of psoriasis. This cross-sectional study was conducted from May to September 2018. Difference in the average of serum NO levels in psoriasis patients with control groups is analyzed using t-test. The Spearman correlation test was used to see the correlation of serum NO levels with type and severity of psoriasis measured by Psoriasis Area and Severity Index (PASI) score. There was significant difference between serum NO level in the control group compared to the group of psoriasis patients (p=0.037). Patient with generalized pustular psoriasis has the highest mean of NO level (59.07 µmol/L). There was no significant correlation between serum NO level with type (r=0.008, p=0.9710 and severity (r=0.157, p=0.486) of psoriasis. Nitric oxide levels are elevated in psoriasis patients, which indicate that oxidative stress plays an important role in the etiopathogenesis of psoriasis.

Analisis In Silico Potensi Minyak Kedelai (Glycine max) dalam Terapi Dermatitis Atopik Primadhanty. R. S. Bhadra; Mardiana; Ahmad Fiqri; Ummi Rinandari; Didik H. Utomo; Muhammad Eko Irawanto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Soybean oil contains various bioactive phytochemicals such as phenolic acids, flavonoids, isoflavones, saponins, phytosterols and sphingolipids which might give benefit in the treatment of atopic dermatitis (AD). This study aimed to evaluate the soybean oil compounds using computational in silico analysis for the treatment of atopic dermatitis. The active compounds of soybean oil were extracted from the KNApSAcK database. Results showed that soybean oil might possess some potential bioactivity such as immunosuppressant, antiinflammatory, improves skin barrier function, antieczema and histamine inhibitor. The highest potential bioactivity of soybean oil was as antiinflammatory, with an average value of probable to be active (Pa) 0.684; while the high potency active compound is alpha-tocopherol (Pa: 0.956).

Ulkus Marjolin yang Berkembang dari Ulkus Trofik Kronis pada Pasien Kusta Adniana Nareswari; Harijono Kariosentono; Nugrohoaji Dharmawan; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Marjolin’s ulcer is a malignant complication of chronic ulcer. Changes in ulcer lesions to malignancy can be caused by chronic irritation, infection, decreased vascular variation, and increased expression of proto-oncogene. The most common histopathological form of Marjolin's ulcer is squamous cell carcinoma. A 55-year-old man, complaining of a protruding wound on his left hand that has not healed since three years ago. The patient was diagnosed with leprosy 30 years ago with a history of incomplete treatment. On physical examination, the left palmar region showed solitary ulcer, ±10x8x1.5 cm in size, nodular surface, reddish, hard consistency, with bulging and irregular edge. Slit-skin smear (SSS) examination with Ziehl-Neelsen staining found abundant acid-fast bacilli. Histopathological examination of the ulcer edge shows appearance of epithelial tumor, with differentiated epidermal cells invading the dermis, tumor cells arranged focally and concentrically with a mass of keratin appeared as horn pearl cells. Fite-Faraco staining found abundant M. leprae acid-fast bacilli. Based on the patient’s medical history and clinical examination, patient was diagnosed with Marjolin's ulcer in multibacillary (MB) leprosy. Patient was treated with MB multidrug therapy for 12 months and below-wrist amputation.

Pengaruh Astaxantine Oral terhadap Kadar Serum Tumor Necrosis Factor Alpha pada Pasien Akne Vulgaris-lores Reti Anggraeni; Niluh Widjayanti; Harijono Kariosentono; Indah Julianto; Endra Yustin; Muhammad Eko Irawanto; Prasetyadi Mawardi
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Background: Acne vulgaris (AV) is chronic inflammatory disease affecting the pilosebaceous unit manifested as closed and open comedones, papules, pustules, and nodules. Treatment of AV generally involves more than one drug due to multifactorial pathogenesis. Objective: This study aims to determine the efficacy of 4 mg oral astaxanthin as an adjuvant AV therapy in decreasing serum level of inflammatory marker tumor necrosis factor alpha (TNF-α). Method: This is a double-blind randomized controlled trial. Subjects were 34 patients with mild and moderate AV (Global Acne Grading System/GAGS 1-30) that were treated with combination of tretinoin 0.025% and clindamycin phosphate 1.2%. Astaxanthin was added to the treatment group and lactulose as placebo was added to the control groups, given for 4 weeks. The pretest and posttest results in both groups were analyzed statistically using nonparametric test. Results: Decrease in TNF-α serum levels occurred in both groups but significant difference compared to baseline were only found in treatment group (p=0.015). There was no significant difference in the reduction of TNF-α levels between both groups (p=0.459). Conclusion: Although the results did not show a significant difference overall, but in the treatment group, astaxanthin can significantly lower TNF-α serum levels compared to baseline.

Tingkat Perbedaan Serum Nitric Oxide terhadap Derajat Keparahan dan Durasi Psoriasis Ambar Aliwardani; Bobby Febrianto; Fiska Rosita; Putti Fatiharani Dewi; Muhammad Eko Irawanto
MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS
Publisher : PT Dexa Medica

Psoriasis belongs to erythrosquamous dermatosis with uncertain etiology. Nitric oxide (NO) that acts as growth and differentiation regulator of keratinocytes is thought to play an important role in the pathogenesis of this disease. This study was aimed to determine the difference of nitric oxide serum level with the severity and duration of psoriasis patients. A cross-sectional study was conducted in 22 subjects with psoriasis vulgaris in the outpatient clinic of Dr. Moewardi Hospital Surakarta from May-September 2018 with 22 healthy individuals as control group. The severity of psoriasis was assessed using psoriasis area severity index (PASI), and serum NO is measured using Greiss method. Data then analysed using T-test and Kruskal Wallis tests (p<0.05). There was a significant difference in serum NO between the psoriasis patients and control group (p=0.020); there was no significant difference between serum NO patients and PASI score and duration of disease. It can be concluded that NO is an important factor in the inflammatory process in psoriasis, especially in active lesion.

Terapi Zink Oral pada Vitiligo Eka Devinta Novi Diana; Muhammad Eko Irawanto
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/g52hfk35

Background: World Health Organization (WHO) estimates that 2 billion people in the world have zinc deficiency. Clinical manifestation of zinc deficiency includes immune system dysfunction, increase of oxidative stress, and release of proinflammatory cytokines. Oxidative stress is one of main factors that plays important role in various autoimmune diseases such as vitiligo. Discussion: Vitiligo is the most common depigmentation disease caused by melanocyte damages which characterized by depigmentation macule or patch on the skin or mucous membranes. Treatment of vitiligo is still considered a challenge, and various treatment modalities show varying results. Zinc is a micronutrient and antioxidant that posseses antiapoptotic activity by influencing melanogenesis and eliminating free radicals. Conclusion: Zinc inhibits oxidative stress and prevent melanocyte damage so it can bd considered as an adjuvant treatment for vitiligo.

Co-Authors Adniana Nareswari Ahmad Fiqri Alfina Rahma Ambar Aliwardani Anindya Oktafiani Arie Kusumawardani Ayu Kusuma Dewi Ayu Kusuma Dewi Benedicta Lauda Anandita Benedikta Lauda Bobby Febrianto Dharmawan, Nugrohoaji Didik H. Utomo Eka Devinta Novi Diana Endra Yustin Endra Yustin Ellistasari Fiska Rosita Frieda Harijono Kariosentono Indah Julianto Ivani Kamilah, Lian Lidjaja, Lifesia Natali MARDIANA Moerbono Mochtar Niluh Widjayanti Novan Adi Setyawan Nur Rachmat Mulianto Nurrachmat Mulianto Osdatilla Esa Putri Prasetyadi Mawardi Primadhanty. R. S. Bhadra Putti Fatiharani Putti Fatiharani Dewi Rahmat Firdaus Dwi Utama Reti Anggraeni Sesia Pradestine Shelly Lavenia Sambodo Stella Gracia Octarica Sugih Primas Adjie Trya Oktaviani Ummi Rinandari Vrenda Alia Wibisono Nugraha

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