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Efek Teripang Terung (Phyllophorus Sp.) Terhadap Kadar HDL Dan LDL Tikus Dengan Diet Tinggi Lemak ANAK AGUNG ISTRI AGUNG, SRILA NATASWARI; LESTARI DEWI; SOEDARSONO; INDRI NGESTI RAHAYU
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.576

Cholesterol is divided into two different forms, including HDL (high-density lipoprotein, also referred to as "good fat". LDL (low-density lipoprotein), sometimes known as "bad fat". A buildup of cholesterol levels in the blood that can lead to cardiovascular disease. Sea cucumbers contain flavonoids which are a class of phenolic compounds. Flavonoids have properties as antioxidants. This study was conducted to determine the effect of ethanol extract of sea cucumber (Phyllophorus sp.) on HDL and LDL levels in wistar strain white rats induced by high fat diet. This study was conducted in the biochemistry laboratory of the Faculty of Medicine, Hang Tuah University using 30 white rats (Rattus norvegicus) male wistar strain. The rats were divided into 5 groups, namely, groups of animals that did not receive treatment, groups of animals fed a high-fat diet, groups of animals fed a high-fat diet and sea cucumber ethanol extract 8.5mg/kgBB, groups of animals fed a high-fat diet and sea cucumber ethanol extract at a dose of 17mg/kgBB, groups of animals fed a high-fat diet and simvastatin. On the 35th day, HDL and LDL levels were examined in all groups. The conclusion of the results of this study is that the administration of sea cucumber ethanol extract can increase HDL levels even though it is not significant, and can significantly reduce LDL levels. Keywords: Sea cucumber ethanol extract (Phyllophorus sp.), HDL, LDL, Wistar white rat, high fat diet

Karakteristik dan Faktor Risiko Pasien Kanker Kulit Di Rspal Dr. Ramelan Surabaya Periode Januari 2021-Desember 2023 HIBATULLAH, HISYAM; OCTAVIANDA, YOHANA; RAHAYU, INDRI NGESTI; MUTIADESI, WAHYU PRASASTI
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.771

Skin cancer is one of the most common types of cancer diagnosed worldwide. The incidence and mortality rates of skin cancer have also continued to increase in recent decades. In Indonesia, skin cancer is the cancer with the third highest incidence after uterine cancer and breast cancer. The purpose of this study was to determine the characteristics and risk factors of skin cancer patients at RSPAL dr. Ramelan Surabaya for the period January 2021-December 2023. Using a qualitative descriptive approach with variables in the form of secondary data that has been recorded in the medical records of skin cancer patients at RSPAL dr. Ramelan Surabaya for the period January 2021-December 2023. The data examined were the type of skin cancer, symptoms of skin cancer, location of skin cancer, patient age, and patient gender. The most characteristic type of skin cancer is Basal Cell Carcinoma in 51 cases. The most characteristic symptom of skin cancer was the formation of new moles/bumps in 67 cases. The characteristic of the location of skin cancer is mostly on the head in 69 cases. The age characteristics of cancer patients were most common in elderly patients at 56 cases. The sex characteristics of skin cancer patients were mostly female at 51 cases. The occupational characteristics of skin cancer patients were mostly indoor workers at 86 cases. Most cases were of the BCC type, with the most common symptom being the formation of new moles.

PENURUNAN KADAR MDA TIKUS PUTIH JANTAN DENGAN PEMBERIAN DIET TINGGI LEMAK DAN EKSTRAK BIJI MAHONI: 38-50 Indri Ngesti Rahayu; Asami Rieta Kumala
Surabaya Biomedical Journal Vol. 1 No. 1 (2021): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i1.7

Masyarakat modern saat ini mengalami perubahan gaya hidup yang mengakibatkan perubahan pada pola konsumsi makanan menjadi pola makanan yang tinggi lemak jenuh, tinggi gula dan rendah serat. Hal tersebut sering berakibat tingginya asupan makanan yang berkolesterol tunggi kemudian ditambah dengan seringnya frekuensi makan serta konsumsi sayur dan buah yang rendah, akan berpotensi menyebabkan kegemukan. stroke, aterosklerosis dan penyakit jantung koroner (PJK) memiliki faktor risiko paling besar menjadi penyakit serius di masyarakat yaitu hiperlipidemia sehingga diduga menjadi penyebab kesakitan dan kematian di negara adidaya dan berkembang. Membuktikan pengaruh ekstrak biji mahoni terhadap kadar MDA plasma tikus putih jantan galur wistar yang diberikan diet tinggi lemak. 32 ekor tikus dikelompokkan dalam kelompok kontrol negatif yang diberikan diet standart, kontrol positif yang diberikan diet tinggi lemak dan perlakuan yang mendapatkan diet tinggi lemak bersama ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB. Diet tinggi lemak dikonsumsi tikus selama 14 hari dan pada hari ke 15 pada kelompok perlakuan ditambahkan ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB Derajat stres oksidatif diukur dengan menggunakan indikator malondialdehyde (MDA). Kelompok kontrol negatif menunjukkan kadar MDA 78,5±16,92 µg/ml. Kelompok kontrol positif menunjukkan kadar MDA 97,17±26,559 µg/ml. Kelompok perlakuan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dengan dosis 100 mg/kgBB, kadar MDAnya 65,25±24,126 µg/ml dan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dosis 200 mg/kgBB 82±22,836 µg/ml. Uji ANOVA tidak mendapatkan hasil dengan perbedaan yang bermakna (p=0,151).

PENGARUH PUASA INTERMITEN MENGGUNAKAN METODE PUASA DAUD TERHADAP KADAR SGOT TIKUS PUTIH (Rattus norvegicus) ALIRAN WISTAR YANG DIINDUKSI PARACETAMOL Eric Mayo Dagradi; Judya Sukmana; Indri Ngesti Rahayu
Surabaya Biomedical Journal Vol. 2 No. 1 (2022): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i1.43

Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases. Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol. Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol. Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p > 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment. Conclusion: There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol. Keywords: intermittent fasting, SGOT, paracetamol

Perbedaan Derajat Keparahan Akne Vulgaris berdasarkan Pemakaian Alphadan Beta Hydroxy Acid LAKSMITA SEKAR ANGGRAENI; RIETTA KUMALA, ASAMI; NGESTI RAHAYU, IINDRI
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.237

Background : Indonesia has a tropical climate that gets very strong sun exposure. With extreme weather conditions, various skin problems can be seen, one of which is acne vulgaris. Topical therapy is the preferred choice for the treatment of mild to moderate acne and is also helpful for the treatment of severe acne, such as alpha hydroxy acids and beta hydroxy acids (AHAs and BHAs). Objective : To determine the differences in the severity of acne vulgaris based on the use of alpha hydroxy acid and beta hydroxy acid (AHA and BHA) in 6th semester students of the Hang Tuah University Faculty of Medicine. Methods: An analytic observational method in a cross sectional study with a simple random sampling method. The study was conducted from April to December using 58 samples by distributing questionnaires through the google form link. Results : The Mann-Whitney U statistical test between users and non-users of alpha hydroxy acid and beta hydroxy acid (AHA and BHA) showed a significance 0,068. So there was no difference in the two groups. Conclusion : The most classification of acne vulgaris severity is mild in female students who use and do not use alpha hydroxy acid and beta hydroxy acid (AHA and BHA). Keywords : AHA and BHA, Acne Vulgaris, Facial Skin.

Efek Teripang Terung (Phyllophorus Sp.) Terhadap Kadar HDL Dan LDL Tikus Dengan Diet Tinggi Lemak ANAK AGUNG ISTRI AGUNG, SRILA NATASWARI; LESTARI DEWI; SOEDARSONO; INDRI NGESTI RAHAYU
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.576

Cholesterol is divided into two different forms, including HDL (high-density lipoprotein, also referred to as "good fat". LDL (low-density lipoprotein), sometimes known as "bad fat". A buildup of cholesterol levels in the blood that can lead to cardiovascular disease. Sea cucumbers contain flavonoids which are a class of phenolic compounds. Flavonoids have properties as antioxidants. This study was conducted to determine the effect of ethanol extract of sea cucumber (Phyllophorus sp.) on HDL and LDL levels in wistar strain white rats induced by high fat diet. This study was conducted in the biochemistry laboratory of the Faculty of Medicine, Hang Tuah University using 30 white rats (Rattus norvegicus) male wistar strain. The rats were divided into 5 groups, namely, groups of animals that did not receive treatment, groups of animals fed a high-fat diet, groups of animals fed a high-fat diet and sea cucumber ethanol extract 8.5mg/kgBB, groups of animals fed a high-fat diet and sea cucumber ethanol extract at a dose of 17mg/kgBB, groups of animals fed a high-fat diet and simvastatin. On the 35th day, HDL and LDL levels were examined in all groups. The conclusion of the results of this study is that the administration of sea cucumber ethanol extract can increase HDL levels even though it is not significant, and can significantly reduce LDL levels. Keywords: Sea cucumber ethanol extract (Phyllophorus sp.), HDL, LDL, Wistar white rat, high fat diet

Karakteristik dan Faktor Risiko Pasien Kanker Kulit Di Rspal Dr. Ramelan Surabaya Periode Januari 2021-Desember 2023 HIBATULLAH, HISYAM; OCTAVIANDA, YOHANA; RAHAYU, INDRI NGESTI; MUTIADESI, WAHYU PRASASTI
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.771

Skin cancer is one of the most common types of cancer diagnosed worldwide. The incidence and mortality rates of skin cancer have also continued to increase in recent decades. In Indonesia, skin cancer is the cancer with the third highest incidence after uterine cancer and breast cancer. The purpose of this study was to determine the characteristics and risk factors of skin cancer patients at RSPAL dr. Ramelan Surabaya for the period January 2021-December 2023. Using a qualitative descriptive approach with variables in the form of secondary data that has been recorded in the medical records of skin cancer patients at RSPAL dr. Ramelan Surabaya for the period January 2021-December 2023. The data examined were the type of skin cancer, symptoms of skin cancer, location of skin cancer, patient age, and patient gender. The most characteristic type of skin cancer is Basal Cell Carcinoma in 51 cases. The most characteristic symptom of skin cancer was the formation of new moles/bumps in 67 cases. The characteristic of the location of skin cancer is mostly on the head in 69 cases. The age characteristics of cancer patients were most common in elderly patients at 56 cases. The sex characteristics of skin cancer patients were mostly female at 51 cases. The occupational characteristics of skin cancer patients were mostly indoor workers at 86 cases. Most cases were of the BCC type, with the most common symptom being the formation of new moles.

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