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Journal : Hang Tuah Medical Journal

Ekstrak Kulit Pisang Kepok (Musa paradisiaca) Menurunkan Kadar AST pada Tikus Putih yang Diinduksi Diet Tinggi Lemak STEFANUS DJONI HUSODO; ASAMI RIETTA KUMALA; INDRI NGESTI RAHAYU
HANG TUAH MEDICAL JOURNAL Vol 18 No 2 (2021): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v18i2.122

Abstract

ABSTRACT Background. Non-alcoholic fatty liver disease (NAFLD) is closely related to the incidence of obesity and dyslipidemia. Increased levels of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) are the most frequently performed liver function tests that can be used as a benchmark for suspicion of NAFLD. Banana peels contain flavonoids and phenolics which are antioxidants that can function as hepatoprotectors. Aim. Proving the effect of Kepok banana peel extract on AST and ALT of Wistar rats induced high fat diet. Method. experimental study with a post-test only control group design, with four treatment groups. There is negative control group only given four weeks standard diet (K-), positive control group only given four weeks high-fat diet (K+), and two treatment group where the rats were given two weeks high-fat diet then were given two weeks high-fat diet plus Kepok banana peel extract at a dose of 200 mg/kg BW (K1) and 400 mg/kg BW (K2). Result. the highest mean AST levels were in the negative control group and the lowest was the K2 group. Meanwhile, the highest mean of ALT was in the positive control group and the lowest was the K2 group. Based on the Kruskal Wallis test, the significance of the AST variable was not different (p>0,05), but the ALT variable was significantly different (p<0,05). Significant differences from the Mann Whitney-U test (p<0,05) were obtained between the negative control group and the positive control, the negative control group with K2 and the positive control group with the K2 group). Conclusion. The administration of Kepok banana peel extract (Musa paradisiaca formatypica) showed a significant decrease in ALT levels in Wistar strain white rats induced by a high-fat diet, but it was not significant for AST levels
Perbedaan Derajat Keparahan Akne Vulgaris berdasarkan Pemakaian Alphadan Beta Hydroxy Acid LAKSMITA SEKAR ANGGRAENI; RIETTA KUMALA, ASAMI; NGESTI RAHAYU, IINDRI
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.237

Abstract

Background : Indonesia has a tropical climate that gets very strong sun exposure. With extreme weather conditions, various skin problems can be seen, one of which is acne vulgaris. Topical therapy is the preferred choice for the treatment of mild to moderate acne and is also helpful for the treatment of severe acne, such as alpha hydroxy acids and beta hydroxy acids (AHAs and BHAs). Objective : To determine the differences in the severity of acne vulgaris based on the use of alpha hydroxy acid and beta hydroxy acid (AHA and BHA) in 6th semester students of the Hang Tuah University Faculty of Medicine. Methods: An analytic observational method in a cross sectional study with a simple random sampling method. The study was conducted from April to December using 58 samples by distributing questionnaires through the google form link. Results : The Mann-Whitney U statistical test between users and non-users of alpha hydroxy acid and beta hydroxy acid (AHA and BHA) showed a significance 0,068. So there was no difference in the two groups. Conclusion : The most classification of acne vulgaris severity is mild in female students who use and do not use alpha hydroxy acid and beta hydroxy acid (AHA and BHA). Keywords : AHA and BHA, Acne Vulgaris, Facial Skin.
Efek Teripang Terung (Phyllophorus Sp.) Terhadap Kadar HDL Dan LDL Tikus Dengan Diet Tinggi Lemak ANAK AGUNG ISTRI AGUNG, SRILA NATASWARI; LESTARI DEWI; SOEDARSONO; INDRI NGESTI RAHAYU
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.576

Abstract

Cholesterol is divided into two different forms, including HDL (high-density lipoprotein, also referred to as "good fat". LDL (low-density lipoprotein), sometimes known as "bad fat". A buildup of cholesterol levels in the blood that can lead to cardiovascular disease. Sea cucumbers contain flavonoids which are a class of phenolic compounds. Flavonoids have properties as antioxidants. This study was conducted to determine the effect of ethanol extract of sea cucumber (Phyllophorus sp.) on HDL and LDL levels in wistar strain white rats induced by high fat diet. This study was conducted in the biochemistry laboratory of the Faculty of Medicine, Hang Tuah University using 30 white rats (Rattus norvegicus) male wistar strain. The rats were divided into 5 groups, namely, groups of animals that did not receive treatment, groups of animals fed a high-fat diet, groups of animals fed a high-fat diet and sea cucumber ethanol extract 8.5mg/kgBB, groups of animals fed a high-fat diet and sea cucumber ethanol extract at a dose of 17mg/kgBB, groups of animals fed a high-fat diet and simvastatin. On the 35th day, HDL and LDL levels were examined in all groups. The conclusion of the results of this study is that the administration of sea cucumber ethanol extract can increase HDL levels even though it is not significant, and can significantly reduce LDL levels. Keywords: Sea cucumber ethanol extract (Phyllophorus sp.), HDL, LDL, Wistar white rat, high fat diet
Karakteristik dan Faktor Risiko Pasien Kanker Kulit Di Rspal Dr. Ramelan Surabaya Periode Januari 2021-Desember 2023 HIBATULLAH, HISYAM; OCTAVIANDA, YOHANA; RAHAYU, INDRI NGESTI; MUTIADESI, WAHYU PRASASTI
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.771

Abstract

Skin cancer is one of the most common types of cancer diagnosed worldwide. The incidence and mortality rates of skin cancer have also continued to increase in recent decades. In Indonesia, skin cancer is the cancer with the third highest incidence after uterine cancer and breast cancer. The purpose of this study was to determine the characteristics and risk factors of skin cancer patients at RSPAL dr. Ramelan Surabaya for the period January 2021-December 2023. Using a qualitative descriptive approach with variables in the form of secondary data that has been recorded in the medical records of skin cancer patients at RSPAL dr. Ramelan Surabaya for the period January 2021-December 2023. The data examined were the type of skin cancer, symptoms of skin cancer, location of skin cancer, patient age, and patient gender. The most characteristic type of skin cancer is Basal Cell Carcinoma in 51 cases. The most characteristic symptom of skin cancer was the formation of new moles/bumps in 67 cases. The characteristic of the location of skin cancer is mostly on the head in 69 cases. The age characteristics of cancer patients were most common in elderly patients at 56 cases. The sex characteristics of skin cancer patients were mostly female at 51 cases. The occupational characteristics of skin cancer patients were mostly indoor workers at 86 cases. Most cases were of the BCC type, with the most common symptom being the formation of new moles.