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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Oceana Biomedicina Journal Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology International Islamic Medical Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Surabaya Biomedical Journal
Indri Ngesti Rahayu
Physiology Department FK UHT
Religion Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Surabaya Biomedical Journal

 1 
PENURUNAN KADAR MDA TIKUS PUTIH JANTAN DENGAN PEMBERIAN DIET TINGGI LEMAK DAN EKSTRAK BIJI MAHONI: 38-50 Rahayu, Indri Ngesti; Kumala, Asami Rieta
Surabaya Biomedical Journal Vol. 1 No. 1 (2021): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i1.7

Abstract

Masyarakat modern saat ini mengalami perubahan gaya hidup yang mengakibatkan perubahan pada pola konsumsi makanan menjadi pola makanan yang tinggi lemak jenuh, tinggi gula dan rendah serat. Hal tersebut sering berakibat tingginya asupan makanan yang berkolesterol tunggi kemudian ditambah dengan seringnya frekuensi makan serta konsumsi sayur dan buah yang rendah, akan berpotensi menyebabkan kegemukan. stroke, aterosklerosis dan penyakit jantung koroner (PJK) memiliki faktor risiko paling besar menjadi penyakit serius di masyarakat yaitu hiperlipidemia sehingga diduga menjadi penyebab kesakitan dan kematian di negara adidaya dan berkembang. Membuktikan pengaruh ekstrak biji mahoni terhadap kadar MDA plasma tikus putih jantan galur wistar yang diberikan diet tinggi lemak. 32 ekor tikus dikelompokkan dalam kelompok kontrol negatif yang diberikan diet standart, kontrol positif yang diberikan diet tinggi lemak dan perlakuan yang mendapatkan diet tinggi lemak bersama ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB. Diet tinggi lemak dikonsumsi tikus selama 14 hari dan pada hari ke 15 pada kelompok perlakuan ditambahkan ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB Derajat stres oksidatif diukur dengan menggunakan indikator malondialdehyde (MDA). Kelompok kontrol negatif menunjukkan kadar MDA 78,5±16,92 µg/ml. Kelompok kontrol positif menunjukkan kadar MDA 97,17±26,559 µg/ml. Kelompok perlakuan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dengan dosis 100 mg/kgBB, kadar MDAnya 65,25±24,126 µg/ml dan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dosis 200 mg/kgBB 82±22,836 µg/ml. Uji ANOVA tidak mendapatkan hasil dengan perbedaan yang bermakna (p=0,151).
PENGARUH PUASA INTERMITEN MENGGUNAKAN METODE PUASA DAUD TERHADAP KADAR SGOT TIKUS PUTIH (Rattus norvegicus) ALIRAN WISTAR YANG DIINDUKSI PARACETAMOL Dagradi, Eric Mayo; Sukmana, Judya; Rahayu, Indri Ngesti
Surabaya Biomedical Journal Vol. 2 No. 1 (2022): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i1.43

Abstract

Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases. Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol. Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol. Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p > 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment. Conclusion: There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol. Keywords: intermittent fasting, SGOT, paracetamol
Co-Authors ANAK AGUNG ISTRI AGUNG, SRILA NATASWARI Anggilia Vanny Aryati Asami Rieta Kumala Bambang Purwanto Cahya, Nilam Damayanti, Azarine Ahnafia Diah Purwaningsari Eric Mayo Dagradi Fadilah, Alifiah Wahyu Nur Fanani, Erika Nur HANDAJANI, FITRI HIBATULLAH, HISYAM Komalasari, Intan Kumala, Asami Rieta LAKSMITA SEKAR ANGGRAENI Lani Diana Lestari Dewi M. Yogiarto Moh. Ali Azis Mutiadesi, Wahyu Prasasti Nefertiti, Eva Pravitasari Octavianda, Yohana Permata, Viranda Senora Purwoko, Agus Roostantia Indrawati Roostantia Indrawati, Roostantia S. Soedarsono Salsabila Yumna Fathony Sihning E. J. Tehupuring STEFANUS DJONI HUSODO Sukmana, Judya TARUNA, DODY Wienta Diarsvitri Wijayanti, Ni Luh Putu Ratih