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All Journal Medical Journal of Indonesia Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

Andrijono Andrijono

Faculty of Medicine, University of Indonesia, Jakarta

Author-ID : 227930

Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 36 Documents Claim Missing Document

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Articles

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Surgical management of stage I and II vulvar cancer:The role of the separated incision Andrijono, Andrijono; Aziz, M. F.; Kampono, N.
Medical Journal of Indonesia Vol 12, No 2 (2003): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Vulvar cancer is a gynecological cancer whose incidence rate is relatively low. Patients generally were admitted at advanced stage, and radiation therapy at advanced stage does not provide favorable prognosis. Two main modalities in the treatment of vulvar cancer are surgery and radiation therapy. However, radiation can be performed in early stage vulvar cancer but surgery is thought to have more benefits, such as in side effect on the ovary/ reproductive function disorder, patients hygiene factor, and the ease in performing therapy if recurrence occurs. There are various techniques of vulvar cancer surgery, such as radical vulvectomy with butterfly incision (RVBI) and radical vulvectomy with separated incision (RVSI). The objective of this study was to identify the benefits of radical vulvectomy with separated incision in comparison with radical vulvectomy with butterfly incision in terms of the length of surgery, wound recovery, infection incidence, length of hospital stay. This study was a clinical trial performed during the period of 1990-2000. Fifteen cases of vulvar cancer were found and underwent surgery. Fourteen cases were at stage II and 14 cases were histologically defined as squamous-cell carcinoma and 1 case was adenocarcinoma. The average length of surgery in RVSI was 168 minutes, this was shorter than that in VRBI which reached an average of 275 minutes. The incidence of infection in RVSI group was 3 of 11 cases (27.27%), while in RVBI group all cases had infection in surgical wound. Failure of surgical wound approximation was 1 of 12 cases (9.99%), while in RVBI all cases experienced the failure such that cosmetic surgery was required. Length of postoperative care in RVSI group was 12.3 days, while in RVBI 21.5 days. Thus, complications in VRBI were lower, and length of surgery and length of postoperative care were shorter. (Med J Indones 2003; 12: 103-8) Keywords: vulvar cancer, separated incision

A Case-control study of vitamin A level in hydatidiform mole Andrijono, Andrijono; Kurnia, Kukung; Asikin, Nur
Medical Journal of Indonesia Vol 6, No 3 (1997): July-September
Publisher : Faculty of Medicine Universitas Indonesia

[no abstract available]

Presurgical cytologic diagnostic test of uterine cavity in ovarian malignant tumor Andrijono, Andrijono; Ilyas, Isrin; Hamdani, Chairil
Medical Journal of Indonesia Vol 14, No 2 (2005): April-June
Publisher : Faculty of Medicine Universitas Indonesia

There are several methods for diagnosing ovarian carcinoma, such as gynecological examination, ultrasonographic examination, andÂ tumor marker examination. However, all these combinations have not yielded high specificity antl sensitivity results. For this reason, itÂ is necessary to perform other examinations to enhance both specificity and sensitivity, and one of them which is of interest to beÂ studied is cytological examination of uterine cavity. By cytological examination of uterine cavity, it is hope that malignant cellsÂ originating from ovarian malignant tumor can be found. Discovery of ovarian malignant cells is possible because of peristalticÂ mechanism in the fallopian tube and negative pressure from uterine cavity, that makes possible the transportation of ovarianÂ malignant cells into uterine cavity through the tube. The objective of this study is to understand the sensitiviry and specificity ofÂ cytological examination of uterine cavity in detecting ovarian malignancy. This stucty was a diagnostic test with histologicalÂ examination as the gold standard, to understand sensitivity, specificity, positive prediction value, and negative prediction value ofÂ cytological examination of uterine cavity. A total of 30 cases were included in the study. A nurnber of factors enhanced positive resultsÂ in cytology of uterine cavity. Those factors were stage and ascites. The more advanced the stage, the greater the positive results, andÂ the presence of ascites increased positive results. On diagnostic test, sensitivity of uterine cavity cytology was 48%, specificity 60,Â positive predictive value 85.7%, and negative predictive value 18.8% respectively. In conclusion, cytological examination of uterineÂ cavity could be used as one of the methods in assistirtg the diagnosis of ovarian carcinoma. (Med J Indones 2005; 14: 92-6)Keywords : cytology, uterine cavity, ovarian malignant tumor

Survival rate and prognostic factors in advanced cervical cancer patients accompanied by renal impairment Rasjidi, Imam; Nuranna, Laila; Aziz, M. F.; Andrijono, Andrijono; Purbadi, Sigit; Rochani, Rochani; Supriana, Nana; Dharmeizar, Dharmeizar; Sutrisna, Bambang
Medical Journal of Indonesia Vol 14, No 3 (2005): July-September
Publisher : Faculty of Medicine Universitas Indonesia

The objective of this study was to obtain information on theÂ survival rateÂ of advanced cervical cancer patients withÂ renal impairment (ACCRI) and its prognostic factors. In addition, it is hoped that by this method the scoring system for predicting the death ofÂ ACCRI patients hopetullyÂ could be obtained.Â Design of the study used was retrospective cohort study. Data collectedÂ were retrieved fromÂ medicalÂ records ofÂ ACCRI patients from 1 January 1998 toÂ 31 December 2003 at Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, with a total sample of 70 cases. The results of the study showed that mean survival ofÂ all ACCRI patientsÂ was 8.2 months,Â mean survival at sixth month was 39%, and mean survivalÂ at one year was 3.2%. Median survival wasÂ 5.3 months. Prognostic factors affecting the survival of ACCRI patients includedÂ histopathological type (adenosquamous cell and cell differentiation), cortical thickness of the kidney less than 1 cm, and nephrostomy. (Med J Indones 2005; 14: 173-8)Keywords:Â Advance cervical cancer, renal impairment, nephrostomy, survival prognostic factor, scoring system

Diagnostic test of endometrial cytobrush in cases of perimenopausal and postmenopausal hemorrhage Andrijono, Andrijono; Prayitno, Gunawan D.; Hamdani, Chairil
Medical Journal of Indonesia Vol 14, No 2 (2005): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Perimenopausal menopausal hemorrhage can be due to by a variety of causative factors. One of its dangerous causes is atypicalÂ hyperplasia and endometrial carcinoma. There are a number of risk factors for the occurrence of endometrial carcinoma. The groupÂ that has this risk belongs to high-risk group. In this high-risk group, it is necessary to have a method to identify the changes inÂ endometrial abnormality. One of the alternatives is the examination of endometrial cytology. The objective of this study was toÂ evaluate the sensitivity, specificity and correlation test between endometrial cytology and endometrial histology. This study was aÂ diagnostic test of cytological examination of the endometrium as compared with endometrial histology. Endometrial cytology wasÂ performed with a modification of cytubrush and IUD shell. Specimen was dissolved into the centrifuged NaCl, and its depositsÂ were then processed for cytological examination with Papanicolaou and Giemsa staining. After the taking of cytology, the processÂ was continued with curettage of the endometrium, and the specimens were processed for cytological examination. Both of them wereÂ examined by anatomic pathologist. Statistical analysis used diagnostic test using histological examination of curetage specimens asÂ gold standard. During the period of study 45 study samples were collected, among which 12 (26.66%) were endometrialÂ adenocarcinoma, 6 (13.33%) with atypical hyperplasia, 11 (24.44%) with non-atypical hyperplasia, 15 (33.33%) were samplesÂ without abnormality, and one sample with endometritis. Actual correlation value was 57.8%, correlation because of possibility 3.38%,Â and correlation not because of possibility 54.42%, potential correlation not because of possibility 96.62%, and Kappa value 0.56. ItÂ was concluded that cytological examination of the endometriurn with cytobrush could be employed as a screening method in theÂ abnormalities of endometrial thickness, with sensitivity of 62.5% and specificity of 62.2%. (Med J Indones 2005; 14: 87-91)Keywords: Endometrial cencer, endometrial cytology

Clinical-pathologic factors, as predictor of lymph nodes metastasis in cervical cancer stage IB and IIA Aziz, M. F.; Andrijono, Andrijono; Nuranna, Laila; Purbadi, Sigit; Mangunkusumo, Rukmini T.; Siregar, Budiningsih; Cornain, Santoso; Saifuddin, Abdul B.; Tjarta, Achmad; Sutrisna, Bambang
Medical Journal of Indonesia Vol 13, No 2 (2004): April-June
Publisher : Faculty of Medicine Universitas Indonesia

The aim of this study was to identify possible predictor factors of lymph node metastases in patients with cervical cancer stage IB and IIA. Study was conducted between May 1996 and December 2001. There were 183 patients of cervical cancer with FIGO Stage IB and IIA who were underwent radical hysterectomy and lymphadenectomy. From those 158 patients could be evaluated, consisting 43 patients with node metastases 115 patients without metastases. Research design was case control study. Case was patients with node metastases and control was those without node metastases. Multivariate analysis was made after bivariate analysis. On bivariate analysis age < 39 years, diameter of lesion > 4 cm, stage IIA > 4 cm, histopathology moderate and poor differentiation, blood and lymphatic vessel invasion were independent variables for node metastases with p value â¤ 0.05. However, on multivariate analysis younger age, parity â¥ 4, diameter of lesion, histopathology adenosquamous, and lymph vascular invasion (+) as independent factors for node metastases with p value â¤ 0.05. Conclusion: Younger age, parity â¥ 4, stage IIA > 4 cm, diameter of lesion, histopathology adenosquamous, and lymph vascular invasion (+) were risk factors for node metastases and can be used as predictors. (Med J Indones 2004; 13: 113-8)Keywords: cervical cancer, radical hysterectomy, node metastases, case control study, predictor

Study on retinol binding protein (RBP) receptor in hydatidiform mole trophoblastic cells Andrijono, Andrijono; Taufik, E.; Hartati, M.; Kodaria, R.
Medical Journal of Indonesia Vol 16, No 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Hydatidiform mole is an abnormal pregnancy characterized by the proliferation of cytotrophoblastic, syncytiotrophoblastic, and intermediate trophoblastic cells in histological specimens. Vitamin A plays a role in controlling cell proliferation, and decrease in vitamin A level will cause an uncontrollable proliferation. To date, it is not known whether there is a relationship between vitamin A deficiency and hydatidiform mole. This study aimed to demonstrate the presence of retinol binding protein (RBP) receptors in the hydatidiform mole trophoblastic cells, that would provide explanation on the relationship of vitamin A and hydatidiform mole. The study was a descriptive study. The specimens of the study were paraffin blocks of hydatidiform mole made in 2005, and the examinations were performed by indirect immunohistochemistry. We examined the distribution of the cells showing expression of RBP receptor, the strength of expression, and location of the expression. As many as 21 specimens were collected, and the distributions of RBP receptor expression in hydatidiform mole trophoblastic cells ranged from moderate to dense. The expression in syncytiotrophoblastic cells was stronger than that in cytotrophoblastic cells. Furthermore, the expressions were found in the cell membranes and cytoplasm. (Med J Indones 2007; 16:146-50) Keywords: cytotrophoblastic, syncytiotrophoblastic, intermediate trophoblastic cells

VEGF-C level as a predictor of pelvic lymph node metastases of cervical cancer at early stage Andrijono, Andrijono; Priyanto, Heru
Medical Journal of Indonesia Vol 18, No 4 (2009): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Aim: Vascular endothelial growth factor (VEGF) works to stimulate angiogenesis and lymphogenesis which is one of the factors in the metastasis process. This study aimed to identify whether VEGF level could be used to predict metastasis into pelvic lymph node of stage IB-IIA cervical cancer.Methods: The study was case control study, a case (cervical cancer metastasis into pelvic lymph node), a control (cervical cancer without metastasis). Independent variables included primary lesion size, histological type, grade of cell differentiation, lymph vascular space involvement, and VEGF level. Dependent variable was metastasis into pelvic lymph node.Results: Based on cut-off point, VEGF-C serum level, i.e., 10,066.90 pg/ml, 11/47 patients or 23.41%, had the level above that value, and 10/11 of the group of patient or 90.91% were found to develop metastasis into pelvic lymph node. Sensitivity of the examination of VEGF-C level in relation to the risk for the incidence of lymph node in this study was 71.43%, with a specifi city of 96.97%, positive predictive value (PPV) of 90.91%, and negative predictive value (NPV) of 88.89%.Conclusion: VEGF-C level in the serum could be used to predict lymph node metastasis of stage IB-IIA cervical cancer, with a sensitivity of 71.43% and specifi city of 96.97%. (Med J Indones 2009; 18: 257-61)Keywords: cervical cancer, metastasis, VEGF

CD133, CD44, and ALDH1A1 as cancer stem cell markers and prognostic factors in epithelial ovarian cancer Andrijono, Andrijono; Sutrisna, Bambang; Harahap, Alida Roswita; Kanoko, Mpu; Nuranna, Laila; Siregar, Budiningsih; Wulandari, Dewi; Pelupessy, Nugraha Utama
Medical Journal of Indonesia Vol 28, No 1 (2019): March
Publisher : Faculty of Medicine Universitas Indonesia

BACKGROUND Ovarian cancer is a heterogeneous disease, and most patients are diagnosed at an advanced stage. Epithelial ovarian cancer type II is characterized by rapid tumor growth and is genetically more labile than type I. This study was aimed to demonstrate the prognostic value of CSC by using the markers CD133, CD44, and ALDH1A1 in EOC.METHODS Clinicopathological and demographic data were collected from medical records. The markers CD133, CD44, and ALDH1A1 were examined with flow cytometry and immunohistochemistry. Cancer stem cell (CSC) marker expression in patients with ovarian cancer types I and II were related to chemotherapy and survival. In multivariate analysis, the prognosis model was tested for ten months.RESULTS The largest demographic consisted of patients aged ≥45 years, with stage I, poor differentiation, and type II, of which there were 40 samples (72.7%), 23 samples (41.8%), 30 samples (54.5%), and 16 samples (29.1%), respectively. There is a high correlation between the 10-month chemotherapy response and the 4 variables, i.e., age ≥45 years, type II, stage III–IV, and CD44, with an ROC of 80.75% and a post-test probability of 82.5%. Using the ROC curve, the highest chemoresistance score was 0.841, based on the combination of CSCs markers and clinicopathological factors, that is stage III–IV, age ≥45 years, poor differentiation, type II, negative CD133, high CD44, and high ALDH1A1.CONCLUSIONS CSC (CD133, CD44, and ALDH1A1) markers and clinicopathological factors are prognostic of epithelial ovarian cancer.

Co-Authors A. F. Tangdialla A.A. Ketut Agung Cahyawan W Abdul B. Saifuddin Achmad Noerkhaerin Putra Achmad Tjarta Ahmad Fuady Aldri Frinaldi Ani Retno Prijanti B. A. Tjokroprawiro B. Siregar Bambang Sutrisna Bram Pradipta Budiningsih Siregar Chairil Hamdani Christin Wigin, Christin Dewi Wulandari Dharmeizar Dharmeizar DJAENUDIN, A. E. Taufik FAUZIAH, I. Fera Ibrahim Ferry Armanza, Ferry Fiastuti Witjaksono Gatot Purwoto Ginealdy, Wahyu Gunawan D. Prayitno Harahap, Alida Roswita Hariyono Winarto Heru Priyanto Imam Rasjidi Isrin Ilyas J. Prihartono Junizaf Junizaf Kukung Kurnia Laila Nuranna Liem, Isabella Kurnia Luh Putu Ratna Sundari M. F. Aziz M. Hartati M. Iskandar Markus, Unedo H Markus, Unedo H Mongan, Suzanna P Mpu Kanoko Muhammad F Aziz MUHILAL, M. N. Kampono N. Supriana Nana Supriana Nur Asikin P. Hartono Pelupessy, Nugraha Utama R. Kodaria Rinaldy, Dino Risfiandi, Risa Rochani Rochani Rukmini T. Mangunkusumo S. G. Mihardja Santoso Cornain Sigit Purbadi Sri Wuryanti Susworo Susworo Tiffani, Wely L Tjahadi, Hartono Tjam Diana Samara Tofan W Utami UTAMI, T. W. W. L. Heffen Y. M. Hidayat

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