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Inderiyani, Inderiyani
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UJI AKTIVITAS ANTELMINTIK SIRUP EKSTRAK ETANOL UMBI BATANG ROTAN (CALAMUS ROTANG L.) TERHADAP CACING GELANG (ASCARIDIA GALLI) SECARA IN VITRO Herdaningsih, Sulastri; Inderiyani, Inderiyani; Fauzan, Suhaimi; Aulia, Gina
Edu Masda Journal Vol 9, No 1 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i1.278

Abstract

                                                   ABSTRACTAnthelmintics are drugs used to eradicate worms from the human or animal body. This study aims to determine whether ethanol extract of rattan stem tubers can be formulated as a syrup preparation and to determine how the physical evaluation of ethanol extract syrup preparation of rattan stem tubers. The research method used was laboratory experimental design. The test animals used were 75 heads, which were divided into 5 groups with 3 replications. The research was conducted with activity tests using Ascaridia galli worms soaked in rattan stem tuber extract syrup (Calamus rotang L.) with concentrations of 0.5%; 0.75%; and 1%. Piperazine citrate 0.9% was used as positive control and NaC1 0.9% physiological solution as negative control. Observations were made every 15 minutes by looking at whether lysis occurred in the worms. The results of testing the activity of rattan stem tuber extract showed that all concentrations of rattan stem tuber extract syrup (0.5%; 0.75%; and 1%) had a mortality percentage of 100%. Statistical results at concentrations of 0.75% and 1% are not significantly different from the positive control (> 0.05). This shows that rattan stem tuber extract syrup (Calamus rotang L.) has anthelmintic activity.                                       ABSTRAKABSTRAKAntelmintik merupakan obat yang digunakan untuk memberantas cacing dari dalam tubuh manusia atau hewan. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol umbi batang rotan dapat diformulasikan sebagai sediaan sirup dan untuk mengetahui bagaimana evaluasi fisik sediaan sirup ekstrak etanol umbi batang rotan. Metode penelitian yang digunakan adalah desain eksperimental laboratorium. Hewan uji yang digunakan sebanyak 75 ekor, yang dibagi menjadi 5 kelompok dengan 3 replikasi. Penelitian dilakukan dengan uji aktivitas menggunakan cacing Ascaridia galli yang direndam dalam sirup ekstrak umbi batang rotan (Calamus rotang L.) dengan konsentrasi 0,5%; 0,75%; dan 1%. Pada kontrol positif digunakan Piperazine sitrat 0,9 % dan larutan fisiologis NaC1 0,9 % sebagai kontrol negatif. Pengamatan diakukan tiap 15 menit dengan cara melihat apakah terjadi lisis pada cacing. Hasil pengujian aktivitas ekstrak umbi batang rotan menunjukkan bahwa semua konsentrasi sirup ekstrak umbi batang rotan (0,5%; 0,75%; dan 1%) memiliki persentase mortalitas sebesar 100%. Hasil statistik pada kosentrasi 0,75% dan 1% tidak berbeda makna dengan kontrol positif (> 0,05). Hal ini menunjukan bahwa sirup ekstrak umbi batang rotan (Calamus rotang L.) memiliki aktivitas sebagai antelmintik.
Virtual Screening to Identification The Active Compounds from Kratom (Mitragyna speciosa) as Analgetics Arief, Ihsanul; Inderiyani, Inderiyani
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.19911

Abstract

Kratom (Mytragina speciosa) is one of the endemic plants in Southeast Asia in general and Kalimantan in particular which is proven to have activities as an analgesic, sedative (antidepressant), and, antiobesity, breast anticancer, antinociceptive, CYP450 induction, anti-inflammatory, opiate, antimicrobial, and antioxidant. However, no report states the active compounds from kratom leaves that have these activities. Therefore, this study will identify the active compounds contained in kratom leaves with a virtual screening process responsible for analgesic activity along with the prediction of adsorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. The virtual screening process was performed based on molecular tethering, while the prediction of ADMET properties was done with the help of a web server. The results obtained showed that the compound (-)-epicatechin was most responsible for the analgesic activity of kratom leaves. The ADMET profile of this compound predicts that it has good bioavailability and is non-toxic.
FORMULASI SEDIAAN SIRUP SENGKUANG Dracontomelon dao (Blanco) Merr & Rofle DAN UJI EFEKTIVITASNYA SEBAGAI ANTELMINTIK inderiyani, Inderiyani; Puspasari, Heny; Puspita, Weni; Febrianti, Ririn
Jurnal Insan Farmasi Indonesia Vol 8 No 2 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/498ewz96

Abstract

The bark of the sengkuang Dracontomelon dao (Blanco) Merr & Rofle stem contains secondary metabolites alkaloids, saponins, tannins, flavonoids and triterpenoids which are efficacious as anthelmintics. This study aims to formulate, physically evaluate and test the effectiveness of sengkuang stem bark ethanol extract syrup as anthelmintic against chicken roundworms (Ascaridia galli). The syrup preparation was formulated in 3 variations of extract concentrations i.e 0.2%; 0.4% and 0.6%. The syrup was physically evaluated in the form of organoleptic tests, pH, displaced volume and specific gravity.  Inserting 5 chicken roundworms into each test solution i.e 0.9% NaCl (negative control), 0.5% mebendazole (positive control), sengkuang stem bark syrup 0.2%, 0.4%, and 0.6%. It was incubated at 37°C and the time and number of worm deaths were observed every 1 hour for 24 hours. The results showed the sengkuang bark ethanol extract syrup (0.2%; 0.4% and 0.6%) met the requirements in syrup preparations with brownish yellow, brownish orange and brown colors, distinctive aroma and sweet taste; pH ± 6; displaced volume ± 97-98% and specific gravity ± 1.2. All sengkuang bark ethanol extract syrup formulations had the ability to kill 100% of worms with LT50 values ​​of 11.40 hours; 10.33 hours and 6.87 hours.
Co-Authors Asmara, Ratna Dewi Lintang Aulia, Gina Dian Kartikasari Fauzan, Suhaimi Febrianti, Ririn Hairunnisa Hairunnisa Heny Puspasari Herdaningsih, Sulastri Ihsanul Arief Muharami, Savitri Olivia Puspa Sari, Heni Puspasari, Heny Puspita, Weni Risma Wahyu Architasari Sulastri Sulastri Yoga Pramana Yolanda, Riska