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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Insan Farmasi Indonesia
Chrismawan Ardianto
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

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The Effect of Quercetin on Coenzyme HMG-CoAR, ABCA1 Transporter, Dyslipidemia Profile and Hepatic Function in Rats Dyslipidemia Model Ignasius Agyo Palmado; Sulistyanaengci Winarto; Honey Dzikri Marhaeny; Yusuf Alif Pratama; Chrismawan Ardianto; Khotib, Junaidi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.274-290

Abstract

Background: Dyslipidemia is a lipid metabolic disorder that increases the risk of cardiovascular disease, typically marked by abnormalities in triglycerides (TG), low-density lipoprotein (LDL), and total cholesterol (TC), along with decreased high-density lipoprotein (HDL) levels. This study explored the potential of quercetin, a natural substance, as a preventive agent against dyslipidemia induced by high-fat diet (HFD) in a rat model. Simvastatin, a standard cholesterol-lowering drug, was used for the comparison. Objective: The main objective of this research was to evaluate the potential of quercetin in lipid metabolism for dyslipidemia caused by HFD and compare its effects with the first-line drug therapy simvastatin, which has a similar mechanism. Methods: Rats fed a HFD were treated with quercetin and simvastatin, and their lipid profiles, liver enzyme activities, and molecular markers related to cholesterol metabolism were analyzed. Results: Quercetin markedly decreased cholesterol levels by inhibiting the enzyme 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMG CoAR). Cellular observation revealed that it also prevented liver damage and showed a protective effect on liver enzyme activity. Quercetin enhanced the expression of the Adenosine Triphosphate Binding Cassette subfamily A member 1 (ABCA1) protein, showing a protective effect against dyslipidemia akin to simvastatin, yet with a reduced likelihood of liver toxicity. Conclusion: Quercetin may serve as an effective and safer alternative to simvastatin for treating dyslipidemia, offering cholesterol-lowering benefits without hepatotoxic risks associated with long-term statin therapy.
Co-Authors Abdul Rahem, Abdul Aprilia, Pingkan Arie Sulistyarini Budiatin, Aniek Setiya Budiman, Clarissa Dini Retnowati Farida Ifadotunnikmah Gesnita Nugraheni Gusti Noorrizka Veronika Ahmad Hermansyah, Andi Honey Dzikri Marhaeny I NYOMAN WIJAYA Ignasius Agyo Palmado Junaidi Khotib Mahardian Rahmadi Miatmoko, Andang Priyandani, Yuni Sukorini, Anila Impian Sulistyanaengci Winarto Sumarno . Sumartha, I Nengah Budi Toetik Aryani Tyas, Veronika Earline Pudji Setianing Umi Athiyah, Umi Yuda, Ana Yusuf Alif Pratama Zulkarnain, Bambang Subakti