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All Journal HAYATI Journal of Biosciences Jurnal Akuakultur Indonesia Jurnal Ilmu Dasar Protobiont: Jurnal Elektronik Biologi Jurnal Biologi Tropis JURNAL PENGABDI Biosaintifika: Journal of Biology & Biology Education Jurnal Penelitian Perikanan Indonesia Jurnal Labora Medika Jurnal Riset Biologi dan Aplikasinya Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Life Science Life Science
Ari Hepi Yanti
Program Studi Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Tanjungpura Jalan Prof. Dr. H. Hadari Nawawi, Pontianak
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Mathematics Mechanical Engineering Medicine & Pharmacology Social Sciences

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Journal : Jurnal Riset Biologi dan Aplikasinya

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The Therapeutic Potential of Humic Acid in Streptozotocin-Induced Hyperglycemic White Rats (Rattus norvegicus L.) Sirait, Evi Marina; Rousdy, Diah Wulandari; Yanti, Ari Hepi
Jurnal Riset Biologi dan Aplikasinya Vol. 7 No. 1 (2025)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jrba.v7n1.p110-117

Abstract

Humic acid, an organic compound from peat soil, rich in antioxidants such as quinone and phenol, shows potential as an antidiabetic agent. This study aims to identify the optimal dose of humic acid extract for increasing body weight, lowering blood glucose levels, reducing malondialdehyde (MDA) levels, and improving the microanatomical structure of the pancreas in streptozotocin-induced diabetic rats. The humic acid was extracted from peat soil at Tanjungpura University. The study utilized 25 male Wistar rats (Rattus norvegicus), aged 8-12 weeks, organized in a group randomized design (GRD). Interventions included a single dose of streptozotocin (40 mg/kg b.w.) and varying doses of humic acid extract administered over 14 days post-induction. Results indicated that a dose of 375 mg/kg b.w. humic acid extract resulted in an increased final body weight by 11.86%, a reduction in fasting blood glucose levels by 79.23%, an AUC0-120 value of 19.311, and a final MDA level of 1.09 ±0.27 nmol/ml. These findings indicate the potential of humic acid as a therapeutic agent for diabetes.
Co-Authors Amriani Amir Anggita, Via Arbi, Florensius Joko Barrata Barrata Dea, Uray Desriani Lestari Diah Pratiwi Diah Wulandari Rousdy Edi Kurniadi Edo, Febry Valianto Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Esta Br Tarigan Firman Saputra Hamidah, Kamisah Nurul Herina Marlisa Irfina Manda Astari, Irfina Manda Irwan Lovadi Junardi Junardi Kustiati Kustiati Mukarlina, Mukarlina Nabila, Vioni Talitha Neva Satyahadewi OKTAVIANI, RISKA Putri, Fiqih Fazira Rafdinal Rafdinal Rahmanisya, Afifah Rahmawati Rahmawati, Rahmawati Rikhsan Kurniatuhadi, Rikhsan Ristanto, Andi Riyandi Riyandi Riza Linda Romini, Romini Saputra, Firman Sari, Lala Sinaga, Lia Resa Sirait, Evi Marina Siti Ifadatin Siti Khotimah Syahir, Sutan Tri Rima Setyawati Turnip, Masnur Wibowo, Raynata Zwietenia Williem, Albertus Wiranata, Aufar Ismi Wirda Andani YPandayu Putra, Harits Yowansyah Zulfa Zakiah