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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Riset Biologi dan Aplikasinya Molucca Medica PAMERI : Pattimura Medical Review Folia Medica Indonesiana
Bandjar, Fitri Kadarsih
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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ANTIFUNGAL ACTIVITY OF NUTMEG MACE (<i>Myristica Fragrans</i> Houtt) ETHANOL EXTRACT AGAINST <i>Candida</i> spp. Yandji, Muhammad Akbar; Astuty, Eka; Bandjar, Fitri Kadarsih
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Candida infections are increasingly common worldwide and represent one of the leading causes of death after cardiovascular disease. There are three types of candida that often infect humans, namely Candida albicans, Candida tropicalis and Candida parapsilosis. In the standard treatment used, immunity and side effects of treatment have been found. Therefore, other treatment options are needed, one of which is by using mace (Myristica fragrans Houtt) which is a native plant of Maluku and has secondary metabolite compounds that can be antifungal agents. This study aims to test the ability of ethanol extract of mace nutmeg (Myristica fragrans Houtt) with concentrations of 5%, 10%, 25%, 50%, 75%, and 100% on the growth of Candida albicans ATCC 10231, Candida tropicalis ATCC 750, and Candida parapsilosis ATCC 22019. This study was conducted using the disc diffusion method (Kirby-Bauer). The results showed that the strongest inhibition zone was shown at a concentration of 100% against Candida tropicalis with an average inhibition zone diameter of 7.93 mm. Meanwhile, the lowest inhibition zone was shown at a concentration of 5% against Candida parapsilosis with an average inhibition zone of 3.25 mm. This research can be concluded that ethanol extract of mace nutmeg at all concentrations is able to inhibit the growth of Candida albicans, Candida tropicalis and Candida. parapsilosis.
Co-Authors Amanda Gracia Manuputty Astuty, Eka de Lima, Filda Vionita Irene Effendi Effendi Elpira Asmin Farah Christina Noya Fatimah Azzahra Filda de Lima Latuheru, Grace Malawat, Siti Rabida Nurhasanah Melda Yunita Mus, Rosdiana Pangestu, Juan Felix Rachmawati Dwi Agustin Rahawarin, Halidah SILALAHI, PARNINGOTAN YOSI Soumena, Rifah Zafarani SULFIANA, SULFIANA Tahitu, Ritha Tanamal, Rita Tanamal, Rita Sugiono Tanasal, Hanny Theodorus, Prilly Pricilya Titaley, Christiana Rialine Warella, Juen Carla Yandji, Muhammad Akbar