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All Journal Jurnal Ilmu Kefarmasian Indonesia Edu Masda Journal Jurnal Farmasi dan Sains Indonesia (JFSI) KOLONI Pharmaceutical Science Journal Jurnal Sains Farmasi dan Kesehatan
Ayu Werawati
STIKes Widya Dharma Husada Tangerang
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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FORMULASI DAN EVALUASI AKTIVITAS ANTIOKSIDAN SABUN CAIR BERBAHAN DASAR EKSTRAK DAUN KEMANGI DAN MADU Dewi, Bheta Sari; Utami, Sheila Meitania; Werawati, Ayu; Bachtiar, Wahyu; Dewantoro, Agung
PHRASE (Pharmaceutical Science) Journal Vol 4, No 2 (2024): Pharmaceutical Science Journal Vol 4 No 2
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v4i2.903

Abstract

Basil leaves  (Ocimum sanctum L.) and honey contain flavonoids and polyphenol compounds such as methyl eugenol, which are known to have antioxidant activity. Liquid soap is a form of pharmaceutical product that is often used to cleanse the body and provide additional protection to the skin. Objective: The aim of this study was to obtain the best physical formulation of a liquid soap combination of basil leaf extract and honey and its antioxidant activity. Method: Liquid soap preparations were made by adding basil leaf extract with various concentrations of 2g (FI), 4g (FII) and 8g (FIII) and honey, namely 5g (FI), 5g (FII) and 5g (FIII). Evaluation of liquid soap preparations included organoleptic, pH, and homogenity, as well as antioxidant activity test using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a wavelength of 516 nm. Results: The results showed that Formula III (FIII) had the best results, namely organoleptic milk chocolate color, pH preparation (9.71-9.89), homogeneous preparation, stable preparation in storage for 12 days and showed the best IC50 value of 118.39 ppm. Conclusion: In conclusion, the combination of basil leaf extract and honey can be formulated as a liquid soap preparation with a concentration of 8g basil leaf extract and 5g honey in formula III (FIII) showing the effectiveness as the best formulation.
EFEKTIVITAS TERAPI INSULIN TERHADAP GLUKOSA DARAH DAN HbA1c PASIEN DIABETES MELITUS DI RUMAH SAKIT UMUM X JAKARTA SELATAN Aulia, Gina; Azzahra, Aristi; Purwaningsih, Neneng Sri; Ismaya, Nurwulan Adi; Hasanah, Nur; Putri, Annisa Septyana; Kurniawati, Dewi Indah; Werawati, Ayu; Sayyidah, Sayyidah
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p167-172

Abstract

Diabetes mellitus is a serious and chronic condition. Diabetes mellitus patients often experience serious acute and chronic complications, even causing death. South Jakarta has the 4th highest prevalence of diabetes mellitus, namely 2.83%. The aim of this study was to analyze the effectiveness of insulin therapy by examining differences in blood glucose and HbA1c after 4 months and 8 months of therapy in diabetes mellitus patients. The research method in this research is quantitative descriptive analysis with a cohort retrospective approach. The sample in this study was 92 diabetes mellitus patients on insulin therapy who had their HbA1c checked with blood glucose routinely in 2023 taken using the purposive sampling method. The results showed that most patients were in the 56-65 years age group (45.7%), the most common gender was female (57.6%), and 76.1% of patients had comorbidities. The most widely used insulin therapy is a combination of Rapid acting and Long acting insulin (63%). The conclusion in this study was that there was no significant difference in either blood glucose levels after 4 months of therapy (P=0.442) or blood glucose levels after 8 months of therapy (P=0.148), compared with 1st month blood glucose, and there was a difference significant both HbA1c levels after 4 months of therapy (P=0.000) and HbA1c levels after 8 months of therapy (P=0.000), compared with HbA1c in the 1 month
FORMULASI DAN EVALUASI FISIK SEDIAAN SERUM ANTI-AGING YANG MENGANDUNG EKSTRAK TANAMAN DARI BERBAGAI LITERATUR Dewi, Bheta Sari; Werawati, Ayu
KOLONI Vol. 1 No. 4 (2022): DESEMBER 2022
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v1i4.426

Abstract

Currently, beauty products are developing very fast, especially anti-aging facial care products. One of the most popular products is serum. Serum contains many concentrates that are useful for nourishing and moisturizing the skin. Several plants that have been studied have the potential to be used as serum preparations, namely apuh-apuhan leaves, brown rice, Malacca fruit, gotu kola, jamblang leaves, cempedak leaves, black pepper, and Perilla Frutescens. This study aims to determine the formulation and physical evaluation of serum preparations containing plant extracts in terms of various literatures. The method used is descriptive literature review by collecting various sources from several national journals. The number of national journals used is 7 and 1 international journal. The results of a literature study on serum formulations containing plant extracts can be formulated into serum dosage forms. Evaluation of serum preparations includes organoleptic tests, pH tests, spreadability tests, and viscosity tests. The results of the study concluded that the formulation with the most complete physical evaluation and had good stability without any signs of damage to the dosage form in the serum formulation with a pH value of 5.5, a spreadability of 6.63 cm and a viscosity value of 2900 cP were found in formulations containing the extract. malacca fruit plants. Keywords: anti-aging, serum, formulation, evaluation, extract
UJI EFEKTIVITAS SERUM EKSTRAK DAUN KELOR (Moringa oleifera L.) SEBAGAI ANTIJERAWAT Staphylococcus aureus Dewi, Bheta Sari; Werawati, Ayu; Hasanah, Uswatun; Sayyidah, Sayyidah; Dewantoro, Agung; Saputra, Aldi
Edu Masda Journal Vol 9, No 1 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i1.281

Abstract

                                                       ABSTRACTAcne is among the most prevalent dermatological issues caused by the bacterium Staphylococcus aureus. Moringa leaf extract (Moringa oleifera L.) is known to contain bioactive compounds such as flavonoids, tannins, and alkaloids, which serve as anti-acne agents. This research seeks to assess the efficacy of a serum formulated with moringa leaf extract in inhibiting the growth of acne-causing Staphylococcus aureus. The extraction of moringa leaves was carried out using the maceration technique with 96% ethanol serving as the solvent. The extract was then formulated into a serum preparation with concentrations of 4%, 7%, and 10%, using Clindamycin as the positive control and the serum base as the negative control. The antibacterial efficacy was evaluated through the agar well diffusion technique to determine the inhibition zone against Staphylococcus aureus. Each treatment was conducted in triplicate. Additionally, the physical stability of the serum was assessed, covering organoleptic characteristics, homogeneity, pH, spreadability, and adhesion. The findings revealed that moringa leaf extract exhibited inhibitory effects on the growth of Staphylococcus aureus, as evidenced by the presence of inhibition zones. The inhibition zone diameters were 14.21 mm at 4% concentration, 17.30 mm at 7%, and 19.20 mm at 10%. In comparison, the positive control showed a diameter of 30.78 mm, while the negative control showed no inhibition (0 mm). This research suggests that serum formulated with moringa leaf extract holds promise as an effective topical solution for treating acne.                                                  ABSTRAKJerawat ialah satu diantara masalah kulit yang umum disebabkan oleh bakteri Staphylococcus aureus. Ekstrak daun kelor (Moringa oleifera L.) dikenal punya senyawa bioaktif seperti flavonoid, tanin, dan alkaloid sebagai agen antijerawat. Kajian ini memiliki tujuan guna melakukan uji efektivitas serum berbahan dasar ekstrak daun kelor dalam menghambat pertumbuhan bakteri jerawat Staphylococcus aureus. Ekstrak daun kelor diperoleh lewat metode maserasi dengan pelarut etanol 96%. Ekstrak ini kemudian diformulasi ke sediaan serum dengan konsentrasi 4%, 7%, dan 10% serta digunakan Clindamycin sebagai kontrol positif dan basis serum menjadi kontrol negatif. Uji aktivitas antibakteri memakai metode difusi sumuran agar, guna mengukur zona hambat pada Staphylococcus aureus. Perlakuan diulang sebanyak 3 kali. Stabilitas fisik serum juga diuji meliputi organoleptis, homogenitas, pH, daya sebar dan daya lekat. Hasilnya diperoleh bahwa ekstrak daun kelor mempunyai kemampuan menghambat pertumbuhan Staphylococcus aureus bisa diamati dengan adanya zona hambat yang dibentuk. Diameter zona hambat di konsentrasi 4% senilai 14,21 mm, konsentrasi 7% sebesar 17,30 mm, konsentrasi 10% senilai 19,20 mm, kontrol positif senilai 30,78 mm, dan kontrol negatif sebesar 0 mm. Kajian ini memberi indikasi jika serum ekstrak daun kelor punya potensi jadi sediaan topikal yang efektif bagi pengobatan jerawat.
Co-Authors Agung Dewantoro Alexandre, Nahla Dany Andriyani Rahmah Fahriati Anis Dwi Kristiyowati Aryanti, Fitriya Yuni Aulia, Gina Azzahra, Aristi Bachtiar, Wahyu Beny Maulana Satria Bheta Sari Dewi Diah Permata Sari Dian Ratih Laksmitawati Esti Mumpuni Fatwa Hikmatul Kurnia Firdha Senja Maelaningsih Fitriani, Reka Gina Aulia Herdaningsih, Sulatri Kristiyowati, Anis Dwi Kurniawati, Dewi Indah Kusmardi Kusmardi Mochammad Hasan, Mochammad Neneng Sri Purwaningsih Nur Hasanah Nurwulan Adi Ismaya Putri, Annisa Septyana Saputra, Aldi Saputri, Laras Tri Sayyidah Sayyidah Sayyidah Sayyidah Sayyidah Sayyidah, Sayyidah Sheila Meitania Utami Syamsudin Abdillah Uswatun Hasanah Zahra, Annisa Fairuz