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All Journal Jurnal Ilmu Kefarmasian Indonesia Edu Masda Journal Jurnal Farmasi dan Sains Indonesia (JFSI) KOLONI Pharmaceutical Science Journal Jurnal Sains Farmasi dan Kesehatan
Ayu Werawati
STIKes Widya Dharma Husada Tangerang
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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FORMULASI DAN EVALUASI AKTIVITAS ANTIOKSIDAN SABUN CAIR BERBAHAN DASAR EKSTRAK DAUN KEMANGI DAN MADU Dewi, Bheta Sari; Utami, Sheila Meitania; Werawati, Ayu; Bachtiar, Wahyu; Dewantoro, Agung
PHRASE (Pharmaceutical Science) Journal Vol 4, No 2 (2024): Pharmaceutical Science Journal Vol 4 No 2
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v4i2.903

Abstract

Basil leaves  (Ocimum sanctum L.) and honey contain flavonoids and polyphenol compounds such as methyl eugenol, which are known to have antioxidant activity. Liquid soap is a form of pharmaceutical product that is often used to cleanse the body and provide additional protection to the skin. Objective: The aim of this study was to obtain the best physical formulation of a liquid soap combination of basil leaf extract and honey and its antioxidant activity. Method: Liquid soap preparations were made by adding basil leaf extract with various concentrations of 2g (FI), 4g (FII) and 8g (FIII) and honey, namely 5g (FI), 5g (FII) and 5g (FIII). Evaluation of liquid soap preparations included organoleptic, pH, and homogenity, as well as antioxidant activity test using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a wavelength of 516 nm. Results: The results showed that Formula III (FIII) had the best results, namely organoleptic milk chocolate color, pH preparation (9.71-9.89), homogeneous preparation, stable preparation in storage for 12 days and showed the best IC50 value of 118.39 ppm. Conclusion: In conclusion, the combination of basil leaf extract and honey can be formulated as a liquid soap preparation with a concentration of 8g basil leaf extract and 5g honey in formula III (FIII) showing the effectiveness as the best formulation.
EFEKTIVITAS TERAPI INSULIN TERHADAP GLUKOSA DARAH DAN HbA1c PASIEN DIABETES MELITUS DI RUMAH SAKIT UMUM X JAKARTA SELATAN Aulia, Gina; Azzahra, Aristi; Purwaningsih, Neneng Sri; Ismaya, Nurwulan Adi; Hasanah, Nur; Putri, Annisa Septyana; Kurniawati, Dewi Indah; Werawati, Ayu; Sayyidah, Sayyidah
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p167-172

Abstract

Diabetes mellitus is a serious and chronic condition. Diabetes mellitus patients often experience serious acute and chronic complications, even causing death. South Jakarta has the 4th highest prevalence of diabetes mellitus, namely 2.83%. The aim of this study was to analyze the effectiveness of insulin therapy by examining differences in blood glucose and HbA1c after 4 months and 8 months of therapy in diabetes mellitus patients. The research method in this research is quantitative descriptive analysis with a cohort retrospective approach. The sample in this study was 92 diabetes mellitus patients on insulin therapy who had their HbA1c checked with blood glucose routinely in 2023 taken using the purposive sampling method. The results showed that most patients were in the 56-65 years age group (45.7%), the most common gender was female (57.6%), and 76.1% of patients had comorbidities. The most widely used insulin therapy is a combination of Rapid acting and Long acting insulin (63%). The conclusion in this study was that there was no significant difference in either blood glucose levels after 4 months of therapy (P=0.442) or blood glucose levels after 8 months of therapy (P=0.148), compared with 1st month blood glucose, and there was a difference significant both HbA1c levels after 4 months of therapy (P=0.000) and HbA1c levels after 8 months of therapy (P=0.000), compared with HbA1c in the 1 month
FORMULASI DAN EVALUASI FISIK SEDIAAN SERUM ANTI-AGING YANG MENGANDUNG EKSTRAK TANAMAN DARI BERBAGAI LITERATUR Dewi, Bheta Sari; Werawati, Ayu
KOLONI Vol. 1 No. 4 (2022): DESEMBER 2022
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v1i4.426

Abstract

Currently, beauty products are developing very fast, especially anti-aging facial care products. One of the most popular products is serum. Serum contains many concentrates that are useful for nourishing and moisturizing the skin. Several plants that have been studied have the potential to be used as serum preparations, namely apuh-apuhan leaves, brown rice, Malacca fruit, gotu kola, jamblang leaves, cempedak leaves, black pepper, and Perilla Frutescens. This study aims to determine the formulation and physical evaluation of serum preparations containing plant extracts in terms of various literatures. The method used is descriptive literature review by collecting various sources from several national journals. The number of national journals used is 7 and 1 international journal. The results of a literature study on serum formulations containing plant extracts can be formulated into serum dosage forms. Evaluation of serum preparations includes organoleptic tests, pH tests, spreadability tests, and viscosity tests. The results of the study concluded that the formulation with the most complete physical evaluation and had good stability without any signs of damage to the dosage form in the serum formulation with a pH value of 5.5, a spreadability of 6.63 cm and a viscosity value of 2900 cP were found in formulations containing the extract. malacca fruit plants. Keywords: anti-aging, serum, formulation, evaluation, extract
UJI EFEKTIVITAS SERUM EKSTRAK DAUN KELOR (Moringa oleifera L.) SEBAGAI ANTIJERAWAT Staphylococcus aureus Dewi, Bheta Sari; Werawati, Ayu; Hasanah, Uswatun; Sayyidah, Sayyidah; Dewantoro, Agung; Saputra, Aldi
Edu Masda Journal Vol 9, No 1 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i1.281

Abstract

                                                       ABSTRACTAcne is among the most prevalent dermatological issues caused by the bacterium Staphylococcus aureus. Moringa leaf extract (Moringa oleifera L.) is known to contain bioactive compounds such as flavonoids, tannins, and alkaloids, which serve as anti-acne agents. This research seeks to assess the efficacy of a serum formulated with moringa leaf extract in inhibiting the growth of acne-causing Staphylococcus aureus. The extraction of moringa leaves was carried out using the maceration technique with 96% ethanol serving as the solvent. The extract was then formulated into a serum preparation with concentrations of 4%, 7%, and 10%, using Clindamycin as the positive control and the serum base as the negative control. The antibacterial efficacy was evaluated through the agar well diffusion technique to determine the inhibition zone against Staphylococcus aureus. Each treatment was conducted in triplicate. Additionally, the physical stability of the serum was assessed, covering organoleptic characteristics, homogeneity, pH, spreadability, and adhesion. The findings revealed that moringa leaf extract exhibited inhibitory effects on the growth of Staphylococcus aureus, as evidenced by the presence of inhibition zones. The inhibition zone diameters were 14.21 mm at 4% concentration, 17.30 mm at 7%, and 19.20 mm at 10%. In comparison, the positive control showed a diameter of 30.78 mm, while the negative control showed no inhibition (0 mm). This research suggests that serum formulated with moringa leaf extract holds promise as an effective topical solution for treating acne.                                                  ABSTRAKJerawat ialah satu diantara masalah kulit yang umum disebabkan oleh bakteri Staphylococcus aureus. Ekstrak daun kelor (Moringa oleifera L.) dikenal punya senyawa bioaktif seperti flavonoid, tanin, dan alkaloid sebagai agen antijerawat. Kajian ini memiliki tujuan guna melakukan uji efektivitas serum berbahan dasar ekstrak daun kelor dalam menghambat pertumbuhan bakteri jerawat Staphylococcus aureus. Ekstrak daun kelor diperoleh lewat metode maserasi dengan pelarut etanol 96%. Ekstrak ini kemudian diformulasi ke sediaan serum dengan konsentrasi 4%, 7%, dan 10% serta digunakan Clindamycin sebagai kontrol positif dan basis serum menjadi kontrol negatif. Uji aktivitas antibakteri memakai metode difusi sumuran agar, guna mengukur zona hambat pada Staphylococcus aureus. Perlakuan diulang sebanyak 3 kali. Stabilitas fisik serum juga diuji meliputi organoleptis, homogenitas, pH, daya sebar dan daya lekat. Hasilnya diperoleh bahwa ekstrak daun kelor mempunyai kemampuan menghambat pertumbuhan Staphylococcus aureus bisa diamati dengan adanya zona hambat yang dibentuk. Diameter zona hambat di konsentrasi 4% senilai 14,21 mm, konsentrasi 7% sebesar 17,30 mm, konsentrasi 10% senilai 19,20 mm, kontrol positif senilai 30,78 mm, dan kontrol negatif sebesar 0 mm. Kajian ini memberi indikasi jika serum ekstrak daun kelor punya potensi jadi sediaan topikal yang efektif bagi pengobatan jerawat.
FORMULASI DAN EVALUASI SEDIAAN LIP BALM DARI EKSTRAK KULIT BUAH DELIMA (Punica granatum L.) Werawati, Ayu; Romlah, Siti Novy; Dewi, Bheta Sari; Sopian, Ahmad; Aulia, Gina; Manuruyah, Phuja Arinda
PHRASE (Pharmaceutical Science) Journal Vol 5, No 1 (2025): Vol 5 No 1 : Pharmaceutical Science Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v5i1.996

Abstract

Lips are a part of the body that is easily damaged by environmental factors so that it requires special care, such as lip balm. Natural lip balm products are preferred because they are safe and effective for lip health. Pomegranate peel has high antioxidant and tannin content, but is still rarely used in cosmetics such as lip balm. The purpose of this study was to formulate and evaluate lip balm preparations from pomegranate peel extract (Punica granatum L.) with concentrations of 10%, 15% and 20%. The research method in this study is an experimental method with stages of lip balm preparation formulation and continued with examination of the physical quality of the preparation, namely homogeneity test, organoleptic test, pH test, adhesion test, and spreadability test.. The results showed that the observation of the color of the preparation was peach red, semi-solid in shape and had a distinctive odor of oleum cacao, pH 5.92-6.45 which had met the specification range. The conclusion of this study is that F1, F2 and F3 have met the requirements of organoleptic test, homogeneity, spreading power, adhesion, pH test. 
INOVASI SPRAY GEL KOMBINASI SAMBILOTO, BROTOWALI, KUNYIT, DAN LADA HITAM SEBAGAI ALTERNATIF NON-STEROID UNTUK PEMULIHAN EKSIM TOPICAL STEROID WITHDRAWAL Bachtiar, Wahyu; Dewi, Bheta Sari; Werawati, Ayu
Edu Masda Journal Vol 9, No 2 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i2.277

Abstract

                                                        ABSTRACTsynergistically for the treatment of Topical Steroid Withdrawal by inhibiting the main inflammatory pathways (TNF-α and IL-6, IL-17, NF-κB, and MAPK pathways). The objective of this study was to determine the optimal formulation of a spray gel containing extracts of sambiloto, brotowali, turmeric, and black pepper based on physical characteristics (organoleptic properties, pH, and viscosity). The optimal formulation was analysed using Design Expert software version 13 and the Mixture D-Optimal method. The independent variables in this study were brotowali extract, sambiloto extract, and turmeric extract. The dependent variables were black pepper extract 1%, carbopol 0.5%, TEA 1%, citric acid 1%, ethanol 15%, phenoxyethanol 0.5%, and propylene glycol 5%. The results obtained indicate that the optimal formulation is based on the highest desirability value from the analysis using the Design Expert program, which is 0.867. The optimal formulation for the spray gel formulation is 3% brotowali extract, 4% sambiloto extract, and 3% turmeric extract.                                                ABSTRAKSambiloto, Brotowali, Kunyit, Dan Lada Hitam merupakan tanaman yang bekerja sinergis untuk pengobatan Topical Steroid Withdrawal dengan aktivitas menekan jalur-jalur inflamasi utama ( jalur TNF-α dan IL-6, IL-17, NF-κB, dan MAPK). Tujuan penelitian ini adalah untuk menentukan formula optimal sediaan spray gel yang mengandung ekstrak sambiloto, brotowali, kunyit, dan lada Hitam berdasarkan karakteristik fisik (organoleptis, pH dan viskositas). Formula optimal dianalisis menggunakan perangkat lunak Design Expert versi 13 dan melalui metode Mixture D-Optimal. Variabel independen dalam penelitian ini adalah ekstrak brotowali, ekstrak sambiloto dan ekstrak kunyit. Variabel dependen adalah ekstrak lada hitam 1%, carbopol 0,5%, TEA 1%, Asam sitrat 1%, Etanol 15%, Fenoksietanol 0,5% dan Propilenglikol 5%. Hasil yang diperoleh menunjukkan bahwa formulasi optimal didasarkan pada nilai keinginan tertinggi dari hasil analisis menggunakan program Design Expert sebesar 0,867. Formulasi optimal untuk sediaan spray gel adalah ekstrak brotowali 3%, ekstrak sambiloto 4% dan ekstrak kunyit 3%.  
Co-Authors Agung Dewantoro Ahmad Sopian, Ahmad Alexandre, Nahla Dany Andriyani Rahmah Fahriati Anis Dwi Kristiyowati Aryanti, Fitriya Yuni Aulia, Gina Azzahra, Aristi Bachtiar, Wahyu Beny Maulana Satria Bheta Sari Dewi Diah Permata Sari Dian Ratih Laksmitawati Esti Mumpuni Fatwa Hikmatul Kurnia Firdha Senja Maelaningsih Fitriani, Reka Gina Aulia Herdaningsih, Sulatri Kristiyowati, Anis Dwi Kurniawati, Dewi Indah Kusmardi Kusmardi Manuruyah, Phuja Arinda Mochammad Hasan, Mochammad Neneng Sri Purwaningsih Nur Hasanah Nurwulan Adi Ismaya Putri, Annisa Septyana Saputra, Aldi Saputri, Laras Tri Sayyidah Sayyidah Sayyidah Sayyidah Sayyidah Sayyidah, Sayyidah Sheila Meitania Utami Siti Novy Romlah Syamsudin Abdillah Uswatun Hasanah Zahra, Annisa Fairuz