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All Journal E-Jurnal Medika Udayana Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Multidisciplinary Science Eduvest - Journal of Universal Studies Glosains: Jurnal Sains Global Indonesia
Darmaputra, I Gusti Nyoman
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Expandable Ranitidine HCl tablets with Salak Bali seed matrix (Salacca zalacca) Putra, I Gusti Ngurah Agung Dewantara; Darmaputra, I Gusti Nyoman; Tamim, Imron Hadi
Indonesian Journal of Multidisciplinary Science Vol. 4 No. 2 (2024): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v4i2.1061

Abstract

This research aims to develop ranitidine HCl tablets that can be expanded with a matrix from Balinese salak seeds (Salacca zalacca) as a natural matrix material. This formulation is expected to prolong the release time of the drug in the body, thereby increasing the effectiveness of ranitidine therapy in the treatment of gastric diseases. The research method included the extraction of the active components from Balinese salak seeds and the process of making tablets using the wet granulation method, followed by physical tests of the tablets which included the hardness, crushing time, and ability of the tablets to expand. The results showed that ranitidine HCl tablets with Balinese salak seed matrix had physical characteristics that met the requirements of pharmacopooeia, with a slower drug release time than tablets without a developer matrix. Analysis of development capabilities shows that Balinese salak seeds are effective as natural matrix agents to prolong the release time of ranitidine HCl. In conclusion, Balinese salak seed matrix can be used as an alternative in the development of expandable ranitidine HCl tablets, potentially increasing the therapeutic effect of the drug.
Mixed Type Basal Cell Carcinoma Treated with Excision and Defect Closure Using Advancement Flap: A Case Report Darmaputra, I Gusti Nyoman; Ketut Kwartantaya Winaya; Adelia Suryani; Herman Saputra; Putu Setiani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 2 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i2.931

Abstract

Background: Basal cell carcinoma (BCC) is a localized malignant tumor in the basal layer of the epidermis thought to be the result of prolonged sun exposure and associated with gene mutations in most cases. Although rarely metastazises, BCC can cause high levels of morbidity due to its locally destructive nature. There are several modalities for managing BCC, and the defect caused by the lesion can reconstructed by local flap. Case presentation: We present a 55-year-old woman with a chief complaint of a blackish lump on the left maxillary region, growing bigger, and frequent episodes of bleeding. The lesion was excised and followed by histopathological examination, which revealed mixed subtype BCC. Closure of the defect with an advancement flap was performed with favorable results. Conclusion: Surgical excision is the best option for managing BCC, while a skin flap is preferred to close defects for lesions on the cheek.
Characteristics of Cutaneous Lupus Erythematosus Patients in Dermatology and Venereology Outpatient Clinic Suryawati, Nyoman; Praharsini, I Gusti Ayu Agung; Elis Indira, I Gusti Ayu Agung; Darmaputra, I Gusti Nyoman
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.153-162

Abstract

Background: Cutaneous lupus erythematosus (CLE) is a specific skin manifestation of lupus erythematosus. This condition can be accompanied by systemic involvement that affect patient therapy and prognosis. The characteristics of CLE patients in Indonesia have not been widely reported. This study aims to determine the prevalence and characteristics of CLE patients at Dermatology and Venereology Outpatient Clinic of Allergy and Immunology Division at Ngoerah Hospital. Methods: This research used descriptive analysis with a cross-sectional design and total sampling method. Result: The total number of patients was 34, with prevalence of 6.7 cases per 1,000 patients. The majority of patients were female (85.3%), Balinese ethnicity (70.6%), unemployed (53%), with a high school/vocational high school education (56%), and risk factors of sun exposure (80.0%). Most patients had no family history of Lupus erythematosus (LE) (65.7%). The most frequent skin manifestation was chronic type CLE (28.6%). Based on The European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) score, 27 patients (77.1%) met Systemic lupus erythematosus (SLE) criteria. Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) activity, damage, and Mexican Systemic Lupus Erythematosus Disease Activity (MEX-SLEDAI) scores were 3.35±4.52, 0.88±1.96, and 7.5±5.09. Systemic therapy included methylprednisolone (47%) and hydroxychloroquine (35.2%), topical treatment included high to very high-potency steroids (67.6%), and sunscreen (14.7%). Response therapy was generally good in 68.6% of patients. Conclusion: The most common type of CLE is chronic cutaneous lupus erythematosus. Most patients improved, with the majority using systemic methylprednisolone and topical high-potency corticosteroids. Oral treatment responses tend to be good.
Comparison of Platelet, Leukocyte, and Erythrocyte Levels in Platelet-Rich Plasma with Centrifugation Speeds of 100 g/400 g and 300 g/750 g in Healthy Individuals Halim, Irene Andriani; Winaya, Ketut Kwartantaya; Puspawati, Ni Made Dwi; Darmaputra, I Gusti Nyoman; Suryawati, Nyoman; Indira, I Gusti Ayu Agung Elis
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 38 No. 1 (2026): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V38.1.2026.7-13

Abstract

Background: Background: Platelet-rich plasma (PRP) is an autologous blood product obtained through centrifugation and is widely applied in dermatology. Its cellular composition—particularly platelet, leukocyte, and erythrocyte levels—is influenced by various centrifugation parameters, with centrifugation speed being a critical factor. Purpose: This study aimed to compare the impact of two different centrifugation speeds, 100 g/400 g and 300 g/750 g, on the cellular composition of PRP. Methods: This cross-sectional study involved collecting blood samples from 34 healthy female subjects aged between 18 and 40 years. The samples were processed into PRP using two centrifugation speeds: 100g/400g (referred to as PRP1) and 300g/750g (referred to as PRP2). The counts of platelets, leukocytes, and erythrocytes were measured before and after centrifugation. Results: The mean platelet count in PRP2 (1,946.76 ± 436.98 × 10³/μL) was significantly higher than in PRP1 (1,445.00 ± 366.34 × 10³/μL; p = 0.000). The mean leukocyte count was significantly greater in PRP1 (58.69±22.82×10³/μL; p = 0.000) compared to PRP2 (32.68±16.20×10³/μL). Erythrocyte contamination was notably lower in PRP1 (0.16 ± 0.06 × 106/μL; p = 0.007) than in PRP2 (0.19 ± 0.06 × 106/μL). Multivariate regression analysis indicated that centrifugation speed was the most significant factor influencing variations in platelet, leukocyte, and erythrocyte counts (p < 0.05), while age and BMI had no significant impact. Conclusion: A centrifugation speed of 300 g/750 g was more effective in increasing platelet concentration but with erythrocyte levels, whereas the 100 g/400 g speed resulted in PRP with a higher leukocyte content.
Autologous Fat Grafting for Mixed-Type Atrophic Acne Scars: A Case Report in Female Darmaputra, I Gusti Nyoman; Devi , Putu Akopita
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 2 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i2.708

Abstract

Background: Acne scars are a clinically prevalent and psychologically significant sequela of acne vulgaris, affecting up to 95% of patients and associated with reduced quality of life, social withdrawal, and diminished self-esteem. Despite decades of research, evidence for fat grafting in mixed-type atrophic acne scars remains limited to small case series. Objective: This case report aims to evaluate the short-term clinical outcomes of autologous fat grafting in a 37-year-old female with Goodman and Baron Grade IV mixed-type atrophic acne scars. Methods: This case study identified a 37-year-old female with atrophic acne scars. The tumescent technique was utilized to harvest fat from her abdomen, which was processed into microfat and nanofat using the Lipocube® NanoKit-5 and then injected subcutaneously and applied topically to the patient’s face. The efficacy of the procedures was assessed during different follow-up visits, with an emphasis on scar reduction and dermal regeneration. Results: A significant reduction in edema was clinically observed on Day 4 post-procedure. As this was a single case with a 4-day observation period, no statistical analysis was performed. Descriptive assessment tools were used at baseline and will be repeated at scheduled follow-up visits. Conclusion: Autologous fat transfer using microfat and nanofat is a promising preliminary therapy for atrophic acne scars. It provides cosmetic improvement with low morbidity. However, longer-term evaluation is needed to establish its efficacy. Future studies with larger cohorts and standardized multi-timepoint assessments are warranted to establish the role of this technique in standard dermatological practice.
Co-Authors Adelia Suryani Devi , Putu Akopita Elis Indira, I Gusti Ayu Agung Gunawan, Regina Halim, Irene Andriani Hendrayanta, Michelle Herman Saputra I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Praharsini I Gusti Ngurah Agung Dewantara Putra Imron Hadi Tamim, Imron Hadi Indira, I Gusti Ayu Agung Elis Ketut Kwartantaya Winaya Kewatiting, Agnes Susanti Luh Made Mas Rusyati Muhammad Yusron Maulana El-Yunusi Ni Kadek Setyawati, Ni Kadek Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Nyoman Suryawati Phinari, Handelia Putu Setiani Richard Richard Triatmakusuma, Yogi Wardhana, I Made Winaya, Ketut Kwartantaya