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All Journal Majalah Patologi Indonesia Nusantara Hasana Journal Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Indonesian Journal of Biomedicine and Clinical Sciences
Nana Liana
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal Nana Liana; Noza Hilbertina; Loli Devianti; Husna Yetti
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.332 KB) | DOI: 10.55816/mpi.v31i1.490

Abstract

BackgroundColorectal carcinoma is the third most common malignancy in the world. Colorectal carcinoma is a heterogeneous tumor withdifferent clinical pathologic features and prognostic values. For the same tumor-stage, patients could have difference prognosis andit has been suggested that the angiogenesis might be correlated with the prognosis, especially expression of vascular endothelialgrowth factor (VEGF) as the main pro-angiogenic factor. High VEGF expression in colorectal adenocarcinoma is associated withincreased blood vessels in invasive tumor area, cell proliferation and metastases. However, relation VEGF expression with thedegree of differentiation and lymphovascular invasion is not known.MethodsThis was a retrospective observational study with cross sectional approach. Samples were obtained from 39 paraffin blocks withdiagnosis adenocarcinoma not otherwise specific (NOS) in four Anatomical Pathology Laboratory in West Sumatera 2018 andevaluated for degree of differentiation and lymphovascular invasion. VEGF expressions in tumor cell were analyzed usingimmunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant.ResultsColorectal adenocarcinoma with high grade differentiation entirely had high VEGF expression (100%), while low gradedifferantiation with high VEGF expression was 60.7%. Lymphovascular invasion positive was mostly found with high VEGFexpression (80.6%). Statistical analysis showed significant association between VEGF expression with degree of differentiation(p=0.017) and lymphovascular invasion (p=0.028).ConclusionThe conclusion was VEGF expression had significant association with degree of differentiation and lymphovascular invasion ofcolorectal adenocarcinoma.
Correlation between differentiation grade and lymphovascular invasion in colorectal adenocarcinoma Nana Liana; Loli Devianti; Yessy Setiawati; Sri Nani Jelmila; Ruhsyahadati
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.20536

Abstract

Colorectal carcinoma is the third most common malignant tumor worldwide. It is a heterogeneous disease with diverse clinicopathological and prognostic characteristics. The TNM (tumor, node, metastasis) staging system is currently used as a prognostic predictor. However, its predictive value is limited, as approximately 30% of patients with lymph node-negative disease die due to metastasis progression. It is suspected that other prognostic factors other than TNM staging system, may play a significant role. Differentiation grade and lymphovascular invasion have been proposed as essential prognostic factors for lymph node-negative colorectal carcinoma. This study aimed to evaluate the correlation between differentiation grade and lymphovascular invasion in colorectal carcinoma. It was an observational study with a cross-sectional design. Samples were collected from 4 Anatomical Pathology laboratories in West Sumatera in 2018. A total of 97 paraffin blocks of colorectal adenocarcinoma met the inclusion criteria. Differentiation grade and lymphovascular invasion were evaluated according to the 2019 World Health Organization (WHO) classification. The correlation between differentiation grade and lymphovascular invasion was analyzed using Fisher's Exact test. A p value <0.05 considered statistically significant. The most prevalent age group for cases of colorectal adenocarcinoma was 51–60 yr (36.1%). Low-grade differentiation was the most common grade of differentiation (72.2%). Lymphovascular invasion in small vessels was commonly encountered (73.3%). High-grade differentiation adenocarcinomas had 100% lymphovascular invasion. A significant correlation between differentiation grade and lymphovascular invasion was observed (p = 0.031). This study confirms that lymphovascular invasion is a valuable predictor of colorectal carcinoma progressiveness.
HUBUNGAN TINGKAT PENGETAHUAN, SIKAP, TINDAKAN IBU TERHADAP INFEKSI CACING SOIL TRANSMITTED HELMINTH PADA SISWA SD NEGERI 23 PASIR SEBELAH TAHUN 2023 Rahma Triyana; Utari Felia Anggaraini; Nurwiyeni, Nurwiyeni; Ruhsyahadati, Ruhsyahadati; Nana Liana; Prima Adelin; Melya Susanti; Rifkind Malik; Roland Helmizar; Muhammad Rizki Saputra; Alif Dhuha
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1423

Abstract

Soil Transmitted Helminth (STH) infections remain a major public health issue in Indonesia, particularly among elementary school children. Behavioral and socioeconomic factors, including mothers' knowledge, attitudes, and practices, are suspected to influence the incidence of these infections. This study aimed to determine the relationship between mothers’ level of knowledge, attitudes, and practices and the incidence of STH infections among students of SD Negeri 23 Pasir Sebelah, Koto Tangah, Padang, in 2023. An analytic observational study with a cross-sectional design was conducted involving 87 first to third-grade students and their mothers, selected through total sampling. Data were analyzed using the Chi-square test. The results showed that 6.9% of the children were infected with STH. Most mothers demonstrated good levels of knowledge, attitudes, and practices. There were significant associations between mothers’ knowledge (p=0.028), attitudes (p=0.000), and practices (p=0.000) and the incidence of STH infections. In conclusion, mothers’ knowledge, attitudes, and practices were significantly associated with STH infections among elementary school children, highlighting the importance of family health education in preventing parasitic infections.
EDUKASI MENGENAI POLA HIDUP BERSIH DAN SEHAT DI SDN 18 BUKIT KECIL KABUPATEN PESISIR SELATAN Saputra, Muhammad Rizki; Tosi Rahmaddian; Irwadi, Irwadi; Rahma Triyana; Rifkind Malik; Nana Liana; Ruhsyahadati, Ruhsyahadati; Suharni, Suharni; Roland Helmizar; Sri Wahyuni; Alief Dhuha; Betty Fitriyasti1
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1429

Abstract

Clean and Healthy Living Behavior (PHBS) refers to a conscious effort by individuals to adopt healthy habits in their personal lives, within their families, and in the broader community. PHBS aims to prevent health problems through simple yet effective daily practices. The role of parents, the environment, and teachers is crucial in shaping students' behavior, especially during childhood. However, many elementary school students still lack sufficient knowledge about the importance of clean and healthy living habits. Therefore, educational initiatives are necessary to instill these positive behaviors from an early age. The session was carried out in an educational and interactive manner, incorporating direct practice, games, and quizzes. The PHBS education program took place at SDN 18 Bukit Kecil, Pesisir Selatan Regency, involving 30 student participants. The activity had a clear positive impact on students' knowledge and behavior regarding clean and healthy living practices. The success of the program was supported by strong collaboration between the community service team and the school. It is hoped that similar initiatives will continue to be implemented on a regular basis to cultivate a culture of clean and healthy living from an early age.
EDUKASI DAN SKRINING OBESITAS SEBAGAI FAKTOR RISIKO ATEROSKLEROSIS: - Adelin, Prima; Rahmatriyana; Ruhsyahadati; M.Rizki Putra; Nana Liana; Roland Helmizar; Amelia Azzahra
Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Vol. 3 No. 3 (2025): Juni
Publisher : CV. Alina

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59407/jpki2.v3i3.2229

Abstract

Obesitas merupakan salah satu faktor risiko utama terjadinya aterosklerosis, yang menjadi penyebab utama penyakit kardiovaskular. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan masyarakat mengenai obesitas dan kaitannya dengan risiko aterosklerosis serta melakukan deteksi dini melalui pengukuran indeks massa tubuh (IMT). Kegiatan ini melibatkan 33 orang peserta dari masyarakat umum dengan rerata usia 59 tahun dan rerata lingkar perut 86,69 cm. Hasil pemeriksaan menunjukkan bahwa 63,7% peserta mengalami obesitas, 9,09% overweight, dan hanya 27,3% memiliki berat badan normal. Edukasi diberikan dalam bentuk penyuluhan interaktif oleh tim dosen dan mahasiswa Fakultas Kedokteran Universitas Baiturrahmah. Hasil kegiatan menunjukkan tingginya prevalensi obesitas pada masyarakat usia lanjut dan pentingnya intervensi berbasis edukasi untuk meningkatkan kesadaran dan pencegahan aterosklerosis. Program ini diharapkan dapat memberikan dampak berkelanjutan dalam perubahan gaya hidup sehat pada masyarakat.
Co-Authors Adelin, Prima Alief Dhuha Alif Dhuha Amelia Azzahra Betty Fitriyasti1 Husna Yetti Irwadi, Irwadi Loli Devianti M.Rizki Putra Malik, Rifkind Melya Susanti Muhammad Rizki Saputra Muhammad Rizki Saputra, Muhammad Rizki Noza Hilbertina Nurwiyeni, Nurwiyeni Rahma Triyana Rahmaddian, Tosi Rahmatriyana Roland Helmizar Ruhsyahadati Ruhsyahadati, Ruhsyahadati Sri Nani Jelmila Sri Wahyuni Suharni Suharni Utari Felia Anggaraini Yessy Setiawati