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All Journal Majalah Patologi Indonesia Nusantara Hasana Journal Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Indonesian Journal of Biomedicine and Clinical Sciences
Nana Liana
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal Nana Liana; Noza Hilbertina; Loli Devianti; Husna Yetti
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.332 KB) | DOI: 10.55816/mpi.v31i1.490

Abstract

BackgroundColorectal carcinoma is the third most common malignancy in the world. Colorectal carcinoma is a heterogeneous tumor withdifferent clinical pathologic features and prognostic values. For the same tumor-stage, patients could have difference prognosis andit has been suggested that the angiogenesis might be correlated with the prognosis, especially expression of vascular endothelialgrowth factor (VEGF) as the main pro-angiogenic factor. High VEGF expression in colorectal adenocarcinoma is associated withincreased blood vessels in invasive tumor area, cell proliferation and metastases. However, relation VEGF expression with thedegree of differentiation and lymphovascular invasion is not known.MethodsThis was a retrospective observational study with cross sectional approach. Samples were obtained from 39 paraffin blocks withdiagnosis adenocarcinoma not otherwise specific (NOS) in four Anatomical Pathology Laboratory in West Sumatera 2018 andevaluated for degree of differentiation and lymphovascular invasion. VEGF expressions in tumor cell were analyzed usingimmunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant.ResultsColorectal adenocarcinoma with high grade differentiation entirely had high VEGF expression (100%), while low gradedifferantiation with high VEGF expression was 60.7%. Lymphovascular invasion positive was mostly found with high VEGFexpression (80.6%). Statistical analysis showed significant association between VEGF expression with degree of differentiation(p=0.017) and lymphovascular invasion (p=0.028).ConclusionThe conclusion was VEGF expression had significant association with degree of differentiation and lymphovascular invasion ofcolorectal adenocarcinoma.
Correlation between differentiation grade and lymphovascular invasion in colorectal adenocarcinoma Nana Liana; Loli Devianti; Yessy Setiawati; Sri Nani Jelmila; Ruhsyahadati
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.20536

Abstract

Colorectal carcinoma is the third most common malignant tumor worldwide. It is a heterogeneous disease with diverse clinicopathological and prognostic characteristics. The TNM (tumor, node, metastasis) staging system is currently used as a prognostic predictor. However, its predictive value is limited, as approximately 30% of patients with lymph node-negative disease die due to metastasis progression. It is suspected that other prognostic factors other than TNM staging system, may play a significant role. Differentiation grade and lymphovascular invasion have been proposed as essential prognostic factors for lymph node-negative colorectal carcinoma. This study aimed to evaluate the correlation between differentiation grade and lymphovascular invasion in colorectal carcinoma. It was an observational study with a cross-sectional design. Samples were collected from 4 Anatomical Pathology laboratories in West Sumatera in 2018. A total of 97 paraffin blocks of colorectal adenocarcinoma met the inclusion criteria. Differentiation grade and lymphovascular invasion were evaluated according to the 2019 World Health Organization (WHO) classification. The correlation between differentiation grade and lymphovascular invasion was analyzed using Fisher's Exact test. A p value <0.05 considered statistically significant. The most prevalent age group for cases of colorectal adenocarcinoma was 51–60 yr (36.1%). Low-grade differentiation was the most common grade of differentiation (72.2%). Lymphovascular invasion in small vessels was commonly encountered (73.3%). High-grade differentiation adenocarcinomas had 100% lymphovascular invasion. A significant correlation between differentiation grade and lymphovascular invasion was observed (p = 0.031). This study confirms that lymphovascular invasion is a valuable predictor of colorectal carcinoma progressiveness.
HUBUNGAN TINGKAT PENGETAHUAN, SIKAP, TINDAKAN IBU TERHADAP INFEKSI CACING SOIL TRANSMITTED HELMINTH PADA SISWA SD NEGERI 23 PASIR SEBELAH TAHUN 2023 Rahma Triyana; Utari Felia Anggaraini; Nurwiyeni, Nurwiyeni; Ruhsyahadati, Ruhsyahadati; Nana Liana; Prima Adelin; Melya Susanti; Rifkind Malik; Roland Helmizar; Muhammad Rizki Saputra; Alif Dhuha
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1423

Abstract

Soil Transmitted Helminth (STH) infections remain a major public health issue in Indonesia, particularly among elementary school children. Behavioral and socioeconomic factors, including mothers' knowledge, attitudes, and practices, are suspected to influence the incidence of these infections. This study aimed to determine the relationship between mothers’ level of knowledge, attitudes, and practices and the incidence of STH infections among students of SD Negeri 23 Pasir Sebelah, Koto Tangah, Padang, in 2023. An analytic observational study with a cross-sectional design was conducted involving 87 first to third-grade students and their mothers, selected through total sampling. Data were analyzed using the Chi-square test. The results showed that 6.9% of the children were infected with STH. Most mothers demonstrated good levels of knowledge, attitudes, and practices. There were significant associations between mothers’ knowledge (p=0.028), attitudes (p=0.000), and practices (p=0.000) and the incidence of STH infections. In conclusion, mothers’ knowledge, attitudes, and practices were significantly associated with STH infections among elementary school children, highlighting the importance of family health education in preventing parasitic infections.
EDUKASI MENGENAI POLA HIDUP BERSIH DAN SEHAT DI SDN 18 BUKIT KECIL KABUPATEN PESISIR SELATAN Saputra, Muhammad Rizki; Tosi Rahmaddian; Irwadi, Irwadi; Rahma Triyana; Rifkind Malik; Nana Liana; Ruhsyahadati, Ruhsyahadati; Suharni, Suharni; Roland Helmizar; Sri Wahyuni; Alief Dhuha; Betty Fitriyasti1
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1429

Abstract

Clean and Healthy Living Behavior (PHBS) refers to a conscious effort by individuals to adopt healthy habits in their personal lives, within their families, and in the broader community. PHBS aims to prevent health problems through simple yet effective daily practices. The role of parents, the environment, and teachers is crucial in shaping students' behavior, especially during childhood. However, many elementary school students still lack sufficient knowledge about the importance of clean and healthy living habits. Therefore, educational initiatives are necessary to instill these positive behaviors from an early age. The session was carried out in an educational and interactive manner, incorporating direct practice, games, and quizzes. The PHBS education program took place at SDN 18 Bukit Kecil, Pesisir Selatan Regency, involving 30 student participants. The activity had a clear positive impact on students' knowledge and behavior regarding clean and healthy living practices. The success of the program was supported by strong collaboration between the community service team and the school. It is hoped that similar initiatives will continue to be implemented on a regular basis to cultivate a culture of clean and healthy living from an early age.
EDUKASI DAN SKRINING OBESITAS SEBAGAI FAKTOR RISIKO ATEROSKLEROSIS: - Adelin, Prima; Rahmatriyana; Ruhsyahadati; M.Rizki Putra; Nana Liana; Roland Helmizar; Amelia Azzahra
Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Vol. 3 No. 3 (2025): Juni
Publisher : CV. Alina

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59407/jpki2.v3i3.2229

Abstract

Obesitas merupakan salah satu faktor risiko utama terjadinya aterosklerosis, yang menjadi penyebab utama penyakit kardiovaskular. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan masyarakat mengenai obesitas dan kaitannya dengan risiko aterosklerosis serta melakukan deteksi dini melalui pengukuran indeks massa tubuh (IMT). Kegiatan ini melibatkan 33 orang peserta dari masyarakat umum dengan rerata usia 59 tahun dan rerata lingkar perut 86,69 cm. Hasil pemeriksaan menunjukkan bahwa 63,7% peserta mengalami obesitas, 9,09% overweight, dan hanya 27,3% memiliki berat badan normal. Edukasi diberikan dalam bentuk penyuluhan interaktif oleh tim dosen dan mahasiswa Fakultas Kedokteran Universitas Baiturrahmah. Hasil kegiatan menunjukkan tingginya prevalensi obesitas pada masyarakat usia lanjut dan pentingnya intervensi berbasis edukasi untuk meningkatkan kesadaran dan pencegahan aterosklerosis. Program ini diharapkan dapat memberikan dampak berkelanjutan dalam perubahan gaya hidup sehat pada masyarakat.
GAMBARAN INFEKSI CACING SOIL TRANSMITTED HELMINTH PADA MURID SD NEGERI 23 PASIR SEBELAH KOTO TANGAH TAHUN 2023 Rahma Triyana; Muhammad Riandi; Dian Puspita; Ruhsyahadati, Ruhsyahadati; Nana Liana; Prima Adelin; Rifkind Malik; Roland Helmizar; Muhammad Rizki Saputra; Alief Dhuha
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1777

Abstract

Soil-transmitted helminth (STH) infections remain a significant public health issue in developing countries, particularly among primary school children who are highly exposed to contaminated environments and often have inadequate personal hygiene practices. This study aimed to describe the presence of STH eggs in fecal samples of first- to third-grade students at SDN 23 Pasir Sebelah, located in Koto Tangah District, an area with historically high helminth infection rates. A descriptive cross-sectional design was used, involving total sampling of 124 students. Fecal specimens were examined microscopically using the direct smear method. Results showed that 6 students (6.9%) tested positive for STH eggs. The species identified included Ascaris lumbricoides (50%), Trichuris trichiura (40%), and hookworm (10%). Infections were more frequently found in male students and those aged 7–8 years. Most infected children demonstrated poor personal hygiene, particularly related to handwashing, nail cleanliness, and consistent use of footwear. In conclusion, the prevalence of STH infection among students at SDN 23 Pasir Sebelah was relatively low; however, inadequate personal hygiene remains a key contributing factor. Strengthening health education and promoting proper hygiene practices are essential to reduce the risk of STH transmission in school-aged children
SOSIALISASI MENGENAI PENCEGAHAN STUNTING PADA ANAK KEPADA IBU DI NAGARI DUSUN TANGAH KABUPATEN SOLOK SELATAN Saputra, Muhammad Rizki; Rahma Triyana; Ruhsyahadati, Ruhsyahadati; Nana Liana; Rifkind Malik; Roland Helmizar; Suharni, Suharni; Sri Wahyuni; Rosmaini, Rosmaini; Alif Dhuha; Kendall Malik
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1778

Abstract

This community service activity was carried out to support the acceleration of stunting reduction in Nagari Dusun Tangah, Solok Selatan Regency. Stunting is a public health problem that affects physical growth, cognitive development, and long-term productivity. This condition is primarily caused by inadequate maternal nutrition during pregnancy, improper child-feeding practices, recurrent infections, and poor environmental sanitation. The activity involved 22 participants, consisting of pregnant women and mothers of children under five. The methods used included interactive lectures, discussions, demonstrations of locally sourced complementary feeding (MP-ASI), sanitation education, promotion of clean and healthy living behaviors, and basic training for posyandu cadres. Pre-test and post-test assessments were conducted to measure the increase in participants' knowledge. The results showed positive responses and strong interest among participants in improving child-feeding practices and household hygiene. The MP-ASI demonstration using local ingredients such as eggs, freshwater fish, and homegrown vegetables was considered highly beneficial. The increase in participants' knowledge aligns with theoretical causes of stunting, particularly related to optimal nutrition, infection prevention, and sanitation. This activity also strengthened the capacity of posyandu cadres and enhanced collaboration between the puskesmas, local government, and the community. Overall, the socialization successfully improved family understanding of stunting prevention and is expected to serve as an initial step toward sustainable community-based nutrition interventions.
UNEXPECTED EXTRAPYRAMIDAL REACTION: ACUTE TARDIVE DYSKINESIA FOLLOWING SHORT-TERM METOCLOPRAMIDE USE IN A PATIENT WITH DIABETES AND CHRONIC KIDNEY DISEASE Helmizar, Roland; Yuri Haiga; Vina Tri Septiana; Nana Liana; Ruhsyahadati Ajisman; Rahma Triyana; Muhammad Rizki Saputra
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1781

Abstract

Tardive dyskinesia (TD) is a potentially irreversible extrapyramidal movement disorder characterized by involuntary, repetitive movements, predominantly affecting the orofacial region. Although most commonly associated with prolonged exposure to dopamine receptor–blocking agents, TD may also arise following the use of gastrointestinal prokinetics such as metoclopramide. Female sex, diabetes mellitus, advanced age, and renal impairment are recognized risk factors that increase susceptibility, yet TD remains underrecognized outside psychiatric settings. A 49-year-old woman with poorly controlled type 2 diabetes mellitus presented with nausea, vomiting, and generalized weakness. Laboratory findings demonstrated normocytic anemia, uncontrolled hyperglycemia (HbA1c 9.2%), and acute-on-chronic kidney disease (eGFR 22 mL/min/1.73 m²). She received standard supportive therapy, including intravenous metoclopramide. Within 24 hours, she developed repetitive tongue protrusion and orofacial dyskinesia. Neuroimaging and electrolyte evaluation were unremarkable, and there was no history of prior neuroleptic exposure. Metoclopramide was promptly discontinued, leading to gradual improvement and complete resolution of symptoms within two weeks. Antiemetic therapy was switched to ondansetron. This case underscores that acute TD may occur after short-term metoclopramide use, particularly in patients with diabetes and renal dysfunction. Heightened clinical awareness and cautious prescribing are essential to prevent this potentially disabling adverse effect.
Co-Authors Adelin, Prima Alief Dhuha Alif Dhuha Amelia Azzahra Betty Fitriyasti1 Dian Puspita Haiga, Yuri Helmizar, Roland Husna Yetti Irwadi, Irwadi Kendall Malik Loli Devianti M.Rizki Putra Malik, Rifkind Melya Susanti Muhammad Riandi Muhammad Rizki Saputra Muhammad Rizki Saputra, Muhammad Rizki Noza Hilbertina Nurwiyeni, Nurwiyeni Rahma Triyana Rahmaddian, Tosi Rahmatriyana Roland Helmizar Rosmaini Rosmaini, Rosmaini Ruhsyahadati Ruhsyahadati Ajisman Ruhsyahadati, Ruhsyahadati Sri Nani Jelmila Sri Wahyuni Suharni Suharni Utari Felia Anggaraini Vina Tri Septiana Yessy Setiawati