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Ruhsyahadati, Ruhsyahadati
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ADULT GRANULOSA CELL TUMORS: A COMPREHENSIVE REVIEW OF CLINICOPATHOLOGICAL FEATURES AND MOLECULAR INSIGHTS Liana, Nana; Helmizar, Roland; Ruhsyahadati, Ruhsyahadati; Triyana, Rahma; Rasyid, Lismawati; Aliefia, Desi
Nusantara Hasana Journal Vol. 4 No. 6 (2024): Nusantara Hasana Journal, November 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i6.1252

Abstract

Adult granulosa cell tumor (AGCT) is a rare subtype of ovarian cancer, accounting for 2-5% of all ovarian malignancies and originating from granulosa cells that are involved in oocyte development and sex steroid production. Although AGCT is often diagnosed at an early stage and has a better prognosis compared to other types of ovarian cancer, challenges in diagnosis persist. Clinical symptoms such as abdominal pain and distension are often nonspecific and may be accompanied by signs of hyperestrogenism. Histopathological examination of AGCT reveals a characteristic cell pattern; however, variations in histological appearance can complicate diagnosis. Despite a favorable prognosis, there remains a risk of recurrence, with many cases experiencing relapse several years post-initial treatment. This underscores the necessity for long-term monitoring of patients following treatment. This article aims to explore the clinicopathological characteristics of AGCT and provide guidance for more effective patient management through a deeper understanding of molecular mechanisms and appropriate therapeutic approaches
DIAGNOSTIC HISTOPATHOLOGY OF JUVENILE GRANULOSA CELL TUMOR: HALLMARK MORPHOLOGICAL AND CYTOLOGICAL FINDINGS Liana, Nana; Ruhsyahadati, Ruhsyahadati; Triyana, Rahma; Helmizar, Roland; Dhuha, Alief; Malik, Rifkind; Saputra, Muhammad Rizki
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1417

Abstract

Juvenile granulosa cell tumour (JGCT) is a subtype of granulosa cell tumour that predominantly affects young females, particularly those who are premenarchal, with a mean age at diagnosis of 13 years. Although rare, this tumour can occur across a wide age range, from 10 months to 67 years. Histologically, JGCT resembles the adult-type granulosa cell tumour but presents with distinct features, including aggressive growth and the absence of FOXL2 mutations. Common clinical manifestations include an abdominal mass, abdominal pain, precocious puberty in prepubertal girls due to estrogen secretion, and menorrhagia or amenorrhea in premenopausal women. Macroscopically, the tumour typically exhibits a dominant solid component, frequently accompanied by hemorrhagic and necrotic areas. High mitotic activity and variable degrees of cytological atypia are characteristic findings. The diagnosis is supported by positive immunoreactivity for inhibin, calretinin, and CD99. In early-stage disease, the primary treatment is unilateral oophorectomy with fertility preservation. In contrast, advanced stages often require total hysterectomy and adjuvant chemotherapy. Prognosis is highly dependent on disease stage; patients with stage I disease have a survival rate of up to 97%, whereas advanced-stage disease is associated with a poorer outcome. This review aims to provide a comprehensive overview of the epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, and management strategies of Juvenile Granulosa Cell Tumour (JGCT). It also underscores the importance of early detection and the development of more effective therapeutic options to enhance clinical outcomes.
HUBUNGAN TINGKAT PENGETAHUAN, SIKAP, TINDAKAN IBU TERHADAP INFEKSI CACING SOIL TRANSMITTED HELMINTH PADA SISWA SD NEGERI 23 PASIR SEBELAH TAHUN 2023 Rahma Triyana; Utari Felia Anggaraini; Nurwiyeni, Nurwiyeni; Ruhsyahadati, Ruhsyahadati; Nana Liana; Prima Adelin; Melya Susanti; Rifkind Malik; Roland Helmizar; Muhammad Rizki Saputra; Alif Dhuha
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1423

Abstract

Soil Transmitted Helminth (STH) infections remain a major public health issue in Indonesia, particularly among elementary school children. Behavioral and socioeconomic factors, including mothers' knowledge, attitudes, and practices, are suspected to influence the incidence of these infections. This study aimed to determine the relationship between mothers’ level of knowledge, attitudes, and practices and the incidence of STH infections among students of SD Negeri 23 Pasir Sebelah, Koto Tangah, Padang, in 2023. An analytic observational study with a cross-sectional design was conducted involving 87 first to third-grade students and their mothers, selected through total sampling. Data were analyzed using the Chi-square test. The results showed that 6.9% of the children were infected with STH. Most mothers demonstrated good levels of knowledge, attitudes, and practices. There were significant associations between mothers’ knowledge (p=0.028), attitudes (p=0.000), and practices (p=0.000) and the incidence of STH infections. In conclusion, mothers’ knowledge, attitudes, and practices were significantly associated with STH infections among elementary school children, highlighting the importance of family health education in preventing parasitic infections.
EDUKASI MENGENAI POLA HIDUP BERSIH DAN SEHAT DI SDN 18 BUKIT KECIL KABUPATEN PESISIR SELATAN Saputra, Muhammad Rizki; Tosi Rahmaddian; Irwadi, Irwadi; Rahma Triyana; Rifkind Malik; Nana Liana; Ruhsyahadati, Ruhsyahadati; Suharni, Suharni; Roland Helmizar; Sri Wahyuni; Alief Dhuha; Betty Fitriyasti1
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1429

Abstract

Clean and Healthy Living Behavior (PHBS) refers to a conscious effort by individuals to adopt healthy habits in their personal lives, within their families, and in the broader community. PHBS aims to prevent health problems through simple yet effective daily practices. The role of parents, the environment, and teachers is crucial in shaping students' behavior, especially during childhood. However, many elementary school students still lack sufficient knowledge about the importance of clean and healthy living habits. Therefore, educational initiatives are necessary to instill these positive behaviors from an early age. The session was carried out in an educational and interactive manner, incorporating direct practice, games, and quizzes. The PHBS education program took place at SDN 18 Bukit Kecil, Pesisir Selatan Regency, involving 30 student participants. The activity had a clear positive impact on students' knowledge and behavior regarding clean and healthy living practices. The success of the program was supported by strong collaboration between the community service team and the school. It is hoped that similar initiatives will continue to be implemented on a regular basis to cultivate a culture of clean and healthy living from an early age.
MEKANISME PENSINYALAN VASCULAR ENDOTHELIAL GROWTH FACTOR DALAM PERKEMBANGAN DAN PENYEBARAN KANKER Liana, Nana; Helmizar, Roland; Ruhsyahadati, Ruhsyahadati; Triyana, Rahma; Saputra, Muhammad Rizki
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1598

Abstract

Vascular Endothelial Growth Factor (VEGF) is a key mediator in the process of angiogenesis, playing a crucial role in the development and spread of malignant tumors. VEGF consists of several isoforms, primarily VEGF-A, which exert their effects through receptors VEGFR-1, VEGFR-2, and VEGFR-3, as well as co-receptors neuropilin-1 and -2. Activation of VEGF signaling pathways stimulates endothelial cell proliferation, migration, and survival, increases vascular permeability, and facilitates the formation and invasion of tumor-associated blood vessels. VEGF expression is regulated by various factors, including hypoxia via HIF-1α activation, oncogenes such as KRAS and Src, and the suppression of tumor suppressor genes such as p53 and PTEN. Additionally, several growth factors including EGF, PDGF, and IGF contribute to the regulation of VEGF. VEGF signaling also promotes tumor invasion by activating proteolytic enzymes such as MMP-2, MMP-9, and uPA, which degrade the basement membrane. Due to its central role in angiogenesis and tumor invasion, VEGF is a strategic target in anti-angiogenic therapies for various types of cancer. A comprehensive understanding of the structure, function, and regulation of VEGF is essential for the development of more effective molecular therapies.
THE PROFILE OF COLORECTAL ADENOCARCINOMA AT DR. M. DJAMIL GENERAL HOSPITAL PADANG, INDONESIA Liana, Nana; Helmizar, Roland; Ruhsyahadati, Ruhsyahadati; Jelmila, Sri Nani; Triyana, Rahma; Lismawati, Lismawati
Nusantara Hasana Journal Vol. 4 No. 1 (2024): Nusantara Hasana Journal, Juny 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i1.1132

Abstract

Colorectal carcinoma is the third most common malignancy in the world. This malignancy originates from the epithelium of the colon and/or rectum, showing glandular or mucinous differentiation, where tumor cells have penetrated the muscularis mucosae layer. The study aims to report on epidemiological, clinical, and pathological characteristics of colorectal adenocarcinoma. Methods: We performed a retrospective descriptive study of 140 cases of colorectal adenocarcinoma in the gastroenterology and general surgery departments of M. Djamil General Hospital Padang, Indonesia conducted from January 2022 to December 2022. Data collection using medical records of patients in M. Djamil General Hospital Padang, Indonesia. We reported different data: Age, sex, site, and differentiation grade of the tumor. Results: Our study included 140 patients 80 males (57,1%) and 60 females (42.9%), with a median age range of 51-60 years. The tumors were found in the rectum 82 (58.6%), distal colon 37(26.4%), and proximal colon 21(15.0%). The differentiation grade was majority low grade 117 (83.6%). Conclusion: In conclusion, our result showed that colorectal adenocarcinoma is highest in the male population with an age range of 61-70 years. The most common site of adenocarcinoma is rectum. A low grade is the most differentiated grade. Keywords: colorectal adenocarcinoma, anatomical location, differentiation grade, profile
Perbandingan Efektivitas Infusa Bunga Lawang (Illicium Verum) dan Infusa Daun Kunyit Terhadap Mortalitas Larva Aedes aegypti Instar III Triyana, Rahma; Adelin, Prima; Ruhsyahadati, Ruhsyahadati; Helmizar, Roland
Health and Medical Journal Vol 6, No 2 (2024): HEME May 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i2.1490

Abstract

Pendahuluan: Nyamuk Aedes sp merupakan vektor penyebab penyakit Demam Berdarah (DBD) yang menginfeksi jutaan orang setiap tahunnya. Salah satu penanganan DBD yaitu membasmi vektor dengan cara pemberian insektisida alami pada larva nyamuk. Bunga Lawang (Illicium verum) dan daun kunyit berpotensi sebagai larvasida alami. Tujuan: Membandingkan efektivitas larvasida infusa bunga lawang dan daun kunyit terhadap mortalitas larva Aedes aegypti. Metode: Penelitian eksperimental menggunakan rancangan Post Test Only Control Group Design, populasi terjangkau penelitian ini adalah larva Aedes aegypti instar III dengan kebutuhan total sampel 560 larva, analisa data menggunakan uji one way anova. Hasil penelitian: Infusa bunga lawang efektif membunuh larva Aedes aegypti instar III pada konsentrasi 2% selama 24 jam dengan kematian sebanyak 8,75%,  konsentrasi 32% sebanyak 100% dalam waktu 24 jam sedangkan kematian larva pada konsentrasi infusa daun kunyit sebesar 30% dalam 24 jam sebanyak 2,5%,   pada konsentrasi 100% selama 24 jam kematian larva hanya mencapai 17,5%. Kesimpulan: Infusa bunga lawang lebih efektif sebagai larvasida dibandingkan infusa daun kunyit.
Stunting Management Education with the Application of Yodiwa Innovation Products in Padang Panjang City, West Sumatra, Indonesia Amelia, Rinita; Suryanis, Ira; Siana, Yusti; Ruhsyahadati, Ruhsyahadati; Harun, Harnavi; Pratama, Yudha Endra
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 6 (2024): Volume 7 No 6 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i6.14974

Abstract

ABSTRAK Pemerintah telah meluncurkan program Rencana Aksi Nasional Penanganan stunting pada tingkat nasional, daerah terutama desa. Salah satu bagian dari program tersebut adalah pencegahan stunting yang terjadi di masyarakat. Karena sebagian besar masyarakat belum paham dengan benar menganai stunting, dan beranggapan bahwa stunting atau kerdil sebutan yang biasa digunakan di masyarakat adalah faktor keturunan. Penanganan bagi pasien stunting dilakukan dengan memberikan makanan yang bergizi tinggi, salah satu dengan pemanfaatan susu kambing sebagai sumber pretein hewani. Penerapan produk inovasi YODIWA (Yogurt dadiah Etawa) sebagai salah satu olahan susu kambing menjadi yogur dengan menggunakan starter dari dadiah. Metode yang dilakukan dalam pengabdian ini yaitu edukasi tentang manfaat dari susu kambing, dadiah dan probiotik; pelatihan pembuatan Yodiwa serta launching Pojok Yodiwa. Peserta pelatihan terdiri dari anggota TP-PKK Kota Padang Panjang yang berasal dari perakilan tiap kelurahan. Dengan diadakan pelatihan tentang pengolahan makanan tinggi protein berbahan dasar susu kambing in diharapkan mampu mengurangi prevalensi stunting di Kota Padang Panjang serta launching pojok Yodiwa ini sebagai centre pengolahan Yodiwa di Kota Padang Panjang yang berpusat di Kelurahan ganting. Kata Kunci: Dadiah, Stunting, Susu Kambing, Yodiwa, Padang Panjang  ABSTRACT The government has launched the National Action Plan program for handling stunting at the national, regional, and village levels. One part of the program is preventing stunting that occurs in the community. Most people do not understand properly about stunting and think that stunting or dwarfism, the term commonly used in society, is a hereditary factor. Treatment for stunting patients is carried out by providing highly nutritious food, one of which is using goat's milk as a source of animal protein. Application of the innovative YODIWA (Etawa dadiah yoghurt) as a form of processing goat's milk into yoghurt using a starter from dadiah. The method used in this service is education about the benefits of goat's milk, dadiah, and probiotics, as well as training on making Yodiwa and launching Pojok Yodiwa. The training participants comprised the Padang Panjang City TP-PKK members who came from each sub-district. By holding training on processing high protein foods made from goat's milk, it is hoped that it will be able to reduce the prevalence of stunting in Padang Panjang City and launch this Yodiwa corner as a Yodiwa processing centre in Padang Panjang City, which is based in Ganting Village. Keywords: Dadiah, Stunting, Goat's Milk, Yodiwa, Padang Panjang
PENYULUHAN MENGENAI PENTINGNYA KEBUTUHAN ZAT GIZI DENGAN POLA MAKAN SEHAT BAGI MASYARAKAT DI AULA KANTOR BUPATI PADANG PARIAMAN Saputra, Muhammad Rizki; Yurizali, Bun; Malik, Rifkind; Helmizar, Roland; Dhuha, Alief; Suharni, Suharni; Triyana, Rahma; Ruhsyahadati, Ruhsyahadati; Liana, Nana; Adelin, Prima
Jurnal Abdimas Saintika Vol 6, No 2 (2024): November Jurnal Abdimas Saintika
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jas.v6i2.2958

Abstract

ABSTRAKLatar Belakang : Gizi merupakan salah satu aspek penting dalam kehidupan manusia. Asupan nutrisi yang seimbang dan optimal sangat penting untuk menjaga kesehatan, meningkatkan kualitas hidup, serta mendukung pertumbuhan dan perkembangan yang optimal. Gizi yang baik sangat penting untuk memperkuat sistem kekebalan tubuh. Asupan nutrisi seimbang dapat meningkatkan ketahanan tubuh terhadap infeksi, sedangkan kekurangan vitamin dan mineral tertentu dapat melemahkan sistem kekebalan dan meningkatkan risiko infeksi.Metode : Metode yang digunakan dalam kegiatan penyuluhan ini meliputi presentasi, diskusi, serta sesi tanya jawab mengenai pentingnya memenuhi kebutuhan zat gizi dengan pola makan sehat.Hasil: Kegiatan penyuluhan mengenai pentingnya kebutuhan zat gizi dengan pola makan sehat di Kantor Bupati Padang Pariaman diikuti oleh masyarakat sekitar. Pelaksanaan kegiatan ini dihadiri sebanyak 62 orang. Selama penyampaian presentasi materi, Masyarakat dengan semangat memeperhatikan narasumber. Setelah itu, banyak pertanyaan yang muncul mengenai kebutuhan gizi perhari dan juga pola makan yang seimbang. Kata Kunci: Zat Gizi, Pola Makan Sehat, Padang Pariaman. ABSTRACTBackground: Nutrition is one of the important aspects of human life. Balanced and optimal nutritional intake is necessary to maintain health, improve quality of life, and support optimal growth and development. Good nutrition is essential to strengthen the immune system. Balanced nutritional intake can increase the body's resistance to infection, while deficiencies in certain vitamins and minerals can weaken the immune system and increase the risk of infection. Method: This counseling activity uses presentations, discussions, and question-and-answer sessions to discuss   the importance of meeting nutritional needs with a healthy diet. Results: The surrounding community attended counseling activities regarding the importance of nutritional needs and a healthy diet at the Padang Pariaman Regent's Office. 62 people attended the implementation of this activity. During the presentation of the material, the community enthusiastically paid attention to the resource person. After that, many questions arose regarding daily nutritional needs and a balanced diet. Keywords: Nutrients, Healthy Diet, Padang Pariaman.
Co-Authors Adelin, Prima Alief Dhuha Aliefia, Desi Alif Dhuha Amelia, Rinita Betty Fitriyasti1 Dhuha, Alief Harun Harnavi Helmizar, Roland Irwadi, Irwadi Jelmila, Sri Nani liana, nana Lismawati, Lismawati Malik, Rifkind Melya Susanti Muhammad Rizki Saputra Muhammad Rizki Saputra, Muhammad Rizki Nana Liana Nurwiyeni, Nurwiyeni Pratama, Yudha Endra Rahma Triyana Rahmaddian, Tosi Rasyid, Lismawati Roland Helmizar Siana, Yusti Sri Wahyuni Suharni Suharni Triyana, Rahma Utari Felia Anggaraini Yurizali, Bun