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All Journal Jurnal Riset Kimia Jurnal Pengabdian UntukMu NegeRI Lantanida Journal ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry JURNAL PHOTON Molekul: Jurnal Ilmiah Kimia Acta Chimica Asiana Jurnal Pengabdian kepada Masyarakat Nusantara Makara Journal of Science Mestaka: Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia Jurnal Kesehatan Masyarakat
Jufrizal Syahri
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Muhammadiyah Riau, Pekanbaru 28156, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Nursing Physics Public Health Social Sciences Other

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Bio-insecticide’s Extract of Scented Root (Polygala paniculata) in Controlling the Mosquito Aedes aegypti (L.) Wahyuni, Denai; Sari, Nila Puspita; Jasril, Jasril; Syahri, Jufrizal
Makara Journal of Science Vol. 26, No. 2
Publisher : UI Scholars Hub

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Abstract

Controlling Aedes aegypti mosquitoes with chemical insecticides causes resistance on humans, environmental residues, and contaminates food and water. Polygala paniculata is a potential alternative to insecticides in controlling Ae. aegypti. This study aimed to determine the effect of the Insecticide Score of P. paniculata extracts on the mortality of Ae. aegypti mosquitoes based on KT50. A total of 20 mosquitoes for each concentration were used to examine the effectiveness of 10%, 15%, 20%, and 25% concentration of P. paniculata extracts compared to a positive and a negative control with four replications. The results showed that P. paniculata extracts had an effect on Aeaegypti mosquito mortality. There were significant differences in mortality rate between concentrations (Kruskal-Wallis test, p = 0.001). Spearman Correlation test gave a p-value of 0.008 < 0.05. Similarly, there was a weak but significant correlation between plant extract concentration and mortality (Spearman correlation: r = +0.312, p = 0.008). The 10% and 15% concentrations had KT50with Insecticide Scores of 1 and 2, respectively, implying that both had no knockdown effect. A 20% concentration had a KT50 with an Insecticide Score of 3, indicating a weak knockdown effect, whereas a 25% concentration had KT50with an Insecticide Score of 5, signifying a quick knockdown effect. These results show that a 25% concentration has a quick knockdown time on Ae. aegypti mosquitoes. Therefore, extract P. paniculata extract at a concentration of 25% has a potential for use as a bio-insecticide in controlling Ae. aegypti mosquitoes.
Evaluation of the Antibacterial Activity of the Jackfruit Parasite Leaf Plant Extract (Macrosolencochinchinensis (Lour.) van Tiegh) with Vitro and In Silico approach Rahmiwati Hilma; Suma Rahmani Harahap; Jufrizal Syahri
Acta Chimica Asiana Vol. 5 No. 2 (2022)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v5i2.141

Abstract

In traditional Melayu Riau medicine, the jackfruit parasite plant, also known as Macrosolen cochinchinensis (Lour.) van Tiegh, has been utilized as a remedy for coughs, a treatment for cancer, a diuretic, and to speed up the recovery process after giving birth. Through in vitro and in silico testing, this investigation aims to learn more about the bioactive components and antibacterial activity of n-hexane, ethyl acetate, and ethanol obtained from the extracts of the jackfruit parasite plant (Macrosolen cochinchinensis (Lour.) van Tiegh. The disc diffusion method was used for the in vitro testing, and the molecular docking method was used for the in silico testing. Both were conducted against Staphylococcus aureus ATCC 12600 and Escherichia coli ATCC 25922. Each sample extract was prepared in three different concentrations (10%, 30%, and 50%), while chloramphenicol was used as the positive control. Inhibition zones of the extract against E. coli bacteria were found to be as follows: 6 mm, 8.4 mm, and 10.6 mm for the n-hexane extract; 8.2 mm, 10.7 mm, and 15.6 mm for the ethyl acetate extract; and 6 mm, 7.1 mm, and 14.1 mm for the methanol extract. The results of the test to determine the extract's antibacterial activity were as follows: The following is a list of the zones of inhibition that the extract has against S. aureus bacteria: 6 mm, 7.5 mm, and 13.7 mm in diameter for the extract of n-hexane; 12.8 mm, 14.2 mm, and 19.2 mm in diameter for the extract of ethyl acetate. Test results of 7.2 mm, 9.3 mm, and 15.3 mm were obtained for the methanol extract. In accordance with the findings of the study, the ethyl acetate extract of jackfruit parasite leaves exhibited the highest level of antibacterial activity, as measured by an inhibition zone diameter of 19.2 mm, when tested on S. aureus bacteria. In the meantime, the results of molecular docking of punicalin and rutin, which have been reported to have activity against proteins 6GOS.pdb and 1OJZ.pdb, have potential as antibacterials because they form 5 and 9 hydrogen bonds with important amino acids of the target protein, with cDOCKER values of -57.9239 and -88.3993, respectively. It suggests that punicalin and rutin can inhibit the growth of bacteria.
Molecular Docking of Xanthone Derivatives as Therapeutic Agent for Covid-19 Emmy Yuanita; Sudirman Sudirman; Ni Komang Tri Dharmayani; Maria Ulfa; Saprizal Hadisaputra; Jufrizal Syahri
Molekul Vol 17 No 1 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.1.5600

Abstract

Covid-19 has caused more than 14 million confirmed cases and more than 6 hundred deaths as of 21 July 2020 globally. However, there is no approved drug to treat the disease. Xanthone is a potential therapeutic option for the virus that have been tested using molecular docking. There were 12 of xanthone compounds and its derivatives which have been docked against two protein crystals, 2GX4.pdb and 6FV1.pdb, which obtained two potential compounds of hydroxyxanthone derivatives with sulfonate and chloro substitution. These compounds are potentially developed into one of the agents for the treatment of infection COVID-19 disease. Based on energy data and interactions with amino acid residues when compared with its own native ligands, namely NOL and E8E, respectively. Energy docking and energy docking interactions are equal to - 43.3057and - 45.5805 Kcal/mol respectively, during interactions with amino acid residues in the form of Gly 142, His 163, Cys144, Glu166, Gln164 and His 41. Based on these two data, it can be concluded that trihydroxyxanthone compounds 4 and 8 with chloro and sulfonate substitution are very potential to be developed as drug agents for Covid-19 disease therapy through protease inhibition.
Ekstraksi, Fraksinasi, Dan Uji Antioksidan Daun Pakis Sawit (Davallia denticulata) Eti Norhaslinda; Jufrizal Syahri; Fitra Perdana
Sistem Informasi Vol 13 No 2 (2023): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v13i2.4116

Abstract

Pada penelitian ini telah dilakukan ekstraksi, fraksinasi, dan uji antioksidan daun pakis sawit (Davallia denticulata). Metode ekstraksi daun pakis sawit dilakukan secara maserasi menggunakan pelarut etanol dan fraksinasi dilakukan sebanyak tiga fraksi yaitu fraksi etanol, etil asetat dan n-heksan. Kemudian dilakukan uji fitokimia dari ekstrak dan fraksi daun pakis sawit yang didapat. Ekstrak etanol menunjukkan adanya senyawa flavonoid, saponin, tanin, triterpenoid dan steroid, pada fraksi n-heksan menunjukkan adanya senyawa flavonoid dan fenolik, fraksi etil asetat menunjukkan adanya senyawa flavonoid, tanin dan fenolik, dan pada fraksi etanol menunjukkan adanya senyawa flavonoid, saponin, tanin, triterpenoid dan steroid. Pengujian aktivitas antioksidan ekstrak etanol menunjukkan nilai IC50 1,406 μg/mL, fraksi n-heksan menunjukkan nilai IC50 2,91 μg/mL, fraksi etil asetat menunjukkan nilai IC50 103 μg/mL, fraksi etanol menunjukkan nilai IC50 18,99 μg/mL, dan vitamin C sebagai pembanding menunjukkan nilai IC50 2,22 μg/mL. Berdasarkan perbandingan dengan vitamin C dapat diketahui bahwa terdapat aktivitas antioksidan yang sangat kuat pada ekstrak etanol dan aktivitas sedang pada fraksi etil asetat.
SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES Eryanti, Yum; Nurulita, Yuana; Hendra, Rudi; Yuharmen, Yuharmen; Syahri, Jufrizal; Zamri, Adel
Makara Journal of Science Vol. 15, No. 2
Publisher : UI Scholars Hub

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Abstract

Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives under a base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone (a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c) which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMR spectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatory activities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presence of hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities.
Synthesis of Chalcone Derivative Compounds from 4 Chloro Acetophenone and In Silico Activity Test as Candidate Antidiabetic Compounds nasution, Nurlaili; Jannah, Mifthahul; Syahri, Jufrizal
Photon: Jurnal Sain dan Kesehatan Vol. 15 No. 1 (2024): Journal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v15i1.7829

Abstract

This study aims to synthesize chalcone derivative compounds (E)-1-(4-Chlorophenyl)-3-(3-Hydroxyphenyl)Prop-2-En-1-One (CX) in alkaline conditions through a stirring method using a magnetic stirrer. 4 chloro acetophenone was reacted with 3 hydroxy benzaldehyde using ethanol p.a as a solvent and 60% KOH as a base catalyst. Furthermore, purification was carried out by recrystallization using ethanol p.a solvent and a yield of 72.67% was obtained. The purity test of the compound was carried out using TLC and melting point tests. Furthermore, the reaction compound was tested for activity as an antidiabetic in silico. In silico studies were carried out to predict the interaction of compounds with proteins (1GFY.pdb). In silico studies show that the cDOCKER energy value obtained by the original COL ligand is higher than the CX compound obtained. The results of the COL ligand docking with the 1GFY protein have a cDOCKER energy value of -49.4051 kcal/mol and have four hydrogen bonds that bind to the important amino acid residues Gly220, Arg221, Ser216 and Asp181. While the docking of the synthetic compound ligand (CX) produces a cDOCKER energy value of -29.293 kcal/mol and shows 3 hydrogen bonds to the important amino acid residues Ser216, Asp181 and Lys120. Based on these results, it is known that the CX compound has the potential to be used as an antidiabetic candidate compound.
Respons Siswa Terhadap Program Sekolah Binaan SMK Se-Riau Program Kimia Fakultas MIPA Dan Kesehatan UMRI Nasution, Hasmalina; Siregar, Sri Hilma; Rahayu, Anggi Putri; Syahri, Jufrizal; Prasetya, Prasetya; Hilma, Rahmiwati; Syafri, Rahmadini; Sari, Meidita Kemala
Mestaka: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2025): Februari 2025
Publisher : Pakis Journal Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/mestaka.v4i1.585

Abstract

The goal of education is to actively develop students' potential by establishing a learning environment and process. Most students still find learning chemistry in high school or trade school to be challenging. One way for universities to help schools grow and enhance secondary school students' skills is through the Assisted School Program. Students in this program receive training to help them develop a broad perspective, expose them to the working world, and encourage their innovative spirit. Students at the target school responded favorably to this exercise, as evidenced by the average proportion of their responses on the indicators of interest, responsiveness, and satisfaction that met positive criteria. Students at this aided school, SMK Negeri 2 Pekanbaru, responded actively to the activities 94% of the time, whereas SMK Negeri 1 Tualang received the fewest replies (72%). In general, student responses regarding their level of enthusiasm in the targeted school activities are excellent. Overall, the guided inquiry method's student replies were rated as good. This is demonstrated by the percentage of each statement falling into the very good category, the overall student response rate of 81.88%, and the pre-test and post-test results, which showed that it had an impact on students' knowledge growth as indicated by the higher post-test scores compared to the pre-test score.
EXTRACTION, PHYTOCHEMICAL SCREENING, TOTAL PHENOLIC CONTENT, AND ANTIBACTERIAL ACTIVITY OF MISTLETOE ON OIL PALM (Ficus heteropleura Blume) LEAVES Hamiro, Fauzia; Perdana, Fitra; Syahri, Jufrizal
Lantanida Journal Vol 13 No 2 (2025): July-December 2025: In Press ....
Publisher : UIN AR-RANIRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/37mpve13

Abstract

Ficus heteropleura Blume, commonly known as mistletoe on oil palm, is a semi-parasitic plant that grows on oil palm trees. This study aimed to investigate the secondary metabolite profile, determine of total phenolic content, and evaluate antibacterial activity of ethyl acetate extract of F. heteropleura leaves. Extraction was performed using a grade maceration method. Qualitative phytochemical screening was conducted to identify major classes of secondary metabolites, and total phenolic content was quantitatively determined using the Folin–Ciocalteu method with gallic acid as the standard. Ethyl acetate extraction yielded 19.27 g of crude extract. Phytochemical analysis revealed the presence of steroids, flavonoids, saponins, and tannins. The total phenolic content was determined to be 35.730 mg GAE/g. UV-Vis spectrophotometric analysis showed characteristic absorption peaks at 475.0 nm and 432.8 nm, indicating the presence of phenolic pigments with conjugated C=O groups and a peak at 666.3 nm associated with chlorophyll, contributing to the green coloration. FTIR analysis confirmed the presence of functional groups such as O–H, C≡C, C=O, C=C, and C–O. Antibacterial activity demonstrated that the ethyl acetate extract exhibited strong inhibitory effects against Staphylococcus aureus and Escherichia coli, with average inhibition zone diameters ranging from 5 to 10 mm, indicating strong antibacterial activity.
Red Ginger Essential Oil (Zingiber officinale var. Rubrum) as a Biolarvicide in the Control of Aedes Aegypti Mosquitoes Denai Wahyuni; Sari, Wulan; Jasril, Jasril; Syahri, Jufrizal
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.1558

Abstract

Synthetic larvicides are often used to control Aedes aegypti mosquitoes, but they are detrimental to humans, the environment, and the occurrence of resistance. The purpose of the study was to determine the influence and effectiveness of red ginger essential oil (Zingiber officinale var. Rubrum) as the biolarvicide of Ae. Aegypti and the most effective concentration (LC50). A total of 25 instar 3 larvae with concentrations of 200, 400, 600, and 800 ppm and K+(temephos), K-(aquaade), four repetitions every 30 minutes of observation for 3 HSPs. The results of the study showed that red ginger essential oil affected the death of Ae. Aegypti larvae. There was a significant difference in mortality rates between concentrations (Kruskal-Wallis test, p = 0.001). Likewise, there was a moderate but significant correlation between concentration and mortality (Spearman correlation: r = +0.503, p = 0.001). The probit analysis, LC50 was 257.89 ppm, most effectively influencing mortality in Ae. Aegypti larvae based on LC50. Red ginger essential oil (Zingiber officinale var. Rubrum) is effective and effective as a bio-larvicide to control Ae. aegypti so that it can reduce dengue fever cases.
Pemberdayaan Ibu-Ibu PKK Desa Suka Ramai, Kec. Tapung Hulu, Kab. Kampar dengan Produk Facemist Berbahan Dasar Aloevera Dan Ekstrak Green Tea Hilma, Rahmiwati; Prasetya, Prasetya; Syahri, Jufrizal; `Nasution, Hasmalina; Syafri, Rahmadini; Siregar, Sri Hilma; Perdana , Fitra
Jurnal Pengabdian UntukMu NegeRI Vol. 5 No. 2 (2021): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v5i2.3067

Abstract

Pandemik Covid-19 memberikan dampak yang signifikan terhadap tatanan kehidupan sosial dan ekonomi masyarakat global, termasuk masyarakat di Desa Suka Ramai, Kec. Tapung, Kab, Kampar. Tingginya harga obat-obatan termasuk kosmetik, krisis ekonomi yang belum juga berangsur pulih menimbulkan depresi bagi masyarakat, terutama bagi Ibu-ibu. Pada kegiatan ini dilakukan pemberdayaan berupa penyuluhan dan pelatihan bagi Ibu-ibu PKK, kader posyandu dan remaja putri untuk memproduksi sendiri produk facemist multiguna untuk kesehatan dan kecantikan. Dibidang Kesehatan produk ini bersifat antidepresan dan kecantikan memberikan kesegaran, bersifat sebagai antioksidan, antiaging dan mengurangi jerawat pada wajah. Kegiatan ini dilakukan secara luring dengan protokol kesehatan yang ketat. Kegiatan terlaksana dengan baik, terlihat dengan antusias peserta akan materi-materi pelatihan, jumlah peserta yang tidak berubah dari awal kegiatan sampai selesai. Dari kegiatan ini dihasilkan produk facemist “ESM” yang diproduksi oleh peserta pelatihan. Ibu-ibu PKK dan Bapak Kepala Desa Suka Ramai, sangat berterima ksih atas terlaksananya kegiatan di Desa mereka dan berharap akan ada kegiatan lain yang juga dilaksanakan di Desa tersebut.
Co-Authors Adel Zamri Adel Zamri Bambang Purwono Beta Achromi Nurohmah Beta Achromi Nurohmah Chairil Anwar Denai Wahyuni Denai Wahyuni Emmy Yuanita Emmy Yuanita Eti Norhaslinda Fitra Perdana Hamiro, Fauzia Hasmalina Nasution Hendra, Rudi Ika Septiana Jasril Jasril Kamal Rullah Lazulva Lazulva, Lazulva Lisa Utami Maria Ulfa Mifthahul Jannah Nasution, Annio Indah Lestari nasution, Nurlaili Netti Gustina Nur Enizan Nurlaili Nurlaili Nurlaili Nurlaili Nurlailli Nasution Nurul Hidayah Olif Syahbella Perdana , Fitra Prasetya Prasetya Prasetya Prasetya, Prasetya Putri, Rahmayani Indah Rahayu, Anggi Putri Rahmadini Syafri Rahmiwati Hilma Ramadhanti, Aulia Rizki Retno Hidayati Rudi Hendra Saprizal Hadisaputra Sari, Meidita Kemala Sari, Nila Puspita Siregar, Sri Hilma Siregar, srihilma Sri Hilma Siregar Sudirman Sudirman Suma Rahmani Harahap Tri Dharmayani, Ni Komang Trisiwi Kusuma Ningrum Wirdati Irma Wulan Sari, Wulan Yeni Yernita Yuana Nurulita Yuana Nurulita Yuharmen Yuharmen Yuharmen, Yuharmen Yum Eryanti Yum Eryanti Yuni Fatisa `Nasution, Hasmalina