Article Per Year (5 Year)
p-Index From 2020 - 2025
2.998
P-Index
This Author published in this journals
All Journal Jurnal Pengabdian UntukMu NegeRI Lantanida Journal ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry JURNAL PHOTON Molekul: Jurnal Ilmiah Kimia Acta Chimica Asiana Jurnal Pengabdian kepada Masyarakat Nusantara Makara Journal of Science Mestaka: Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia Jurnal Kesehatan Masyarakat
Jufrizal Syahri
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Muhammadiyah Riau, Pekanbaru 28156, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Nursing Physics Public Health Social Sciences Other

Published : 22 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 22 Documents
Search

 1   2   3 
Design of Trolox Compounds as Antioxidant and Their Analysis Using Quantitative Structure Activity Relationship Hasmalina Nasution; Nur Enizan; Nurlaili Nurlaili; Jufrizal Syahri
Acta Chimica Asiana Vol. 3 No. 2 (2020)
Publisher : Chemistry Education Program, the University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v3i2.40

Abstract

Antioxidant compound can inhibit the oxidation of lipids and other biomolecules. The role of antioxidants is very important in neutralizing and destroying free radicals that can cause the damage to cells in the body. This research was carried out to design trolox derivate compounds as antioxidants using the QSAR method. The semi empirical AM1(Austin Model 1)method was used to generate the QSAR model. The statistical analysis result using multiple linier regression methods revealed thet antioxidant activity was influenced by the descriptors of qC1, qC4, qO7, qC13 and qO18. The QSAR equation model obtained was log IC50 = 0.821 + 7.067 (qC1) + 2.585 (qC4) + 4.812 (qO7) – 5.363 (qC13) – 0.887 (qO18) with the best predicted IC50 value was 4.699 µM. Keywords: Antioxidants, QSAR, semi empirical AM1, trolox
Bio-insecticide’s Extract of Scented Root (Polygala paniculata) in Controlling the Mosquito Aedes aegypti (L.) Wahyuni, Denai; Sari, Nila Puspita; Jasril, Jasril; Syahri, Jufrizal
Makara Journal of Science Vol. 26, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Controlling Aedes aegypti mosquitoes with chemical insecticides causes resistance on humans, environmental residues, and contaminates food and water. Polygala paniculata is a potential alternative to insecticides in controlling Ae. aegypti. This study aimed to determine the effect of the Insecticide Score of P. paniculata extracts on the mortality of Ae. aegypti mosquitoes based on KT50. A total of 20 mosquitoes for each concentration were used to examine the effectiveness of 10%, 15%, 20%, and 25% concentration of P. paniculata extracts compared to a positive and a negative control with four replications. The results showed that P. paniculata extracts had an effect on Aeaegypti mosquito mortality. There were significant differences in mortality rate between concentrations (Kruskal-Wallis test, p = 0.001). Spearman Correlation test gave a p-value of 0.008 < 0.05. Similarly, there was a weak but significant correlation between plant extract concentration and mortality (Spearman correlation: r = +0.312, p = 0.008). The 10% and 15% concentrations had KT50with Insecticide Scores of 1 and 2, respectively, implying that both had no knockdown effect. A 20% concentration had a KT50 with an Insecticide Score of 3, indicating a weak knockdown effect, whereas a 25% concentration had KT50with an Insecticide Score of 5, signifying a quick knockdown effect. These results show that a 25% concentration has a quick knockdown time on Ae. aegypti mosquitoes. Therefore, extract P. paniculata extract at a concentration of 25% has a potential for use as a bio-insecticide in controlling Ae. aegypti mosquitoes.
Evaluation of the Antibacterial Activity of the Jackfruit Parasite Leaf Plant Extract (Macrosolencochinchinensis (Lour.) van Tiegh) with Vitro and In Silico approach Rahmiwati Hilma; Suma Rahmani Harahap; Jufrizal Syahri
Acta Chimica Asiana Vol. 5 No. 2 (2022)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v5i2.141

Abstract

In traditional Melayu Riau medicine, the jackfruit parasite plant, also known as Macrosolen cochinchinensis (Lour.) van Tiegh, has been utilized as a remedy for coughs, a treatment for cancer, a diuretic, and to speed up the recovery process after giving birth. Through in vitro and in silico testing, this investigation aims to learn more about the bioactive components and antibacterial activity of n-hexane, ethyl acetate, and ethanol obtained from the extracts of the jackfruit parasite plant (Macrosolen cochinchinensis (Lour.) van Tiegh. The disc diffusion method was used for the in vitro testing, and the molecular docking method was used for the in silico testing. Both were conducted against Staphylococcus aureus ATCC 12600 and Escherichia coli ATCC 25922. Each sample extract was prepared in three different concentrations (10%, 30%, and 50%), while chloramphenicol was used as the positive control. Inhibition zones of the extract against E. coli bacteria were found to be as follows: 6 mm, 8.4 mm, and 10.6 mm for the n-hexane extract; 8.2 mm, 10.7 mm, and 15.6 mm for the ethyl acetate extract; and 6 mm, 7.1 mm, and 14.1 mm for the methanol extract. The results of the test to determine the extract's antibacterial activity were as follows: The following is a list of the zones of inhibition that the extract has against S. aureus bacteria: 6 mm, 7.5 mm, and 13.7 mm in diameter for the extract of n-hexane; 12.8 mm, 14.2 mm, and 19.2 mm in diameter for the extract of ethyl acetate. Test results of 7.2 mm, 9.3 mm, and 15.3 mm were obtained for the methanol extract. In accordance with the findings of the study, the ethyl acetate extract of jackfruit parasite leaves exhibited the highest level of antibacterial activity, as measured by an inhibition zone diameter of 19.2 mm, when tested on S. aureus bacteria. In the meantime, the results of molecular docking of punicalin and rutin, which have been reported to have activity against proteins 6GOS.pdb and 1OJZ.pdb, have potential as antibacterials because they form 5 and 9 hydrogen bonds with important amino acids of the target protein, with cDOCKER values of -57.9239 and -88.3993, respectively. It suggests that punicalin and rutin can inhibit the growth of bacteria.
Workshop Sertifikasi Pranata Laboratorium Untuk Guru Sains Tingkat SLTA Se-Provinsi Riau Sri Hilma Siregar; Prasetya Prasetya; Hasmalina Nasution; Rahmiwati Hilma; Fitra Perdana; Rahmadini Syafri; Jufrizal Syahri
Jurnal Pengabdian UntukMu NegeRI Vol 7 No 1 (2023): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v7i1.4932

Abstract

Saat ini banyak sekolah tingkat SLTA se-Provinsi Riau dan sekitarnya tidak memiliki pranata laboratorium pendidikan yang berkompeten dibidangnya. Hal ini menyebabkan banyak sekolah yang memiliki laboratorium tapi tidak digunakan secara maksimal, dan siswa siswi tidak dapat melaksanakan praktikum yang semestinya di laboratorium. Laboratorium hanya menjadi tempat pajangan alat peraga dan instrumentasi. Berdasarkan hal tersebut, kami merasa perlu memfasilitasi para pranata laboratorium pendidikan dengan memberikan pelatihan pengelolaan dan penggunaan laboratorium untuk praktikum siswa siswi di sekolah. Sehingga dihasilkan lulusan yang berkompeten. Kegiatan dirancang dalam bentuk pengembangan wawasan keilmuan melalui pemberian berbagai teori selama 2 hari dan dilanjutkan dengan praktik dan penugasan pada 2 hari berikutnya. Materi yang diberikan kepada peserta diantaranya tentang inovasi hasil penelitian, pengenalan dan pengelolaan laboratorium, praktikum ciri-ciri reaksi kimia, hokum kekekalan massa, reaksi zat makanan. pemahaman dan kemampuan guru terhadap materi pelatihan, yang nantinya dapat digunakan sebagai acuan dalam melaksanakan praktikum di laboratorium sekolah. Kegiatan workshop ini mendapat sambutan yang baik dari peserta dan berhasil dengan baik. Keadaan ini dapat dilihat dari kehadiran peserta yang hampir mencapai 100%. Peserta terdiri guru dan pranata laboratrium pendidikan ingkat SLTA se-Provinsi Riau.
Molecular Docking of Xanthone Derivatives as Therapeutic Agent for Covid-19 Emmy Yuanita; Sudirman Sudirman; Ni Komang Tri Dharmayani; Maria Ulfa; Saprizal Hadisaputra; Jufrizal Syahri
Molekul Vol 17 No 1 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.1.5600

Abstract

Covid-19 has caused more than 14 million confirmed cases and more than 6 hundred deaths as of 21 July 2020 globally. However, there is no approved drug to treat the disease. Xanthone is a potential therapeutic option for the virus that have been tested using molecular docking. There were 12 of xanthone compounds and its derivatives which have been docked against two protein crystals, 2GX4.pdb and 6FV1.pdb, which obtained two potential compounds of hydroxyxanthone derivatives with sulfonate and chloro substitution. These compounds are potentially developed into one of the agents for the treatment of infection COVID-19 disease. Based on energy data and interactions with amino acid residues when compared with its own native ligands, namely NOL and E8E, respectively. Energy docking and energy docking interactions are equal to - 43.3057and - 45.5805 Kcal/mol respectively, during interactions with amino acid residues in the form of Gly 142, His 163, Cys144, Glu166, Gln164 and His 41. Based on these two data, it can be concluded that trihydroxyxanthone compounds 4 and 8 with chloro and sulfonate substitution are very potential to be developed as drug agents for Covid-19 disease therapy through protease inhibition.
Ekstraksi, Fraksinasi, Dan Uji Antioksidan Daun Pakis Sawit (Davallia denticulata) Eti Norhaslinda; Jufrizal Syahri; Fitra Perdana
Sistem Informasi Vol 13 No 2 (2023): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v13i2.4116

Abstract

Pada penelitian ini telah dilakukan ekstraksi, fraksinasi, dan uji antioksidan daun pakis sawit (Davallia denticulata). Metode ekstraksi daun pakis sawit dilakukan secara maserasi menggunakan pelarut etanol dan fraksinasi dilakukan sebanyak tiga fraksi yaitu fraksi etanol, etil asetat dan n-heksan. Kemudian dilakukan uji fitokimia dari ekstrak dan fraksi daun pakis sawit yang didapat. Ekstrak etanol menunjukkan adanya senyawa flavonoid, saponin, tanin, triterpenoid dan steroid, pada fraksi n-heksan menunjukkan adanya senyawa flavonoid dan fenolik, fraksi etil asetat menunjukkan adanya senyawa flavonoid, tanin dan fenolik, dan pada fraksi etanol menunjukkan adanya senyawa flavonoid, saponin, tanin, triterpenoid dan steroid. Pengujian aktivitas antioksidan ekstrak etanol menunjukkan nilai IC50 1,406 μg/mL, fraksi n-heksan menunjukkan nilai IC50 2,91 μg/mL, fraksi etil asetat menunjukkan nilai IC50 103 μg/mL, fraksi etanol menunjukkan nilai IC50 18,99 μg/mL, dan vitamin C sebagai pembanding menunjukkan nilai IC50 2,22 μg/mL. Berdasarkan perbandingan dengan vitamin C dapat diketahui bahwa terdapat aktivitas antioksidan yang sangat kuat pada ekstrak etanol dan aktivitas sedang pada fraksi etil asetat.
Pembuatan Nugget Dari Biji Nangka Upaya Mengoptimalkan Sumber Daya Masyarakat Desa Kualu Nenas Hasmalina Nasution; Rahmayani Indah Putri; Retno Hidayati; Prasetya Prasetya; Fitra Perdana; Rahmadini Syafri; Jufrizal Syahri; Rahmiwati Hilma; srihilma Siregar; Aulia Rizki Ramadhanti
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 4 No. 4 (2023): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN)
Publisher : Cv. Utility Project Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kualu Nenas Village is a village that produces quite a lot of jackfruit flesh in the form of chips for sale. UMKM that process jackfruit as the main ingredient will have an impact on the amount of easily damaged organic solid waste from the jackfruit itself, such as jackfruit seeds. However, in processing jackfruit seeds are more often just boiled or fried as a snack. One way to process jackfruit seed waste is to make nuggets. Socialization and nugget making training activities were carried out in Kualu Nenas Village with the PPK Ormawa HIMAKI team. The aim of this activity is to increase knowledge and skills for the people of Kualu Nenas Village in processing waste, optimizing natural resources, and improving the community's economy by selling jackfruit seed nuggets. The activity began with a presentation through socialization of material about waste jackfruit seeds and nuggets in general, then continued with practical training in making nuggets from waste jackfruit seeds. The results obtained from this community service activity are that the community can understand the techniques for processing jackfruit seed waste into nuggets well as shown by the achievement percentage ≤ 74%.
SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES Eryanti, Yum; Nurulita, Yuana; Hendra, Rudi; Yuharmen, Yuharmen; Syahri, Jufrizal; Zamri, Adel
Makara Journal of Science Vol. 15, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives under a base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone (a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c) which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMR spectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatory activities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presence of hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities.
Synthesis of Chalcone Derivative Compounds from 4 Chloro Acetophenone and In Silico Activity Test as Candidate Antidiabetic Compounds nasution, Nurlaili; Jannah, Mifthahul; Syahri, Jufrizal
Photon: Journal of Natural Sciences and Technology Vol 15 No 1 (2024): Journal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v15i1.7829

Abstract

This study aims to synthesize chalcone derivative compounds (E)-1-(4-Chlorophenyl)-3-(3-Hydroxyphenyl)Prop-2-En-1-One (CX) in alkaline conditions through a stirring method using a magnetic stirrer. 4 chloro acetophenone was reacted with 3 hydroxy benzaldehyde using ethanol p.a as a solvent and 60% KOH as a base catalyst. Furthermore, purification was carried out by recrystallization using ethanol p.a solvent and a yield of 72.67% was obtained. The purity test of the compound was carried out using TLC and melting point tests. Furthermore, the reaction compound was tested for activity as an antidiabetic in silico. In silico studies were carried out to predict the interaction of compounds with proteins (1GFY.pdb). In silico studies show that the cDOCKER energy value obtained by the original COL ligand is higher than the CX compound obtained. The results of the COL ligand docking with the 1GFY protein have a cDOCKER energy value of -49.4051 kcal/mol and have four hydrogen bonds that bind to the important amino acid residues Gly220, Arg221, Ser216 and Asp181. While the docking of the synthetic compound ligand (CX) produces a cDOCKER energy value of -29.293 kcal/mol and shows 3 hydrogen bonds to the important amino acid residues Ser216, Asp181 and Lys120. Based on these results, it is known that the CX compound has the potential to be used as an antidiabetic candidate compound.
Respons Siswa Terhadap Program Sekolah Binaan SMK Se-Riau Program Kimia Fakultas MIPA Dan Kesehatan UMRI Nasution, Hasmalina; Siregar, Sri Hilma; Rahayu, Anggi Putri; Syahri, Jufrizal; Prasetya, Prasetya; Hilma, Rahmiwati; Syafri, Rahmadini; Sari, Meidita Kemala
Mestaka: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2025): Februari 2025
Publisher : Pakis Journal Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/mestaka.v4i1.585

Abstract

The goal of education is to actively develop students' potential by establishing a learning environment and process. Most students still find learning chemistry in high school or trade school to be challenging. One way for universities to help schools grow and enhance secondary school students' skills is through the Assisted School Program. Students in this program receive training to help them develop a broad perspective, expose them to the working world, and encourage their innovative spirit. Students at the target school responded favorably to this exercise, as evidenced by the average proportion of their responses on the indicators of interest, responsiveness, and satisfaction that met positive criteria. Students at this aided school, SMK Negeri 2 Pekanbaru, responded actively to the activities 94% of the time, whereas SMK Negeri 1 Tualang received the fewest replies (72%). In general, student responses regarding their level of enthusiasm in the targeted school activities are excellent. Overall, the guided inquiry method's student replies were rated as good. This is demonstrated by the percentage of each statement falling into the very good category, the overall student response rate of 81.88%, and the pre-test and post-test results, which showed that it had an impact on students' knowledge growth as indicated by the higher post-test scores compared to the pre-test score.
Co-Authors Adel Zamri Adel Zamri Aulia Rizki Ramadhanti Bambang Purwono Beta Achromi Nurohmah Beta Achromi Nurohmah Chairil Anwar Denai Wahyuni Denai Wahyuni Emmy Yuanita Emmy Yuanita Eti Norhaslinda Fitra Perdana Hamiro, Fauzia Hasmalina Nasution Hendra, Rudi Ika Septiana Jasril Jasril Kamal Rullah Maria Ulfa Mifthahul Jannah Nasution, Annio Indah Lestari nasution, Nurlaili Netti Gustina Nur Enizan Nurlaili Nurlaili Nurlaili Nurlaili Nurlailli Nasution Nurul Hidayah Olif Syahbella Prasetya Prasetya Prasetya Prasetya Prasetya Prasetya, Prasetya Rahayu, Anggi Putri Rahmadini Syafri Rahmayani Indah Putri Rahmiwati Hilma Retno Hidayati Rudi Hendra Saprizal Hadisaputra Sari, Meidita Kemala Sari, Nila Puspita Siregar, Sri Hilma Sri Hilma Siregar Sudirman Sudirman Suma Rahmani Harahap Tri Dharmayani, Ni Komang Trisiwi Kusuma Ningrum Wirdati Irma Wulan Sari, Wulan Yeni Yernita Yuana Nurulita Yuana Nurulita Yuharmen Yuharmen Yuharmen, Yuharmen Yum Eryanti Yum Eryanti