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All Journal Jurnal Riset Kimia Jurnal Pengabdian UntukMu NegeRI Lantanida Journal ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry JURNAL PHOTON Molekul: Jurnal Ilmiah Kimia Acta Chimica Asiana Jurnal Pengabdian kepada Masyarakat Nusantara Makara Journal of Science Mestaka: Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia Jurnal Kesehatan Masyarakat
Jufrizal Syahri
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Muhammadiyah Riau, Pekanbaru 28156, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Nursing Physics Public Health Social Sciences Other

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Pembuatan Nugget Dari Biji Nangka Upaya Mengoptimalkan Sumber Daya Masyarakat Desa Kualu Nenas Nasution, Hasmalina; Putri, Rahmayani Indah; Hidayati, Retno; Prasetya, Prasetya; Perdana, Fitra; Syafri, Rahmadini; Syahri, Jufrizal; Hilma, Rahmiwati; Siregar, srihilma; Ramadhanti, Aulia Rizki
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 4 No. 4 (2023): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN)
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kualu Nenas Village is a village that produces quite a lot of jackfruit flesh in the form of chips for sale. UMKM that process jackfruit as the main ingredient will have an impact on the amount of easily damaged organic solid waste from the jackfruit itself, such as jackfruit seeds. However, in processing jackfruit seeds are more often just boiled or fried as a snack. One way to process jackfruit seed waste is to make nuggets. Socialization and nugget making training activities were carried out in Kualu Nenas Village with the PPK Ormawa HIMAKI team. The aim of this activity is to increase knowledge and skills for the people of Kualu Nenas Village in processing waste, optimizing natural resources, and improving the community's economy by selling jackfruit seed nuggets. The activity began with a presentation through socialization of material about waste jackfruit seeds and nuggets in general, then continued with practical training in making nuggets from waste jackfruit seeds. The results obtained from this community service activity are that the community can understand the techniques for processing jackfruit seed waste into nuggets well as shown by the achievement percentage ≤ 74%.
Studi Molecular Docking dan Evaluasi Farmakokinetik Senyawa Analog Pirazol Turunan Benzen-Sulfonilurea sebagai Inhibitor Enzim Aldose Reduktase and α-Glukosidase Menggunakan Pendekatan In Silico Fatisa, Yuni; Utami, Lisa; Syahri, Jufrizal; Jasril, Jasril; Lazulva, Lazulva
Jurnal Riset Kimia Vol. 15 No. 2 (2024): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v15i2.633

Abstract

The pyrazole scaffold modification in various chemical structures on several studies has shown various biopharmacological activities. This study aims to predict the potential inhibition of pyrazole analogs derived benzene-sulfonylurea (4A, 4B, 4E, 5A, 5C, 5D) against the α-glucosidase (3A4A) and aldose reductase (3RX2) enzymes based on a molecular docking approach using Molecular Operating Environment (MOE) 2020.0102 software and evaluate pharmacokinetic profile (ADMET). In this study, the six test compounds were obtained from previous studies that have been proven antihyperglycemic. The results showed that all the 3,5-disubstituted benzene-sulfonylurea derivative pyrazole analogs are predicted to have low inhibitory activity against the α-glucosidase enzyme. Further, all compounds showed good aldose reductase inhibitor activity and had lower binding free energy values ​​than tolrestat as the positive control (-6.82 kcal/mol). Compound 5C has the best potential inhibitory activity against the aldose reductase enzyme compared to the other test compounds, because it has the lowest binding free energy value (-8.76 kcal/mol) and interacts with important residues on the receptor forming four hydrogen bonds, namely the carbonyl group of SO2 with residues Trp111 and His110, and the carbonyl group of the amide with residues His110 and Tyr48, as well as 3 hydrophobic bonds, namely a pyrazole ring with residues Leu300, Trp219 and a furan ring with Phe122. ADMET properties of the compounds are also predicted. This information provides an opportunity for a 5C compound as an aldose reductase inhibitor agent to develop drug candidates with better and safer activities.
Pengukuran Total Fenolik, Flavonoid, Aktivitas Antioksidan dan Antidiabetes Ekstrak Etil Asetat Daun Katemas (Euphorbia heterophylla, L.) Secara In Vitro dan In Silico Melalui Inhibisi Enzim α-Glukosidase Rahmiwati Hilma; Netti Gustina; Jufrizal Syahri
ALCHEMY Jurnal Penelitian Kimia Vol 16, No 2 (2020): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.16.2.40087.240-249

Abstract

Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antioksidan dan antidiabetes ekstrak etil asetat daun katemas (Euphorbia heterophylla L.) secara in vitro dan in silico melalui inhibisi terhadap enzim α-glukosidase. Pada penelitian ini ekstraksi sampel dilakukan menggunakan maserasi bertingkat, dimulai dengan n-heksana, selanjutnya dengan etil asetat. Ekstrak etil asetat yang didapatkan dilakukan pengujian kuantitiatif total fenolik dan flavonoid. Uji aktivitas antioksidan terhadap ekstrak dilakukan menggunakan metode DPPH. Uji aktivitas antidiabetes terhadap ekstrak dilakukan secara in vitro dan in silico melalui inhibisi terhadap enzim α-glukosidase menggunakan akarbose sebagai standar. Uji aktivitas antidiabetes terhadap kandungan senyawa bioaktif ekstrak secara in silico atau molecular docking menggunakan software Discovery Studio 4.1. Hasil penelitian menunjukkan bahwa nilai total fenolik dari ekstrak adalah 4,24 mg GAE/g berat kering dan nilai flavonoid total adalah: 3,22 mg KE/g berat kering. Hasil uji aktivitas antioksidan ekstrak didapatkan nilai IC50 sebesar 37,56 µg/mL, digolongkan sebagai aktivitas antioksidan yang sangat kuat. Hasil uji aktivitas antidiabetes secara in vitro didapatkan nilai IC50 sebesar 138,63 µg/mL. Hasil molecular docking memperlihatkan bahwa senyawasenyawa aktif yang terdapat didalam ekstrak mampu membentuk ikatan hidrogen antara ligan dengan reseptor, tapi lebih sedikit jika dibandingkan dengan akarbose.Measurement of Total Phenolic, Flavonoids, Antioxidant and Antidiabetic Activity of Catemas Leaf Ethyl Acetate Extract (Euphorbia heterophylla L.) by In Vitro and In Silico through Enzim α-Glucosidase Inhibition. This study aims to determine the antidiabetic activity of katemas (Euphorbia heterophylla L.) ethyl acetate extract in vitro and in silico through inhibition of the αglucosidase enzyme. In this study, the sample extraction was carried out by multilevel maceration, starting with n-hexane, then with ethyl acetate. The ethyl acetate extract obtained was quantitatively tested by total phenolic and flavonoids. The antioxidant activity of the extract was tested using the DPPH method. The antidiabetic activity of the extract was examined through inhibiting the enzyme αglucosidase in vitro using a microplate reader and in silico (molecular docking) using Discovery Studio 4.1 software. The results showed that the total phenolic value of the extract was 4.24 mg GAE/g of dry weight, and the total flavonoid value was 3.22 mg KE/g of dry weight. Antioxidant activity test obtained IC50 of 37,56 µg/mL, classified as verry strong antioxidant. The in vitro antidiabetic test examined that IC50 is 138.63 µg/mL. The results of molecular docking showed that the active compounds in the extracts are able to form hydrogen bonds between ligand and receptor; however, the amount was less than the hydrogen bonds formed by acarbose.
Co-Authors Adel Zamri Adel Zamri Bambang Purwono Beta Achromi Nurohmah Beta Achromi Nurohmah Chairil Anwar Denai Wahyuni Denai Wahyuni Emmy Yuanita Emmy Yuanita Eti Norhaslinda Fitra Perdana Hamiro, Fauzia Hasmalina Nasution Hendra, Rudi Ika Septiana Jasril Jasril Kamal Rullah Lazulva Lazulva, Lazulva Lisa Utami Maria Ulfa Mifthahul Jannah Nasution, Annio Indah Lestari nasution, Nurlaili Netti Gustina Nur Enizan Nurlaili Nurlaili Nurlaili Nurlaili Nurlailli Nasution Nurul Hidayah Olif Syahbella Prasetya Prasetya Prasetya Prasetya, Prasetya Putri, Rahmayani Indah Rahayu, Anggi Putri Rahmadini Syafri Rahmiwati Hilma Ramadhanti, Aulia Rizki Retno Hidayati Rudi Hendra Saprizal Hadisaputra Sari, Meidita Kemala Sari, Nila Puspita Siregar, Sri Hilma Siregar, srihilma Sri Hilma Siregar Sudirman Sudirman Suma Rahmani Harahap Tri Dharmayani, Ni Komang Trisiwi Kusuma Ningrum Wirdati Irma Wulan Sari, Wulan Yeni Yernita Yuana Nurulita Yuana Nurulita Yuharmen Yuharmen Yuharmen, Yuharmen Yum Eryanti Yum Eryanti Yuni Fatisa `Nasution, Hasmalina