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Administration of Oral Curcumin to Resistance Exercise after Immobilization Does Not Affect Skeletal Muscle Fiber Diameter in Rattus Norvegicus I Putu Alit Pawana; Martha Kurnia Kusumawardani; Lydia Arfianti
Indonesian Journal of Physical Medicine & Rehabilitation Vol 11 No 01 (2022): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36803/ijpmr.v11i01.328

ABSTRACTIntroduction: The aim of this study was to explore the effect of adding oral curcumin to resistance exerciseafter immobilization on the diameter of skeletal muscle fiber in Rattus Norvegicus.Methods: This was a post-test only study design on animal model. Subjects of the study were male Rattusnorvegicus strain Wistar, age 10-12 weeks old, weigh between 150-300 g, were immobilized at soleusmuscle for 2 weeks, then randomly allocated to 3 groups: (i) control group, (ii) resistance exercise, (iii)oral curcumin + resistance exercise. After 4 weeks of intervention, the diameter of the muscle fibers wasmeasured.Result: The results of this study showed a significant difference on the diameter of skeletal muscle fiberbetween control group and resistance exercise, as well as control group and resistance exercise + oralcurcumin (p<0.05). There was no significant difference between resistance exercise only and resistanceexercise + oral curcumin (p>0.05).Conclusion: Administration of oral curcumin to resistance exercise after immobilization does not affectskeletal muscle fiber diameter in Rattus Norvegicus.Keywords : curcumin, good health and well-being, immobilization, resist ance exercise, skeletal muscle.

Comparison of Neutrophyl Lymphocyte Ratio and Nerve Conduction Study Between Male Type 2 Diabetes Mellitus With or Without Peripheral Neuropathy Complication Martha Kurnia Kusumawardani; Surdiana; I Putu Alit Pawana; Sony Wibisono
Indonesian Journal of Physical Medicine & Rehabilitation Vol 11 No 01 (2022): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36803/ijpmr.v11i01.326

ABSTRACT Background: Diabetic Peripheral Neuropathy (DPN) is one of the type 2 Diabetes Melitus (T2DM) complication, which may lead to diabetic foot ulcer and lower extremity amputation. Inflammation plays a role in the pathogenesis of this type 2 DM complication. Recent studies showed neutrophyl-lymphocyte ratio (NLR) is a potential inflammation marker. Early screening for neuropathy is an important part of the medical rehabilitation management of this condition. Material and methods: This study uses data analysis independent sample T-2 test with a significant (p<0.05). This study is a analytic observation cross-sectional study with type 2 diabetic male subjects, screened with Michigan Neuropathy Screening Instrument then divided into 2 groups, with DPN group (11 subjects) and without DPN group (7 subjects). This was followed with complete blood count laboratory testing (neutrophyl and lymphocyte level) and NCS to measure distal latency, amplitudo, and NCV of the tibial, peroneal, and suralnerve on both lower extremities. Result: There were 18 subjects in this study. Independent T-2 test showed that there was no significant difference in neutrophils (p=0.679), lymphocytes (p=0.127), and NLR (p=0.190) in the DM group without or with neuropathy. NCS showed that there were significant differences on the amplitude of the three nerves peroneal (p=0.003), tibial (p=0.017), sural (p=0.033), also in NCV of peroneal (p=0.001) and tibial (p=0.008). There were no significant differences found on the three distal latency of peroneal (p=0.074), tibial (p=0.151), sural(p=0.294), and NCV of sural (p=0.262). Conclusions: This study shows that there is no significant difference in NLR on both groups. There were significant differences in the amplitude of the three peroneal, tibial, and sural nerves and the conduction velocity of the peroneal and tibial nerves. However, there was no significant difference in the distal latency of the threeperoneal, tibial, sural, and the NCV of the sural nerves.Keywords: diabetes melitus, diabetic peripheral neuropathy, nerve conduction studies, neutrophyl-lymphocyte ratio, rehabilitation management.

Administration of Oral Curcumin to Resistance Exercise after Immobilization Does Not Affect Skeletal Muscle Fiber Diameter in Rattus Norvegicus I Putu Alit Pawana; Martha Kurnia Kusumawardani; Lydia Arfianti
Indonesian Journal of Physical Medicine & Rehabilitation Vol 11 No 01 (2022): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36803/ijpmr.v11i01.328

ABSTRACTIntroduction: The aim of this study was to explore the effect of adding oral curcumin to resistance exerciseafter immobilization on the diameter of skeletal muscle fiber in Rattus Norvegicus.Methods: This was a post-test only study design on animal model. Subjects of the study were male Rattusnorvegicus strain Wistar, age 10-12 weeks old, weigh between 150-300 g, were immobilized at soleusmuscle for 2 weeks, then randomly allocated to 3 groups: (i) control group, (ii) resistance exercise, (iii)oral curcumin + resistance exercise. After 4 weeks of intervention, the diameter of the muscle fibers wasmeasured.Result: The results of this study showed a significant difference on the diameter of skeletal muscle fiberbetween control group and resistance exercise, as well as control group and resistance exercise + oralcurcumin (p<0.05). There was no significant difference between resistance exercise only and resistanceexercise + oral curcumin (p>0.05).Conclusion: Administration of oral curcumin to resistance exercise after immobilization does not affectskeletal muscle fiber diameter in Rattus Norvegicus.Keywords : curcumin, good health and well-being, immobilization, resist ance exercise, skeletal muscle.

Conventional Low Intensity Pulsed-Ultrasound Therapy Increase Osteoblast, Serum Alkaline Phosphatase and Serum Calcium Levels in Fracture Healing Process Indrayuni Lukitra Wardhani; I Ketut Gede Agus Budi Wirawan; I Putu Alit Pawana; Andriati -; Patricia Maria
Cermin Dunia Kedokteran Vol 45, No 3 (2018): Muskuloskeletal
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i3.179

Introduction: Application of ultrasound waves to improve bone healing generally use specific bone stimulator equipment not available in Indonesia. Frequency and duration of therapy from previous studies are very difficult to apply in clinical practice. This study aims to observe the therapeutic effect of conventional low-intensity pulsed-ultrasound to osteoblast, alkaline phosphatase and serum calcium levels. Method: Thirty six male white rats were divided into three groups (control, USD 5x/week, and USD 3x/week). Tibial fracture in ultrasound groups were treated 3x/week and 5x/week with ultrasound waves (1 MHz, pulsed mode, 20% of duty cycle, intensity of 0.2 W/cm2, duration 10 minutes, stationary) for 3 weeks. Callus tissue and blood from all animals were assessed quantitatively using histological and biochemical analyses. Result: Significant differences (p<0.05) in the average number of osteoblasts, level of alkaline phosphatase and serum calcium among all three groups. Conclusion: Conventional low intensity pulsed-ultrasound either 5x/week or 3x/week improve bone healing process.

Conventional Low Intensity Pulsed-Ultrasound Therapy Increases Osteoblast, Serum Alkaline Phosphatase, and Serum Calcium Levels in Fracture Healing Process Indrayuni Lukitra Wardhani; I Ketut Gede Agus Budi Wirawan; I Putu Alit Pawana; Andriati; Patricia Maria
Cermin Dunia Kedokteran Vol. 45 No. 3 (2018): Muskuloskeletal
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i3.807

Introduction: Application of ultrasound waves to improve bone healing generally use specific bone stimulator equipment not available in Indonesia. Frequency and duration of therapy from previous studies are very difficult to apply in clinical practice. This study aims to observe the therapeutic effect of conventional low-intensity pulsed-ultrasound to osteoblast, alkaline phosphatase, and serum calcium levels. Method: Thirty six male white rats were divided into three groups (control, USD 5x/week, and USD 3x/week). Tibial fracture in ultrasound groups were treated 3x/week and 5x/week with ultrasound waves (1 MHz, pulsed mode, 20% of duty cycle, intensity of 0.2 W/cm2, duration 10 minutes, stationary) for 3 weeks. Callus tissue and blood from all animals were assessed quantitatively using histological and biochemical analyses. Result: Significant differences (p<0.05) in the average number of osteoblasts, level of alkaline phosphatase, and serum calcium among all three groups. Conclusion: Conventional low intensity pulsed-ultrasound either 5x/week or 3x/week improve bone healing process. Pendahuluan: Penggunaan gelombang ultrasonik untuk memperbaiki penyembuhan tulang umumnya menggunakan alat stimulasi khusus yang tidak tersedia di Indonesia. Frekuensi dan durasi terapi penelitian sebelumnya sulit diterapkan dalam praktik klinis. Tujuan penelitian ini adalah untuk membandingkan efek stimulasi gelombang ultrasonik menggunakan alat terapi konvensional ultrasound diathermy (USD) antara kelompok kontrol, kelompok perlakuan USD 5x/minggu dan 3x/minggu terhadap jumlah osteoblas, kadar alkali fosfatase, dan kalsium serum. Metode: Sejumlah 36 ekor tikus putih jantan dibagi tiga kelompok (kontrol, USD 5x/minggu, dan USD 3x/minggu). Fraktur tibia pada kelompok ultrasound diterapi 3x/minggu dan 5x/minggu dengan gelombang ultrasonik (1 MHz, pulsed-mode, 20% duty cycle, intensitas 0,2 W/cm2, durasi 10 menit, stasioner) selama 3 minggu. Jaringan kalus dan darah semua hewan dinilai secara kuantitatif dengan analisis histologi dan biokimia. Hasil: Ada perbedaan signifikan (p <0,05) jumlah rata-rata osteoblas, kadar alkali fosfatase, dan kalsium serum antara ketiga kelompok. Simpulan: Terapi konvensional dengan pulsed-ultrasound intensitas rendah frekuensi 5x/minggu ataupun 3x/minggu memperbaiki proses penyembuhan tulang.

Effect Of Wearable Tubing Assistive Walking Device on Anterior Tibial Muscle Activity at Swing Phase in Post-Stroke Patients Tri Rahayu Septyaningrum; Subagyo Subagyo; R.A. Meisy Andriana; I Putu Alit Pawana
Surabaya Physical Medicine and Rehabilitation Journal Vol. 5 No. 1 (2023): SPMRJ, FEBRUARY 2023
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/spmrj.v5i1.25121

Background: One-third of post-stroke patients experience gait disturbance which is commonly associated with drop foot at three months after acute stroke. One of the orthoses that are proposed to improve gait in stroke patient is Wearable Tubing Assistive Walking Devices (WTAWD). It is hypothesized that WTAWD reduce the anterior tibial muscle activity which may become hyperactive during the swing phase in post-stroke patient with drop foot as an attempt to perform foot clearance. Aim: This study aims to investigate the effect of WTAWD on anterior tibial muscle activity during the swing phase in post-stroke patients. Material and Methods: Eleven patients, aged 30-60 years, with post-stroke hemiparesis in the subacute and chronic phase who fulfill the inclusion criteria are chosen as research subjects. The subjects were asked to wear WTAWD on the leg with weakness. Surface Electromyography (sEMG) examination of anterior tibial muscle was performed when the patient walked with and without wearing the WTAWD. Results: All 11 subjects completed the sessions and study protocol, with no losses throughout the study. None of the subjects reported any adverse effects during or after the intervention. A significant reduction of sEMG value on anterior tibial muscle activity was found when the patient wore WTAWD (p=0.001). Conclusion: There is an effect of WTAWD on decreasing anterior tibial muscle activity during the swing phase in post-stroke patients. Further research is needed to measure the kinematic and temporospatial values to increase knowledge about the effect of additional WTAWD to improve gait in stroke patients.

Evaluasi Status Fungsional Pasien Stroke Iskemik Di Ruang Rawat Inap Saraf RSUD Dr. Soetomo Menggunakan Instrumen Functional Independence Measure (FIM) Inez Anabela Suprijadi Suprijadi; Florentina Sustini; I Putu Alit Pawana; Devi Ariani Sudibyo
JURNAL WIDYA MEDIKA Vol. 5 No. 1 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v5i1.1994

Introduction: Stroke is a sudden and acute functional focal and global brain disorder that lasts more than 24 hours due to brain blood circulation disorders. Strokes can influence several aspects of life including ADL. Aim: To analyze the patients with ischemic stroke in Neurology Department of RSUD Dr. Soetomo by Functional Independence Measure (FIM) scale at the times of admission to hospital, discharge, and one month after follow-up. Methods: The design of study was cohort. Sample was 60 patients that suitable with the inclusion criteria and was selected by consecutive sampling. Patient’s age, sex, length of stay, nutritional intake, compliance of drugs intake, and the ability of physical activity were recorded. After that, motor assessment and daily activities skills were evaluated by FIM scale. Data was collected by interview and examination for 5 months. Data was analyzed by t-test. Results: A sum of 60 patients are studied. Most frequent genders are male (53,3%), age ranging from 60-69 years old (36,7%), length of stay mostly less than a week (88,3%), nutritional intake is mostly balanced (31,7%), most of the patients take their drugs regularly (66,7%), and most of the patients are only need supervision (45%). The FIM score at admission ranged between 54-71 (40%), at discharged ranged between 72-89 (46,7%), and after one month follow-up ranged between 72-89 (48,3%). There were significant change at p=0,001 between FIM Score at discharged and admission and also between FIM score after one month follow-up and discharged. Conclusion: All patients’ FIM scores were improved. There was a correlation between patient’s length of stay and FIM score at admission and also the ability of physical activity. Significant correlation was found between patient’s age and the ability of physical activity with the FIM score at discharge. Patient’s age, length of stay, and the ability of physical activity have significant correlation with The FIM score after one month follow-up.

Conventional Low Intensity Pulsed-Ultrasound Therapy Increases Osteoblast, Serum Alkaline Phosphatase, and Serum Calcium Levels in Fracture Healing Process Indrayuni Lukitra Wardhani; I Ketut Gede Agus Budi Wirawan; I Putu Alit Pawana; Andriati; Patricia Maria
Cermin Dunia Kedokteran Vol 45 No 3 (2018): Muskuloskeletal
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i3.807

Introduction: Application of ultrasound waves to improve bone healing generally use specific bone stimulator equipment not available in Indonesia. Frequency and duration of therapy from previous studies are very difficult to apply in clinical practice. This study aims to observe the therapeutic effect of conventional low-intensity pulsed-ultrasound to osteoblast, alkaline phosphatase, and serum calcium levels. Method: Thirty six male white rats were divided into three groups (control, USD 5x/week, and USD 3x/week). Tibial fracture in ultrasound groups were treated 3x/week and 5x/week with ultrasound waves (1 MHz, pulsed mode, 20% of duty cycle, intensity of 0.2 W/cm2, duration 10 minutes, stationary) for 3 weeks. Callus tissue and blood from all animals were assessed quantitatively using histological and biochemical analyses. Result: Significant differences (p<0.05) in the average number of osteoblasts, level of alkaline phosphatase, and serum calcium among all three groups. Conclusion: Conventional low intensity pulsed-ultrasound either 5x/week or 3x/week improve bone healing process. Pendahuluan: Penggunaan gelombang ultrasonik untuk memperbaiki penyembuhan tulang umumnya menggunakan alat stimulasi khusus yang tidak tersedia di Indonesia. Frekuensi dan durasi terapi penelitian sebelumnya sulit diterapkan dalam praktik klinis. Tujuan penelitian ini adalah untuk membandingkan efek stimulasi gelombang ultrasonik menggunakan alat terapi konvensional ultrasound diathermy (USD) antara kelompok kontrol, kelompok perlakuan USD 5x/minggu dan 3x/minggu terhadap jumlah osteoblas, kadar alkali fosfatase, dan kalsium serum. Metode: Sejumlah 36 ekor tikus putih jantan dibagi tiga kelompok (kontrol, USD 5x/minggu, dan USD 3x/minggu). Fraktur tibia pada kelompok ultrasound diterapi 3x/minggu dan 5x/minggu dengan gelombang ultrasonik (1 MHz, pulsed-mode, 20% duty cycle, intensitas 0,2 W/cm2, durasi 10 menit, stasioner) selama 3 minggu. Jaringan kalus dan darah semua hewan dinilai secara kuantitatif dengan analisis histologi dan biokimia. Hasil: Ada perbedaan signifikan (p <0,05) jumlah rata-rata osteoblas, kadar alkali fosfatase, dan kalsium serum antara ketiga kelompok. Simpulan: Terapi konvensional dengan pulsed-ultrasound intensitas rendah frekuensi 5x/minggu ataupun 3x/minggu memperbaiki proses penyembuhan tulang.

Pengaruh Circuit Training terhadap Peningkatan Agility pada Pemain Futsal Yeni, Yeni Tri Nurhayati; Wardana, Farid Aditya; Pawana, I Putu Alit
Jurnal Ilmu Medis Indonesia Vol. 4 No. 1 (2024): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v4i1.4393

Purpose: Futsal requires skills and individual techniques such as agility and speed. Agility is the ability to change body position quickly without losing balance. Circuit training is a training system that can simultaneously improve the overall body fitness, the elements such as speed, agility, and other components of physical conditions. This study aims to determine the effect of circuit training on improving agility in futsal players. Methodology/approach: A quasi-experimental study was conducted among 26 male futsal players who were divided non-randomly into 2 groups of 13 people, 1) experimental group which was doing circuit training twice a week for 6 weeks; 2) control group. Agility was measured using the illinois agility test of both groups. Descriptive analysis was done by using EZR (Easy R) to find out the results of the study. Results/findings: The result of this study is the average difference between pretest-posttest circuit training groups was 0,95±0,23 and the control group 0,03±0,06. Analysis of different effect between both groups means by using two sample t-test showed a result of p = 0,001 where the value of p value <0.05 so that H1 is accepted which means that there are significant differences in the effect on the research subject after being given circuit training. In conclusion, there was significant effect of circuit training to improve agility in futsal players. This results show that circuit training was reasonably effective in improving agility, suggesting that other factors such as BMI and training frequency should also be considered in future research. Based on the results of data analysis, it can be concluded that the provision of circuit training has an effect on increasing agility in futsal players as measured by the Illinois agility test measuring instrument at pre-test and post-test. Limitations: This study has several limitations. First, the sample size was relatively small, which may limit the generalizability of the findings. Second, there were potential external factors that were not strictly controlled, may still contributing to the study outcomes. Third, the study design was non-randomized, which could introduce selection bias. Contribution: This research is expected to increase knowledge, provide an alternative form of circuit training to increase the agility performance of futsal players

The Relationship Between Quadriceps Muscle Atrophy and Proprioception Function in Knee Osteoarthritis Patients Susanti, Ayu; Wardhani, Rr. Indrayuni Lukitra; Pawana, I Putu Alit
Surabaya Physical Medicine and Rehabilitation Journal Vol. 1 No. 2 (2019): SPMRJ, Agustus 2019
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Osteoarthritis of the knee (OA) patients can experience impaired proprioceptive function which causes instability, balance disorder and limited activity. Further analysis is needed to detect changes that occur. There are two methods to evaluate the speed and angle of a particular motion as an analysis of the function of proprioception, Time to Detect Passive Movements (TTDPM) and Joint Position Sense (JPS).Aim: To analyze the relationship between quadriceps muscle atrophy with proprioception in knee osteoarthritis patients.Methods: The design of this research is cross sectional analysis done in Dr. Soetomo General Hospital Surabaya, Indonesia. There were 25 knee OA patients (2 men and 23 women) with each subject had proprioception (JPS and TTDPM) function measured using isokinetics dynamometer on both sides of the knee.Results: This study shows the atrophic side had greater pain intensity and greater disturbance of proprioception. In addition, there were significant differences in JPS measurements at angle of 30â°, and 60â° and TTDPM (p <0.05). No difference obtained at 45â° measurements angle.Conclusion: In this study, there was no association between quadriceps atrophy and function of proprioception in knee osteoarthritis patients. This was due to a number of confounding factors that cannot be controlled such as duration, difference in pain intensity, OA severity, physical activity before measurement, and fatigue which can affect proprioception function and bring misinterpretation on measurements.

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