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All Journal HAYATI Journal of Biosciences Damianus Journal of Medicine The Indonesian Biomedical Journal Jurnal Medik Veteriner Acta Biochimica Indonesiana JISIP: Jurnal Ilmu Sosial dan Pendidikan Neurologico Spinale Medico Chirurgico Asian Australasian Neuro and Health Science Journal (AANHS-J) JSIP: Jurnal Studi Ilmu Pemerintahan The Indonesian Journal of Community and Occupational Medicine Salam (Islamic Economics Journal) Saraq Opat : Jurnal Administrasi Publik Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Wawan Mulyawan
Aviation Medicine Program, Department Of Community Medicine, Faculty Of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary

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Expression of Hypoxia-Inducible Factor-1α and Myoglobin in Rat Heart as Adaptive Response to Intermittent Hypobaric Hypoxia Exposure Margaretha Herawati; . Wardaya; Wawan Mulyawan; Fanny Septiani Farhan; Frans Ferdinal; Sri Widia A. Jusman; Mohamad Sadikin
HAYATI Journal of Biosciences Vol. 24 No. 3 (2017): July 2017
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (826.933 KB) | DOI: 10.4308/hjb.24.3.131

Abstract

The aim of this study was to investigate the influence of intermittent hypobaric hypoxia on the expression hypoxia adaptation proteins, namely hypoxia inducibla factor-1a (HIF-1a) and myoglobin (Mb). Twenty five male Sprague-Dawley rats were exposed to intermittent hypobaric hypoxia in a hypobaric chamber in Indonesian Air Force Institute of Aviation Medicine, for 49.5 minutes at various low pressure, 1 week interval for 4 times (day 1, 8, 15 and 22). HIF-1α and Mb protein were measured with ELISA. mRNA expression of Mb was measured with one step real time RT-PCR. HIF-1α protein levels increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0437). mRNA expression and protein of Mb increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0283; 0.0170), and both are strongly correlated (Pearson, r = 0.6307). The heart of rats adapted to intermittent hypoxia conditions by upregulation the expression of HIF-1a and myoglobin and then both return to normal level.
The effect of intermittent hypobaric hypoxia on oxidative stress status and antioxidant enzymes activity in rat brain Syarifah Dewi; Wawan Mulyawan; Septelia Inawati Wanandi; Mohamad Sadikin
Acta Biochimica Indonesiana Vol. 1 No. 2 (2018): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.v1i2.16

Abstract

Background: High altitude can cause hypobaric hypoxia (HH), resulted from the lower barometric pressure and hence partial pressure of oxygen. Hypoxia can lead to a lot of deleterious molecular and cellular changes, such as generation of free radicals or reactive oxygen species (ROS). Increasing of ROS can cause oxidative stress if the antioxidant enzyme does not increase simultaneously. Oxidative damage in brain has toxic effect on cognitive functions. Objective: In this study, we investigate effect of acute intermittent HH on oxidative stress and antioxidant enzyme activity in rat brain. Method: Wistar rats divided into 5 groups, consisting control group and four experimental groups which treated to HH. Rats were exposed to simulated HH equivalent to 35.000 feet in hypobaric chamber for 1 minute, repeated once a week. Results: Level of malondialdehyde and carbonyl in rat brain under acute HH increased at HH exposure (group I) compare to control group. These levels decreased afterward at intermittent HH exposure (group II-IV). Specific activity of superoxide dismutase (SOD) shows increasing level at intermittent HH exposure, especially group IV was increasing of SOD level significantly. The increasing pattern of specific activity of catalase was inversely from SOD pattern, but it still has higher activity in intermittent HH compare to control group. Conclusion: Brain tissue seems to be able to perform an adequate adaptive response to hypobaric hypoxia after the training, shown by its significantly decreased MDA and carbonyl level and also increased specific activity of SOD and catalase.
PERCUTANEOUS EPIDURAL NEUROPLASTY (PEN) USING COMBINATION OF HYALURONIDASE AND HYPERTONIC SALINE (NaCl 3%) IN TREATING FAILED BACK SURGERY SYNDROME Wawan Mulyawan; Yudi Yuwono Wiwoho; Syaiful Ichwan
Neurologico Spinale Medico Chirurgico Vol 1 No 1 (2018)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1051.323 KB)

Abstract

Background: Following surgical treatments for low back pain, lower extremity pain or neurologic symptoms would last or recur, this is defined as failed sack surgery syndrome (FBSS). FBSS usually occurs in 5-40% of these surgical patients. The most common cause is an epidural scar adhesion. Percutaneous epidural neuroplasty is the non-mechanical treatment for this condition. Previously, the use of hyaluronidase and hypertonic saline separately is commonly used for epidurolysis but the combination of hyaluronidase and hypertonic saline 3% has not been explored.Objective: To investigate the two-year outcomes of percutaneous epidural neuroplasty using a combination of hyaluronidase and hypertonic saline 3% in patients with FBSS.Methods: Twelve patients who experience low back pain, with or without radiculopathy, who have underwent lumbar spine surgery previously were assigned to the study. Parameters, such as the visual analogue scale scores for the back (VAS-B) and legs (VAS-L), and the Oswestry disability index (ODI), were recorded and compared between pretreatment, 1 week, 1 month, 3 months, 1 year and 2 years follow-up.Results: For all 12 patients, the postoperative VAS-B, VAS-L, and ODI were significantly different from the preoperative values in all follow-up periods: 1 month, 3 months, 1 year, and 2 years.Conclusion: Based off this study group, percutaneous epidural neuroplasty using a combination of hyaluronidase and hypertonic saline 3% has a favourable outcome in the 2 years follow-up
Relationship between Total Flight Hours and Individual Factors with Low Back Pain in Indonesian Military Helicopter Pilots Fazlin Khuzaima; Retno Wibawanti; Agus Sugiharto; Wawan Mulyawan;  M.  Ilyas;  Dewi S. Soemarko
The Indonesian Journal of Community and Occupational Medicine Vol. 3 No. 1 (2023): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v3i1.89.9-16

Abstract

Introduction: Helicopter pilots are potentially at risk of Low Back Pain (LBP) and are twice as likely as fighter pilots to experience it. Helicopter pilots’ LBP is caused by a combination of risk factors: engine and rotor vibration, ergonomic risks due to cockpit design, static seating position due to operations, and individual factors. These factors are incorporated into cumulative aviation risk exposure, which can be measured by total flight hours. The prevalence of LBP in Caucasians is high, at 50.5%-92%. However, there has not been any research on Indonesian military helicopter pilots who have a different posture from Caucasians.Objective: To determine the prevalence of LBP, to analyze the relationship between total flight hours and individual factors (age, height, BMI, exercise habits, and smoking habits) with LBP in Indonesian military helicopter pilots.Methods: The study was conducted at the Indonesian Army and Indonesian Air Force with total sampling method as many as 124 people. An explanation was carried out followed by filling in the consent to become a research subject, filling in personal data, anamnesis, Numeric Rating Scale (NRS), physical examination, neurological examination, and total flight hour data.Results: There were 124 subjects, consisting of 37.9% pilots and 62.1% copilots, 87.9% of pilots operate large helicopters, have average total flight hours of 450 hours, age of 30 years, the height of 172.66 cm, low intensity exercise habits of 61.3%, and smokers as much as 45.2%. A total of 57 people (46%) experienced LBP. Statistical results showed that total flight hours had an association with LBP (p = 0.035) where each 1 unit increase in total flight hours had a 1.02 times greater chance of LBP.Conclusion: The prevalence of LBP is 46% and there is an association between total flying hours and LBP in Indonesian military helicopter pilots.
Oxidative Stress, Hypoxia-Inducible Factor-1α, and Nuclear Factor-Erythroid 2-Related Factor 2 in the Hearts of Rats Exposed to Intermittent Hypobaric Hypoxia Wardaya Wardaya; Wawan Mulyawan; Sri Widia A Jusman; Mohamad Sadikin
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.39-47

Abstract

Hypobaric hypoxia is situation that might occur to helicopter pilots in Indonesia who must fly at an altitude of more than 3,048 m such as in Papua. It can be dangerous because hypoxic condition can affect person's performance. So far, the heart is known as an aerobic organ and very sensitive to hypoxic conditions. Hitherto, the effects of hypobaric hypoxia exposure on biomolecular aspects of the heart are still unclear. Therefore, this study assessed cardiac response in rats exposed to intermittent hypobaric hypoxia (IHH) (equivalent to 3,048 meters/10,000 feet). Sprague-Dawley rats were divided into six groups: control; acute hypobaric hypoxia (AHH); and IHH, for 7; 14; 21; and 28 days. We measured super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, reduced glutathione (GSH), malondialdehyde (MDA), cytoglobin, myoglobin, HIF-1α, and Nrf2 level as our parameters. Activities of SOD, CAT, GPx and GSH increased while the levels of MDA, cytoglobin, myoglobin, HIF-1α, and Nrf2 decreased in all IHH groups compared with the AHH group. A biphasic pattern was observed as IHH sessions increased from 14 to 21 or 28. Where the IHH treatment for more than 14 sessions caused a decrease in endogenous antioxidants, but the response to hypoxia and oxidative stress increased. Our findings presented the molecular alterations of cardiac rats exposed to intermittent hypobaric hypoxia.
How can local Governments become Pioneers in Tourism Development? Analysis of Organizational Performance and Influencing Factors Mulyawan, Wawan
Jurnal Studi Ilmu Pemerintahan Vol. 5 No. 1 (2024): JSIP: Jurnal Studi Ilmu Pemerintahan
Publisher : Department of Government Studies, Universitas Muhammadiyah Buton.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35326/jsip.v5i1.5073

Abstract

This study examines the pivotal role of accountability and responsibility, together with the influence of organizational structure, human resource capabilities, and financial management, in enhancing the performance of tourist sector growth in Bima Regency. This study employs qualitative primary and secondary data-gathering techniques, including interviews, documentation analysis, and direct observation. The research informants included officials from the Bima Regency Culture and Tourism Service, Village Heads, and community leaders in the local government. The research findings indicate that the regional government's dedication to performance accountability, achieved through the transparent allocation of budget and monitoring of tourism destination performance, along with its responsibility to preserve the environment, develop sustainable products, and promote community participation, establishes a harmonious equilibrium between economic growth and environmental sustainability. A well-designed organizational structure promotes efficient coordination and decision-making, while improved human resource skills and prudent financial management bolster the success of tourist development programs, establishing a strong basis for sustained growth in Bima Regency. This study offers valuable insights into how local governments may lead tourist development by prioritizing accountability, responsibility, organizational structure, and efficient administration of human and financial resources.
Surgery of Left Temporal Region Arachnoid Cyst with Neuroendoscopy: A Case Report Wiwoho, Yudi Yuwono; Rolian, Danu; Ichwan, Syaiful; Mulyawan, Wawan
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 3 No. 1 (2021): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhsj.v3i1.5935

Abstract

Introduction: Today, the development of minimally invasive neurosurgery technique, has become a choice of treatment for many neurosurgical disease.  Dr.Suyoto Hospital, Rehabilitation Center, Ministry of Defence of the Republic of Indonesia and Indonesian Airforce Hospital Dr. Esnawan Antariksa, Halim Perdanakusuma, Jakarta, Indonesia, has responsibility in public health services for military and civilian community. This paper has an objective to share experience in giving treatment with intracranial neuroendoscopy technique for patient with left temporal region arachnoid cyst. Case Report: Case Report 1 : Girl, 17 years old, with headache. There was no neurological deficit, and from brain CT Scan, there was a cystic lesion at the left temporal region. The diagnosis was arachnoid cyst. She performed neuroendoscopic cystotomy and insertion of Omaya reservoir. After surgery, she had no headache, and there were no post-operative complications. Histopatology finding was arachnoid cyst. From follow up of brain CT Scan, there was improvement. We used intracranial neuroendoscopy device from B-Braun Aesculap, Germany, 2015. Case Report 2 : Boy, 8 years old, with seizure and headache. There was no neurological deficit, and from brain CT Scan, there was a cystic lesion at the left temporal region. The diagnosis was arachnoid cyst. He performed neuroendoscopic cystotomy and insertion of Omaya reservoir. Dicussion: After surgery, he had no headache and also had no seizure, and there were no post-operative complications. Histopatology finding was arachnoid cyst. From follow up of brain CT Scan, there was improvement. We used intracranial neuroendoscopy device from B-Braun Aesculap, Germany, 2015. Conclusion: Intracranial neuroendoscopy technique can be applied for the treatment of many special and selective neurosurgical diseases, including arachnoid cyst. In this patient, intracranial neuroendoscopy had good result. We still need more many of cases for determine the success rate of this intracranial neuroendoscopy technique statistically
APBN DAN PENDAPATAN NASIONAL Mulyawan, Wawan
Salam (Islamic Economics Journal) Vol. 1 No. 2 (2020): December 2020
Publisher : Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/slm.v1i2.7929

Abstract

Perencanaan anggaran dalam sebuah Negara mutlak diperlukan sebagai instrument untuk mencapai stabilitasi suatu pemerintahan dalam jangka waktu tertentu, termasuk didalamnya Anggaran Pendapatan dan Belanja Negara (APBN). Sedangkan pendapatan nasional sendiri memiliki cakupan yang lebih spesifik dari APBN itu sendiri dimana pendapatan nasional itu dihitung berdasarkan jumlah pendapatan yang diterima oleh seluruh Rumah Tangga Keluarga (RTK) di suatu Negara dari penyerahan faktor-faktor produksi dalam satu periode waktu tertentu (biasanya dihitung dalam jangka waktu satu tahun).
Intermittent Hypobaric Hypoxia Preconditioning Ameliorates Kidney Damage Compared to Acute Hypoxia Sadikin, Abdul Halim; Jusman, Sri Widia Azraki; Mulyawan, Wawan; Prijanti, Ani Retno
HAYATI Journal of Biosciences Vol. 32 No. 6 (2025): November 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.6.1437-1446

Abstract

Many studies have reported that intermittent hypobaric hypoxia (IHH) can cause oxidative stress and tissue damage in the kidneys, which can lead to impaired kidney function. However, a study using simulated intermittent hypobaric hypoxia was considered to have a protective role for the kidneys. This study aims to determine the effect of IHH on kidney adaptation to oxidative stress and kidney damage. Twenty-five rats were divided into five groups: control, one-time hypoxia (AHH), two-time hypoxia (IHH 1), three-time hypoxia (IHH 2), and four-time hypoxia (IHH 3). The intermittent interval was one week, and at the time of treatment, the rats were placed in a hypoxic chamber. At the end of treatment, the rats were sacrificed, and the kidneys, urine, and blood were collected. The kidney tissues were used for protein assay, ELISA (HIF-1α and VEGF), qPCR (cytoglobin (Cygb) and renin), SOD and GPx activity assay. Blood was used for creatinine and urea assay, and urine was used for KIM-1 ELISA. Formalin-submerged tissues were used for histopathological analysis. The level of HIF-1α and VEGF increased significantly from AHH to IHH 1. Cygb and renin expressions peaked at AHH and decreased at subsequent IHH groups. The Nrf2 level and GPx activity didn’t show any difference, but SOD activity peaked at IHH 1. The creatinine level only peaked at IHH 2; other groups remained the same as the control. Urea levels decreased with more IHH sessions, and KIM-1 didn’t show any difference. Our findings exhibit that hypoxia preconditioning by IHH treatment leads to the kidney’s adaptability to hypoxia and does not cause kidney damage.
Analisis Penanggulangan Kemiskinan melalui metode Sharing Profit pada Pengelolaan wisata “Pulau Ular” di Desa Pai Kecamata Wera Kabupaten Bima Firdaus, Firdaus; Tasrif, Tasrif; Mulyawan, Wawan
Saraq Opat: Jurnal Administrasi Publik Vol 4 No 2 (2022): Juli : Saraq Opat: Jurnal Administrasi Publik
Publisher : Universitas Gajah Putih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55542/saraqopat.v4i2.359

Abstract

Tourism has an influence on economic growth through several channels (Brida et al, 2010). First, the tourism sector as a foreign exchange earner to obtain capital goods used in the production process (McKinnon, 1964). Second, tourism development stimulates investment in infrastructure (Sakai, 2006). Third, the development of the tourism sector encourages the development of other economic sectors through direct, indirect, and induced effects (Spurr, 2006). Fourth, tourism contributes to increasing job opportunities and increasing income (Lee & Chang, 2008). Fifth, tourism causes positive economies of scale (Weng & Wang, 2004). Tourism is also an important factor in the dissemination of technical knowledge, encouraging research and development, and the accumulation of human capital (Blake et al, 2006). The purpose of this study is to describe the process of Poverty Reduction through the Profit Sharing method in the management of "Snake Island" tourism in Pai Village, Wera District, Bima Regency towards improving the welfare of the community. Qualitative data analysis used an interaction analysis model consisting of data collection, data reduction, data presentation, conclusion drawing, and verification.
Co-Authors Adilansyah, Adilansyah Agus Sugiharto Ahmad Aulia Ani Retno Prijanti ARDYANSAH, ADY Atikah Chalida Barasila Defli Yuandika Ruso Dewi Sukmawati Fanny Septiani Farhan Fazlin Khuzaima Firdaus Firdaus Frans Ferdinal Frans Ferdinal Hendra Hendra Irawan Satriotomo Mohamad Sadikin Muhammad Arza Putra Ninik Mudjihartini Novi S. Hardiany Nurhadi Ibrahim Nurhadi Ibrahim Puspita Eka Wuyung Retno Wibawanti Rolian, Danu Sadikin, Abdul Halim Septelia I. Wanandi Sri Nurbowo Ardi Sri Widia A.Jusman Syaiful Ichwan Syarifah Dewi Tasrif Tasrif Wardaya Wardaya Wardaya Wardaya Wardaya Wiwien Heru Wiyono Wiwoho, Yudi Yuwono Yudi Yuwono Wiwoho Yulhasri  Dewi S. Soemarko  M.  Ilyas