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All Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indian Journal of Forensic Medicine & Toxicology Vision Science and Eye Health Journal Ophthalmologica Indonesiana JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Folia Medica Indonesiana
Nurwasis Nurwasis
Department Of Ophthalmology, Dr. Soetomo General Academic Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Difference between hs-CRP and Serum IL-6 Levels in Patients with Glaucoma and Non Glaucoma Muhammad Riduan1, Endang Retnowati Kusumowidagdo1, Nurwasis1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3195

Abstract

Background: Glaucoma is a group of eye diseases that have the characteristic of optic nerve damage with a specific pattern and field loss of view with or without increased intraocular pressure (IOP). The objective of the study was to analyze the association between glaucoma incidence with hs-CRP and IL-6 levels. Method: This study used patients who fulfilled the inclusion criteria. Inclusion criteria were in the form of patients with a primary closed-angle diagnosis, willing to participate in the research. The study was conducted in the period from March to August 2013. The research procedure included patient examination, hsCRP and IL-6 level examination. Results: Mann-Whitney test result showed difference of hs-CRP with p value of 0.755 and difference of IL-6 level with p = 0.95. Thus, there was no significant difference in the levels of hs-CRP and IL-6 in patients with glaucoma and non-glaucoma. Conclusion: Hs-CRP and serum IL-6 levels in the glaucoma group did not differ from the non-glaucoma group.
Time-dependent Expression of Caspase-3 and Degeneration of Lateral Rectus Muscle on Experimental Esotropia in Rabbits Luki Indriaswati; Nurwasis; Gatut Suhendro; Soetjipto; Retno Handajani
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14785

Abstract

Background: To identify correlation between caspase-3 expression and degeneration of lateral rectus muscleon experimental esotropia in rabbits by using time dependent analysis. Methods: Twenty four rabbits weredivided into 4 groups, first month sham (S1); second month sham (S2); first month esotropia (E1); andsecond month esotropia (E2) model groups. Immunohistochemical and haematoxyllin eosin staining wereperformed. Results: In first month observation no significant difference in caspase-3 expression between S1(1.56 ± 1.03) and E1 (3.93 ± 1.66) groups (p >0.05) and in the degeneration score of lateral rectus musclebetween S1 (1.33 ± 1.36) and E1 (3.83 ± 2.04) groups (p> 0.05). In second month observation no significantdifference in caspase-3 expression between S2 (1.80 ±1.08) and E2 (6.50 ± 3.26) groups (p >0.05); butthere was significant difference in the degeneration score of lateral rectus muscle between S2 (1.16 ± 1.16)and E2 (4.50 ± 1.04) groups (p <0.05). There was a significant correlation between caspase-3 expressionand the degeneration score of lateral rectus muscle (p=0.020; r=0.471). Conclusion: On the experimentalesotropia with prolonged lateral muscle contraction in rabbits, the increasing trend of caspase-3 expressionhas a correlation with the increasing degeneration score of lateral rectus muscle.
Mechanism of Corneal Epithelial Cells Death by Infection of pseudomonas Aeruginosathrough Analysis Expression of Caspase-1, TNF, RIPK1, RIPK3, Caspase-3 in Rats Model Ismi Zuhria; Nurwasis; Eddy Bagus Wasito; Winarto; I Ketut Sudiana; Reny I’tishom; Nyilo Purnami
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15802

Abstract

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A Rare Case of Chronic Primary Angle-Closure Glaucoma in a Young Woman with Coexisting Pathologic Myopia Ni Putu Ayu Reza Dhiyantari; Nurwasis Nurwasis; Evelyn Komaratih; Yulia Primitasari
Vision Science and Eye Health Journal Vol. 1 No. 1 (2021): Vision Science and Eye Health Journal
Publisher : Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1436.726 KB) | DOI: 10.20473/vsehj.v1i1.2021.10-16

Abstract

Introduction: Primary Angle-Closure Glaucoma (PACG) is usually present in adults older than forty and is more common in hyperopic eyes. Angle-closure is usually related to structural or developmental ocular abnormalities in young individuals. Case presentation: We presented a rare case of PACG in a 32 years old woman with pathologic myopia of -23.0 RLE. The chief complaint was blurring of the right eye three months before the visit. Right eye Intraocular Pressure (IOP) was 30mmHg-38mmHg despite treatment with three intra-ocular pressure-lowering agents. Axial length was 32.36 mm and 31.19 mm RLE. Anterior chamber depth was 2.36 mm and 2.60 mm RLE. Lens thickness was 5.07 mm and 5.40 mm RLE. Signs of GON and pathologic myopia were found in both eyes. GON was present asymmetrically (0.9 and 0.6 RLE), with the myopic crescent as well as baring and peripapillary atrophy. The optic disc was slightly tilted with the myopic crescent. There was also a marked sign of retinal pigment epithelium thinning and attenuation along with myopic chorioretinal atrophy. Conclusions: PACG in a young myopic individual is challenging to diagnose because myopia and glaucoma share similar optic nerve head pathology. Comprehensive examinations including gonioscopy, biometry, and OCT may confirm the diagnosis. In the presented case, angle-closure was caused by thick lenses and a shallow anterior chamber, along with excessively long axial length. Primary angle-closure at a young individual with myopic eyes is highly uncommon. Nonetheless, clinicians should always consider glaucoma even in the presence of high axial length and myopic fundus.
The Difficulties of Trabeculectomy in a Primary Angle-Closure Glaucoma Patient Herdina Ramadhani; Nurwasis Nurwasis; Yulia Primitasari; Evelyn Komaratih
Vision Science and Eye Health Journal Vol. 1 No. 2 (2022): Vision Science and Eye Health Journal
Publisher : Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5082.62 KB) | DOI: 10.20473/vsehj.v1i2.2022.38-44

Abstract

Introduction: Trabeculectomy is an incisional surgery for glaucoma patient. Performing trabeculectomy in primary angle-closure glaucoma (PACG) is quite difficult. Caution is needed for the occurrence of flat anterior chamber (FAC) and malignant glaucoma. We present a case management of trabeculectomy in a PACG patient. Case presentation: A 52-year-old male had blurred vision in his left eye since one year ago. The patient felt left visual field narrowing since eight months ago. Patient had type 2 diabetes mellitus. Visual acuity on the left eye was 5/7.5. Intraocular pressure (IOP) increased (29 mmHg). Gonioscopy showed closed angle and peripheral anterior synechiae. Glaucomatous optic neuropathy was found with C/D ratio value of 0.9 and superior-inferior RNFL thinning on optical coherence tomography (OCT). Anterior segment OCT revealed shallow anterior chamber depth (ACD) 2.54 mm. The right eye visual acuity was 5/5, normal IOP, and shallow ACD (2.66 mm). Patient was underwent left eye trabeculectomy. Postoperatively, left eye anterior chamber and bleb were formed. He had normal IOP without glaucoma medications. Conclusions: Trabeculectomy is a surgical procedure for glaucoma. Close monitoring is required to avoid the risk of postoperative FAC and malignant glaucoma in PACG.
Effectiveness of Medication, Surgery, and Combination Therapy to Decrease Intraocular Pressure on Glaucoma Outpatient at Outpatient Ophthalmic Clinic Dr. Soetomo General Hospital Surabaya in January – December 2017 Muhammad Bagas Pratista; Nurwasis Nurwasis; Kusuma Eko Purwantari; Indri Wahyuni
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.67-72

Abstract

Highlights:1. Combination of medication and surgery on glaucoma had the least post-therapy intraocular pressure.2. There was no significant difference in the efficacy of drugs, surgeries, and combination of both therapies for glaucoma intraocular pressure reduction. AbstractIntroduction: Glaucoma leads to blindness in its end stage. Quality of life drops as visual field loss as progressive optic nerve damage since high intraocular pressure elevation. Glaucoma treatment focused on aqueous humor regulation, thus the intraocular pressure is maintained at normal.Methods: This was a retrospective analytical study using secondary data gathered from medical records as total sampling data. The sample was determined by the purposive non-probability technique. The mean of intraocular pressure after therapies was defined as the dependent variable while the independent variable was the type of therapy.Results: Combined therapy (16.00 ± 6.77 mmHg) had the least post-therapy intraocular pressure. The statistical test indicated no significant difference in the effectiveness of medication, surgery, and combination therapy for glaucoma intraocular pressure reduction.Conclusion: There was no prominent difference in the efficacy of drugs, surgeries, and combined therapies for glaucoma intraocular pressure reduction.
Visual Outcome of Phacoemulsification at Griya Husada Eye Center, Madiun, Indonesia Astrid Feriza; Nurwasis Nurwasis; Sukoto Sukoto
Vision Science and Eye Health Journal Vol. 2 No. 1 (2022): Vision Science and Eye Health Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/vsehj.v2i1.2022.24-28

Abstract

Introduction: Sight is one of the most important senses that absorbs more than 80% of visual information. However, visual disturbances are common, ranging from mild to severe disturbances that can lead to blindness. A cataract is the leading cause of blindness in Indonesia; it is accountable for 77.7% of all blindness. Phacoemulsification is a new ECCE technique in which cloudy or cataractous lenses are removed through a 2-3 mm incision with no sutures. The advantages of this small incision are faster visual recovery, minimal astigmatic induction due to surgery, and minimal postoperative complications and inflammation. Purpose: This study aimed to measure visual outcomes in senile cataract patients after phacoemulsification surgery at Griya Husada Eye Center, Madiun, Indonesia. Methods: A Retrospective study was carried out among senile cataract patients who had phacoemulsification surgery at Griya Husada Eye Center, Madiun, Indonesia between January and May 2021. The best corrected visual acuity (BCVA) was recorded on the fourteenth day. Results: From 292 patients, postoperative visual acuity in the good category (6/6 - 6/18) was 94.9%, in the moderate category (<6/18 - 6/60) was 1.7%, and in the poor category (<6/60) was 3.4%. Conclusions: Postoperative visual acuity with phacoemulsification at Griya Husada Eye Center, Madiun, Indonesia showed satisfactory results and met World Health Organization’s (WHO) standards.
Difficulties of Cataract Surgery in Lens-Induced Glaucoma Due to Subluxated Cataract Meidiana Devira Aristanti; Nurwasis; Jamaluddin
Vision Science and Eye Health Journal Vol. 2 No. 3 (2023): Vision Science and Eye Health Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/vsehj.v2i3.2023.57-62

Abstract

Introduction: Cataract is a disease of the eye in which the normal clear lens has opacified and obscured the passage of light. A mature cataract occurs when the lens is opacified. Lens subluxation is a condition when the crystalline lens is not in its anatomical position that can result in decreased anterior chamber depth. It is a potentially high risk of developing pupillary block, leading to lens-induced glaucoma (secondary angle closure glaucoma). In this case, the definitive therapy is lens extraction, which is challenging for cataract surgeons. This case report aims to expose the difficulties of cataract surgery in lens-induced glaucoma due to subluxated cataract. Case Presentation: A 56-year-old male presented with unable to see in his right eye, followed by foggy vision, glare when seeing the light, and a history of an acute glaucoma attack. His right best corrected visual acuity (BCVA) was 1/300, and the intraocular pressure (IOP) was 5 mmHg on therapy with glaucoma medications. Slit lamp examination of the right eye showed a shallow anterior chamber, irradiated iris, mid-dilated pupil, completely cloudy lens, and a capsular instability around 12 to 6 clock hours (180°/2 quadrant). This patient was diagnosed with mature cataract and lens-induced glaucoma due to subluxated mature cataract and was given glaucoma medications also underwent phacoemulsification (PE) along with Intraocular lens (IOL) and capsular tension ring implantation due to the lens instability and excessive lens movement. Conclusions: Cataract surgery for subluxated mature cataract and lens-induced glaucoma is challenging because of the shallow anterior chamber, capsular instability, and excessive lens movement. A thorough diagnosis, preoperative evaluation, postoperative monitoring, and evaluation are essential for safe cataract surgery, reducing the risk of complications and achieving a good result.
CONQUERING THE AMBIGUITY OF OPTIC ATROPHY IN NORMAL TENSION GLAUCOMA: FROM MYSTERY TO MASTERY: Poster Presentation - Case Report - Resident Hakim, Affannul; Komaratih, Evelyn; Nurwasis; Primitasari, Yulia
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/nha7y421

Abstract

Introduction : The dilemma in diagnosing glaucoma often arises when optic atrophy is found alongside nonspecific glaucomatous findings and normal intraocular pressure (IOP), particularly in cases of normal tension glaucoma (NTG). This gray zone often leads to doubt and misdiagnosis. Case Illustration : A 70-year-old man previously diagnosed with idiopathic bilateral optic atrophy complained of blurred vision in both eyes. The visual acuity was 5/5 in the right eye (RE) and hand movement in the left eye (LE). Both eyes had normal IOP, open angles with Sampaolesi lines on gonioscopy, fibrin deposits at pupillary margins, and a large cup-to-disc ratio with baring and peripapillary atrophy on funduscopy. The OCT examination revealed thinning in the ONH-RNFL, ILM-RPE, and GCL-IPL complexes. HFA revealed tunnel vision in RE and general depression in LE. The patient was suspected of having NTG. We performed BMO-MRW (less than 100 ?m in both eyes) and 24-hour ocular perfusion pressure (OPP) measurements (less than 50 mmHg at night) to support the diagnosis. Discussion : The BMO-MRW examination is a new parameter that can help establish the diagnosis of glaucoma. A thin BMO-MRW finding suggests that optic atrophy originates from glaucoma. It is important to perform a comprehensive examination in cases of NTG to identify risk factors and prevent the development of glaucoma. Decreased OPP to less than 50 mmHg and PEX syndrome may be risk factors for NTG. Conclusion : In cases of doubtful optical atrophy, it is important to consider the possibility of NTG by performing a comprehensive examination, including BMO-MRW and twenty-four hour OPP measurements.
ANGLE RECESSION, THE SEQUELA OF EIGHT-BALL HYPHEMA AFTER SPRAYED BY FIRE HYDRANT: A CASE REPORT: Poster Presentation - Case Report - Resident Asti, Annisa Kinanti; Komaratih, Evelyn; Nurwasis; Primitasari, Yulia
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/gkke0y72

Abstract

Introduction : Hyphema results from damage to the blood vessels of the iris or anterior ciliary body after blunt trauma, and in 56–100% of cases can occur angle recession. Case Illustration : A 40-year-old man complaints of pain and blurred left eye after being sprayed by a high-pressure fire hydrant five hours before coming to the emergency room. Visual acuity was 20/20 and hand movement in right and left eye, IOP is 13 mmHg and 18 mmHg in both eyes. Subconjunctival bleeding, conjunctival and pericorneal injections were found with punctate fluorescein test in the left eye. The cornea was edema and the anterior chamber was full of hyphema. Five days after being hospitalized and treated with topical atropine, antibiotics, and steroid in combination with oral tranexamic acid, the visual acuity was 5/6.5 and the hyphema was resolved. The IOP elevated after 1-6 weeks of follow-up in the outpatient clinic then timolol eyedrops were given. Gonioscopy showed widening of CBB, torn iris processus 2 clock hours in the inferior quadrant. The antiglaucoma medication was stopped due to the controlled IOP in the end episode of the treatment. Discussion : Angle recession involves a tear between the longitudinal and circular muscle fibres of the ciliary body. Medication is needed to control the IOP, while surgical management only indicated in cases where medical treatment fails to control the IOP and risk of progressive visual loss. Conclusion : Angle recession can occur after blunt eye trauma with hyphema and IOP control is needed to prevent the development of secondary glaucoma.
Co-Authors Asti, Annisa Kinanti Astrid Feriza Bintoro, Ugresone Y Clevia Levana Herryawan Clevia Levana Herryawan Eddy Bagus Wasito Endang Retnowati Endang Retnowati Fitriani, Dila Nur Gatut Suhendro Hakim, Affannul Hendrian D Soebagjo Herdina Ramadhani Heriyawati, Heriyawati I'tishom, Reny Indri Wahyuni Indri Wahyuni Jamaluddin Karunika, Anindya Ramadian Komaratih, Evelyn Kusuma Eko Purwantari Luki Indriaswati Meidiana Devira Aristanti Mohamad Nurdin Zuhri Muhammad Bagas Pratista Ni Putu Ayu Reza Dhiyantari Nyilo Purnami Primitasari, Yulia Pudji Lestari Retno Handajani S.Pd. M Kes I Ketut Sudiana . Soebagjo, Hendrian D Soemitro, Sutiman B SOETJIPTO Sukoto Sukoto Sutiman B Soemitro Ugresone Y Bintoro Widyati, Dyah Ratri WINARTO Windhu Purnomo Yuliawati, Diana Zuhri, Mohamad Nurdin Zuhria, Ismi