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All Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indian Journal of Forensic Medicine & Toxicology Vision Science and Eye Health Journal Ophthalmologica Indonesiana JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Folia Medica Indonesiana
Nurwasis Nurwasis
Department Of Ophthalmology, Dr. Soetomo General Academic Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Various Corneal Foreign Body Materials Fitriani, Dila Nur; Nurwasis
Vision Science and Eye Health Journal Vol. 4 No. 1 (2024): Vision Science and Eye Health Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/vsehj.v4i1.2024.17-23

Abstract

Introduction: Cornea is an important refractive part of the eye. The corneal foreign body can disturb corneal function, depending on its material. Any materials are inert and can be retained with serial observation, while others can cause an inflammatory reaction. Purpose: To determine the effects of various foreign body materials on the cornea. Review: Corneal foreign body materials are divided into non-organic and organic materials. Organic foreign bodies (plant and insect parts) often cause severe inflammation; meanwhile, the effects of non-organic foreign bodies (metal, glass, graphite) depend on their materials. Some metals, such as iron and copper, can develop a stained deposition, disturb corneal clarity, and lead to inflammation. Other metals such as gold, silver, and platinum are almost inert and cause little or no reaction. Glass, sand, or stone is relatively inert if it is sterile. Intrastromal graphite is also inert, however, organic materials are associated with infection. Wood can lead to bacterial or fungal infection. Insect parts such as caterpillar hair can cause ophthalmia nodosa, and insect stings elicit an inflammatory response. Conclusions: Any non-organic corneal foreign bodies (gold, silver, platinum, glass, sand, stone, and graphite) may be retained safely if the removal of the foreign body results in significant scarring, which can distort the topography of the cornea. Iron, copper, and organic materials (wood and insect parts) must be removed due to their toxicity or risk of infection.
Bilateral Pigment Dispersion Syndrome (PDS) in a Young Female Patient Karunika, Anindya Ramadian; Komaratih, Evelyn; Nurwasis; Primitasari, Yulia
Vision Science and Eye Health Journal Vol. 4 No. 2 (2025): Vision Science and Eye Health Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/vsehj.v4i2.2025.55-59

Abstract

Introduction: Pigment dispersion syndrome (PDS) is characterized by pigment accumulation in the anterior chamber and a concave peripheral iris. Many PDS patients are not diagnosed until the disease has progressed to pigmentary glaucoma or other visual problems. Since glaucoma is the primary cause of permanent blindness globally, it is crucial to perform a thorough examination on patients with PDS to identify early indicators of pigmentary glaucoma (PG). Case Presentation: A 17-year-old female presented to the ophthalmology outpatient unit with eye pain and headache. The intraocular pressure (IOP) in the right eye was 30 mmHg, while in the left eye, it was 20.5 mmHg due to the peripheral iris' concavity and heavy pigmentation in the trabecular mesh in both eyes. The patient was diagnosed with pigment dispersion syndrome in both eyes and was given timolol maleate 0.5% eye drops. A follow-up examination revealed a decrease in the IOP and pain. Conclusions: Many young PDS patients go undiagnosed, and those with glaucoma are misdiagnosed as having juvenile onset glaucoma or primary open angle glaucoma. When high IOP is seen in young myopic patients, a thorough evaluation of the anterior segment is required. The patient should be aware of the progression of PG, and regular follow-up is recommended.
Pengaruh Kebiasaan Paparan Radiasi Blue Light terhadap Kelainan Refraksi Mata pada Mahasiswa Fakultas Kedokteran Universitas Airlangga angkatan 2018 Clevia Levana Herryawan; Indri Wahyuni; Pudji Lestari; Nurwasis Nurwasis
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.257

Abstract

Background: Refractive disorders are in the third rank of causes of blindness. Refractive disorders are not uncommon among medical students. Exposure to blue light from the device acts as one of the causes of refractive errors. In this modern era, medical students are often exposed to blue light from their devices in their studies. The study was conducted to see the effect of the habit of exposure to blue light radiation on refractive errors. Method: This study was an analytical study with a cross-sectional design. Determination of the research sample using total sampling technique by taking data from all students of the Faculty of Medicine, Airlangga University, class 2018. Results: Of the 83 study subjects, it was found that 62.7% were women, 37.3% were men. 16.9% were less than 19 years old, 51.8% were 19 years old, 22.9% were 20 years old and 8.4% were over 20 years old. The p value between the cylinder relationship with the eye distance to the device is 0.727. P value cylinder relationship with position 0.891. The p value of the cylinder relationship with the duration of the use of the device is 0.140. The relationship between myopia and the distance of the eye to the device obtained a p value of 0.702. The relationship between myopia and position, the p value was 0.382 and the relationship between myopia and duration was p value 0.552. Discussion: The results of this study are in line with previous studies but some are contradictory. The same results were obtained due to the use of the same method. Meanwhile, the results are conflicting due to differences in research methods and also the age of the sample. Conclusion: There is no significant relationship between the habit of exposure to blue light radiation and eye refractive error among students of the Faculty of Medicine, Airlangga University, class 2018. Keywords: Astigmatism, Blue Light, Gadget, Myopia, Radiation, Refraction Abnormalities, Refractive Error
Evaluation of KI-67, Apoptosis, and Hyaluronic Acid in Grading Retinoblastoma Soebagjo, Hendrian D; Nurwasis, Nurwasis; Bintoro, Ugresone Y; Soemitro, Sutiman B
Folia Medica Indonesiana Vol. 55, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Hyaluronic acid (HA) is a glycosaminoglycan with a straight-chain polymer arrangement defined as the extracellular matrix constituent. High molecular weight HA has normal physicochemical, biological, and physiological properties whereas low molecular weight has the property of angiogenesis, inflammation, and suppresses apoptosis. This study occupied the samples of 35 paraffin block from poorly and well differentiated retinoblastoma tissue and 8 normal retinal block which have been collected for 4 years from 2010-2013 at Dr. Soetomo Hospital, Surabaya, Indonesia. Afterwards, the paraffin blocks were immunohistochemically examined for HA staining, expression of cell proliferation (Ki-67), and cell apoptosis to determine intratumoral aggressiveness of retinoblastoma. HA on poorly differentiated retinoblastoma stain with a high immunostaining of 76.2%, while well differentiated retinoblastoma on the highest HA staining was revealed to be at moderate level of 64.3%, and not appear in normal retina. In poorly differentiated retinoblastoma, the location of most HA stain is in the cell cytoplasm (87.5%). In the well differentiated retinoblastoma, the HA immunostaning mainly occurred in the cell membrane (73.7%). Histopathological retinoblastoma grading showed a significant correlation (p <0.01) towards several variables of HA immunostaining, Ki-67, and cell apoptosis. In addition, the histopathological retinoblastoma grading also revealed a significant correlation (p <0.01) towards the location of HA staining (cell membrane and cytoplasm). Both stainings are also play role in retinoblastoma differentiation. The malignancy of retinoblastoma can be proven by the increased HA staining at cytoplasm in poorly differentiated and associated with increased of cell proliferation along with decreased apoptosis.
Difference of Heat Shock Protein 70 Serum Level Between Primary Angle Closure Glaucoma and Open Angle Glaucoma Patients: Indonesia Single Center Experience Zuhri, Mohamad Nurdin; Nurwasis, Nurwasis; Retnowati, Endang; Purnomo, Windhu
Folia Medica Indonesiana Vol. 57, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

This study aimed to analyze the differences in Hsp 70 serum levels in patients with primary angle-closure compared to patients with open-angle glaucoma at Dr. Soetomo General Academic Hospital, Surabaya, East Java. This cross-sectional study was conducted on 41 subjects divided into 2 groups consisting of 21 patients with primary angle-closure glaucoma and 20 patients with open-angle glaucoma. Anterior segment examination was assessed by slit-lamp biomicroscope examination. Intraocular pressure on both eyes was measured by Perkin's tonometry. Posterior segment examination was performed with 78 D lens and anterior chamber angle was assessed by goniolens. The serum level of Hsp 70 was assessed using a human Hsp 70 sandwich ELISA kit. The data were statistically analyzed with the Mann-Whitney test. The mean serum levels of Hsp 70 in the primary angle-closure group was 5.55  4.75 ng/ml, while the open-angle group was 3.62  2.39 ng/ml (p = 0.134). There was no difference in Hsp 70 serum levels between the two groups, although the trend obtained serum levels of Hsp 70 patients with primary angle-closure was higher compared to patients with open-angle.
The Effect of Subconjunctival Bevacizumab on Angiogenesis in Rabbit Model Nurwasis, Nurwasis; Yuliawati, Diana; Komaratih, Evelyn; Heriyawati, Heriyawati
Folia Medica Indonesiana Vol. 55, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Bone is an important organ for supports the body that stores reserve of calcium, phosphorus, and other minerals. In fracture conditions where bleeding, soft tissue edema, nerve damage, and blood vessels around the bone damage happen, they can cause the mobilization of these minerals in the surrounding tissue. One of the efforts made in the treatment of these fractures is reconnection, in which it works by filling of bone defect with a matrix and administration of anti-infection. Biomaterial filling in defective bone is thought to accelerate the healing process of bone fracture and prevent osteomyelitis. For this reason, this study evaluates the acceleration of bone fracture healing using natural hydroxyapatite (NHA) bone filler in rabbits with bone defect model. Fracture modeling was performed by surgical technique and drilling of bones with a 4.2 mm diameter to form a defect in the rabbit femur. Bone implant contained bovine hydroxyapatite-gelatin-glutaraldehyde (BHA implant) or bovine hydroxyapatite-gelatin-glutaraldehyde-gentamicin (BHA-GEN implant) that was inserted in bone defects. 27 rabbits were divided into 3 groups: the control group who had bone defect, the bone defect group was given BHA implant and the bone defect group was given BHA-GEN implant. Observation of osteoclast, osteoblast, osteocyte, BALP level, and bone morphological integrity was carried out on the 14th, 28th, and 42nd days after surgery. Histological observation of rabbit femur showed a significant difference on the number of osteoclast, osteoblast and osteocyte in all three groups. The BALP level also showed a significant difference in the group given the natural BHA bone implant compared to the control group on day 14 (p = 0.0361). Based on the result of the X-ray, there was also a better integration of rabbit femur bone in groups with the use of BHA or BHA-GEN bone implant. Thus, it can be concluded that the use of a natural BHA implant can accelerate the process of bone repair in the fracture of rabbit femur. In addition, BHA implants were compatible as a matrix for supporting the bone cell growth.
Gonioscopy in Practical Ophthalmology: A Comprehensive Review of Its Principles, Practice, and Clinical Relevance Widyati, Dyah Ratri; Primitasari, Yulia; Komaratih, Evelyn; Nurwasis
Vision Science and Eye Health Journal Vol. 5 No. 1 (2025): Vision Science and Eye Health Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/vsehj.v5i1.2025.39-45

Abstract

Introduction: Gonioscopy is a vital ophthalmic examination that enables direct visualization of the anterior chamber angle, which is primarily essential for glaucoma diagnosis and management. Despite being the gold standard, it remains underutilized in clinical practice. Purpose: This review synthesizes current knowledge on gonioscopy's principles, techniques, and clinical relevance, emphasizing its predominant role in glaucoma while acknowledging its broader diagnostic utility. Reviews: Gonioscopy allows detailed assessment of angle structures, which are crucial for distinguishing between open-angle and angle-closure glaucoma and for detecting secondary glaucomas such as neovascular or pigment dispersion glaucoma. Its dynamic indentation capability uniquely differentiates appositional angle closure from permanent synechiae, unlike static imaging modalities. The review highlights historical evolution, technique nuances, indications, and technological advancements, including digital imaging tools. Gonioscopy guides clinical decision-making by identifying angle pathology that influences interventions like laser peripheral iridotomy or surgical procedures. Challenges include operator skill requirements and patient cooperation, with underuse reported even among surgical candidates. Guidelines advocate routine gonioscopic examination for glaucoma suspects. Conclusions: Gonioscopy remains indispensable, especially in glaucoma care, providing dynamic, real-time anatomical insights that cannot be replaced by imaging alone. Improving clinical training and integration into routine practice is critical to optimize early detection, accurate diagnosis, and tailored management of glaucoma and other anterior segment disorders.
Co-Authors Asti, Annisa Kinanti Astrid Feriza Bintoro, Ugresone Y Clevia Levana Herryawan Clevia Levana Herryawan Eddy Bagus Wasito Endang Retnowati Endang Retnowati Fitriani, Dila Nur Gatut Suhendro Hakim, Affannul Hendrian D Soebagjo Herdina Ramadhani Heriyawati, Heriyawati I'tishom, Reny Indri Wahyuni Indri Wahyuni Jamaluddin Karunika, Anindya Ramadian Komaratih, Evelyn Kusuma Eko Purwantari Luki Indriaswati Meidiana Devira Aristanti Mohamad Nurdin Zuhri Muhammad Bagas Pratista Ni Putu Ayu Reza Dhiyantari Nyilo Purnami Primitasari, Yulia Pudji Lestari Retno Handajani S.Pd. M Kes I Ketut Sudiana . Soebagjo, Hendrian D Soemitro, Sutiman B SOETJIPTO Sukoto Sukoto Sutiman B Soemitro Ugresone Y Bintoro Widyati, Dyah Ratri WINARTO Windhu Purnomo Yuliawati, Diana Zuhri, Mohamad Nurdin Zuhria, Ismi