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AKTIVITAS ANTIPLASMODIUM In vitro DAN IDENTIFIKASI GOLONGAN SENYAWA DARI EKSTRAK ETANOL BATANG MANURAN (Coptosapelta tomentosa Valeton ex K.Heyne) ASAL KALIMANTAN SELATAN Arnida Arnida; Eka Rahmawaty Sahi; Sutomo Sutomo
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 2 No 2 (2017): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.024 KB) | DOI: 10.36387/jiis.v2i2.119

Abstract

Resistensi Plasmodium terhadap obat malaria mengakibatkan kegagalan pengobatan. Hal ini merupakan ancaman terlebih belum ditemukannya obat alternatif yang efektif untuk melawan resistensi.  Oleh karena itu ketersediaan antimalaria baru sangat diperlukan untuk melawan resistensi. Pencarian obat baru terus dilakukan melalui berbagai cara termasuk eksplorasi dan pengembangan bahan alam. Pemilihan bahan alam biasanya berdasarkan penggunaan secara empiris oleh masyarakat. Tanaman Manuran (Coptosapelta tomentosa Valeton ex K.Heyne) digunakan oleh masyarakat di Kotabaru Kalimantan Selatan untuk mengobati malaria. Penelitian yang dilaksanakan adalah melakukan uji aktivitas antiplasmodium in vitro dengan menentukan nilai konsentrasi penghambatan (IC50­­) dan melakukan identifikasi golongan senyawa dari ekstrak etanol batang C. tomentosa Valeton ex K.Heyne. Berdasarkan identifikasi golongan senyawa kimia dengan skrining fitokimia dan Kromatografi Lapis Tipis menunjukkan adanya senyawa flavonoid, terpenoid, saponin, tanin dan antrakuinon pada batang C. tomentosa Valeton ex K.Heyne. Ekstrak etanol batang C. tomentosa Valeton ex K.Heyne mempunyai aktivitas antiplasmodium in vitro tergolong aktif dengan IC50 45,864 ± 0,76 µg/mL.
SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN RACUN AYAM (Brucea javanica [L.] Merr.) ASAL KALIMANTAN SELATAN Sutomo Sutomo; Fahriah Fahriah; Arnida Arnida
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.647 KB) | DOI: 10.36387/jiis.v6i1.607

Abstract

Racun ayam is one of the plants which has several activities in its fruits, one of which is an antibacterial. This study aims to determine the antibacterial activity of ethanol extract of racun ayam leaves. The extraction was done by maceration method using ethanol as a solvent. Antibacterial activity assay was carried out on S. aureus, E. coli, and P. aeruginosa bacteria by disk diffusion method at the concentrations of 80, 100, and 120 ppm. The results showed that the ethanol extract of B. javanica leaves had the greatest inhibition zone on E. coli with inhibition zone diameter values ​​at 80, 100, and 120 ppm were 11.7 mm, 14.5 mm and 19.67 mm respectively. Inhibition zones in S. aureus could only be seen at 100 and 120 ppm which had inhibition zone diameters at 1.17 mm and 2.17 mm respectively, whereas in P. aeruginosa they did not have any inhibitory zone values. The results of statistical analysis showed a significance of the inhibition zone diameter values ​​of E. coli bacteria starting at 80 ppm with a sig value of 0.034. Due to a sig value was <0.05, it was categorized as significantly different from the negative control. The bacteria of S. aureus which had ​​<0.05 for sig values only found on 100 ppm and 120 ppm. Bacteria P. aeruginosa which had sig value >0.05 was not significantly different at all concentrations
Heme Polymerization Inhibitory Activity And Phytochemical Screening Of Ethyl Acetate Fraction In Manuran (Coptosapelta tomentosa Valeton ex K. Heyne) Stem Arnida; Siti Humairah Z.A; Sutomo; Fadlillahturrahmah
Jurnal Jamu Indonesia Vol. 6 No. 1 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i1.165

Abstract

The native Indonesian plant that is empirically used as an antimalarial agent is manuran (Coptosapelta tomentosa Valeton ex K. Heyne). This study aims to determine chemical compound and heme polymerization inhibitory activity of ethyl acetate fraction of C. Tomentosa stem based on IC50 value. The method identification of chemical compound used tube test, and the method of heme polymerization inhibitory activity was Basilico through in vitro method. The results of chemical compound identification of the ethyl acetate fraction of C. Tomentosa showed the presence of flavonoids, terpenoids, saponins, tannins, and anthraquinones. The average percentages of heme polymerization inhibitory activity of ethyl acetate fraction of C. Tomentosa stem from concentration 20; 10; 5; 2.5; 1.25; 0.625; 0.3125 mg / mL were 98.507; 97,872; 96,407; 93,560; 88,419; 80,680; and 45.467%.The averages of IC50 of ethyl acetate fraction and chloroquine diphosphate were 0.24 &plusmn; 0.018 mg/mL and 0.214 &plusmn; 0.012 mg/mL. This shows that the ethyl acetate fraction of C. Tomentosa stem has heme polymerization inhibitory activity. The result of the independent sample t-Test obtained the significance value of 0.111 (p more than 0.05) that there was no significant difference. It means that the ethyl acetate fraction of C. Tomentosa stem has heme polymerization inhibitory activity as well as chloroquine diphosphate. This suggests the potentiation of the methyl acetate fraction of the stem C. Tomentosa as anti-malarial.
KAJIAN FARMAKOGNOSTIK TUMBUHAN JERUJU (HYDROLEA SPINOSA L.)ASAL DESA TELUK SELONG MARTAPURA KABUPATEN BANJAR KALIMANTAN SELATAN Dyera Forestryana; Arnida Arnida; Rahmat Yunus
BORNEO JOURNAL OF PHARMASCIENTECH Vol 2 No 2 (2018): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

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Abstract

KAJIAN FARMAKOGNOSTIK TUMBUHAN JERUJU (HYDROLEA SPINOSA L.)ASAL DESA TELUK SELONG MARTAPURA KABUPATEN BANJAR KALIMANTAN SELATAN PHARMACOGNOSTIC STUDY OF JERUJU (HydroleaspinosaL.)FROM TELUK SELONG MARTAPURASOUTH BORNEO Dyera Forestryana*1 , Arnida2, Rahmat Yunus2 1STIKES Borneo Lestari, 2Universitas LambungMangkurat *dyera¬_forestryana@stikesborneolestari.com ABSTRAK Hydrolea spinosa L., dikenal dengan nama “Jeruju” di desa Teluk Selong Martapura. Daun jeruju digunakan untuk penyakit demam oleh masyarakat sekitar. Tujuan penelitian ini adalah untuk memberikan data-data yang diperoleh dari investigasi jeruju sebagai obat herbal. Parameter studi farmakognostik digunakan sebagai alat untuk melakukan identifikasi keaslian tumbuhan. Investigasi farmakognostik dilakukan pada tumbuhan yang segar, serbuk daun dan anatomi daun jeruju yang memberikan karakter makroskopik dan mikroskopik (kualitatif) serta secara kuantitatif. Anatomi daun jeruju menunjukkan adanya stomata tipe anomositic, trikoma, kristal kalsium oksalat dan serat elemen. Serbuk daun jeruju diekstrak dengan etanol menggunakan metode maserasi. Identifikasi kimia serbuk daun menunjukkan adanya alkaloid, steroid, tanin, flavanoid dan beberapa karbohidrat. Spesifikasi kuantitatif farmakognostik jeruju digambarkan dengan bahan organik asing 0,01%, abu tidak larut asam 5,30%, abu larut air 4,21 %, abu total 5,85%, kadar sari larut air 26,30 %, kadar sari larut etanol 22,26% dan susut pengeringan 15,34%. Kata kunci : Hydrolea spinosa L., jeruju, kualitatif, kuantitatif, farmakognostik
PENYULUHAN PADA IBU-IBU ANGGOTA DHARMA WANITA FMIPA ULM DALAM PENGOLAHAN BAHAN ALAM MENJADI OBAT TRADISIONAL Okta Muthia Sari; Arnida Arnida
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2022): Vol.7, No.2 (2022)
Publisher : Universitas Negeri Surabaya

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Abstract

Pengobatan secara alami menggunakan tanaman obat sedang ramai dilakukan oleh masyarakat. Namun, pengolahan obat tradisional perlu dilakukan dengan cara yang baik. Pemanfaatan bahan alam menjadi obat tradisonal, dapat dimulai dari ruang lingkup keluarga. Ibu-ibu yang tergabung dalam Dharma Wanita memiliki peran sebagai fasilitator dan  pelaksana dalam kesehatan. Tujuan kegiatan ini untuk meningkatkan pengetahuan dan minat ibu-ibu anggota Dharma Wanita FMIPA ULM terhadap teknik pengolahan dan cara pembuatan obat tradisional yang baik.  Pengabdian ini dilaksanakan secara online dengan metode penyuluhan dan penayangan video. Evaluasi dilaksanakan pada akhir kegiatan. Evaluasi dilakukan menggunakan lembar angket. Berdasarkan hasil angket, diketahui bahwa kegiatan yang telah dilakukan membantu meningkatkan pengetahuan (100%) dan minat (50%) khususnya dalam pembuatan serbuk obat tradisional dari bahan alam. Kesimpulan kegiatan ini, penyuluhan dan penayangan video membantu meningkatkan pengetahuan dan minat ibu-ibu Dharma Wanita dalam pengolahan bahan alam menjadi obat tradisional.Kata Kunci: Bahan Alam, Dharma Wanita, Obat Tradisional
PEMBERDAYAAN SANTRI YAYASAN IKHWANUL MUSLIMIN DAN WARGA DESA BATU AMPAR TENTANG PENGOLAHAN OBAT TRADISIONAL Aditya Maulana Perdana Putra; Okta Muthia Sari; Arnida Arnida
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 6, No 4 (2022): Desember
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v6i4.11328

Abstract

ABSTRAKIndonesia merupakan negara dengan keanekaragaman hayati nomor 2 tertinggi di dunia. Banyak tumbuhan di Indonesia berpotensi sebagai tanaman obat, dan sebagian besar telah di budidaya dan konsumsi oleh masyarakat. Tujuan pengabdian ini adalah memberikan penyuluhan dan pelatihan tentang pengolahan tanaman obat menjadi sediaan instan siap minum. Mitra dalam pengabdian ini adalah Yayasan Ikhwanul Muslimin dan Warga Desa Batu Ampar. Permasalahan yang dihadapi oleh mitra adalah kurangnya pengetahuan tentang cara pengolahan tanaman obat menjadi suatu produk dengan nilai ekonomis yang tinggi. Metode yang digunakan untuk menyelesaikan masalah tersebut dengan pemberian penyuluhan tentang manfaat tanaman obat dan pelatihan pembuatan produk sediaan instan temulawak. Pelaksanaan Pengabdian di Yayasan Ikhwanul Muslimin dengan 44 orang yang terdiri dari Santri dari Yayasan Ikhwanul Muslimin dan Warga Desa Batu Ampar. Evaluasi yang dilaksanakan dengan membagikan kuesioner pada akhir pelaksanaan pengabdian. Hasil akhir dari kegiatan ini adalah adanya pemahaman dan kemampuan mengenai cara pengolahan temulawak menjadi suatu sediaan yang mempunyai nilai ekonomis. Kata Kunci: penyuluhan; pelatihan; tanaman obat; temulawak ABSTRACTIndonesia is the country with the 2nd highest biodiversity in the world. Many plants in Indonesia have the potential to be medicinal plants, and most of them have been cultivated and consumed by the community. This service aims to provide counselling and training on processing medicinal plants into instant preparation product. Partners in this service are Yayasan Ikhwanul Muslimin and the Resident of Batu Ampar Village. The problem faced by partners is the lack of knowledge about how to process medicinal plants into a product with high economic value. Methods used to solve the problems by providing counselling o the benefits of medicinal plants and training on the manufacture of temulawak instant preparation products. Implementation of Service at Yayasan Ikhwanul Muslimin with 44 people consisting of santri from Yayasan Ikhwanul Muslimin and Residen of Batu Ampar Village. Evaluation carried out by distributing questionnaires at the end of the community service. The final result of this activity is an understanding and ability of how to process Temulawak into a preparation that has economic value. Keywords: counseling; training; medical plants; temulawak
Edukasi Cara Penggunaan dan Penyimpanan Obat Rumah Tangga yang Tepat di Yayasan Ikhwanul Muslimin: Health Education on The Proper Use and Storage of Household Medicines at Ikhwanul Muslimin Foundation Okta Muthia Sari; Aditya Maulana P.P; Arnida
Jurnal Pengabdian Kepada Masyarakat : Kesehatan Vol. 2 No. 4 (2022): Desember
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) STIKES Notokusumo Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (287.35 KB)

Abstract

Abstrak: Upaya pengobatan mandiri atau dikenal dengan swamedikasi relatif tinggi dilakukan oleh masyarakat Kalimantan Selatan. Perilaku pengobatan mandiri yang dilakukan oleh masyarakat rentan terjadi penggunaan dan penyimpanan obat yang tidak tepat.  Penggunaan dan penyimpanan obat secara tidak tepat berpotensi menyebabkan masalah kesehatan. Sehingga, tim pengabdian melakukan kegiatan pengabdian pemberian edukasi penggunaan dan penyimpanan obat rumah tangga. Pengabdian ini bertujuan untuk meningkatkan pengetahuan penggunaan & penyimpanan obat serta keterampilan penyimpanan obat di masyarakat. Strategi yang diaplikasikan dalam pengabdian diantaranya penyuluhan, pemutaran video dan simulasi dengan kotak obat. Lokasi pengabdian di Yayasan Ikhwanul Muslimin Desa Batu Ampar Kecamatan Cempaka Kota Banjarbaru Kalimantan Selatan pada 6 Agustus 2022. Evaluasi kegiatan melalui mengukur pengetahuan (pretest-postest) menggunakan kuesioner dan mengamati simulasi praktek. Partisipan dalam pengabdian sebanyak 33 orang. Pengetahuan responden meningkat dari 7,24±1,25 (pretest) menjadi sebesar 9,36±0,89 (posttest) sesudah pemberian edukasi. Adapun hasil pengamatan simulasi menunjukkan semua partisipan mampu mempraktekkan penyimpanan obat dengan tepat berdasarkan cara penggunaan dan indikasi obat. Kegiatan pengabdian perlu dilaksanakan secara terstruktur dan berkelanjutan dengan target sasaran yang lebih luas.   Abstract: Self-medication is widely practiced in South Kalimantan. Self-medication is widely practiced in South Kalimantan. Self-medication behavior increases the likelihood of inappropriate drug use and storage. Improper drug use and storage has the potential to cause health issues. As a result, the service team performs community service by educating people about the proper use and storage of household medications. This service aims to increase community knowledge of drug use and storage, as well as drug storage skills. Counseling, video and medicine box simulations were used in this study. On August 6, 2022, the activity was held at Ikhwanul Muslimin Foundation, Batu Ampar Village, Cempaka District, Banjarbaru City, South Kalimantan. Activities are evaluated by measuring knowledge with questionnaires and observing practical simulations.There were 33 people who took part in the service. The evaluation results showed that after education, the average pretest knowledge score increased from 7.24 1.25 to 9.36 0.89 in the posttest. The simulation observations revealed that all participants could practice proper drug storage. Community service must be structured and sustainable in order to reach a larger target audience.
Simplicia and Extracts Standardization from Jualing Leaves (Micromelum minutum Wight & Arn.) from South Kalimantan Sutomo Sutomo; Herwina Dita Lestari; Arnida Arnida; Agung Sriyono
Borneo Journal of Pharmacy Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i2.898

Abstract

Jualing (Micromelum minutum Wight & Arn.) is a plant from South Kalimantan that has the potential to be developed as natural medicine. This study aims to establish standardization which includes specific and non-specific parameters of M. minutum leaf simplicia and extracts from three growing locations, namely Banua Botanical Garden, Sultan Adam Forest Park, and Forest Areas with Specific Objects of Rantau, South Kalimantan. The method of setting standardization parameters refers to the Indonesian Herbal Pharmacopoeia and General Standard Extracts Parameters. Organoleptic standardization of simplicia is brownish-green, has a distinctive odor, has a bitter and slightly spicy taste. Microscopic observations showed the presence of stomata, cell walls, cytoplasm, calcium oxalate crystals, upper epidermis, palisade tissue, spongy tissue, cortex, xylem, phloem, lower epidermis, and trichomes. Water content test showed the results of 21.9-22.07%; ethanol extract content of 12.87-13.17%; drying losses 4.64-4.84%; total ash content of 6.04-6.14%; acid insoluble ash content 1.13-1.19%; Pb levels of 0.022-0.025 mg/kg; Cd levels of 0.017-0.020 mg/kg; and Hg levels <0.0004 mg/kg. Extract standardization shows thick green-black, thick-smelling extract and bitter taste. Micromelum minutum leaves contain alkaloids, flavonoids, saponins, terpenoids, tannins, anthraquinones, phenols, and glycosides. Thin Layer Chromatography profiles show the similarity of chemical compounds in each growth location. Other parameters are extract yield of 8.08-8.32%; moisture content of 6.07-6.27%; total ash content of 4.22-4.27%; and acid insoluble ash content 1.11-1.12%. All standardization parameters meet the requirements in the Media Materia Indonesia and the Republic of Indonesia Drug and Food Control Center.
Pharmacognostic Study and Antioxidant Activity of Mundar (Garcinia forbesii King.) leaves from Banua Botanical Gardens of South Kalimantan Sutomo Sutomo; Dina Noor Kamali; Arnida Arnida; Normaidah Normaidah; Agung Sriyono
Borneo Journal of Pharmacy Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i4.1541

Abstract

Mundar (Garcinia forbesii King.) is a plant from South Kalimantan. This plant has chemical contents that have potential as medicine. The purpose of this study is to provide a pharmacognostic picture of a specific, nonspecific and determine the antioxidant activity of G. forbesii leaves. Specific parameters include organoleptic, microscopic testing, thin-layer chromatography profiles, and phytochemical screening. Nonspecific parameters include total ash content, acid insoluble ash content, drying loss, water-soluble extract content, and ethanol-soluble extract content. Antioxidant activity was determined by the DPPH method based on IC50 values. Specific parameter test results are green powder, characteristic odor, and sour taste. Microscopic tests showed stomata, upper epidermis, lower epidermis, cell walls, xylem, phloem, palisade tissue, spongy tissue, and cuticles. Garcinia forbesii leaves contain alkaloids, flavonoids, phenols, tannins, and steroids. The TLC profile showed good separation of polar eluents, and yellow spots appeared after spraying DPPH reagents. The non-specific parameter test is the total ash content of 6.52±0.1%; acid insoluble ash content 1.06±0.08%; drying shrinkage 6.43±0.38%; water-soluble extracts 34.3±0.3%; and ethanol-soluble extracts 23.47±0.35%. Ethanol extract of G. forbesii leaves has antioxidant activity with IC50 of 65.7 ppm. Pharmacognostic study fulfills the requirements, and G. forbesii leaves extract has strong antioxidant activity.
Ethnobotanical Study and Phytochemical Screening of Medicinal Plants Used by Local People in Belangian Village, South Kalimantan Sutomo Sutomo; Vita Vitriana Awaliyah; Arnida Arnida
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2717

Abstract

The local people of Belangian Village are people of the Banjar ethnic group who utilize plants in the surrounding environment for medicinal purposes. This study aims to determine the number of plants, parts of plants that can be used, methods of application, methods of preparation, and phytochemical screening of plants with medicinal properties in Belangian Village. This study employed the descriptive-explorative method. The technique used for data collection was an interview with a semi-structured questionnaire. Respondents of this study were “Pananamba” who were selected by using the Purposive sampling technique. Phytochemical screening was carried out on plants with no previously known scientific names and which had never been tested before. The results showed 17 families and 31 species of plants with medicinal properties. Empirically, the plants were used as medicines for cough, bloody urine, diabetes, cancer, sprue, ulcer, hypertension, skin diseases, nausea, diarrhea, coronary heart disease, sinusitis, kidney stones, cleansing kidneys, menstrual pain, itchy eyes, paralysis, bone pain, increasing stamina, antibiotic, reducing body odor, wounds, bleeding, worm diseases, increasing appetite, boosting the immune system, and yellow fever. The most frequently used part of the plants were the leaves (45%), the most widely used method of preparation was boiling (52%), the most commonly used method of application was by drinking (81%). Phytochemical screening was conducted on three plants: Asam daun, Lukun, and Ulur-ulur. The results of phytochemical screening revealed the presence of quinones, saponins, and terpenoids in Asam daun, saponins in Lukun, and terpenoids in Ulur-ulur.