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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Berkala Epidemiologi Jurnal Farmasi Klinik Indonesia Pharmacon Sinkron : Jurnal dan Penelitian Teknik Informatika Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JFIOnline Jurnal Kesehatan Jurnal EduHealth PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Endang Darmawan
Fakultas Farmasi Universitas Ahmad Dahlan, Jl. Prof. Dr. Soepomo S.H., Janturan Umbulharjo, Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)

 1 
THE COMPARISON OF THE EFFICACY OF CEFTRIAXONE AND COMBINATION OF AMPICILLIN-CHLORAMPHENICOL OF CHILDREN WITH PNEUMONIA OF PKU MUHAMMADIYAH HOSPITAL IN BANTUL Astuti Wulandari, Nur; Darmawan, Endang; Umam Kurniawan, Nurcholid
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 1 (2022): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (419.083 KB) | DOI: 10.55047/comorbid.v1i1.56

Abstract

Pneumonia is an infectious disease that occurs in the lungs caused by various microorganisms. Patients of children with pneumonia in Indonesia experienced an increase in 2013. Antibiotics therapy is the main therapy for patients with pneumonia. This study aims to compare of the efficacy of ceftriaxone and combination of ampicillin-chloramphenicol of children with pneumonia of PKU Muhammadiyah hospital in Bantul. The study design was a randomized controlled trial with prospective Open trial do in March 2018 to June 2018. The outcomes used were tightness, cough, retraction, temperature, respiration rate, and length of stay. Research data were analyzed using Chi Square test, Fisher test, independent t test and Mann Whitney test. The results of the study of ceftriaxone (n=26) and ampicillin chloramphenicol groups (n=26) showed that the percentage of patients who had not experienced tightness was 82.7%, not cough 7.7%, and there was no retraction of 76.9% with p<0.05. The mean ±SD temperature of the ceftriaxone group was 36.5±0.12 and the ampicillin chloramphenicol group was 36.57±0.09 with a p<0.05. The mea n±SD respiration rate of the ceftriaxone group was 27.9±3.22 and the ampicillin chloramphenicol group was 27.92±2.62 with a p <0.05. The mean ±SD length of stay in the ceftriaxone group was 4.5±0.81 and the ampicillin chloramphenicol group was 4.26±0.66 with a p<0.05. Conclusions showed that there was no significant difference between the effectiveness of ceftriaxone and ampicillin chloramphenicol on fever, spasms, cough, retraction, temperature, respiration rate and length of stay.
EVALUATION OF THE SECURITY OF THE USE OF GUAJAVA PSIDIUM EXTRACT CAPSULE ON HEART FUNCTION IN DENGUE FEVER AND DENGUE HEMORAGIC FEVER PATIENTS IN TYPE C HOSPITAL Agamasi, Amalia; Darmawan, Endang; Akrom
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 1 (2022): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.691 KB) | DOI: 10.55047/comorbid.v1i1.64

Abstract

There are 126,675 DHF sufferers in 34 provinces and 1,229 of them died, while the Incidence Rate (IR) in Central Java is 47.9 per 100,000 population. Based on the safety of Psidium guajava Linn on the liver by calculating the lethal dose average showed that there were no deaths from the two experimental models of Swiss mice and Wistar mice in the dose range up to 2,000 mg/kg BB. Safety tests in rats proved lethal dose 50 (LD50) of guava leaf extract more than 5 g/kg. This study aims to determine the effect of psidii capsules containing guava leaf extract (Psidium guajava Linn.) toward levels (SGOT and SGPT) of DF and DHF patients in PKU Muhammadiyah Wonosobo Hospital. This study belongs to perspective cohort analytic observational using blood plasma patients of PKU Muhammadiyah Wonosobo Hospital of 37 patients in the period of March to August 2018 which were divided into two groups, namely standard therapy + guava leaf extract capsules and the group receiving standard therapy only. Dosage of Psidium guajava 3x2 capsules for 3 to 4 days. Examination of SGOT and SGPT levels used UV-vis spectrophotometry. General linear model was used for analyzing the data. The average SGOT level after treatment was 64 U/L in DF and 99 at DHF while the SGPT levels were 30 U/L and 35 U/L. Average levels of SGOT and SGPT decreased. There were no differences in SGOT and SGPT mean of DF and DHF patients in the two groups after giving guava leaf extract capsules with p>0.05. In SGOT mean, there was an increase in SGOT after giving guava leaf extract probably because there were patients who had chronic liver disorders. Keywords: Dengue Fever, Dengue Hemorrhagic Fever, Guava extract capsule, SGOT SGPT
THE INCREASED RISK OF RANDOM BLOOD GLUCOSE, BODY MASS INDEX AND ABDOMINAL CIRCUMFERENCE IN THE SCHIZOPHRENIC PATIENTS USING CLOZAPINE AND QUETIAPINE Hidayah, Lailatul; Darmawan, Endang; Yuliani, Santi
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 1 (2022): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.85 KB) | DOI: 10.55047/comorbid.v1i1.67

Abstract

The use of atypical antipsychotics often causes an increase in blood glucose levels, body mass index (BMI) and abdominal circumference. This study aims to identify the increased risk of random blood glucose, BMI and abdominal circumference in the schizophrenic patients using clozapine and quetiapine. This cohort study involved 35 schizophrenic patients (19 patients used clozapine and 16 patients used quetiapine). The measurement of random blood glucose BMI and abdominal circumference was done in the zero month, the first month and the second month. The average of random blood glucose, BMI and abdominal circumference were analyzed using Wilcoxon and Chi-square. In the use of clozapine, there is a significant increase in the average of random blood glucose between the first month and the second month (p=0.1) with the difference of 6.37 mg/dl, there is an increase average in BMI between the first month and the second month (p=0.03) with the difference of 0.18 kg/m² and an average increase in abdominal circumference between the zero month and the first month (p=0.04) with the difference of 1.47 cm, between the first month and the second month (p=0.02) with the difference of 1.94 cm. In the use of quetiapine, a significant increase in abdominal circumference between the first month and the second month (p=0.02) with the difference 1.38 cm. The use of clozapine has more risk in increasing random blood glucose (OR 2.00: CI 95% 0.41-9.76), BMI (OR 2.78: CI 95% 0.69-11.10) and abdominal circumference (OR 3.61: CI 95% 0.89-14.64) compared to the use of quetiapine. The use of clozapine has more risk in increasing blood glucose, BMI and abdominal circumference compared to the use of quetiapine.
THE FUNCTION OF RECOMMENDATION OF A PHARMACISTS IN REDUCE PIMs (POTENTIALLY INAPPROPRIATE MEDICATIONS) OF GERIATRIC PATIENTS AT THE GENERAL HOSPITAL DR. MOEWARDI SURAKARTA Dewi Isnaini, Ratna; Darmawan, Endang; Yovita Dewi, Fransiska
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 2 (2022): APRIL
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v1i2.81

Abstract

The prevalence of potentially inappropriate medications (PIMs) is quite high in geriatric patients. PIMs can be detected using an explicit prescription indicator (a criterion). Explicit criteria that can be used in the identification of PIMs in geriatric patients include: BEERS Criteria, STOPP Criteria, and START Criteria. This study aims to analyze drugs included in the PIMs category based on BEERS Criteria, STOPP Criteria, and START Criteria. This research is a semi-experimental study (intervening in the form of giving recommendations) with prospective data collection in the geriatric ward of Regional General Hospital Dr. Moewardi Surakarta in the period from October 2019 to January 2020. The results showed that out of 70 patients, there were 47 PIMs, PIMs based on BEERS Criteria for 20 patients (28.6%), PIMs based on STOPP Criteria for 10 patients (14.3%) and PIMs based on START Criteria for 17 patients (24.3%). Bivariate analysis showed that there was a relationship between the incidence of adverse drug events (ADEs), with recommendations that were followed up on PIMs based on BEERS Criteria with an RR value of 25 (95% CI 1,2: 520,7), P = 0.04 and PIMs based on START Criteria with an RR value of 5 (95% CI 1: 35.9), P = 0.04, whereas the results of the bivariate analysis on PIMs based on STOPP Criteria showed that there was no relationship between the incidence of ADEs with the recommendations that were followed up with a RR value of 4 (95% CI 0.13: 119.2), P = 0.50. Based on the results of univariate and bivariate statistical analysis, it can be concluded that there are still many incidents of PIMs based on BEERs Criteria, STOPP Criteria, and START Criteria and pharmacists have an important function to reduce PIMs so that the incidence of ESO due to PIMs can be minimized in the regional general hospital Dr. Moewardi Surakarta.
Co-Authors Agamasi, Amalia Akrom, Akrom Ananda Muhammad Naafi, Ananda Muhammad Anastasya, Yolanda Andi Namirah Muh. Syuaib AS, Andi Angella, Widi Anggriani, Hesti Annisa Hardikasari Yazin, Annisa Hardikasari Anovia, Rizka Angerti Anwar Sodik, Anwar Ardyati, Sulistia Astuti Wulandari, Nur Dewi Indah Sari, Dewi Indah Dewi Isnaini, Ratna Dyah Aryani Perwitasari Evi Mulyani Fahrian Hipmi, Ahmad Farida Baroroh, Farida Grin Fariah Handayani, Eka Wuri Hariadi Wijaya, Made Insani, Pratamasari Noor Iskak, Iskak Jamhari Jamhari Jastria Pusmarani Kurniati, Tripeni Kurniawan, Nurcholid U. Kurniawan, Nurcholid Umam Kusumawati, Leny Witaning Lailatul Hidayah Maulida, Nuril Meki Pranata Mustofa Mustofa Noerhidayati, Elly Nur Rahmatiya Abas, Siti Nurul Hanifah Pramono, Muji Ramdani, Dewi Riza Alfian Rizky Budi Santoso RR. Ella Evrita Hestiandari Santi Yuliani, Santi Saputri, Ginanjar Zukhruf Sri Mulyaningsih Sri Sulistyorini Sugiyarto Sugiyarto Sugiyarto Surono, Sugiyarto Suyandra Sah Putra, Suyandra Ulfa Ismayani, Ulfa Umam Kurniawan, Nurcholid Uswatun Hasanah Woro Supadmi Yovita Dewi, Fransiska