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INTRODUCTION TO DIABETES MELLITUS RISK FACTORS AS AN EARLY PREVENTION EFFORT AND UNDERSTANDING OF DIABETES AT ARROHYATI ORPHANAGE SURABAYA Choirotussanijjah; Renny Novi Puspitasari; Ratna Sofaria Munir; Muh. Nabil; Nesha Cantika Amalia; Malva Rania Jasmine
Community Service Journal of Indonesia Vol. 8 No. 1 (2026): Community Service Journal of Indonesia
Publisher : Institute for Research and Community Service, Health Polytechnic of Kerta Cendekia, Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36720/csji.v8i1.853

Abstract

Diabetes mellitus is a chronic metabolic disease whose prevalence continues to rise globally, including in Indonesia, and is often triggered by unhealthy lifestyle habits starting from a young age. Early prevention efforts through education about risk factors are crucial to reducing future incidence. This community service activity aimed to improve the knowledge of children and adolescents at Arrohyati Orphanage regarding diabetes mellitus risk factors. The method used was health education delivered through interactive lectures, discussions, and Q&A sessions. Knowledge evaluation was conducted through pre-test and post-test assessments. There were 16 participants with diverse characteristics, consisting of 9 females and 7 males, aged 6–18 years, with educational levels ranging from kindergarten to senior high school. The results showed an improvement in participants' understanding after the educational intervention. In the pre- test, 7 participants were categorized as having good knowledge, 4 were in the fair category, and 5 were in the poor category. After the educational session, the number of participants with good knowledge increased to 9, while fair and poor categories decreased to 3 and 4, respectively. These findings indicate a positive shift towards better understanding. The discussion confirms that health education significantly contributes to improving knowledge among children and adolescents, although repetition and environmental support are required to sustain the outcomes. In conclusion, education on diabetes mellitus risk factors effectively enhanced participants' understanding, and follow-up actions such as monitoring and caregiver involvement are needed to reinforce healthy lifestyle practices.
Effects of Ethanol Extract of Rosa damascene on HbA1c Level and NF-κB Expression in Diabetic Rats Choirotussanijjah Choirotussanijjah; Harianto Notopuro; Ema Qurnianingsih
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 3 No 2 (2021): Molecule analysis to advance laboratory diagnosis
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v3i2.2151

Abstract

Diabetes mellitus (DM) is a chronic hyperglycemic that can cause complications in several organs. It could lead glycosylated hemoglobin or HbA1c formation which has ability undergo further changes into Advanced Glycation End Products (AGEs) and stimulate activation of transcription factors such as nuclear factor kappa B (NF-κB). Some studies showed that anthocyanin has antioxidant and anti-inflammatory activity and it has been found Rosa damascene contain high level of anthocyanin. Total anthocyanin content was 0.459 ± 0.003 mg/L. The aim of this study was to investigate inhibitory effect of R. damascena extract on HbA1c levels and NF-κB activation in diabetic rats. Male wistar rats (n=24) were divided into 6 groups as normal control (KN), streptozotocin-induced diabetic control (KP), diabetic treated with R. damascene (P1, P2, P3; 250, 500 and 1000 mg/kg/d respectively) and diabetic treated with metformin (KM; 500 mg/kg/d). This was carried out for 28 days. The inhibition mode of R. damascene extract was examined by measuring HbA1c levels and expression of NFκB by immunohistochemistry. The results showed p values ​​> 0.05 for HbA1c and p < 0.05 for NFκB. From immunohistochemical staining, it seen the expression of NFκB was low in treated group (P1, P2, P3 and KM) compared with KP. Thus, oral administration of R. damascene extract for 28 days could not reduce HbA1c levels, but can supress NFκB expression.