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All Journal International Journal of Public Health Science (IJPHS) Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kesehatan Masyarakat Indonesia Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kesehatan Lingkungan indonesia e-Journal Pustaka Kesehatan Jurnal Anestesi Perioperatif Journal of Agromedicine and Medical Sciences Majalah Kedokteran Sriwijaya Universa Medicina Paediatrica Indonesiana Medical Laboratory Technology Journal NurseLine Journal Smart Medical Journal Jurnal Kesehatan Prima Indonesian Journal for Health Sciences (IJHS) SRIWIJAYA JOURNAL OF MEDICINE Majalah Kedokteran Andalas Journal of Health Sciences JHECDs: Journal of Health Epidemiology and Communicable Diseases Jurnal Respirasi (JR) Medical and Health Science Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan
M. Ali Shodikin
Departemen Mikrobiologi Fakultas Kedokteran Universitas Jember, Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Medical Laboratory Technology Journal

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Increased levels of IL-4 in the Spleen of BALB/c Mice after 65.5 kDa Pili Protein Klebsiella pneumoniae Immunization Putra Uta, Diego Rafi; Mufida, Diana Chusna; Sutejo, Ika Rahmawati; Agustina, Dini; Suswati, Enny; Shodikin, Muhammad Ali
Medical Laboratory Technology Journal Vol. 10 No. 1 (2024): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i1.575

Abstract

Pneumonia is an infection of the lung parenchyma caused by Klebsiella pneumoniae, resulting in a high mortality rate of millions each year. To reduce these deaths, one potential solution is to create a vaccine that utilizes virulence factors of this microorganism, such as pili. During the early phase of infection, these antigens have a crucial role and can stimulate the production of memory b cells. These cells are activated by IL-4 (interleukin-4) in lymphoid organs, such as the spleen. Pathogen exposure such as virulence factors can stimulate the secretion of IL-4 in the spleen organ. This study aims to investigate the role of Klebsiella pneumoniae pili in this process. The research conducted from May to December 2023 at the Microbiology Laboratory, Faculty of Medicine, University of Jember was purely experimental, using Balb/c mice with IL-4 levels in the spleen organ as variables. The study used 15 mice, divided into control (K1), adjuvant (K2), and antigen (K3) groups. The research data were analyzed using non-parametric tests, specifically the Kruskal-Wallis and Post Hoc tests. The Kruskal-Wallis test revealed significant differences (p=0.003). In the Post Hoc test, a significant difference was found between the control and antigen groups (p=0.002). The results conclusively demonstrate that induction of Klebsiella pneumoniae pili protein 65.5 kDa significantly increases IL-4 levels in the spleen. Future studies should consider adding serum specimens to provide additional information.
Co-Authors Achmad Ma'ruf Fauzi Adelia Handoko Adilah Julinar Irianti Agustin, Aisyiyah Alviana Ainindya Pasca Rachmadiani Aisyiyah Alviana Agustin Anaditya Wahyu Kumudhaningsih Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Annisa Nadhifa Witanto Bagus Hermansyah Bellynda, Wynne Billy Jusup Kurniawan Cholis Abrori, Cholis Cicih Komariah Desi Dwi Wisudanti Desie Dwi Wisudanti Diana Chusna Mufida Dina Luthfiyah Dini Agustina Dissa Yulianita Suryani Dita Diana Parti Dwita Aryadina Dwita Aryadina Rachmawati Ekvan Danang Setya Pramudito Ellen Ocktavironita Elvia Rahmi Marga Putri ENNY SUSWATI Erfan Efendi Eva Deswinta Maharani Firman Pratama Andraputra Gianevan, Nicholas Jirezra Hadi Khoiruddin, Mukhammad Arif Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Inke Kusumastuti Irawan Fajar Kusuma Kristianningrum Dian Sofiana Kurnia Elka Vidyarni Laila Rizqi Kurniawati Lailatis Shofia Marchianti, Ancah C N Muhammad Alif Taryafi Nexia Nevarachell Onny Amirsyah Nisrina Salsabila Firmansyah Nurlaila Ayu Purwaningsih Oessi Salsabila Pradewi, Ranny Tandria Pramono, Anang Putra Uta, Diego Rafi Putri Prameswari Nastiti Ayu Qintar Layallia Faza Rahami, Nahla Ahmad Ramadhanty, Mira Haninda Renny Suwarniaty Rini Riyanti Rosita Dewi Rumastika, Nindya Shinta Safitri, Athiyah Naura Saputra, Antonius Dwi Semita, I Nyoman Sheilla Rachmania, Sheilla Shofia, Lailatis Sudarmanto, Yohanes Susanto Nugroho Tohari, Achmad Ilham Tsintani Nur Aristiana Wahidah Nur Indasyah Widhiasari Normaningtyas Wiwien Sugih Utami Wiwin Sugih Utami Yasmin Auralia Putri Yudha Nurdian Yuli Hermansyah Yuli Hermansyah Yuli Hermansyah, Yuli Yuli Lusiana Sari Yunita Armiyanti