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All Journal Majalah Obstetri dan Ginekologi Majalah Kedokteran Nusantara The Journal Of Medical School Sumatera Medical Journal Narra J Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Deri Edianto
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Sumatera Medical Journal

 1 
VEGF and Cervical Cancer Stage IB – IIA Response after Chemotherapy with Ifosfamide – Cisplatin Edianto, Deri
Sumatera Medical Journal Vol. 2 No. 3 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (467.107 KB) | DOI: 10.32734/sumej.v2i3.1231

Abstract

The aim of this study is to evaluate response of cervical cancer stage IB – IIA after neoadjuvant chemotherapy based on VEGF expression. The data were collected from 51 patients’ cervical cancer stage IB – IIA parafin blocks who received chemotherapy ifosfamide – cisplatin before radical hysterectomy at General Hospital Adam Malik Medan. VEGF expression was evaluated from cervical biopsy tissue, and response therapy was evaluated based on tumor size clinically. 20 out of 51 samples with clinically complete response, and the rest are partial response. 18 out of 20 samples with clinically complete response have negative or weak VEGF expression, and 31 out of 51 samples patients were partialy response with moderate or strong VEGF expression. 23 cases with tumor size > 4 cm and 23 cases stage IIA expressed VEGF moderately or strong. Cervical cancer with tumor size < 4 cm and cervical cenncer stage IB with less expressed of VEGF have good response with chemotherapy adjuvant ifosfamide – cis platin.Keyword: ifosfamide-cisplatin, cervical cancer, VEGF
Review Article: Characteristics of Ovarian Cancer Across Age, Epithelial Histopathology, and Stages Laksmi, Subhika; Rivany, Riza; Edianto, Deri; Rifsal Siregar, Denny
Sumatera Medical Journal Vol. 7 No. 1 (2024): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v7i1.5651

Abstract

Background: Ovarian cancer is a disease that has a high mortality rate, it has 185 thousand deaths in 2018. In Indonesia, it is estimated that there are 100 cancer patients per 100 thousand people. Ovarian cancer is a malignancy with no specific symptoms, as a result advanced stage is commonly found at diagnosis and there is no effective screening test to date. However, genetic factors have been found to play a role in this disease. Aims: The aim of this study is to find out the characteristics of ovarian cancer patients. Methods: This research uses a review article research design, with a narrative type. Data collection was taken from a collection of journals sourced from Pubmed and met the inclusion and exclusion criteria set by the author and then summarized. Six journals that included the characteristics of  ovarian cancer patients are included in this review article. Results: According to the six journals, the mean age is 54 years old, the most stage found is stage 3, and the most epithelial histopathology found is serous. Conclusion: According to the six journals that were reviewed, the characteristics of ovarian cancer patients based on age, stage, and epithelial histopathology were found to be consistent with the theory that has been established.
Co-Authors Albert Fiorentino Cuwardy Aswar Aboet Ayodhia P. Pasaribu, Ayodhia P. David Luther Dwi Faradina Emil Taufik Fahdhy, Muhammad Hasibuan, Reni H. Inriani, Vega Laksmi, Subhika Letta Sari Lintang Lintang, Letta S. Lubis, Inke ND. M Oky Prabudi M. F. Aziz M. Khuwailid M. Wahyu Wibowo Makmur Sitepu, Makmur Ninong Ade Putri Olga R. Siregar, Olga R. Pakpahan, Patrick R. Haryono Roeshadi Rifsal Siregar, Denny Rina Amelia RIZA RIVANY, RIZA Rusda, Muhammad Sanusi Piliang Sari Dewi, Mega Sarma Lumbanaja Sarma Lumbanraja Siregar, Muhammad FG. Sukatendel, Khairani Ugrasena, I DG. Wahyuni, Arlinda S. Yustin Simanjuntak, Roy