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dharmayanti, luky dharmayanti
Sekolah Tinggi Kesehatan Al-Fatah Bengkulu
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Uji Aktivitas Antibakteri Penyebab Jerawat Propionibacterium acnes Menggunakan Ekstrak Etanol 96% Buah Kupa (Syzygium polycephalum) Dharmayanti, Luky; Gina Lestari; Ariesa Oktamauri
Jurnal Vokasi Kesehatan Vol 4 No 1 (2025)
Publisher : Gayaku Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/juvokes.v4i1.1389

Abstract

Buah kupa (Syzygium polysphalum) merupakan tanaman dalam genus Syzygium, umumnya digunakan sebagai analgesik, antijamur, antiinflamasi, dan antipiretik. Zat metabolit sekunder seperti alkaloid, flavonoid, dan tanin ditemukan dalam buah kupa, di mana molekul flavonoid ini memiliki sifat antimikroba. Tujuan penelitian ini adalah menentukan efikasi antibakteri ekstrak buah kupa terhadap bakteri Propionibacterium acnes. Ekstrak buah kupa diperiksa sifat antibakterinya terhadap bakteri Propionibacterium acnes pada berbagai konsentrasi ekstrak, yaitu 2,5%, 5%, dan 7,5%. Cakram kertas dan metode difusi digunakan dalam uji aktivitas antibakteri. Temuan penelitian menunjukkan bahwa ekstrak buah kupa menunjukkan aktivitas antibakteri terhadap bakteri Propionibacterium acnes. 6,5% menghambat bakteri dengan diameter zona hambat 10,8 mm dengan kategori sedang, 7,5% menghambat bakteri dengan diameter zona hambat 11,9 mm dengan kategori sedang, dan 2,5% menghambat pertumbuhan bakteri sebesar 9,46 mm dengan kategori lemah. Pada konsentrasi 7,5%, bahan aktif dalam ekstrak buah kupa lebih poten dibandingkan 2,5% dan 5%, sehingga menjadikannya konsentrasi optimal untuk menghentikan pembentukan bakteri Propionibacterium acnes.
DAMPAK KONSELING FARMASIS TERHADAP LUARAN TERAPI PASIEN DIABETES MELITUS : TINJAUAN LITERATUR Oktamauri, Ariesa; Dharmayanti, Luky; Sulita, Herlin; Afriyani, Neti
JFM (Jurnal Farmasi Malahayati) Vol 8, No 2 (2025)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v8i2.21390

Abstract

Diabetes Melitus (DM) merupakan masalah kesehatan global yang prevalensinya terus meningkat secara signifikan. Komorbiditas pada pasien DM meningkatkan risiko polifarmasi dan Masalah Terkait Obat (MTO). Intervensi farmasis berperan penting untuk mengoptimalkan luaran terapi. Tinjauan ini bertujuan untuk mengidentifikasi jenis-jenis intervensi farmasis terkini pada pasien DM serta mengevaluasi dampaknya terhadap berbagai luaran terapi. Penelusuran literatur dilakukan pada basis data Sciencedirect, SAGE, dan Cochrane menggunakan pendekatan PICO. Artikel yang disertakan adalah riset original berbahasa inggris yang dipublikasikan antara tahun 2021–2025, dengan desain uji klinis acak atau kuantitatif prospektif. Sebanyak 10 artikel diikutsertakan dalam tinjauan ini. Jenis intervensi farmasis yang ditemukan meliputi konseling tatap muka, booklet, video edukatif, maupun pendekatan multifaktorial dan pendekatan kelompok, menunjukkan peningkatan signifikan dalam kepatuhan pengobatan pasien, penurunan kadar HbA1c, glukosa darah puasa, serta perbaikan parameter lipid. Aspek psikososial seperti persepsi pasien dan kepuasan terhadap layanan juga menunjukkan peningkatan. Intervensi farmasis memberikan kontribusi signifikan terhadap pengelolaan DM secara klinis dan holistik. Penyesuaian intervensi berdasarkan kebutuhan individu serta integrasi media edukasi yang adaptif perlu dipertimbangkan dalam pengembangan strategi manajemen diabetes yang lebih efektif dan berbasis bukti.
Effect of Kupa Fruit Extract Concentration (Syzygium polycephalum) on Decreasing Blood Sugar Levels of Alloxan-Induced Male Mice (Mus musculus) Dharmayanti, Luky; Novia, Devi; Sella, Arinda Tri Pramay
SINTA Journal (Science, Technology, and Agricultural) Vol. 5 No. 1 (2024)
Publisher : Perkumpulan Dosen Muda (PDM) Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37638/sinta.5.1.93-100

Abstract

Kupa fruit is a rare fruit that has a blackish purple color which has antioxidant potential, in vitro research is supported by the high levels of antioxidants and vitamin C in kupa fruit so that it can reduce blood sugar levels. Syzygium polycephalum is a plant that contains flavonoids so it has pharmacological potential as an antidiabetic, because it contains flavonoid compounds which can be used as antidiabetic prevention. This research aims to find out how effective Kupa fruit extract is and determine the right dose to reduce minimum blood sugar levels in mice that have been induced by alloxan. The research used an alloxan-induced testing method. There were 30 mice grouped into 6 treatments including normal control group mice, negative group mice, positive control mice, kupa fruit extract at a dose of 500 mg/Kg BW, fruit extract at a dose of 750 mg/kg BW and fruit extract at a dose of 1000 mg/Kg BW. The inducer to increase blood sugar levels in mice was Aloxan monohydrate using a dose of 150 Mg/KgBW using the intraperitoneal route of administration. The extract was administered for 14 days, the blood sugar levels of H0, H7 and H14 were measured using a glucotest strip (Easy Touch GCU) by taking samples from mice whose blood was taken through the tail of the lateral vein. Analysis of Results Through the SPSS One Way Anova test, the test was continued with a confidence level of 95% (p<0.05) using Posct Hoc. The results of the research were that there was a change in effect, namely a decrease in blood sugar levels in mice treated with extract from kupa fruit and the most effective dose was a decrease in blood sugar levels in mice, namely a dose of 1000 Mg/KgBW, followed by a dose of kupa fruit extract of 750 Mg/KgBW and finally with a dose of 500 Mg/KgBB.
Overview of Prescription Administration Screening for Antihypertensive Drugs at Pharmacy X in Bengkulu City Lestari, Gina; Dharmayanti, Luky
SINTA Journal (Science, Technology, and Agricultural) Vol. 5 No. 1 (2024)
Publisher : Perkumpulan Dosen Muda (PDM) Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37638/sinta.5.1.55-58

Abstract

Prescription screening is an activity carried out by pharmacists in reviewing the completeness of prescriptions administratively, pharmaceutically and clinically before the drug is prepared. This activity is carried out to avoid medication errors in patients which can result in the patient not achieving drug therapy. The aim of this study was to determine the administration screening of antihypertensive prescriptions at one of the pharmacies in the city of Bengkulu. This research is descriptive observational in nature and data collection and retrieval was carried out using a retrospective method where data was taken on prescriptions in 2023. The number of antihypertensive prescriptions obtained was 97 pieces. The research results were obtained from patient data, namely (name 100%, age 35%, gender 71%, weight 0%, and address 1%) with an average of 41.4%. Meanwhile, the doctor's data information is (name 84%, SIP number 59%, address 81%, telephone number 22%, initials 43%, and date of prescription writing 82%) with an average of 57.8%. It can be concluded that the screening of antihypertensive prescription administration at one of the pharmacies in Bengkulu City is not complete. 
Co-Authors Adinda Frisca Afriyani, Neti Agnes Monica Agung Giri Samudera Ariesa Oktamauri Astuty, Meilinda Windy Aufa, Dzakiyah Della Triananda Devi Novia Eti Lestari Gina Lestari Gina Lestari Gina Lestari, Gina Herlina Illahi, Yolanda Nur Melandika Dwi Sakinah Novia, Devi nurwani purnama aji Ria Khoiriya Sella, Arinda Tri Pramay Sesi Hervitriwita Setya Enti Rikomah Sulita, Herlin Yosa Hadjiansyah Yoserizal Sesar Yuniarti Z., Panti