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All Journal HAYATI Journal of Biosciences Jurnal Veteriner JURNAL KIMIA SAINS DAN APLIKASI Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo Indonesian Journal of Chemistry Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing) Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Sains dan Praktis
Heny Ekowati
Department Of Pharmacy, Faculty Of Health Sciences, Universitas Jenderal Soedirman. Purwokerto (Indonesia)
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Gastroprotective Effect of Galangal, Turmeric and Their Combination on Rats’ Gastric Ulcers Ekowati, Heny; Anwar, Amalia Meisya; Audina, Fuzilestari Nur; Utami, Esti Dyah
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.49741

Abstract

Galangal (AG) and turmeric (CL) have potential gastroprotective activity. Both have been shown to prevent oxidation by scavenging free radicals and blocking oxidative enzymes. This study evaluated the gastroprotective effects of galangal, turmeric, and their combination extract against gastric mucosal lesions induced by ethanol-hydrochloric acid (HCl). The experimental design comprised 5 groups: group I was administered with Tween 80 (1%), and group II was administered ranitidine (50 mg/kgBW) orally. The other three groups were administered AG and CL, and their combination was administered (1:1) (100 mg/200 kg BW) orally for six days. On the 7th day, the rats were induced by ethanol-HCl (1: 1 v/v) 8 mL/KgBW. Six hours later, the rat was sacrificed and dissected for their gastric. Gross ulcer area, lesion length, histology, pH, and ulcer index were observed. There were improvements in pH, lesion score, ulcer index, and curative ratio. The histopathological profile showed ulcer repairment and lowering of neutrophil inflammatory cell infiltration. Statistical analysis showed the potential equivalence of the single and combination treatments in their gastroprotective effects. Galangal, turmeric, and its combination have gastroprotective activities by repair of ulcer and gastric pH, increasing the curative ratio, and decreasing the ulcer index in the rat model.
Co-Authors . Harwoko . Septiyaningsih Ahmad Fawwaz Dafaulhaq Ahmad Fiki Firdaus Ahmad Fiki Firdaus Ahmad Ghifari Ramadhani ANISYAH ACHMAD Anwar, Amalia Meisya Audina, Fuzilestari Nur Budi Rahardjo Devitasari, Arinda DIAH AYU ANDINI Diah Eko Martini Eka Prasasti Nur Rachmani Endriastuti, Nialiana Endah Esti Dyah Utami Eva Vaulina Yulistia Delsy Faradina Qorina Nadzif Febrian Pradana Febrian Pradana Firster Nugroho Fitri Fauziah hayati Fitri Fauziah Hayati Fitriani, Novita Inawanda Hana, Rifa Khairunnisa Hanif Nasiatul Baroroh Hanif Nasiatul Baroroh Hanif Nasiatul Baroroh Harwoko Harwoko Hasyim, Bellia HENDRI WASITO Hendri Wasito HENDRI WASITO Ika Mustikaningtias Indwiani Astuti Irvan Maulana Firdaus Iskandar Sobri Iskandar Sobri Iskandar Sobri KADEK SRI Laksmi Maharani Maryellen, Geeta Masita Wulandari Suryoputri Masita Wulandari Suryoputri Maylani Permata Saputri Mustofa Mustofa Nadzif, Faradina Qorina Nialiana Endah Nur Fatmi Alisah Oktavian, Firdaus Ponco Iswanto Ponco Iswanto Rahman, Brilian Habib Retno Widiastuti Rizky Farihah Sarmoko Sarmoko Septiyaningsih Septiyaningsih Setiawan, Ely Silitonga, Tasya Melinda Suryoputri, Masita Wulandari Trisnowati . Triyadi Hendra Wijaya Tunggul Adi Purwonugroho TUTI EKASARI Undri Rastuti Waluyo, Syaikah Syahidah Warsinah Warsinah Yudhawan, Indra ZULIA HIDAYATI