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All Journal HAYATI Journal of Biosciences Jurnal Veteriner JURNAL KIMIA SAINS DAN APLIKASI Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo Indonesian Journal of Chemistry Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing) Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Sains dan Praktis

Heny Ekowati

Department Of Pharmacy, Faculty Of Health Sciences, Universitas Jenderal Soedirman. Purwokerto (Indonesia)

Author-ID : 258742

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 31 Documents Claim Missing Document

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Cost Analysis of Cancer Side Effects Therapy in Cancer Patients in Rumah Sakit Prof. Dr. Margono Soekarjo Purwokerto Febrian Pradana; Tunggul Adi Purwonugroho; Heny Ekowati
Indonesian Journal of Cancer Chemoprevention Vol 3, No 3 (2012)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev3iss3pp419-425

Cancer is the leading cause of death in Indonesia. Generally, cancer therapy use chemotherapy, radiation, surgery or combination of those. Various side effects caused by cancer therapy make the use of additional drugs. This leads to an increase in total cost incurred to cancer patients. The purpose of this study was to describe the treatment of cancer therapy’s side effects as well as the average cost of side effects treatment, and its percentage in the total cost of cancer patients in Rumah Sakit Margono Soekarjo. This research was a descriptive study with retrospective data by total sampling method obtained from patients’ medical and receipts records of five most common cancers (breast, nasopharynx, Non Hodgkins Lhympoma (NHL), ovarian, and cervix) during January-December 2010. The average cost of patient’s side effects treatment was calculated by the average cost of side effects compared to the average total direct costs incurred to cancer patients. The samples was obtained from the population of 2261 patients who met the inclusion criteria, that are 73 patients consist of 62 female patients and 11 male patients. The most common side effects of cancer therapy were nausea and vomiting (59.80%), nausea-vomiting, anemia, and pain (16.44%), and nausea-vomiting and anemia (15.07%). The most used therapy was vitamin B complex followed by histamine-2 inhibitor. The average cost of side effects for breast cancer was Rp 1,715,373 (8.73%), nasopharynx was Rp 1,149,049 (6.98 %); NHL was Rp 360,778 (1.97 %); ovary was Rp 911,118 (3.61 %) and cervical was Rp 1,416,027 (8.87 %). The results indicated that the hospital needs to pay more attention on nausea-vomiting effect of chemotherapy, and also cervical cancer side effects therapy as the most costly.Keywords: Cost Analysis, Cancer, Side Effects, Prof. Dr. Margono Soekarjo Hospital

Combination of three species of Zingiberaceae prevents doxorubicin-induced hepatotoxicity Heny Ekowati; Sarmoko Sarmoko; Retno Widiastuti
Universa Medicina Vol. 32 No. 1 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.11 - 19

BACKGROUND Doxorubicin as an anticancer drug has hepatotoxic side effects. Curcuma xanthorrhiza, Curcuma longa and Zingiber officinale are commonly used as herbals in Indonesia and around the world. Several compounds in these plants have antioxidant activities and are known to exhibit protection against doxorubicin-induced toxicities. This study aimed to observe the hepatoprotective effect of a combination of C. xanthorriza, C. longa, and Z. officinale extract on doxorubicin-induced hepatotoxicity in rats. METHODS A total of 28 Wistar male rats were divided into four groups: 1) control group (0.9% NaCl); 2) doxorubicin 5 mg/kg intraperitoneally (ip) four times in 14 days (days 1, 5, 9, 13); 3) doxorubicin + combination of C. xanthorriza, C. longa, and Z. officinale (temulawak, kunyit, and jahe merah, designated as Tekuja) 250 mg/kg/day orally for 14 days; and 4) doxorubicin + Tekuja extract 500 mg/kg/day orally for 14 days. Measurements of parameters based on liver histopathology and the parameters of serum alanine amino transferase (ALT) and aspartate amino tranferase (AST). RESULTS Doxorubicin caused significant elevation in serum ALT and AST enzymes after 14 days of treatment. Rats treated with doxorubicin + Tekuja extract 250 mg/kg/ day showed no histological changes, but had decreased levels of ALT and AST. CONCLUSION This study indicates that the combination of C. xanthorriza, C. longa, and Z. officinale has a protective effect in rats against liver damage induced by doxorubicin

Protective effects of Nigella sativa against 7,12-dimethylbenz [á] anthracene (DMBA) induced carcinogenesis in rats Nur Fatmi Alisah; Hanif Nasiatul Baroroh; Heny Ekowati
Universa Medicina Vol. 31 No. 2 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.88-95

BackgroundLiver cancer is the third most common cause of death from cancer worldwide. Recently, natural products have been widely used as an alternative therapy for liver cancer. Previous studies have reported that Nigella sativa has chemopreventive activity in vitro and in vivo. The objective of this study was to evaluate the effect of a chloroform extract of Nigella sativa seeds (NSS) on female rat hepatocytes after administration of 7,12-dimethylbenz [á] anthracene (DMBA). MethodsThe experimental design comprised five groups of rats. Group I (DBMA control group) received oral DMBA at a dosage of 20 mg/kgBW twice weekly for five weeks, while group V (solvent control group) was given corn oil only. The other three groups received DMBA + NSS at dosages of 250 mg/kgBW, 500 mg/kgBW, and 750 mg/kgBW, respectively. Each group consisted 12 rats. The NSS extract dissolved in corn oil was administered daily by the oral route for 2 weeks before and subsequenyly during DMBA tumor induction. At the end of the study, rat livers were collected and stained with hematoxylin and eosin (H&E) and silver staining by the the AgNOR method. ResultsThere was a difference in liver tissue histopathological profile between the NSS, DMBA control, and the solvent control group. AgNOR counts in the DMBA control group, the DMBA+NSS 250 mg/kgBW group, DMBA+NSS 500 mg/kgBW group, and DMBA+NSS 750 mg/kgBW group were 1.79, 1.51, 1.41, and 1.35, respectively. ConclusionNigella sativa seed extract was able to reduce the liver damage and proliferation in rats induced by DMBA administration.

Nigella Sativa’s Protection Against 7,12 Dimethylbenz [A] Anthracene -Induced Colon Carcinogenesis in Rats Heny Ekowati; Firster Nugroho; Iskandar Sobri
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Colon cancer is the third most common cause of death from cancer worldwide. Recently, natural products have been widely used as an alternative therapy for colon cancer. Previous studies have reported that Nigella sativa has chemopreventive activity in vitro and in vivo.This study aimed to evaluate the effect of Nigella sativa seed (NSS) on rat-colon cell after initiation of 7,12-dimethylbenz [a] anthracene. Rats were divided into five groups, 12 rats in each group: Group I was given 7,12dimetilbenz [a] anthracene (DMBA) orally 20 mg/kgBW twice a week for five weeks, group V is the solvent control group was given corn oil. The other three groups were given DMBA + NSS, at the dosage of 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW. NSS extract was dissolved in corn oil and administered daily per oral during the next two weeks before and during the initiation of DMBA. After 16 weeks, all rats were sacrificed. H&E staining showed that necrosis activity was lower in treated groups compared to DMBA group. AgNOR staining showed mAgNOR was significantly decrease following the increasing dose of NSS (250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW) were subsequently 1.62 ± 0.086, 1.60 ± 0.101 and 1.39 ± 0.049 (p<0.05). The results showed that NNS reduce the damage of colon cells and inhibit colon cell proliferation in DMBA induced rats.

Efek Protektif Nigella sativa Terhadap Karsinogenesis Sel Ginjal Tikus yang Diinduksi 7,12-dimetilbenz(a)antrasena (DMBA) DIAH AYU ANDINI; HANIF NASIATUL BAROROH; HENY EKOWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1715.034 KB)

Black cumin (Nigella sativa) is known to have anticancer activity. Previous study showed that chloroform extract of N. sativa, have cytotoxic activity on T47D cell line. The purpose of this study was to determine the antiproliferation activity of chloroform extract N. sativa in female rats induced-DMBA based on histopathologic changes on renal cell of cell proliferation and to observe the optimal concentration of N. sativa as antiproliferative agent. Sprague Dawley strain female rats were divided into live groups. Group 1 was given DMBA 20 mg/kg BW. Group 2, 3, 4, were given DMBA and chloroform extracts of N. sativa with 250; 500; 750 mg kg BW rank dose. Group 5 was given corn oil. Renal cell histopathology was observed by H&E and AgNOR staining. The inhibition of renal cell proliferation was observed with mAgNOR value. mAgNOR data were analyzed using Kolmogorov-Smirnov test, ANOVA and Tukey HSD. The results of H&E and AgNOR staining showed that at a dose of 7 SOmg/kg BW chloroform extract of N. sativa reduced cell damage and inhibit renal cells proliferation with mAgNOR value of 1.069. This result suggest that the chloroform extract of N. sativa had the potential effect as chemopreventive agent.

Drug utilization of N-Acetylcysteine in COVID-19 inpatients at Santa Elisabeth Hospital, Purwokerto Heny Ekowati; Faradina Qorina Nadzif; Masita Wulandari Suryoputri
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5776

Background: COVID-19 is associated to an oxidant-antioxidant imbalance, which leads to inflammation and tissue damage. N-Acetylcysteine (NAC), in addition to being a mucolytic, has been shown to be an effective antioxidant in the therapy of COVID-19. Objective: The purpose of this study is to evaluate at the NAC usage profile in COVID-19 inpatients at Santa Elisabeth Hospital in Purwokerto. Methods: A descriptive observational design was used to perform the study. Retrospective data were obtained from medical records from July 2020 to July 2021. All patients who met the inclusion criteria were sampled using the total sampling technique. Results: NAC was commonly administered to COVID-19 inpatients who have a mild illness of the disease. The most common symptoms were cough and fever. Patients with mild and moderate severity were given NAC orally (600 mg 3 times a day) and intravenously (5 gram/day), respectively. The duration of NAC administration was in the range of 8-14 days. Conclusion: NAC was one of the therapies used at Santa Elisabeth Hospital Purwokerto for COVID-19 inpatients.

THE ACTIVE FRACTION FROM Nigella sativa AND ITS ACTIVITY AGAINST T47D CELL LINE Heny Ekowati; Eka Prasasti; Undri Rastuti
Indonesian Journal of Chemistry Vol 11, No 3 (2011)
Publisher : Universitas Gadjah Mada

Breast cancer is one of the main causes of death in women. Cancer treatment with surgery, chemotherapy, and radiology often cause undesirable side effects. Therefore, alternative cancer treatment by using plants as traditional medicine was expected to reduce side effects. Nigella sativa is one of the plants used as anticancer empirically. This study conducted to examine the cytotoxic activity of Nigella sativa seeds and identify its components on T47D breast cancer cells. Petroleum ether, chloroform, ethyl acetate, and ethanol were used to extract N. sativa seeds. The extracts were tested their cytotoxic activity on T47D cell line using MTT method. The active compound was separated using column chromatography. Cytotoxic test on T47D cell line was perform for extracts of each separation stage. Data were analyzed by probit analysis to obtain IC50 values. Components identification was performed using GC-MS analysis. The results showed that chloroform extract has cytotoxic activity better than other extracts with IC50 of 124.206 µg/mL. The third fraction has cytotoxic activity better than other fractions with IC50 of 68.568 µg/mL. The GC-MS analysis showed that in the third fraction of the chloroform extract contain linoleat acid, the major compound and tryptamine.

ANTICANCER ACTIVITY OF CALANONE ON HeLa CELL LINE Heny Ekowati; Indwiani Astuti; Mustofa Mustofa
Indonesian Journal of Chemistry Vol 10, No 2 (2010)
Publisher : Universitas Gadjah Mada

Calanone (coumarin derivate compound), isolated from Calophyllum sp. had been shown to have cytotoxic activity on leukemia L1210 cell line with IC50 = 59.40 mg/mL. Calanone presumed have anticancer activity on HeLa cervical carcinoma cell. This study was conducted to investigate the cytotoxic and apoptotic activity of calanone and its effect to p53 and p21 expression on HeLa cervical carcinoma cell. Cytotoxic assay of calanone was performed on HeLa cell line, using MTT assay. Apoptotic assay was performed on HeLa cell line incubated with calanone for 24 h, by immunofluororescence method, using fluorochromes ethidium bromide and acridine orange. Expression of p53 was examined on HeLa cell line, by PCR with p53 wild-type primer. Expression of p21 was examined on HeLa cell line, by immunohistochemistry method. 5-fluorourasil was used as positive control in cytotoxic, apoptotic assay, and p53 expression. The result showed that calanone has cytotoxic activity on HeLa cell line, with IC50 = 22.887 mg/mL, caused cytotoxicity through apoptotic mechanism, increase p53 tumor suppressor gene expression, while the p21 expression test showed a negative result.

IMPROVING PKK CADRES LEVEL OF KNOWLEDGE OF ANTIBIOTIC MANAGEMENT THROUGH PHARMACISTS-DELIVERED EDUCATION INTERVENTION IN BOJONGSARI, BANYUMAS Masita Wulandari Suryoputri; Heny Ekowati; Ika Mustikaningtias; Laksmi Maharani; Nialiana Endah
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.4357

The prevalence of infectious diseases in Indonesia is high, so it can increase the use of antibiotics. The use of antibiotics which is around 40-60%. Inaddition to relatively long antibiotic therapy regimen, the lack of public knowledge in the rational use of antibiotics can cause patients to be less the risk of occurrence of antibiotic resistance, this study aims to determine the level of knowledge of PKK Cadres and to determine the level of community knowledge after providing PKK Cadres education with pharmacist assitance on antibiotic management. PKK cadres are the driving force behind village communities to carry out local health programs. The research method is a comparative descriptive with a cross sectional approach using an instrument in the form of a questionnaire and it is carried out before and after the implementation of pharmacist education. Collecting data by purposive sampling. Knowledge data of pretest and posttest were analyzed bivariately. The results of the evaluation of the education process indicated that there was an increase in the knowledge of PKK Caders. The results of pre-test dan post-test average showed increased of knowledge among PKK cadres from 69.28 to 85. The results of Wilcoxon test showed a significant difference in the PKK cadres level knowledge from the pre-test and post-test data of antibiotic management after receiving education from the pharmacist (p<0.005). Providing education on antibiotic management to PKK cadres by pharmacists has increased PKK cadres’ knowledge of antibiotic management. It is hoped that PKK cadres can disseminate this knowledge to the wider community to preventing antibiotic resistance.

Quantitative Structure-Activity Relationship of 3-Thiocyanate-1H-Indoles Derived Compounds as Antileukemia by AM1, PM3, and RM1 Methods Ponco Iswanto; Irvan Maulana Firdaus; Ahmad Fawwaz Dafaulhaq; Ahmad Ghifari Ramadhani; Maylani Permata Saputri; Heny Ekowati
Jurnal Kimia Sains dan Aplikasi Vol 26, No 3 (2023): Volume 26 Issue 3 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.3.109-117

Cancer is a disease with fatal consequences; thus, searching for innovative compounds with anticancer properties remains an active pursuit. One of the highly promising candidates is a compound derived from 3-thiocyanato-1H-indoles. However, the number of derivative compounds is currently limited. A quantitative structure and activity relationship (QSAR) study was conducted on derivate compounds 3-thiocyanato-1H-indoles to establish equations that predict the anticancer activity of more effective derivatives. This study aims to compare the effectiveness of the AM1 (Austin Model 1), PM3 (Parameterized Model 3), and RM1 (Recife Model 1) semiempirical methods, which are new techniques implemented in the Hyperchem version 8.0. Twenty experimental data were used, 16 derivatives of 3-thiocyanate-1H-indoles as regression compounds (fitting) and four derivates as test compounds. QSAR analysis was performed based on multiple linear regression calculations on 3-thiocyanate-1H-indoles derivative compounds by plotting IC50 (µM) as the dependent variable and descriptors as the independent variable. The best QSAR equation was obtained from the AM1 semiempirical calculation method with the following equation: IC50 = -1.705 + 0.511(Delta) + 0.346(Dipol) + 18.287(qC9) – 0.645(Log P) + 13.952(qC6), with n =20; r =0.814; r2 =0.662; The standard error (SE) =1.044; Fcount/Ftable =1.851; PRESS =15.219.

Co-Authors . Harwoko . Septiyaningsih Ahmad Fawwaz Dafaulhaq Ahmad Fiki Firdaus Ahmad Fiki Firdaus Ahmad Ghifari Ramadhani ANISYAH ACHMAD Anwar, Amalia Meisya Audina, Fuzilestari Nur Budi Rahardjo Devitasari, Arinda DIAH AYU ANDINI Diah Eko Martini Eka Prasasti Nur Rachmani Endriastuti, Nialiana Endah Esti Dyah Utami Eva Vaulina Yulistia Delsy Faradina Qorina Nadzif Febrian Pradana Febrian Pradana Firster Nugroho Fitri Fauziah hayati Fitri Fauziah Hayati Fitriani, Novita Inawanda Hana, Rifa Khairunnisa Hanif Nasiatul Baroroh Hanif Nasiatul Baroroh Hanif Nasiatul Baroroh Harwoko Harwoko Hasyim, Bellia HENDRI WASITO Hendri Wasito HENDRI WASITO Ika Mustikaningtias Indwiani Astuti Irvan Maulana Firdaus Iskandar Sobri Iskandar Sobri Iskandar Sobri KADEK SRI Laksmi Maharani Maryellen, Geeta Masita Wulandari Suryoputri Masita Wulandari Suryoputri Maylani Permata Saputri Mustofa Mustofa Nadzif, Faradina Qorina Nialiana Endah Nur Fatmi Alisah Oktavian, Firdaus Ponco Iswanto Ponco Iswanto Rahman, Brilian Habib Retno Widiastuti Rizky Farihah Sarmoko Sarmoko Septiyaningsih Septiyaningsih Setiawan, Ely Silitonga, Tasya Melinda Suryoputri, Masita Wulandari Trisnowati . Triyadi Hendra Wijaya Tunggul Adi Purwonugroho TUTI EKASARI Undri Rastuti Waluyo, Syaikah Syahidah Warsinah Warsinah Yudhawan, Indra ZULIA HIDAYATI

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