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All Journal HAYATI Journal of Biosciences Jurnal Veteriner JURNAL KIMIA SAINS DAN APLIKASI Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo Indonesian Journal of Chemistry Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing) Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Sains dan Praktis
Heny Ekowati
Department Of Pharmacy, Faculty Of Health Sciences, Universitas Jenderal Soedirman. Purwokerto (Indonesia)
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Drug utilization of N-Acetylcysteine in COVID-19 inpatients at Santa Elisabeth Hospital, Purwokerto Ekowati, Heny; Nadzif, Faradina Qorina; Suryoputri, Masita Wulandari
Acta Pharmaciae Indonesia Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5776

Abstract

Background: COVID-19 is associated to an oxidant-antioxidant imbalance, which leads to inflammation and tissue damage. N-Acetylcysteine (NAC), in addition to being a mucolytic, has been shown to be an effective antioxidant in the therapy of COVID-19. Objective: The purpose of this study is to evaluate at the NAC usage profile in COVID-19 inpatients at Santa Elisabeth Hospital in Purwokerto. Methods: A descriptive observational design was used to perform the study. Retrospective data were obtained from medical records from July 2020 to July 2021. All patients who met the inclusion criteria were sampled using the total sampling technique. Results: NAC was commonly administered to COVID-19 inpatients who have a mild illness of the disease. The most common symptoms were cough and fever. Patients with mild and moderate severity were given NAC orally (600 mg 3 times a day) and intravenously (5 gram/day), respectively. The duration of NAC administration was in the range of 8-14 days. Conclusion: NAC was one of the therapies used at Santa Elisabeth Hospital Purwokerto for COVID-19 inpatients.
Selection of semiempirical calculation methods for insecticide development Iswanto, Ponco; Delsy, Eva Vaulina Yulistia; Setiawan, Ely; Ekowati, Heny
Acta Pharmaciae Indonesia Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.7046

Abstract

Background: Insecticides are substances used to control, repel, or eradicate troublesome organisms, particularly insect-based plant pests. The discovery of new insecticide compounds fuels the ongoing development of insecticides. The integration of computational chemistry into the development of insecticidal chemicals was beneficial. Objective: This study aims to identify the most suitable method among 12 available semiempirical calculation methods in the Hyperchem application. Methods: The selection process involved comparing experimental data of the infra-red spectrum of chlorpyrifos with corresponding calculation data. Results: The largest Predicted Residual of Sum Squares (PRESS) value was observed in the INDO method of 55466.3856. Conversely, the smallest PRESS value was observed in the AM1, measuring 3242.6549. The AM1 semiempirical method yields the smallest value. Conclusion: The results indicated that the calculation chosen was the AM1 semiempirical method.
The effectiveness of N-acetylcysteine in alleviating clinical Symptoms of COVID-19 hospitalized patients at Santa Elisabeth Purwokerto General Hospital, Indonesia Ekowati, Heny; Nadzif, Faradina Qorina; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah; Baroroh, Hanif Nasiatul
Acta Pharmaciae Indonesia Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.7548

Abstract

Background: COVID-19 has been associated with increased innate immune system activation, leading to increased mucus production, inflammation, and tissue damage. N-Acetylcystysteine (NAC), an antioxidant and mucolytic, has demonstrated potential as a COVID-19 therapy. Objective: The purpose of this study was to evaluate the effectiveness of NAC on the clinical symptoms of hospitalized COVID-19 patients at Santa Elisabeth Purwokerto General Hospital in Indonesia. Methods: An observational analytical study design was employed, with data collected from the medical records of hospitalized COVID-19 patients at Santa Elisabeth Purwokerto General Hospital over the period of July 2020 to July 2021. The study included 209 patients who met the eligibility criteria. Results: The results indicated that the use of NAC affected the clinical symptoms of cough, oxygen saturation (SPO2), and respiratory rate in patients with mild and moderate degrees of COVID-19 patients (p<0.05). However, it was found not to affect patients with severe degrees of the disease (p>0.05). Conclusion: This study suggests that NAC may be a useful treatment option for patients with mild and moderate COVID-19. Further research is needed to confirm these findings and determine their effectiveness in severe cases.
Anti-inflammatory activity of combination of ethanol extracts of ginger (Zingiber officinale) and bangle (Zingiber cassumunar) in carrageenan-induced rats Hasyim, Bellia; Yudhawan, Indra; Ekowati, Heny; Rachmani, Eka Prasasti Nur
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.11548

Abstract

Background: Inflammation is an essential innate immune response aimed at antigen elimination and preventing their spread. Ginger (Zingiber officinale) and bangle (Zingiber cassumunar) rhizomes have been empirically utilized as medicinal components due to their anti-inflammatory potential. However, the combined efficacy of these rhizomes has not been previously explored. Objective: This study aimed to assess the anti-inflammatory activity of a combination of ginger and bangle rhizome extracts. Method: Ginger and bangle rhizomes were individually subjected to extraction through maceration with 96% ethanol, followed by purification with n-hexane. The anti-inflammatory activity was evaluated via motility tests on subjects administered orally with 1% CMC-Na (control), diclofenac sodium (4.5 mg/kg body weight), ginger ethanol extract (200 mg/kg body weight), bangle ethanol extract (400 mg/kg body weight), and a combination of both extracts (100:200 mg/kg body weight). Observations were made over 6 hours, with motility scores subsequently analyzed using ANOVA and the LSD test for statistical significance. Results: Treatments involving ginger extract, bangle extract, and their combination significantly improved motility scores compared to the negative control. Furthermore, these treatments displayed no significant difference in effectiveness compared to the diclofenac sodium group (p > 0.05). Conclusion: The combined ethanol extracts of ginger and bangle rhizomes demonstrate anti-inflammatory activity comparable to diclofenac sodium, as evidenced by motility score evaluations. This suggests their potential as alternative anti-inflammatory agents.
HUBUNGAN USIA, PARITAS, DAN JARAK KEHAMILAN TERHADAP KEJADIAN PREEKLAMSIA PADA IBU HAMIL DI PUSKESMAS SUGIO: The Relationship between Age, Parity, and Pregnancy Distance on the Incidence of Preeclampsia in Pregnant Women at the Sugio Community Health Center Rahman, Brilian Habib; Martini, Diah Eko; Ekowati, Heny
Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing) Vol. 10 No. 3 (2024): JiKep | Oktober 2024
Publisher : UPPM STIKES Pemkab Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33023/jikep.v10i3.2294

Abstract

Pendahuluan: Kejadian Preeklampsia merupakan keadaan meningkatnya tekanan darah wanita hamil diatas 140/110 mmHg disertai proteinuria pada usia kehamilan 20 minggu atau lebih pada ibu hamil di Puskesmas Sugio Kabupaten Lamongan pada tahun 2023. Tujuan: mengidentifikasi Adakah Hubungan usia, paritas, dan jarak kehamilan terhadap kejadian preeklamsia. Metode: Desain penelitian ini adalah kuantitatif dengan pendekatan analitic korelasi, populasi sebanyak  ibu hamil pada 2023, menggunakan total sampling didapatkan sebanyak 248 ibu ibu hamil yang tercatat di rekam medik. dengan menggunakan uji chi square dengan tingkat kemaknaan p=<0,05. Hasil: penelitian ini menunjukkan bahwa dari ibu hamil usia resiko rendah sebagian besar tidak terjadi preeklamsia sebanyak (80,5%). Hasil penelitian juga bahwa dari paritas ibu hamil primipara sebagian besar tidak terjadi preeklamsia atau sebanyak 87,4%, dan hasil penelitian ini menunjukkan bahwa dari ibu hamil dengan jarak kehamilan <2 tahun sebagian besar tidak terjadi preeklamsia atau sebanyak 83,6%. Sedangkan dari hasil uji statistik diperoleh nilai usia p=0,00, paritas p=0,00, jarak kehamilan p=0,00 dengan nilai dengan nilai odds ratio 0,298 pada usia, 0,759 pada paritas dan 0,425 pada jarak kehamilan artinya ada hubungan usia, paritas, dan jarak kehamilan terhadap kejadian preeklamsia di Puskesmas Sugio Kabupaten Lamongan dengan tingkat hubungan yang cukup kuat. Kesimpulan: Secara keseluruhan, pengaturan usia kehamilan, memperhatikan paritas, dan jarak antar kehamilan yang optimal dapat membantu mengurangi risiko kejadian preeklamsia. Oleh karena itu, penting bagi calon ibu hamil untuk berkonsultasi dengan tenaga medis guna merencanakan kehamilan yang sehat dan mengurangi risiko komplikasi
Therapeutic Effects of Methylprednisolone on Clinical Symptoms in COVID-19 Patients at Dr. R. Goeteng Taroenadibrata Hospital Baroroh, Hanif Nasiatul; Hana, Rifa Khairunnisa; Ekowati, Heny
Indonesian Journal of Clinical Pharmacy Vol 13, No 1 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.1.1

Abstract

COVID-19 is a respiratory syndrome disease in humans caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Until now, treatment for COVID-19 has not been found. This study aimed to observed a therapeutic effect of methylprednisolone in COVID-19 patients. Medical records of COVID-19 patients at Dr. R. Goeteng Taroenadibrata Purbalingga Hospital were collected retrospectively as part of this descriptive observational study from October 2020 to September 2021. Utilizing the Wilcoxon and Sign Test, a statistical analysis was conducted to determine the therapeutic effect of methylprednisolone on variables such as temperature, respiratory rate, oxygen saturation, cough, and shortness of breath. A total of 132 patients met the inclusion criteria, with 87 patients in mild severity, 22 patients with moderate severity, and 23 patients with severe severity. The clinical symptoms of cough, dyspnea, RR values, and SpO2 improved when methylprednisolone was given to mild COVID-19 patients receiving treatment at RSUD Dr. R. Goeteng Taroenadibrata Purbalingga. Additionally, clinical symptoms related to cough, SpO2, and temperature parameters improved in patients with moderate severity; in contrast, breathlessness, respiratory distress, SpO2, and temperature parameters improved in patients with severe severity. In conclusion, Goeteng Taroenadibrata Hospital COVID-19 patients report improved clinical symptoms when receiving methylprednisolone.
Immunostimulatory Effects of Zingiber ottensii Rhizome Extract on Mouse Lymphocytes and Peritoneal Macrophages Baroroh, Hanif Nasiatul; Warsinah, Warsinah; Suryoputri, Masita Wulandari; Ekowati, Heny
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95105

Abstract

Zingiber ottensii (bangle hantu) is a member of the Zingiberaceae family, known for its pharmacological effects. Several studies have demonstrated immunomodulatory potential of Zingiberaceae rhizomes, including Zingiber officinale, Zingiber zerumbet, and Zingiber cassumunar. This study aimed to evaluate the immunomodulatory effects of Z. ottensii extract on mouse peritoneal macrophages and lymphocytes. The extract was prepared using a maceration method with 96% ethanol (1:6) and the extract compound was observed by phytochemical screening with thin layer chromatography (TLC). Phagocytotic macrophage activity was quantified using a phagocytotic assay, which use mouse peritoneal macrophages. Lymphocyte proliferation was assessed with the MTT assay and absorbance measured at 595 nm. TLC results, showed that Z. ottensii extract tested positive for flavonoids and terpenoids. The Z. ottensii extract stimulated macrophage phagocytosis activity, significantly increasing the phagocytotic index at 25 and 50 µg/mL concentrations compared to the control. Additionally, significant lymphocyte proliferation was observed with the treatment of the extract. The Z. ottensii extract may be developed for adjuvant therapy to enhance the immune responses, offering a promising natural approach to immunomodulation.
Hepatoprotective effects of celery in diethylene glycol induced toxicity in rats Ekowati, Heny; Waluyo, Syaikah Syahidah; Endriastuti, Nialiana Endah
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.172-180

Abstract

Background Diethylene glycol (DEG) is a contaminant in pharmaceutical solvents and potentially induces hepatotoxicity. Celery is hepatoprotective due to its antioxidant properties. The objective of this study was to evaluate the hepatoprotective effects of celery on DEG-induced liver injury in rats. Methods An experimental laboratory study was conducted involving 25 male Wistar rats weighing 200 grams. They were randomized into five groups (5 rats in each group). Group A served as the control group, while Group B received oral administration of DEG at a dose of 3 g/kg BW twice daily for three days, following six days of food and water administration. The other three groups received DEG at 3 g/kg BW following six days of celery extract once daily administration of 100 mg/kg BW (C), 200 mg/kg BW (D), and 400 mg/kg BW (E). After 14 days, all rats were sacrificed. Observations were conducted macroscopically and microscopically using H&E staining. Liver damage was scored, Kruskal-Wallis followed by the Mann-Whitney was used to analyze the data. Results Macroscopic and microscopic examinations of the liver tissue in the celery groups revealed normal histological architecture with a significant reduction in liver damage. The ethanol extract of celery demonstrated hepatoprotective effects, as evidenced by a statistically significant reduction (p<0.05) in the activation of Kupffer cells, sinusoidal dilation, hepatocyte degeneration, and necrosis. Conclusion Celery has a protective effect against DEG-induced liver damage in rats based on the reduction in Kupffer cell activation, sinusoidal dilation, hepatocyte degeneration, and necrosis.
Nephroprotective effect and untargeted metabolomic analysis of celery extract against diethylene glycol induced nephrotoxicity in rats Wijaya, Triyadi Hendra; Ekowati, Heny; Wasito, Hendri; Maryellen, Geeta; Silitonga, Tasya Melinda; Oktavian, Firdaus
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.190-200

Abstract

Background Diethylene glycol (DEG) is known for its nephrotoxic effects as a contaminant. Recent investigations suggest that celery extract potentially protects against DEG-induced renal toxicity, warranting an exploration of the non-targeted metabolomic profile of celery in renal tissue. This study aimed to determine celery nephroprotective effects and identify potential biomarkers using an untargeted metabolomic  celery profile in DEG-induced kidney injury in male rats. Methods An experimental study was conducted involving 24 male Wistar rats, randomized into control and three treatment groups receiving DEG at doses of 1, 3, and 5 g/BW for three days. After 14 days, all rats were sacrificed. For the celery nephroprotective and metabolomic study, 27 male rats were randomized into three groups:  control, DEG group at 3g/BW, and DEG-celery group (receiving celery extract 200mg/kg BW single dose for 6 days). After 14 days, blood was tested for creatinine level and untargeted metabolomic analysis using liquid chromatography-high resolution mass spectrometry. One-way ANOVA was used to analyze creatinine data. Results Diethylene glycol at doses of 1 and 3 g/kg BW caused mild renal damage, while 5 g/kg BW resulted in moderate damage. Creatinine levels in the normal, DEG-induced, and DEG-celery groups were 0.55 ± 0.14, 0.71±0.1, and 0.86± 0.17 mg/dL, respectively, but not statistically significantly different between groups (p>0.05). DEG lead tryptophan and phenylalanine levels increased 45-fold and 123-fold, respectively. Celery reduced levels of these metabolites 21-fold and 65-fold, respectively. Conclusion Diethylene glycol led to mild to moderate renal damage. Celery effectively diminished metabolite levels associated with renal damage, specifically tryptophan and phenylalanine.
Nephroprotective and Hepatoprotective Effects of Turmeric in Diethylene Glycol Induced Toxicity in Rats Ekowati, Heny; Devitasari, Arinda; Fitriani, Novita Inawanda; Endriastuti, Nialiana Endah; Wijaya, Triyadi Hendra
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95225

Abstract

In 2022, children in Indonesia experienced acute renal failure due to antipyretic syrup contaminated with diethylene glycol (DEG). DEG is a known contaminant in pharmaceutical solvents that can induce inflammation and act as a free radical, leading to kidney and liver damage. Turmeric (Curcuma Longa) has been reported to have nephroprotective and hepatoprotective effects due to anti-inflammatory and antioxidant properties. This study aims to evaluate the protective effects of turmeric ethanol extract on rat kidneys and liver subjected to DEG toxicity. Rats were divided into five groups (n=5 per group): Group I served as the normal control, while Group II received DEG orally at 3 g/kg BW twice daily for three days. Groups III, IV, and V were treated with DEG (3 g/kg BW) along with turmeric ethanol extract at a doses of 100, 200, and 400 mg/kg BW, respectively, administered orally twice daily for six days. After 14 days, all rats were sacrificed for macroscopic and microscopic evaluation using hematoxylin-eosin (H&E) staining. The results showed that rats treated with turmeric extract exhibited significantly significantly less kidney and liver damage (p<0.05). Kidney protection was evidenced by improvements in endothelial tissue, glomeruli, and tubules, while liver protection was indicated by reduced Kupffer cell activation, sinusoidal dilatation, hepatocyte degeneration, and necrosis. In conclusion, turmeric ethanol extract effectively protects against DEG-induced kidney and liver toxicity in rats.
Co-Authors . Harwoko . Septiyaningsih Ahmad Fawwaz Dafaulhaq Ahmad Fiki Firdaus Ahmad Fiki Firdaus Ahmad Ghifari Ramadhani ANISYAH ACHMAD Anwar, Amalia Meisya Audina, Fuzilestari Nur Budi Rahardjo Devitasari, Arinda DIAH AYU ANDINI Diah Eko Martini Eka Prasasti Nur Rachmani Endriastuti, Nialiana Endah Esti Dyah Utami Eva Vaulina Yulistia Delsy Faradina Qorina Nadzif Febrian Pradana Febrian Pradana Firster Nugroho Fitri Fauziah hayati Fitri Fauziah Hayati Fitriani, Novita Inawanda Hana, Rifa Khairunnisa Hanif Nasiatul Baroroh Hanif Nasiatul Baroroh Hanif Nasiatul Baroroh Harwoko Harwoko Hasyim, Bellia HENDRI WASITO Hendri Wasito HENDRI WASITO Ika Mustikaningtias Indwiani Astuti Irvan Maulana Firdaus Iskandar Sobri Iskandar Sobri Iskandar Sobri KADEK SRI Laksmi Maharani Maryellen, Geeta Masita Wulandari Suryoputri Masita Wulandari Suryoputri Maylani Permata Saputri Mustofa Mustofa Nadzif, Faradina Qorina Nialiana Endah Nur Fatmi Alisah Oktavian, Firdaus Ponco Iswanto Ponco Iswanto Rahman, Brilian Habib Retno Widiastuti Rizky Farihah Sarmoko Sarmoko Septiyaningsih Septiyaningsih Setiawan, Ely Silitonga, Tasya Melinda Suryoputri, Masita Wulandari Trisnowati . Triyadi Hendra Wijaya Tunggul Adi Purwonugroho TUTI EKASARI Undri Rastuti Waluyo, Syaikah Syahidah Warsinah Warsinah Yudhawan, Indra ZULIA HIDAYATI